ENSG00000172765

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393238 ENSG00000172765 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCC1 protein_coding protein_coding 7.122988 3.725833 12.16779 0.09583081 0.3924529 1.704751 1.6882972 1.3996315 2.049818 0.1621614 0.02867569 0.5471986 0.29124583 0.37426667 0.1687667 -0.20550000 5.626729e-05 5.626729e-05 FALSE TRUE
ENST00000426664 ENSG00000172765 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCC1 protein_coding protein_coding 7.122988 3.725833 12.16779 0.09583081 0.3924529 1.704751 0.1466813 0.2160190 0.000000 0.2160190 0.00000000 -4.4983721 0.02820417 0.06026667 0.0000000 -0.06026667 5.688720e-01 5.626729e-05 FALSE TRUE
MSTRG.23679.17 ENSG00000172765 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCC1 protein_coding   7.122988 3.725833 12.16779 0.09583081 0.3924529 1.704751 2.0302598 0.8966707 4.073943 0.1314513 0.31369144 2.1713123 0.26377083 0.24140000 0.3364000 0.09500000 3.511032e-01 5.626729e-05   FALSE
MSTRG.23679.18 ENSG00000172765 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCC1 protein_coding   7.122988 3.725833 12.16779 0.09583081 0.3924529 1.704751 0.9132996 0.3520803 1.794988 0.1271918 0.66493372 2.3176071 0.11500000 0.09323333 0.1462333 0.05300000 7.136275e-01 5.626729e-05   FALSE
MSTRG.23679.5 ENSG00000172765 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCC1 protein_coding   7.122988 3.725833 12.16779 0.09583081 0.3924529 1.704751 0.7499009 0.0830897 1.108342 0.0830897 0.13789459 3.5865960 0.09213750 0.02316667 0.0908000 0.06763333 1.996632e-01 5.626729e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172765 E001 0.1482932 0.0412171446 2.660491e-01   3 129647792 129647793 2 - 0.000 0.159 9.683
ENSG00000172765 E002 1.3984277 0.0098346305 2.272688e-03 8.067490e-03 3 129647794 129647826 33 - 0.093 0.613 3.696
ENSG00000172765 E003 184.1398236 0.0002988778 2.473772e-27 3.304998e-25 3 129647827 129651427 3601 - 2.143 2.394 0.837
ENSG00000172765 E004 8.7147389 0.1359827032 5.638652e-01 6.912605e-01 3 129651428 129651429 2 - 0.937 1.042 0.388
ENSG00000172765 E005 18.7717057 0.0141471087 4.161786e-02 9.403404e-02 3 129651430 129651491 62 - 1.206 1.395 0.660
ENSG00000172765 E006 19.1290029 0.0017892090 9.585976e-02 1.841820e-01 3 129651492 129651527 36 - 1.243 1.372 0.452
ENSG00000172765 E007 39.2626781 0.0016886010 1.609950e-01 2.764211e-01 3 129651528 129651795 268 - 1.564 1.643 0.269
ENSG00000172765 E008 0.4418608 0.0266495727 2.323247e-01 3.652005e-01 3 129654967 129654967 1 - 0.235 0.000 -13.368
ENSG00000172765 E009 31.0078959 0.0007057515 3.712678e-01 5.156996e-01 3 129654968 129655103 136 - 1.480 1.534 0.186
ENSG00000172765 E010 0.0000000       3 129656656 129656726 71 -      
ENSG00000172765 E011 61.7776409 0.0005291690 6.415156e-01 7.545308e-01 3 129670330 129670795 466 - 1.786 1.805 0.066
ENSG00000172765 E012 46.0931851 0.0004995930 6.571960e-01 7.666113e-01 3 129670796 129671248 453 - 1.676 1.652 -0.082
ENSG00000172765 E013 8.5219893 0.0029385561 5.621728e-01 6.898286e-01 3 129671249 129671264 16 - 0.949 1.013 0.236
ENSG00000172765 E014 0.1451727 0.0430895859 9.055610e-01   3 129688177 129688732 556 - 0.093 0.000 -11.741
ENSG00000172765 E015 0.0000000       3 129827756 129827802 47 -      
ENSG00000172765 E016 21.8403802 0.0010897722 3.038782e-01 4.458612e-01 3 129827803 129828018 216 - 1.314 1.389 0.260
ENSG00000172765 E017 17.4567578 0.0011222962 7.664207e-01 8.489201e-01 3 129828019 129828077 59 - 1.266 1.240 -0.091
ENSG00000172765 E018 22.4891987 0.0008659883 2.853146e-01 4.256297e-01 3 129828078 129828263 186 - 1.392 1.311 -0.281
ENSG00000172765 E019 18.6162037 0.0009644930 1.365851e-01 2.433087e-01 3 129828264 129828450 187 - 1.329 1.206 -0.433
ENSG00000172765 E020 6.2052457 0.0028984296 3.162626e-01 4.590133e-01 3 129828451 129828508 58 - 0.900 0.769 -0.510
ENSG00000172765 E021 0.1515154 0.0430063954 9.053787e-01   3 129832758 129832773 16 - 0.093 0.000 -11.742
ENSG00000172765 E022 9.4643422 0.0018878047 2.766027e-01 4.160538e-01 3 129832774 129832826 53 - 1.052 0.931 -0.450
ENSG00000172765 E023 1.4802183 0.2051169700 1.497187e-01 2.612956e-01 3 129838898 129839060 163 - 0.499 0.158 -2.298
ENSG00000172765 E024 13.3853392 0.0111174510 2.988276e-02 7.173430e-02 3 129848006 129848185 180 - 1.231 0.993 -0.857
ENSG00000172765 E025 7.4880806 0.0026496191 2.709215e-02 6.617917e-02 3 129848186 129848186 1 - 1.014 0.735 -1.075
ENSG00000172765 E026 42.9964104 0.0020064636 4.516528e-08 4.915227e-07 3 129848187 129848342 156 - 1.737 1.397 -1.162
ENSG00000172765 E027 24.2579056 0.0008542372 1.560114e-05 9.916418e-05 3 129848343 129848345 3 - 1.493 1.155 -1.181
ENSG00000172765 E028 32.8592308 0.0006774821 5.107362e-07 4.510205e-06 3 129848346 129848412 67 - 1.622 1.282 -1.171
ENSG00000172765 E029 0.0000000       3 129857248 129857249 2 -      
ENSG00000172765 E030 17.3430799 0.0011091560 3.885803e-04 1.730579e-03 3 129857250 129857359 110 - 1.353 1.031 -1.143
ENSG00000172765 E031 8.5004109 0.0022766649 1.577668e-01 2.721486e-01 3 129857360 129857405 46 - 1.024 0.857 -0.625
ENSG00000172765 E032 4.1258426 0.0174479137 7.125605e-03 2.155052e-02 3 129860940 129861012 73 - 0.828 0.367 -2.108
ENSG00000172765 E033 1.8498415 0.1650850124 8.765471e-01 9.247655e-01 3 129867010 129867098 89 - 0.428 0.449 0.112
ENSG00000172765 E034 0.0000000       3 129867099 129867100 2 -      
ENSG00000172765 E035 0.0000000       3 129868944 129869100 157 -      
ENSG00000172765 E036 52.2714490 0.0051648232 3.606253e-04 1.621325e-03 3 129880309 129880559 251 - 1.789 1.568 -0.748
ENSG00000172765 E037 2.0908706 0.0088129410 8.541736e-02 1.680811e-01 3 129880560 129880562 3 - 0.588 0.275 -1.696
ENSG00000172765 E038 0.2987644 0.0271895903 4.309455e-01   3 129888982 129889104 123 - 0.170 0.000 -12.814
ENSG00000172765 E039 0.7374030 0.0157285804 4.689077e-01 6.082536e-01 3 129892573 129892745 173 - 0.291 0.159 -1.112
ENSG00000172765 E040 1.7327684 0.0188675228 3.392061e-01 4.831262e-01 3 129893182 129893493 312 - 0.342 0.508 0.893
ENSG00000172765 E041 18.8809202 0.0170783662 5.613275e-01 6.891680e-01 3 129893494 129893711 218 - 1.309 1.243 -0.230