ENSG00000172795

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389063 ENSG00000172795 HEK293_OSMI2_2hA HEK293_TMG_2hB DCP2 protein_coding protein_coding 11.79654 4.048379 20.01021 0.7169537 2.031193 2.302482 4.5502578 2.240620853 6.370087 0.231712918 0.42251210 1.5032531 0.49090417 0.567166667 0.32230000 -0.24486667 1.525131e-03 3.072299e-09 FALSE TRUE
ENST00000504961 ENSG00000172795 HEK293_OSMI2_2hA HEK293_TMG_2hB DCP2 protein_coding processed_transcript 11.79654 4.048379 20.01021 0.7169537 2.031193 2.302482 1.1691618 1.326394867 1.600961 0.187993208 0.15128248 0.2695754 0.16037083 0.331400000 0.08223333 -0.24916667 3.072299e-09 3.072299e-09   FALSE
ENST00000510046 ENSG00000172795 HEK293_OSMI2_2hA HEK293_TMG_2hB DCP2 protein_coding retained_intron 11.79654 4.048379 20.01021 0.7169537 2.031193 2.302482 1.2798118 0.000000000 3.580214 0.000000000 1.95359080 8.4879261 0.05927083 0.000000000 0.16150000 0.16150000 3.290634e-01 3.072299e-09 FALSE FALSE
ENST00000513585 ENSG00000172795 HEK293_OSMI2_2hA HEK293_TMG_2hB DCP2 protein_coding protein_coding 11.79654 4.048379 20.01021 0.7169537 2.031193 2.302482 0.5804225 0.009219605 1.285717 0.009219605 0.06685811 6.0750283 0.03438333 0.002900000 0.06623333 0.06333333 2.564073e-05 3.072299e-09 FALSE TRUE
ENST00000515408 ENSG00000172795 HEK293_OSMI2_2hA HEK293_TMG_2hB DCP2 protein_coding protein_coding 11.79654 4.048379 20.01021 0.7169537 2.031193 2.302482 1.8147760 0.027790841 3.989229 0.027790841 0.60169185 6.7255413 0.09931250 0.007966667 0.20786667 0.19990000 6.595635e-06 3.072299e-09 FALSE TRUE
ENST00000674880 ENSG00000172795 HEK293_OSMI2_2hA HEK293_TMG_2hB DCP2 protein_coding nonsense_mediated_decay 11.79654 4.048379 20.01021 0.7169537 2.031193 2.302482 1.2652165 0.007285936 1.799532 0.007285936 0.52851795 6.7098741 0.06727500 0.002300000 0.08630000 0.08400000 2.044339e-04 3.072299e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172795 E001 0.000000       5 112976702 112976709 8 +      
ENSG00000172795 E002 2.866040 0.0224330586 1.344471e-01 2.403455e-01 5 112976710 112976753 44 + 0.509 0.268 -1.382
ENSG00000172795 E003 3.493758 0.0083863486 2.562573e-01 3.932218e-01 5 112976754 112976761 8 + 0.557 0.433 -0.606
ENSG00000172795 E004 8.022087 0.0020460394 1.294804e-02 3.579042e-02 5 112976762 112976793 32 + 0.857 0.552 -1.274
ENSG00000172795 E005 10.981252 0.0015404992 2.931711e-03 1.006258e-02 5 112976794 112976797 4 + 0.980 0.645 -1.324
ENSG00000172795 E006 15.122903 0.0011690097 2.196281e-04 1.048005e-03 5 112976798 112976812 15 + 1.111 0.722 -1.478
ENSG00000172795 E007 45.344191 0.0005818688 1.061391e-05 7.012040e-05 5 112976813 112976941 129 + 1.548 1.349 -0.685
ENSG00000172795 E008 42.757089 0.0069227642 3.104417e-02 7.400374e-02 5 112976942 112976986 45 + 1.505 1.465 -0.138
ENSG00000172795 E009 6.491001 0.0073196524 2.854407e-01 4.257609e-01 5 112981042 112981171 130 + 0.696 0.979 1.105
ENSG00000172795 E010 27.121953 0.0008141030 2.036553e-21 1.532243e-19 5 112983974 112984651 678 + 1.062 1.856 2.749
ENSG00000172795 E011 50.493858 0.0161863141 2.305728e-08 2.656853e-07 5 112985835 112985937 103 + 1.613 1.115 -1.737
ENSG00000172795 E012 41.575425 0.0106640708 3.605100e-07 3.281012e-06 5 112985938 112985986 49 + 1.527 1.113 -1.445
ENSG00000172795 E013 0.147249 0.0449705989 1.000000e+00   5 112985987 112986010 24 + 0.051 0.000 -7.119
ENSG00000172795 E014 59.747419 0.0003807108 2.406104e-15 8.659369e-14 5 112992121 112992248 128 + 1.686 1.191 -1.709
ENSG00000172795 E015 44.680058 0.0005275324 9.516606e-10 1.416477e-08 5 112992672 112992770 99 + 1.557 1.166 -1.360
ENSG00000172795 E016 0.147249 0.0449705989 1.000000e+00   5 112993106 112993173 68 + 0.051 0.000 -7.119
ENSG00000172795 E017 31.377123 0.0006213105 9.228867e-07 7.716738e-06 5 113001084 113001125 42 + 1.405 1.051 -1.252
ENSG00000172795 E018 49.228321 0.0027430020 8.866491e-07 7.447593e-06 5 113001126 113001236 111 + 1.588 1.332 -0.880
ENSG00000172795 E019 48.465861 0.0007961631 1.939402e-08 2.268092e-07 5 113001357 113001469 113 + 1.586 1.277 -1.067
ENSG00000172795 E020 53.236827 0.0014929185 7.072425e-09 8.967003e-08 5 113001567 113001674 108 + 1.626 1.315 -1.072
ENSG00000172795 E021 58.767135 0.0003876539 5.160479e-13 1.325430e-11 5 113003942 113004077 136 + 1.674 1.257 -1.436
ENSG00000172795 E022 47.785523 0.0024837648 1.290021e-05 8.351805e-05 5 113007938 113008042 105 + 1.570 1.366 -0.705
ENSG00000172795 E023 1.186651 0.0603494720 6.045767e-01 7.250556e-01 5 113008043 113008307 265 + 0.242 0.431 1.189
ENSG00000172795 E024 41.639064 0.0014108734 3.669215e-05 2.134153e-04 5 113010756 113010807 52 + 1.512 1.315 -0.680
ENSG00000172795 E025 50.677597 0.0065159802 5.164488e-05 2.899469e-04 5 113013321 113013392 72 + 1.595 1.396 -0.684
ENSG00000172795 E026 60.490620 0.0036646695 6.237695e-13 1.582368e-11 5 113013393 113013536 144 + 1.691 1.214 -1.645
ENSG00000172795 E027 1325.964811 0.0015728809 1.580317e-01 2.725112e-01 5 113013537 113020344 6808 + 2.948 3.111 0.540
ENSG00000172795 E028 262.223430 0.0181224088 2.378921e-19 1.415006e-17 5 113020345 113022195 1851 + 2.065 2.779 2.383