ENSG00000172757

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308162 ENSG00000172757 HEK293_OSMI2_2hA HEK293_TMG_2hB CFL1 protein_coding protein_coding 1321.129 2521.607 600.3208 60.66306 4.763889 -2.070519 1052.21199 1991.629135 454.85077 50.18500 12.13323 -2.130459 0.78230417 0.7899667 0.75750000 -0.03246667 5.076667e-01 1.31394e-15 FALSE TRUE
ENST00000527344 ENSG00000172757 HEK293_OSMI2_2hA HEK293_TMG_2hB CFL1 protein_coding protein_coding 1321.129 2521.607 600.3208 60.66306 4.763889 -2.070519 201.38283 482.203330 73.03350 35.02754 19.87910 -2.722844 0.13850000 0.1912333 0.12146667 -0.06976667 3.401169e-01 1.31394e-15 FALSE TRUE
ENST00000531413 ENSG00000172757 HEK293_OSMI2_2hA HEK293_TMG_2hB CFL1 protein_coding protein_coding 1321.129 2521.607 600.3208 60.66306 4.763889 -2.070519 34.00558 5.362747 46.37117 2.01091 13.61027 3.109807 0.04736667 0.0021000 0.07746667 0.07536667 6.330520e-09 1.31394e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172757 E001 0.000000e+00       11 65823022 65823266 245 -      
ENSG00000172757 E002 0.000000e+00       11 65823267 65824103 837 -      
ENSG00000172757 E003 2.955422e-01 2.957084e-02 2.345469e-01   11 65824523 65824648 126 - 0.239 0.059 -2.342
ENSG00000172757 E004 0.000000e+00       11 65826276 65826321 46 -      
ENSG00000172757 E005 1.534240e+00 7.002712e-01 2.145214e-01 3.438870e-01 11 65826322 65826609 288 - 0.783 0.154 -3.570
ENSG00000172757 E006 0.000000e+00       11 65831298 65831770 473 -      
ENSG00000172757 E007 8.146179e-01 1.659365e-01 5.017007e-01 6.378435e-01 11 65854673 65854674 2 - 0.001 0.233 8.243
ENSG00000172757 E008 5.369413e+02 9.385067e-03 1.527824e-04 7.593903e-04 11 65854675 65854831 157 - 2.379 2.599 0.732
ENSG00000172757 E009 7.930987e+03 1.708031e-03 2.513395e-06 1.913576e-05 11 65854832 65854974 143 - 3.650 3.755 0.348
ENSG00000172757 E010 8.445323e+03 1.054742e-03 3.394597e-09 4.560556e-08 11 65854975 65855008 34 - 3.676 3.782 0.351
ENSG00000172757 E011 9.418193e+03 1.615596e-03 8.036562e-09 1.008280e-07 11 65855009 65855053 45 - 3.709 3.831 0.406
ENSG00000172757 E012 1.418292e+04 1.002053e-03 4.555003e-14 1.358472e-12 11 65855054 65855240 187 - 3.886 4.009 0.408
ENSG00000172757 E013 4.927924e+03 8.382719e-04 1.849540e-03 6.756588e-03 11 65855241 65855256 16 - 3.484 3.542 0.194
ENSG00000172757 E014 1.232030e+04 5.214891e-04 5.095541e-13 1.309995e-11 11 65855257 65855357 101 - 3.852 3.944 0.306
ENSG00000172757 E015 1.187081e+04 8.819115e-05 9.681080e-09 1.197162e-07 11 65855358 65855417 60 - 3.878 3.922 0.146
ENSG00000172757 E016 1.025662e+04 2.614594e-04 2.953443e-03 1.012506e-02 11 65855418 65855448 31 - 3.868 3.850 -0.059
ENSG00000172757 E017 6.751064e+01 3.138890e-03 4.023295e-01 5.460638e-01 11 65855449 65855653 205 - 1.718 1.673 -0.154
ENSG00000172757 E018 1.513101e+04 8.974901e-05 7.223342e-12 1.539303e-10 11 65855654 65855730 77 - 4.047 4.017 -0.101
ENSG00000172757 E019 1.132759e+02 2.804297e-04 1.099762e-08 1.345648e-07 11 65855731 65855934 204 - 2.088 1.860 -0.766
ENSG00000172757 E020 1.069351e+04 3.461863e-04 4.048627e-09 5.363638e-08 11 65855935 65855956 22 - 3.912 3.864 -0.162
ENSG00000172757 E021 1.084233e+04 9.521197e-05 4.289226e-25 4.724308e-23 11 65855957 65855973 17 - 3.925 3.868 -0.189
ENSG00000172757 E022 2.668739e+04 8.327598e-04 2.673608e-12 6.123151e-11 11 65855974 65856242 269 - 4.332 4.257 -0.251
ENSG00000172757 E023 4.932532e+01 1.436398e-02 2.132836e-05 1.313929e-04 11 65856243 65856473 231 - 1.816 1.477 -1.154
ENSG00000172757 E024 2.858083e+01 1.447041e-02 1.580280e-01 2.725074e-01 11 65856885 65856930 46 - 1.425 1.292 -0.463
ENSG00000172757 E025 3.546191e+01 1.045648e-02 2.897318e-01 4.304498e-01 11 65856931 65857033 103 - 1.481 1.394 -0.300
ENSG00000172757 E026 1.777937e+01 2.047503e-02 1.313534e-04 6.648457e-04 11 65857093 65857631 539 - 1.449 1.037 -1.456
ENSG00000172757 E027 1.775076e+02 1.048749e-03 1.706364e-03 6.302175e-03 11 65857632 65858096 465 - 2.186 2.074 -0.373
ENSG00000172757 E028 8.264072e+03 4.321363e-03 3.865939e-03 1.276542e-02 11 65858097 65858342 246 - 3.830 3.746 -0.279
ENSG00000172757 E029 1.436105e+00 9.364930e-03 7.731331e-01 8.535814e-01 11 65858343 65858630 288 - 0.239 0.304 0.469
ENSG00000172757 E030 3.239746e+00 5.180905e-03 5.362951e-01 6.680529e-01 11 65859231 65859415 185 - 0.392 0.521 0.662
ENSG00000172757 E031 6.477549e+00 2.529445e-03 3.318286e-03 1.120070e-02 11 65861257 65861370 114 - 1.051 0.664 -1.503
ENSG00000172757 E032 2.730237e+00 5.781198e-03 4.325254e-02 9.701825e-02 11 65861371 65861588 218 - 0.732 0.389 -1.602
ENSG00000172757 E033 3.729606e-01 3.260753e-02 2.364723e-01 3.700804e-01 11 65861866 65862026 161 - 0.239 0.059 -2.336