ENSG00000172661

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374359 ENSG00000172661 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC2C protein_coding retained_intron 15.27563 8.679338 19.33578 0.4911356 0.07285845 1.1547 1.2869530 0.2183989 1.645466 0.09774505 0.1520758 2.85761006 0.08296667 0.02613333 0.08513333 0.05900000 2.994336e-02 1.246307e-15 FALSE TRUE
ENST00000374362 ENSG00000172661 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC2C protein_coding protein_coding 15.27563 8.679338 19.33578 0.4911356 0.07285845 1.1547 1.8882649 1.1411118 3.148980 0.59064182 0.7189851 1.45643075 0.12407500 0.13873333 0.16303333 0.02430000 8.555847e-01 1.246307e-15 FALSE TRUE
ENST00000420848 ENSG00000172661 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC2C protein_coding protein_coding 15.27563 8.679338 19.33578 0.4911356 0.07285845 1.1547 0.5478796 0.0000000 1.107186 0.00000000 0.6969688 6.80372613 0.02695000 0.00000000 0.05753333 0.05753333 3.018531e-01 1.246307e-15 FALSE TRUE
ENST00000471102 ENSG00000172661 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC2C protein_coding retained_intron 15.27563 8.679338 19.33578 0.4911356 0.07285845 1.1547 2.5010018 2.5174862 2.735942 0.50477725 0.5684784 0.11959766 0.18588750 0.28696667 0.14133333 -0.14563333 8.072076e-02 1.246307e-15 FALSE TRUE
ENST00000623400 ENSG00000172661 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC2C protein_coding protein_coding 15.27563 8.679338 19.33578 0.4911356 0.07285845 1.1547 1.0148638 0.7197158 0.000000 0.71971578 0.0000000 -6.18926274 0.07815000 0.07466667 0.00000000 -0.07466667 6.690047e-01 1.246307e-15 FALSE TRUE
MSTRG.3894.10 ENSG00000172661 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC2C protein_coding   15.27563 8.679338 19.33578 0.4911356 0.07285845 1.1547 2.8079717 0.0000000 5.275252 0.00000000 0.9185924 9.04582841 0.13969583 0.00000000 0.27253333 0.27253333 1.246307e-15 1.246307e-15 FALSE TRUE
MSTRG.3894.12 ENSG00000172661 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC2C protein_coding   15.27563 8.679338 19.33578 0.4911356 0.07285845 1.1547 2.8487617 1.8693672 3.266855 0.32350497 0.2031336 0.80206497 0.19443750 0.21980000 0.16903333 -0.05076667 7.104317e-01 1.246307e-15 FALSE TRUE
MSTRG.3894.6 ENSG00000172661 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC2C protein_coding   15.27563 8.679338 19.33578 0.4911356 0.07285845 1.1547 1.3160141 1.4984000 1.437578 0.44105249 0.3239634 -0.05937798 0.09179583 0.16876667 0.07436667 -0.09440000 1.900460e-01 1.246307e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172661 E001 0.0000000       10 45726089 45726920 832 +      
ENSG00000172661 E002 0.0000000       10 45726921 45727199 279 +      
ENSG00000172661 E003 0.5149242 0.2472060011 3.898281e-01 5.338751e-01 10 45727200 45727218 19 + 0.096 0.269 1.787
ENSG00000172661 E004 1.4674428 0.2197067704 8.768847e-01 9.249705e-01 10 45727219 45727223 5 + 0.351 0.435 0.471
ENSG00000172661 E005 2.4294115 0.0062670524 4.985353e-01 6.349977e-01 10 45727224 45727224 1 + 0.475 0.601 0.589
ENSG00000172661 E006 3.1667008 0.0054344268 8.551125e-01 9.103903e-01 10 45727225 45727234 10 + 0.600 0.645 0.196
ENSG00000172661 E007 4.6101825 0.0034169106 4.595088e-01 5.996349e-01 10 45727235 45727235 1 + 0.696 0.816 0.481
ENSG00000172661 E008 13.3860868 0.0026253064 6.819760e-01 7.855666e-01 10 45727236 45727265 30 + 1.158 1.140 -0.066
ENSG00000172661 E009 18.7201331 0.0011250647 2.765101e-01 4.159742e-01 10 45727266 45727287 22 + 1.314 1.247 -0.236
ENSG00000172661 E010 27.0912153 0.0100184117 3.318126e-02 7.816284e-02 10 45727288 45727320 33 + 1.502 1.341 -0.555
ENSG00000172661 E011 39.5786508 0.0178821864 5.951271e-03 1.848007e-02 10 45727417 45727539 123 + 1.682 1.458 -0.765
ENSG00000172661 E012 64.3243254 0.0003646117 1.173694e-07 1.176969e-06 10 45728862 45729026 165 + 1.889 1.665 -0.757
ENSG00000172661 E013 37.7924489 0.0011653205 9.307018e-03 2.704855e-02 10 45737983 45738045 63 + 1.635 1.501 -0.459
ENSG00000172661 E014 30.3870862 0.0031130089 1.113505e-02 3.149028e-02 10 45740073 45740190 118 + 1.547 1.389 -0.545
ENSG00000172661 E015 16.6689743 0.0010696270 1.167399e-03 4.530207e-03 10 45740191 45740246 56 + 1.334 1.067 -0.950
ENSG00000172661 E016 35.4728024 0.0006653667 6.715373e-07 5.787232e-06 10 45743390 45743483 94 + 1.653 1.357 -1.013
ENSG00000172661 E017 18.5197539 0.0088935157 1.949421e-04 9.423148e-04 10 45744821 45744823 3 + 1.395 1.051 -1.219
ENSG00000172661 E018 54.1196571 0.0055597138 2.822627e-03 9.741641e-03 10 45744824 45744882 59 + 1.795 1.632 -0.553
ENSG00000172661 E019 0.1817044 0.0400966913 3.011581e-01   10 45744883 45744943 61 + 0.000 0.154 9.962
ENSG00000172661 E020 70.1199264 0.0033547169 1.176285e-02 3.296601e-02 10 45746600 45746647 48 + 1.886 1.778 -0.367
ENSG00000172661 E021 101.0483605 0.0082725101 1.076531e-03 4.223060e-03 10 45750096 45750206 111 + 2.063 1.895 -0.566
ENSG00000172661 E022 64.2831678 0.0027939733 2.765280e-03 9.568300e-03 10 45750751 45750838 88 + 1.860 1.728 -0.448
ENSG00000172661 E023 46.0438103 0.0005017730 7.171313e-03 2.166886e-02 10 45751482 45751553 72 + 1.713 1.591 -0.415
ENSG00000172661 E024 43.0799280 0.0070115165 2.336915e-02 5.851770e-02 10 45752588 45752706 119 + 1.689 1.551 -0.468
ENSG00000172661 E025 22.2833295 0.0214174260 1.195569e-01 2.193271e-01 10 45753180 45753237 58 + 1.415 1.268 -0.512
ENSG00000172661 E026 23.5894267 0.0008072857 4.449855e-01 5.865584e-01 10 45754486 45754545 60 + 1.399 1.365 -0.118
ENSG00000172661 E027 71.6883373 0.0003921469 3.038869e-05 1.805679e-04 10 45754936 45755115 180 + 1.915 1.755 -0.538
ENSG00000172661 E028 69.5066850 0.0038310958 4.768723e-04 2.071542e-03 10 45757012 45757139 128 + 1.904 1.741 -0.549
ENSG00000172661 E029 30.4273395 0.0059611683 1.056171e-01 1.990434e-01 10 45759315 45759401 87 + 1.534 1.437 -0.335
ENSG00000172661 E030 52.3692318 0.0005099601 1.001670e-01 1.907324e-01 10 45763388 45763489 102 + 1.751 1.692 -0.200
ENSG00000172661 E031 56.0253779 0.0004752829 7.075689e-01 8.054584e-01 10 45765679 45765810 132 + 1.751 1.755 0.013
ENSG00000172661 E032 22.5370308 0.0009191198 9.636278e-02 1.849084e-01 10 45769449 45769454 6 + 1.408 1.305 -0.356
ENSG00000172661 E033 62.3864939 0.0004156403 4.113079e-01 5.548863e-01 10 45769455 45769618 164 + 1.771 1.830 0.197
ENSG00000172661 E034 35.6476838 0.0067342354 5.100714e-01 6.453243e-01 10 45773256 45773358 103 + 1.528 1.592 0.218
ENSG00000172661 E035 18.6131449 0.0342631659 7.200327e-01 8.147124e-01 10 45777273 45777425 153 + 1.258 1.312 0.192
ENSG00000172661 E036 14.3255714 0.0012561151 6.581506e-02 1.363971e-01 10 45778953 45779015 63 + 1.094 1.277 0.650
ENSG00000172661 E037 41.8276532 0.0007975836 1.101294e-01 2.057217e-01 10 45779016 45779135 120 + 1.580 1.688 0.369
ENSG00000172661 E038 54.8816029 0.0016061813 5.387532e-01 6.701392e-01 10 45784565 45784693 129 + 1.719 1.771 0.175
ENSG00000172661 E039 37.5373916 0.0005831796 4.569499e-01 5.973075e-01 10 45784821 45784901 81 + 1.550 1.614 0.218
ENSG00000172661 E040 40.8530674 0.0041442228 9.037942e-01 9.427856e-01 10 45785509 45785631 123 + 1.604 1.631 0.092
ENSG00000172661 E041 7.0350339 0.0023730814 7.895034e-04 3.221596e-03 10 45785632 45785963 332 + 1.029 0.601 -1.697
ENSG00000172661 E042 8.8165374 0.0039742045 1.850281e-01 3.075285e-01 10 45786370 45786611 242 + 1.029 0.894 -0.502
ENSG00000172661 E043 20.9325577 0.0032340192 1.035285e-01 1.958730e-01 10 45786612 45786674 63 + 1.276 1.424 0.515
ENSG00000172661 E044 14.6413444 0.0104114967 3.675296e-01 5.119096e-01 10 45786675 45787034 360 + 1.214 1.141 -0.263
ENSG00000172661 E045 32.6134869 0.0013021218 2.926724e-04 1.350001e-03 10 45787035 45787247 213 + 1.412 1.656 0.836
ENSG00000172661 E046 197.4337274 0.0007559019 7.099893e-04 2.934619e-03 10 45788871 45789491 621 + 2.243 2.355 0.374
ENSG00000172661 E047 92.4666375 0.0063032185 2.766858e-05 1.659195e-04 10 45790356 45790533 178 + 1.853 2.091 0.799
ENSG00000172661 E048 108.2076438 0.0036595130 3.838845e-10 6.142897e-09 10 45792261 45792410 150 + 1.890 2.186 0.991
ENSG00000172661 E049 45.2058335 0.0121159312 2.291053e-04 1.088184e-03 10 45792411 45792444 34 + 1.516 1.816 1.022
ENSG00000172661 E050 162.8361857 0.0084398529 1.354968e-12 3.248728e-11 10 45792445 45792964 520 + 2.013 2.392 1.268
ENSG00000172661 E051 1.4080945 0.1891113373 5.257765e-01 6.591022e-01 10 45793605 45793646 42 + 0.300 0.440 0.814