ENSG00000172613

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307980 ENSG00000172613 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD9A protein_coding protein_coding 30.2549 39.49155 20.46747 2.90032 0.6002038 -0.9478713 12.399434 17.624174 8.148831 2.3250289 0.4288231 -1.1119397 0.40640417 0.44506667 0.39823333 -0.046833333 7.495354e-01 9.784127e-08 FALSE TRUE
ENST00000530934 ENSG00000172613 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD9A protein_coding retained_intron 30.2549 39.49155 20.46747 2.90032 0.6002038 -0.9478713 2.864504 1.547465 2.919004 0.2830762 0.2903125 0.9112103 0.10385000 0.03856667 0.14336667 0.104800000 9.784127e-08 9.784127e-08 TRUE TRUE
ENST00000535644 ENSG00000172613 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD9A protein_coding processed_transcript 30.2549 39.49155 20.46747 2.90032 0.6002038 -0.9478713 4.082580 6.642243 1.791514 2.6945753 0.9072965 -1.8846313 0.12999167 0.16516667 0.08990000 -0.075266667 7.751005e-01 9.784127e-08 FALSE TRUE
MSTRG.5810.1 ENSG00000172613 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD9A protein_coding   30.2549 39.49155 20.46747 2.90032 0.6002038 -0.9478713 3.788089 6.400527 3.163685 0.3893631 0.4759178 -1.0142840 0.12371667 0.16363333 0.15366667 -0.009966667 9.078715e-01 9.784127e-08   FALSE
MSTRG.5810.12 ENSG00000172613 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD9A protein_coding   30.2549 39.49155 20.46747 2.90032 0.6002038 -0.9478713 2.722099 3.216703 1.662938 1.0621763 0.8692726 -0.9476769 0.08837917 0.08620000 0.07883333 -0.007366667 9.055516e-01 9.784127e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172613 E001 2.6581287 0.0061484511 9.532994e-01 9.747815e-01 11 67317846 67317854 9 + 0.524 0.542 0.082
ENSG00000172613 E002 2.9547151 0.0238509616 7.314963e-01 8.231403e-01 11 67317855 67317855 1 + 0.524 0.593 0.317
ENSG00000172613 E003 3.0998878 0.0272284611 9.916479e-01 9.988776e-01 11 67317856 67317859 4 + 0.581 0.593 0.053
ENSG00000172613 E004 6.6621728 0.0182166126 9.995727e-01 1.000000e+00 11 67317860 67317870 11 + 0.851 0.862 0.042
ENSG00000172613 E005 68.7459110 0.0004730142 2.431167e-01 3.778475e-01 11 67317871 67318197 327 + 1.830 1.787 -0.144
ENSG00000172613 E006 38.3980940 0.0069661531 8.593977e-01 9.132999e-01 11 67321270 67321333 64 + 1.535 1.559 0.082
ENSG00000172613 E007 31.1454035 0.0136703074 5.046583e-01 6.405633e-01 11 67330870 67331034 165 + 1.413 1.485 0.249
ENSG00000172613 E008 0.9650892 0.0344081310 9.376486e-01 9.647926e-01 11 67332853 67332897 45 + 0.287 0.279 -0.060
ENSG00000172613 E009 0.1482932 0.0418795468 1.000000e+00   11 67376013 67376110 98 + 0.000 0.088 7.929
ENSG00000172613 E010 10.7765867 0.0023489870 1.330256e-03 5.076608e-03 11 67387535 67387671 137 + 1.229 0.915 -1.142
ENSG00000172613 E011 20.2229132 0.0009423667 1.545008e-07 1.513194e-06 11 67391398 67391704 307 + 1.517 1.128 -1.360
ENSG00000172613 E012 12.9755412 0.0030005619 2.841934e-04 1.315567e-03 11 67391705 67391890 186 + 1.306 0.972 -1.200
ENSG00000172613 E013 4.9134023 0.0201064550 3.785241e-04 1.691518e-03 11 67391891 67391957 67 + 1.016 0.515 -2.047
ENSG00000172613 E014 5.5625847 0.0062162526 7.649422e-02 1.538893e-01 11 67391958 67391975 18 + 0.930 0.704 -0.885
ENSG00000172613 E015 7.6242324 0.0354455502 8.838481e-02 1.726495e-01 11 67391976 67391982 7 + 1.054 0.821 -0.877
ENSG00000172613 E016 14.7584259 0.0349502738 4.974632e-01 6.340219e-01 11 67391983 67391985 3 + 1.217 1.133 -0.298
ENSG00000172613 E017 94.8013190 0.0037611230 7.678131e-01 8.499567e-01 11 67391986 67392078 93 + 1.912 1.939 0.090
ENSG00000172613 E018 3.7590434 0.0099386746 1.933112e-02 5.005166e-02 11 67392079 67392160 82 + 0.851 0.513 -1.432
ENSG00000172613 E019 113.9133053 0.0019143246 6.922866e-01 7.935645e-01 11 67392161 67392231 71 + 1.992 2.020 0.094
ENSG00000172613 E020 160.4853743 0.0009778230 5.653714e-01 6.924870e-01 11 67392654 67392782 129 + 2.164 2.157 -0.025
ENSG00000172613 E021 38.9455432 0.0081538402 2.057878e-16 8.504773e-15 11 67392882 67393304 423 + 1.870 1.308 -1.921
ENSG00000172613 E022 25.2568886 0.0015400033 4.149481e-10 6.598176e-09 11 67393305 67393495 191 + 1.631 1.208 -1.464
ENSG00000172613 E023 80.6665327 0.0007533423 9.801773e-01 9.916248e-01 11 67393496 67393537 42 + 1.856 1.868 0.039
ENSG00000172613 E024 102.4875961 0.0040872959 7.422982e-01 8.312248e-01 11 67393538 67393610 73 + 1.950 1.977 0.092
ENSG00000172613 E025 64.1415396 0.0004110539 6.739818e-01 7.795343e-01 11 67393691 67393722 32 + 1.747 1.778 0.103
ENSG00000172613 E026 96.8860615 0.0003001421 5.333984e-01 6.655969e-01 11 67393723 67393790 68 + 1.919 1.954 0.117
ENSG00000172613 E027 7.2726466 0.0074161691 8.941362e-01 9.363218e-01 11 67395670 67395715 46 + 0.851 0.878 0.105
ENSG00000172613 E028 129.6248101 0.0002984134 5.485865e-01 6.784303e-01 11 67395716 67395825 110 + 2.046 2.077 0.103
ENSG00000172613 E029 144.5818904 0.0002666345 5.671084e-01 6.939816e-01 11 67395912 67396021 110 + 2.096 2.125 0.096
ENSG00000172613 E030 6.9138382 0.0593857346 1.910719e-02 4.957272e-02 11 67396022 67396110 89 + 1.072 0.712 -1.380
ENSG00000172613 E031 112.7411637 0.0006916593 4.339954e-01 5.763804e-01 11 67396111 67396171 61 + 1.981 2.021 0.134
ENSG00000172613 E032 68.7640341 0.0004019668 3.855773e-01 5.297636e-01 11 67396172 67396175 4 + 1.762 1.812 0.171
ENSG00000172613 E033 179.5105539 0.0002063378 8.883815e-01 9.326337e-01 11 67396263 67396400 138 + 2.198 2.212 0.049
ENSG00000172613 E034 208.9136083 0.0011626581 3.315421e-01 4.751756e-01 11 67397179 67397386 208 + 2.244 2.285 0.137
ENSG00000172613 E035 0.9598778 0.1521106322 5.997110e-01 7.210695e-01 11 67397387 67397424 38 + 0.167 0.284 0.975
ENSG00000172613 E036 681.9105013 0.0029084305 1.148472e-03 4.466262e-03 11 67397464 67398410 947 + 2.720 2.813 0.312