ENSG00000172766

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379406 ENSG00000172766 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA16 protein_coding protein_coding 9.886771 3.354717 15.4676 0.7157128 0.3411983 2.201625 2.9121293 0.68972211 5.4744981 0.11822625 0.4368641 2.97050560 0.27160000 0.22663333 0.35313333 0.12650000 2.840254e-01 8.335717e-10 FALSE TRUE
ENST00000403412 ENSG00000172766 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA16 protein_coding protein_coding 9.886771 3.354717 15.4676 0.7157128 0.3411983 2.201625 0.1867393 0.33717479 0.3449276 0.20584881 0.1587031 0.03186246 0.02404167 0.08550000 0.02203333 -0.06346667 1.908027e-01 8.335717e-10 FALSE TRUE
ENST00000463114 ENSG00000172766 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA16 protein_coding processed_transcript 9.886771 3.354717 15.4676 0.7157128 0.3411983 2.201625 0.8077167 0.00000000 1.9852987 0.00000000 0.1729740 7.64046095 0.05846667 0.00000000 0.12876667 0.12876667 8.335717e-10 8.335717e-10 FALSE FALSE
ENST00000464857 ENSG00000172766 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA16 protein_coding nonsense_mediated_decay 9.886771 3.354717 15.4676 0.7157128 0.3411983 2.201625 0.7758919 0.09936553 1.3790119 0.03618512 0.2027026 3.66682899 0.06092083 0.02820000 0.08926667 0.06106667 4.757778e-02 8.335717e-10 TRUE TRUE
ENST00000469708 ENSG00000172766 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA16 protein_coding processed_transcript 9.886771 3.354717 15.4676 0.7157128 0.3411983 2.201625 1.7807223 0.71926916 2.6074840 0.16325402 0.2199017 1.84365743 0.20520417 0.21370000 0.16830000 -0.04540000 4.909852e-01 8.335717e-10   FALSE
ENST00000477452 ENSG00000172766 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA16 protein_coding processed_transcript 9.886771 3.354717 15.4676 0.7157128 0.3411983 2.201625 0.5832548 0.64505573 0.5965927 0.30640145 0.1039106 -0.11088954 0.08398333 0.20913333 0.03850000 -0.17063333 1.406559e-01 8.335717e-10 FALSE FALSE
ENST00000495148 ENSG00000172766 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA16 protein_coding processed_transcript 9.886771 3.354717 15.4676 0.7157128 0.3411983 2.201625 1.2002989 0.21567754 1.8314888 0.10931600 0.1035575 3.02853788 0.11305417 0.06223333 0.11840000 0.05616667 4.648412e-01 8.335717e-10 FALSE FALSE
ENST00000497143 ENSG00000172766 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA16 protein_coding processed_transcript 9.886771 3.354717 15.4676 0.7157128 0.3411983 2.201625 0.1131897 0.23629331 0.0000000 0.13115952 0.0000000 -4.62230553 0.03219167 0.06440000 0.00000000 -0.06440000 2.492237e-02 8.335717e-10 FALSE TRUE
ENST00000497727 ENSG00000172766 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA16 protein_coding processed_transcript 9.886771 3.354717 15.4676 0.7157128 0.3411983 2.201625 0.2587043 0.25100220 0.0000000 0.25100220 0.0000000 -4.70599005 0.02057083 0.05246667 0.00000000 -0.05246667 4.761339e-01 8.335717e-10 FALSE FALSE
MSTRG.8647.1 ENSG00000172766 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA16 protein_coding   9.886771 3.354717 15.4676 0.7157128 0.3411983 2.201625 0.6594284 0.16115623 1.0438565 0.05147690 0.4224199 2.62229273 0.06864167 0.05770000 0.06860000 0.01090000 9.833485e-01 8.335717e-10 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172766 E001 2.420026 0.0704733334 3.245340e-01 4.678994e-01 13 41311147 41311266 120 + 0.466 0.262 -1.215
ENSG00000172766 E002 2.422103 0.0329296496 2.935007e-01 4.345702e-01 13 41311267 41311274 8 + 0.466 0.262 -1.220
ENSG00000172766 E003 5.811486 0.0068854232 4.179760e-01 5.612882e-01 13 41311275 41311279 5 + 0.730 0.634 -0.404
ENSG00000172766 E004 6.722174 0.0272908514 8.246664e-01 8.895539e-01 13 41311280 41311281 2 + 0.769 0.775 0.026
ENSG00000172766 E005 9.274047 0.0095697953 6.798951e-01 7.839662e-01 13 41311282 41311294 13 + 0.892 0.881 -0.044
ENSG00000172766 E006 36.012598 0.0005998098 4.159787e-02 9.399673e-02 13 41311295 41311582 288 + 1.449 1.335 -0.395
ENSG00000172766 E007 24.647087 0.0009155770 2.906168e-02 7.012688e-02 13 41316846 41316930 85 + 1.296 1.126 -0.600
ENSG00000172766 E008 12.678545 0.0097728694 4.687279e-01 6.081169e-01 13 41318806 41318807 2 + 1.011 0.967 -0.161
ENSG00000172766 E009 27.440598 0.0007469758 5.166863e-01 6.512273e-01 13 41318808 41318910 103 + 1.320 1.318 -0.009
ENSG00000172766 E010 38.863047 0.0005682563 1.153809e-01 2.134095e-01 13 41320667 41320824 158 + 1.478 1.410 -0.232
ENSG00000172766 E011 37.162253 0.0027143749 1.592477e-01 2.741091e-01 13 41323056 41323190 135 + 1.457 1.396 -0.208
ENSG00000172766 E012 43.178246 0.0005171691 1.747483e-01 2.943839e-01 13 41325698 41325851 154 + 1.518 1.475 -0.149
ENSG00000172766 E013 0.000000       13 41327857 41328050 194 +      
ENSG00000172766 E014 39.521112 0.0005580814 8.606308e-01 9.141205e-01 13 41328724 41328843 120 + 1.463 1.531 0.235
ENSG00000172766 E015 34.392614 0.0006214393 6.903276e-01 7.920426e-01 13 41331274 41331369 96 + 1.401 1.487 0.297
ENSG00000172766 E016 27.602878 0.0007287811 4.599899e-01 6.000475e-01 13 41336650 41336756 107 + 1.328 1.318 -0.037
ENSG00000172766 E017 24.775500 0.0166827990 2.199667e-01 3.503791e-01 13 41355144 41355216 73 + 1.290 1.202 -0.312
ENSG00000172766 E018 15.672165 0.0011326166 4.706809e-01 6.099116e-01 13 41358304 41358306 3 + 1.099 1.069 -0.110
ENSG00000172766 E019 31.895102 0.0047875273 4.944694e-01 6.314126e-01 13 41358307 41358473 167 + 1.361 1.476 0.396
ENSG00000172766 E020 2.919402 0.0575963993 2.064606e-05 1.276545e-04 13 41358474 41358718 245 + 0.216 1.009 3.843
ENSG00000172766 E021 32.413264 0.0035731040 8.217845e-01 8.876062e-01 13 41358810 41358962 153 + 1.376 1.451 0.260
ENSG00000172766 E022 35.614337 0.0005738789 5.679755e-01 6.947036e-01 13 41362031 41362125 95 + 1.426 1.438 0.038
ENSG00000172766 E023 26.098422 0.0007303960 1.863020e-01 3.091034e-01 13 41362126 41362159 34 + 1.312 1.243 -0.244
ENSG00000172766 E024 7.527797 0.0022875110 5.665228e-01 6.934907e-01 13 41362160 41362454 295 + 0.815 0.774 -0.159
ENSG00000172766 E025 10.921925 0.0064358813 8.466398e-01 9.046797e-01 13 41362455 41362730 276 + 0.940 0.967 0.100
ENSG00000172766 E026 15.493103 0.0019330744 2.059925e-01 3.336724e-01 13 41362731 41362873 143 + 1.103 1.003 -0.366
ENSG00000172766 E027 58.678508 0.0004115099 1.499061e-02 4.046689e-02 13 41367439 41367652 214 + 1.654 1.552 -0.348
ENSG00000172766 E028 50.616899 0.0004949347 4.479637e-03 1.448437e-02 13 41369090 41369238 149 + 1.598 1.450 -0.507
ENSG00000172766 E029 29.619140 0.0025446961 3.098048e-02 7.387608e-02 13 41369239 41369283 45 + 1.373 1.222 -0.528
ENSG00000172766 E030 33.648208 0.0006830290 2.206387e-02 5.581581e-02 13 41372203 41372311 109 + 1.426 1.282 -0.502
ENSG00000172766 E031 30.115685 0.0152919403 3.280957e-01 4.715453e-01 13 41372732 41372814 83 + 1.370 1.318 -0.180
ENSG00000172766 E032 20.114879 0.0037435248 9.837849e-01 9.939353e-01 13 41372815 41372830 16 + 1.187 1.243 0.197
ENSG00000172766 E033 23.933661 0.0088357464 9.300765e-01 9.599941e-01 13 41373637 41373660 24 + 1.254 1.302 0.169
ENSG00000172766 E034 41.030296 0.0013326190 6.702220e-01 7.767174e-01 13 41373661 41373767 107 + 1.485 1.510 0.085
ENSG00000172766 E035 26.137757 0.0007902945 9.988588e-01 1.000000e+00 13 41373768 41373780 13 + 1.296 1.351 0.192
ENSG00000172766 E036 14.452825 0.0038035621 1.100932e-01 2.056717e-01 13 41373781 41373880 100 + 1.081 0.925 -0.574
ENSG00000172766 E037 19.263918 0.0098218207 6.589200e-01 7.678847e-01 13 41374475 41374741 267 + 1.173 1.178 0.018
ENSG00000172766 E038 42.831129 0.0005646197 3.929183e-01 5.368093e-01 13 41374742 41374839 98 + 1.485 1.599 0.391
ENSG00000172766 E039 217.214471 0.0174968958 4.021445e-06 2.923224e-05 13 41375405 41377030 1626 + 2.133 2.456 1.078