ENSG00000172830

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308127 ENSG00000172830 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH3 protein_coding protein_coding 6.901828 11.63035 4.83831 0.796071 0.3400875 -1.263581 3.5469065 7.4009809 2.0424360 0.65181284 0.33789979 -1.8523273 0.47936250 0.63490000 0.41670000 -0.21820000 0.001875039 0.001875039 FALSE TRUE
ENST00000376757 ENSG00000172830 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH3 protein_coding protein_coding 6.901828 11.63035 4.83831 0.796071 0.3400875 -1.263581 0.6400069 0.8295513 0.4900181 0.04895688 0.15065158 -0.7476381 0.09945833 0.07250000 0.10566667 0.03316667 0.797185311 0.001875039 FALSE TRUE
ENST00000529224 ENSG00000172830 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH3 protein_coding processed_transcript 6.901828 11.63035 4.83831 0.796071 0.3400875 -1.263581 0.3207457 0.2563574 0.1673974 0.08909589 0.04562581 -0.5863782 0.05030417 0.02116667 0.03530000 0.01413333 0.636634550 0.001875039 FALSE FALSE
ENST00000531495 ENSG00000172830 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH3 protein_coding processed_transcript 6.901828 11.63035 4.83831 0.796071 0.3400875 -1.263581 0.5539272 0.5567423 0.6618801 0.08015244 0.37770375 0.2455108 0.09002083 0.04836667 0.12830000 0.07993333 0.461598183 0.001875039 FALSE FALSE
ENST00000534112 ENSG00000172830 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH3 protein_coding processed_transcript 6.901828 11.63035 4.83831 0.796071 0.3400875 -1.263581 0.3766930 0.3624770 0.4126392 0.15579223 0.11566046 0.1822750 0.06593333 0.02970000 0.08933333 0.05963333 0.278983394 0.001875039   FALSE
MSTRG.5808.1 ENSG00000172830 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH3 protein_coding   6.901828 11.63035 4.83831 0.796071 0.3400875 -1.263581 1.0194865 1.5829576 0.5939069 0.18033862 0.21332722 -1.3993097 0.14231667 0.13960000 0.12463333 -0.01496667 0.871924067 0.001875039 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172830 E001 0.1451727 0.0425396076 0.1398248552   11 67303449 67303477 29 + 0.201 0.000 -10.795
ENSG00000172830 E002 0.1451727 0.0425396076 0.1398248552   11 67303478 67303479 2 + 0.201 0.000 -13.530
ENSG00000172830 E003 4.1933112 0.0039570773 0.1624604293 0.2783518368 11 67303480 67303529 50 + 0.799 0.589 -0.879
ENSG00000172830 E004 22.9715138 0.0417577475 0.7269378272 0.8198319486 11 67303530 67303625 96 + 1.310 1.280 -0.102
ENSG00000172830 E005 26.2770776 0.0405739914 0.8811158557 0.9277879552 11 67303626 67303691 66 + 1.346 1.342 -0.013
ENSG00000172830 E006 4.4965415 0.1647067690 0.3251094233 0.4685365596 11 67303709 67304048 340 + 0.800 0.604 -0.814
ENSG00000172830 E007 6.2247674 0.0027731065 0.2172401754 0.3470607044 11 67304049 67304117 69 + 0.906 0.740 -0.650
ENSG00000172830 E008 16.6216225 0.0434575857 0.8524175803 0.9085559459 11 67304118 67304122 5 + 1.162 1.151 -0.039
ENSG00000172830 E009 26.1807721 0.0282631675 0.5565133902 0.6851384656 11 67304123 67304155 33 + 1.389 1.330 -0.205
ENSG00000172830 E010 20.4188447 0.0251090366 0.4175294715 0.5608635329 11 67304773 67304776 4 + 1.310 1.222 -0.308
ENSG00000172830 E011 73.3319401 0.0035734566 0.1742161000 0.2936650161 11 67304777 67305007 231 + 1.829 1.757 -0.244
ENSG00000172830 E012 59.8541013 0.0061882937 0.8320845369 0.8947553066 11 67306838 67306962 125 + 1.671 1.687 0.055
ENSG00000172830 E013 5.9013015 0.0336371889 0.0467128711 0.1033157431 11 67306963 67307041 79 + 0.966 0.667 -1.178
ENSG00000172830 E014 38.6502198 0.0005967013 0.5337864854 0.6659175955 11 67307042 67307113 72 + 1.531 1.490 -0.140
ENSG00000172830 E015 47.9209299 0.0004968144 0.0428751305 0.0963151671 11 67307371 67307436 66 + 1.682 1.566 -0.394
ENSG00000172830 E016 26.0847297 0.0011977819 0.1856268420 0.3082775071 11 67307549 67307572 24 + 1.420 1.318 -0.354
ENSG00000172830 E017 31.8854555 0.0006476779 0.1117072267 0.2080659809 11 67307573 67307656 84 + 1.508 1.397 -0.381
ENSG00000172830 E018 34.7785196 0.0007327976 0.5985606963 0.7201224906 11 67307657 67307737 81 + 1.491 1.455 -0.124
ENSG00000172830 E019 2.5380485 0.0312701724 0.6785136850 0.7829690758 11 67307738 67307845 108 + 0.526 0.450 -0.375
ENSG00000172830 E020 43.7969188 0.0005456299 0.7631074666 0.8465531450 11 67307846 67307906 61 + 1.574 1.555 -0.063
ENSG00000172830 E021 31.5215867 0.0007060912 0.2993276575 0.4408397096 11 67307907 67307939 33 + 1.357 1.436 0.271
ENSG00000172830 E022 56.7174147 0.0004696328 0.6515930202 0.7624274608 11 67308174 67308302 129 + 1.687 1.663 -0.083
ENSG00000172830 E023 40.3856390 0.0067108040 0.2799544618 0.4197555455 11 67308412 67308458 47 + 1.587 1.512 -0.257
ENSG00000172830 E024 5.1888830 0.0055101072 0.0001011604 0.0005272224 11 67309230 67309396 167 + 1.064 0.547 -2.071
ENSG00000172830 E025 59.8952817 0.0064574315 0.6174917628 0.7352850635 11 67309397 67309543 147 + 1.665 1.700 0.118
ENSG00000172830 E026 77.1822194 0.0004005920 0.0259959161 0.0639391399 11 67309768 67309968 201 + 1.703 1.814 0.376
ENSG00000172830 E027 53.6644832 0.0042952665 0.5628940374 0.6904497740 11 67310066 67310163 98 + 1.607 1.645 0.129
ENSG00000172830 E028 76.6171584 0.0059965722 0.5718425094 0.6980723492 11 67310164 67310303 140 + 1.764 1.799 0.117
ENSG00000172830 E029 45.6657273 0.0033970819 0.3577908009 0.5022034560 11 67310304 67310339 36 + 1.523 1.587 0.217
ENSG00000172830 E030 52.7467516 0.0005097790 0.5638449949 0.6912492250 11 67311591 67311624 34 + 1.607 1.640 0.114
ENSG00000172830 E031 53.7007963 0.0006545875 0.8774357515 0.9252650696 11 67311625 67311663 39 + 1.649 1.640 -0.029
ENSG00000172830 E032 200.4887880 0.0028462113 0.0363606028 0.0842700979 11 67311664 67312382 719 + 2.144 2.223 0.264
ENSG00000172830 E033 46.0559472 0.0005646421 0.0058190593 0.0181358096 11 67312383 67312607 225 + 1.430 1.612 0.626