ENSG00000172728

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327671 ENSG00000172728 HEK293_OSMI2_2hA HEK293_TMG_2hB FUT10 protein_coding protein_coding 5.513593 2.533371 8.157898 0.485878 0.1511002 1.683223 3.19702458 1.66900146 4.5296856 0.26095612 0.57417552 1.4349889 0.62970833 0.67923333 0.55623333 -0.12300000 0.557272037 0.009598306 FALSE  
ENST00000416169 ENSG00000172728 HEK293_OSMI2_2hA HEK293_TMG_2hB FUT10 protein_coding retained_intron 5.513593 2.533371 8.157898 0.485878 0.1511002 1.683223 0.42377984 0.33734398 0.6148573 0.10453638 0.01606167 0.8471616 0.08867917 0.13946667 0.07536667 -0.06410000 0.364681690 0.009598306 FALSE  
ENST00000517891 ENSG00000172728 HEK293_OSMI2_2hA HEK293_TMG_2hB FUT10 protein_coding processed_transcript 5.513593 2.533371 8.157898 0.485878 0.1511002 1.683223 0.05764068 0.31946062 0.0000000 0.31946062 0.00000000 -5.0420341 0.01826667 0.10426667 0.00000000 -0.10426667 0.592969054 0.009598306    
ENST00000520503 ENSG00000172728 HEK293_OSMI2_2hA HEK293_TMG_2hB FUT10 protein_coding processed_transcript 5.513593 2.533371 8.157898 0.485878 0.1511002 1.683223 0.30122077 0.00000000 0.5436961 0.00000000 0.23034869 5.7910224 0.03785417 0.00000000 0.06570000 0.06570000 0.009598306 0.009598306 TRUE  
MSTRG.31371.9 ENSG00000172728 HEK293_OSMI2_2hA HEK293_TMG_2hB FUT10 protein_coding   5.513593 2.533371 8.157898 0.485878 0.1511002 1.683223 0.62828258 0.09979587 1.1033415 0.01174448 0.22288907 3.3420004 0.10011250 0.04123333 0.13610000 0.09486667 0.039746609 0.009598306 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172728 E001 21.759629 0.0010379153 0.0380217742 0.087390943 8 33370824 33371060 237 - 1.277 1.433 0.545
ENSG00000172728 E002 70.458740 0.0015948608 0.3166458510 0.459439265 8 33371061 33371808 748 - 1.820 1.867 0.158
ENSG00000172728 E003 11.657753 0.0018545535 0.1554484735 0.268994483 8 33371809 33371828 20 - 1.128 0.980 -0.541
ENSG00000172728 E004 27.698140 0.0007131810 0.2135499735 0.342714358 8 33371829 33372078 250 - 1.466 1.382 -0.289
ENSG00000172728 E005 33.731550 0.0006238340 0.3055090703 0.447621593 8 33372079 33372211 133 - 1.499 1.564 0.223
ENSG00000172728 E006 27.745171 0.0012864164 0.1074542099 0.201782321 8 33372212 33372263 52 - 1.402 1.513 0.384
ENSG00000172728 E007 35.191513 0.0017373310 0.0182123651 0.047594636 8 33372264 33372381 118 - 1.484 1.630 0.498
ENSG00000172728 E008 31.149942 0.0007830138 0.0002821202 0.001307088 8 33372382 33372553 172 - 1.398 1.625 0.778
ENSG00000172728 E009 25.052871 0.0008015876 0.2642247769 0.402180498 8 33372554 33372643 90 - 1.368 1.449 0.281
ENSG00000172728 E010 39.481365 0.0005757602 0.9743342979 0.987987463 8 33372644 33372804 161 - 1.588 1.593 0.017
ENSG00000172728 E011 0.000000       8 33377518 33377580 63 -      
ENSG00000172728 E012 0.658951 0.0231693132 0.0654683553 0.135822642 8 33388896 33388962 67 - 0.083 0.399 2.838
ENSG00000172728 E013 101.220975 0.0003708682 0.0077779533 0.023222434 8 33388963 33389798 836 - 2.020 1.929 -0.306
ENSG00000172728 E014 0.000000       8 33394218 33394255 38 -      
ENSG00000172728 E015 18.651016 0.0163572515 0.0140732245 0.038390309 8 33451728 33453073 1346 - 1.179 1.434 0.890
ENSG00000172728 E016 6.492458 0.0311989056 0.4647834339 0.604494152 8 33453074 33453215 142 - 0.889 0.779 -0.425
ENSG00000172728 E017 36.423027 0.0006754986 0.3498822839 0.494075262 8 33453216 33453381 166 - 1.569 1.514 -0.187
ENSG00000172728 E018 21.904675 0.0022497266 0.1723211049 0.291229110 8 33453382 33453510 129 - 1.376 1.269 -0.373
ENSG00000172728 E019 1.836126 0.0103589442 0.3059731032 0.448120156 8 33455770 33455876 107 - 0.492 0.302 -1.067
ENSG00000172728 E020 1.174997 0.0134683677 0.2572679920 0.394341594 8 33460712 33460771 60 - 0.394 0.177 -1.554
ENSG00000172728 E021 11.931880 0.0076230034 0.0128147168 0.035477789 8 33461372 33461411 40 - 1.167 0.877 -1.069
ENSG00000172728 E022 16.112613 0.0010915153 0.0369344165 0.085336908 8 33461412 33461487 76 - 1.272 1.081 -0.680
ENSG00000172728 E023 34.837652 0.0005967346 0.0011164296 0.004358325 8 33461488 33461725 238 - 1.593 1.382 -0.722
ENSG00000172728 E024 0.000000       8 33461726 33461727 2 -      
ENSG00000172728 E025 12.595746 0.0015714161 0.5059920042 0.641697296 8 33473064 33473146 83 - 1.128 1.063 -0.236