ENSG00000172785

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314367 ENSG00000172785 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD1 protein_coding protein_coding 34.11768 21.38319 47.80522 1.064058 1.171185 1.160318 0.5066936 1.8728060 0.4605194 1.0191213 0.4605194 -2.0005581 0.01651667 0.08503333 0.00960000 -0.07543333 0.3984500349 0.0004817095 FALSE  
ENST00000356521 ENSG00000172785 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD1 protein_coding protein_coding 34.11768 21.38319 47.80522 1.064058 1.171185 1.160318 2.3229206 0.4291663 3.8755068 0.1485103 0.3423730 3.1452634 0.05819167 0.01956667 0.08103333 0.06146667 0.0004817095 0.0004817095 FALSE  
ENST00000377400 ENSG00000172785 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD1 protein_coding protein_coding 34.11768 21.38319 47.80522 1.064058 1.171185 1.160318 0.8469098 2.7615019 0.0000000 1.3813558 0.0000000 -8.1145242 0.03323333 0.13020000 0.00000000 -0.13020000 0.0943004960 0.0004817095 FALSE  
ENST00000382447 ENSG00000172785 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD1 protein_coding protein_coding 34.11768 21.38319 47.80522 1.064058 1.171185 1.160318 13.5501301 8.1411315 19.1260431 0.8648567 3.1985171 1.2312203 0.38872083 0.38606667 0.39726667 0.01120000 0.9862882436 0.0004817095 FALSE  
MSTRG.32303.1 ENSG00000172785 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD1 protein_coding   34.11768 21.38319 47.80522 1.064058 1.171185 1.160318 7.1497838 3.0011611 10.9711588 1.5604551 0.9279622 1.8666385 0.20633750 0.13390000 0.23070000 0.09680000 0.7174203087 0.0004817095 TRUE  
MSTRG.32303.20 ENSG00000172785 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD1 protein_coding   34.11768 21.38319 47.80522 1.064058 1.171185 1.160318 2.3512298 1.7441452 3.4575923 0.9546029 0.6550863 0.9831661 0.07901667 0.08640000 0.07173333 -0.01466667 0.9258195833 0.0004817095 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172785 E001 1.0276467 0.2430250243 7.948137e-01 8.689296e-01 9 119842 119973 132 - 0.285 0.365 0.503
ENSG00000172785 E002 3.5461986 0.0043794776 3.640955e-04 1.635064e-03 9 120837 121040 204 - 0.804 0.163 -3.562
ENSG00000172785 E003 0.2903454 0.3575367331 5.714972e-01   9 121041 121051 11 - 0.166 0.000 -11.965
ENSG00000172785 E004 0.2903454 0.3575367331 5.714972e-01   9 121052 121057 6 - 0.166 0.000 -11.965
ENSG00000172785 E005 0.2903454 0.3575367331 5.714972e-01   9 121058 121059 2 - 0.166 0.000 -11.965
ENSG00000172785 E006 0.4720498 0.2646204007 9.714119e-01 9.861337e-01 9 121060 121078 19 - 0.166 0.163 -0.029
ENSG00000172785 E007 0.9890372 0.0128026626 4.265241e-01 5.693490e-01 9 121079 121088 10 - 0.230 0.373 0.963
ENSG00000172785 E008 1.1707416 0.0139517955 2.169810e-01 3.467721e-01 9 121089 121090 2 - 0.230 0.450 1.378
ENSG00000172785 E009 5.5322163 0.0033069303 4.133228e-06 2.995630e-05 9 121091 121223 133 - 0.491 1.091 2.434
ENSG00000172785 E010 4.7853631 0.0044988960 9.847261e-07 8.181450e-06 9 121224 121245 22 - 0.380 1.058 2.898
ENSG00000172785 E011 22.3113922 0.0014097413 3.730530e-01 5.174911e-01 9 121246 121406 161 - 1.337 1.406 0.239
ENSG00000172785 E012 11.8540939 0.0014834451 1.884627e-02 4.899667e-02 9 121407 121408 2 - 1.182 0.940 -0.882
ENSG00000172785 E013 11.8551380 0.0016017858 3.641157e-02 8.436552e-02 9 121409 121409 1 - 1.176 0.962 -0.776
ENSG00000172785 E014 11.5647927 0.0014944581 5.119586e-02 1.112808e-01 9 121410 121410 1 - 1.162 0.962 -0.727
ENSG00000172785 E015 13.0618491 0.0013671172 1.616220e-02 4.308381e-02 9 121411 121411 1 - 1.221 0.983 -0.857
ENSG00000172785 E016 23.4648459 0.0197855946 7.799577e-02 1.562480e-01 9 121412 121417 6 - 1.441 1.267 -0.608
ENSG00000172785 E017 163.3326167 0.0007110082 1.051764e-02 3.001792e-02 9 121418 121502 85 - 2.175 2.253 0.260
ENSG00000172785 E018 156.8415039 0.0004140832 3.576823e-03 1.194673e-02 9 121503 121573 71 - 2.155 2.241 0.290
ENSG00000172785 E019 1.6135328 0.0139386860 3.099048e-01 4.522495e-01 9 121574 121960 387 - 0.336 0.515 0.962
ENSG00000172785 E020 113.5783942 0.0006812872 1.787130e-05 1.120932e-04 9 121961 122090 130 - 1.988 2.138 0.503
ENSG00000172785 E021 1.1833147 0.0682110932 9.005960e-01 9.405814e-01 9 122091 122136 46 - 0.336 0.371 0.209
ENSG00000172785 E022 2.9409735 0.0378462565 9.254480e-02 1.790987e-01 9 122137 122690 554 - 0.457 0.743 1.283
ENSG00000172785 E023 0.4782907 0.0211413393 2.214808e-02 5.598398e-02 9 122691 122842 152 - 0.000 0.373 13.920
ENSG00000172785 E024 1.7221738 0.0309720452 8.768472e-01 9.249534e-01 9 122843 123216 374 - 0.420 0.449 0.155
ENSG00000172785 E025 24.7562159 0.0173595432 3.225284e-03 1.093079e-02 9 123217 123282 66 - 1.277 1.556 0.964
ENSG00000172785 E026 21.1435015 0.0012353419 1.987116e-01 3.245750e-01 9 123386 123454 69 - 1.299 1.399 0.349
ENSG00000172785 E027 0.5138669 0.0212194628 1.000000e+00 1.000000e+00 9 123455 123747 293 - 0.166 0.163 -0.035
ENSG00000172785 E028 26.0000490 0.0176404779 2.623594e-01 4.001482e-01 9 134979 135030 52 - 1.378 1.487 0.375
ENSG00000172785 E029 16.5115742 0.0059242098 3.562327e-01 5.006245e-01 9 146102 146113 12 - 1.202 1.291 0.314
ENSG00000172785 E030 22.6439826 0.0009815637 7.440550e-01 8.325251e-01 9 146114 146158 45 - 1.356 1.383 0.094
ENSG00000172785 E031 3.2268326 0.0735474849 2.293491e-01 3.616573e-01 9 146159 147900 1742 - 0.696 0.449 -1.131
ENSG00000172785 E032 0.5806908 0.8474005241 5.380108e-01 6.694820e-01 9 147901 147949 49 - 0.284 0.000 -12.585
ENSG00000172785 E033 0.5806908 0.8474005241 5.380108e-01 6.694820e-01 9 147950 148040 91 - 0.284 0.000 -12.585
ENSG00000172785 E034 0.1451727 0.0440392748 1.000000e+00   9 148041 148044 4 - 0.091 0.000 -11.850
ENSG00000172785 E035 5.6478025 0.0031403646 1.649036e-02 4.382171e-02 9 148045 149446 1402 - 0.915 0.571 -1.407
ENSG00000172785 E036 0.2955422 0.0287804114 6.302264e-01   9 150132 150508 377 - 0.091 0.162 0.960
ENSG00000172785 E037 1.3306655 0.0102281420 1.154547e-01 2.135108e-01 9 150509 150641 133 - 0.457 0.163 -2.039
ENSG00000172785 E038 1.4779145 0.0198795600 8.278632e-02 1.639122e-01 9 150642 150725 84 - 0.491 0.162 -2.209
ENSG00000172785 E039 2.0648343 0.1051215926 4.005686e-02 9.113818e-02 9 150726 151304 579 - 0.605 0.162 -2.746
ENSG00000172785 E040 5.3460903 0.0174263361 8.950711e-01 9.369462e-01 9 151305 151427 123 - 0.788 0.809 0.082
ENSG00000172785 E041 0.2987644 0.0273737450 4.606933e-01   9 151428 151576 149 - 0.166 0.000 -12.950
ENSG00000172785 E042 0.4460135 0.0359618681 2.533294e-01 3.898379e-01 9 151577 151744 168 - 0.230 0.000 -13.438
ENSG00000172785 E043 0.8073459 0.0397457522 7.765831e-01 8.561194e-01 9 151745 152033 289 - 0.230 0.281 0.379
ENSG00000172785 E044 61.9757436 0.0036397110 2.036037e-01 3.307192e-01 9 152034 152078 45 - 1.812 1.747 -0.221
ENSG00000172785 E045 0.2924217 0.0276621597 4.606509e-01   9 152914 154708 1795 - 0.166 0.000 -12.947
ENSG00000172785 E046 81.5051968 0.0049224074 4.533131e-01 5.940538e-01 9 154709 154731 23 - 1.918 1.882 -0.123
ENSG00000172785 E047 93.5872744 0.0097875983 4.595800e-01 5.996862e-01 9 154732 154795 64 - 1.979 1.938 -0.138
ENSG00000172785 E048 93.6403530 0.0003871077 5.467103e-04 2.334715e-03 9 156481 156527 47 - 2.009 1.878 -0.442
ENSG00000172785 E049 0.1451727 0.0440392748 1.000000e+00   9 160001 160087 87 - 0.091 0.000 -11.850
ENSG00000172785 E050 0.2903454 0.3575367331 5.714972e-01   9 160088 160140 53 - 0.166 0.000 -11.965
ENSG00000172785 E051 1.5759569 0.0623965922 8.212371e-01 8.872997e-01 9 161567 161654 88 - 0.420 0.374 -0.256
ENSG00000172785 E052 95.1452549 0.0012831192 8.174452e-03 2.422452e-02 9 162432 162469 38 - 2.009 1.903 -0.357
ENSG00000172785 E053 135.6508604 0.0047701934 1.744076e-01 2.939171e-01 9 163978 164037 60 - 2.146 2.084 -0.209
ENSG00000172785 E054 0.0000000       9 164038 164039 2 -      
ENSG00000172785 E055 0.5514428 0.0193874923 2.161028e-02 5.486982e-02 9 164403 164448 46 - 0.000 0.374 13.941
ENSG00000172785 E056 0.0000000       9 165983 167605 1623 -      
ENSG00000172785 E057 1.8801337 0.0077058903 1.839046e-01 3.061231e-01 9 171596 171952 357 - 0.523 0.281 -1.359
ENSG00000172785 E058 1.7747164 0.0077931794 3.756322e-02 8.651686e-02 9 171953 172080 128 - 0.552 0.163 -2.498
ENSG00000172785 E059 177.9696813 0.0003894853 3.430114e-03 1.152439e-02 9 172081 172172 92 - 2.270 2.190 -0.268
ENSG00000172785 E060 7.3746044 0.0061817986 6.259257e-01 7.419627e-01 9 172173 173269 1097 - 0.928 0.867 -0.229
ENSG00000172785 E061 137.6962648 0.0024896946 2.654803e-02 6.505101e-02 9 173270 173362 93 - 2.162 2.074 -0.293
ENSG00000172785 E062 53.1876970 0.0005379162 6.752213e-01 7.805533e-01 9 173363 173366 4 - 1.715 1.737 0.076
ENSG00000172785 E063 0.4804688 0.0218763858 1.000000e+00 1.000000e+00 9 173367 173371 5 - 0.166 0.163 -0.038
ENSG00000172785 E064 83.3944284 0.0003784776 4.855923e-01 6.234641e-01 9 175698 175784 87 - 1.905 1.934 0.099
ENSG00000172785 E065 15.9264482 0.0011377070 2.829905e-02 6.860277e-02 9 177723 177820 98 - 1.133 1.322 0.667
ENSG00000172785 E066 133.0891963 0.0129497720 3.587336e-02 8.333660e-02 9 178816 179147 332 - 2.067 2.185 0.395