ENSG00000172534

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310441 ENSG00000172534 HEK293_OSMI2_2hA HEK293_TMG_2hB HCFC1 protein_coding protein_coding 60.65299 101.1462 36.85713 8.555332 1.112408 -1.456178 19.247233 18.340764 18.0214412 3.7242809 0.2258663 -0.02532542 0.38030000 0.18013333 0.48956667 0.30943333 2.444146e-07 2.25188e-15 FALSE TRUE
ENST00000369984 ENSG00000172534 HEK293_OSMI2_2hA HEK293_TMG_2hB HCFC1 protein_coding protein_coding 60.65299 101.1462 36.85713 8.555332 1.112408 -1.456178 2.548560 1.958581 4.4602016 1.9585813 0.7074222 1.18318357 0.06176667 0.02286667 0.12100000 0.09813333 7.950170e-02 2.25188e-15 FALSE TRUE
ENST00000444191 ENSG00000172534 HEK293_OSMI2_2hA HEK293_TMG_2hB HCFC1 protein_coding protein_coding 60.65299 101.1462 36.85713 8.555332 1.112408 -1.456178 28.649367 68.938209 6.7594508 5.5693805 0.4744134 -3.34840237 0.37562500 0.68533333 0.18300000 -0.50233333 2.251880e-15 2.25188e-15 FALSE TRUE
MSTRG.35088.25 ENSG00000172534 HEK293_OSMI2_2hA HEK293_TMG_2hB HCFC1 protein_coding   60.65299 101.1462 36.85713 8.555332 1.112408 -1.456178 5.295290 4.172054 5.8492618 0.9468172 0.8241771 0.48650710 0.10823333 0.04023333 0.15770000 0.11746667 4.162975e-07 2.25188e-15 FALSE TRUE
MSTRG.35088.5 ENSG00000172534 HEK293_OSMI2_2hA HEK293_TMG_2hB HCFC1 protein_coding   60.65299 101.1462 36.85713 8.555332 1.112408 -1.456178 4.249114 7.224566 0.8455557 3.6168847 0.8455557 -3.07997280 0.06022083 0.06650000 0.02376667 -0.04273333 5.287526e-01 2.25188e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172534 E001 16.6836300 0.0990137158 6.122730e-07 5.324945e-06 X 153947557 153947558 2 - 0.179 1.311 5.256
ENSG00000172534 E002 422.1149962 0.0166465693 6.542522e-12 1.403534e-10 X 153947559 153947653 95 - 2.176 2.645 1.565
ENSG00000172534 E003 512.2950410 0.0177589828 3.642144e-09 4.864589e-08 X 153947654 153947666 13 - 2.317 2.721 1.347
ENSG00000172534 E004 704.7355273 0.0138600406 5.159989e-12 1.126333e-10 X 153947667 153947718 52 - 2.445 2.861 1.383
ENSG00000172534 E005 982.2953995 0.0097445476 1.256713e-14 4.076722e-13 X 153947719 153947839 121 - 2.616 3.001 1.280
ENSG00000172534 E006 1231.8999177 0.0078871630 3.035543e-14 9.300899e-13 X 153947840 153948017 178 - 2.758 3.093 1.115
ENSG00000172534 E007 599.0424531 0.0105164456 8.970388e-09 1.115540e-07 X 153948018 153948042 25 - 2.472 2.776 1.010
ENSG00000172534 E008 490.5196764 0.0097215514 1.890589e-08 2.214595e-07 X 153948043 153948048 6 - 2.395 2.687 0.973
ENSG00000172534 E009 828.7257352 0.0065215884 6.946647e-14 2.017819e-12 X 153948049 153948147 99 - 2.606 2.917 1.036
ENSG00000172534 E010 399.6955209 0.0047829556 4.429650e-13 1.151144e-11 X 153948148 153948151 4 - 2.309 2.597 0.962
ENSG00000172534 E011 2205.7534132 0.0035127125 4.941867e-26 5.914226e-24 X 153948152 153948681 530 - 3.039 3.341 1.002
ENSG00000172534 E012 1017.3892585 0.0008768524 1.897590e-32 3.816270e-30 X 153948682 153949078 397 - 2.765 2.990 0.749
ENSG00000172534 E013 251.1238420 0.0003783007 2.502576e-17 1.158049e-15 X 153949079 153949079 1 - 2.148 2.381 0.778
ENSG00000172534 E014 350.8720289 0.0013581756 1.825746e-11 3.640864e-10 X 153949080 153949123 44 - 2.332 2.519 0.624
ENSG00000172534 E015 281.5377472 0.0006130018 3.118592e-09 4.217045e-08 X 153949124 153949137 14 - 2.263 2.416 0.510
ENSG00000172534 E016 336.0196158 0.0003177018 1.110484e-09 1.632861e-08 X 153949138 153949271 134 - 2.354 2.489 0.449
ENSG00000172534 E017 244.1490145 0.0027529787 4.874373e-02 1.069335e-01 X 153949272 153949386 115 - 2.280 2.340 0.201
ENSG00000172534 E018 362.0126002 0.0009074286 1.050937e-02 3.000164e-02 X 153949553 153949616 64 - 2.455 2.508 0.176
ENSG00000172534 E019 893.4950128 0.0001099492 3.784546e-06 2.769296e-05 X 153950243 153950543 301 - 2.844 2.896 0.173
ENSG00000172534 E020 727.8593762 0.0021246307 3.950790e-01 5.389179e-01 X 153950813 153950998 186 - 2.786 2.803 0.055
ENSG00000172534 E021 574.9237732 0.0010760971 9.774570e-01 9.899829e-01 X 153951350 153951484 135 - 2.701 2.692 -0.030
ENSG00000172534 E022 243.7329672 0.0002500984 7.246138e-01 8.180827e-01 X 153951485 153951487 3 - 2.339 2.315 -0.078
ENSG00000172534 E023 15.5308358 0.0019287334 1.752775e-02 4.610060e-02 X 153951580 153951588 9 - 1.309 1.080 -0.811
ENSG00000172534 E024 454.1628503 0.0059071545 8.315847e-01 8.944600e-01 X 153951589 153951707 119 - 2.604 2.592 -0.041
ENSG00000172534 E025 640.8880938 0.0036759628 9.211409e-01 9.542284e-01 X 153951841 153952158 318 - 2.745 2.744 -0.005
ENSG00000172534 E026 20.1085956 0.0008937551 2.441364e-01 3.790616e-01 X 153952159 153952161 3 - 1.340 1.231 -0.383
ENSG00000172534 E027 867.7268049 0.0041423137 8.811671e-03 2.581288e-02 X 153952514 153952958 445 - 2.942 2.851 -0.301
ENSG00000172534 E028 109.7558060 0.0019380041 2.052162e-02 5.258988e-02 X 153952959 153953087 129 - 2.055 1.946 -0.367
ENSG00000172534 E029 35.8385303 0.0009961204 6.644533e-03 2.030072e-02 X 153953088 153953090 3 - 1.626 1.442 -0.631
ENSG00000172534 E030 483.9382907 0.0025421705 1.192676e-05 7.785971e-05 X 153953607 153953770 164 - 2.719 2.582 -0.457
ENSG00000172534 E031 744.2201387 0.0030397295 7.538424e-07 6.430709e-06 X 153954066 153954500 435 - 2.918 2.765 -0.509
ENSG00000172534 E032 894.0291653 0.0056773859 1.624634e-05 1.028683e-04 X 153954501 153955142 642 - 3.007 2.841 -0.551
ENSG00000172534 E033 728.1616884 0.0034296369 2.702817e-14 8.333993e-13 X 153955143 153955542 400 - 2.968 2.724 -0.811
ENSG00000172534 E034 481.2375428 0.0008923807 2.986036e-21 2.199439e-19 X 153956191 153956411 221 - 2.770 2.550 -0.733
ENSG00000172534 E035 364.1398092 0.0030318370 4.940359e-10 7.739593e-09 X 153956625 153956763 139 - 2.646 2.433 -0.709
ENSG00000172534 E036 375.2014461 0.0031076437 4.618491e-11 8.622837e-10 X 153956918 153957060 143 - 2.668 2.442 -0.753
ENSG00000172534 E037 471.8982633 0.0086771936 4.400837e-08 4.798420e-07 X 153957314 153957533 220 - 2.795 2.528 -0.888
ENSG00000172534 E038 322.0347298 0.0081715758 3.136719e-10 5.090304e-09 X 153957782 153957886 105 - 2.655 2.345 -1.033
ENSG00000172534 E039 435.6697972 0.0071881051 3.995453e-13 1.043317e-11 X 153958025 153958249 225 - 2.797 2.469 -1.095
ENSG00000172534 E040 275.2274425 0.0085192218 9.008066e-07 7.552448e-06 X 153958569 153958766 198 - 2.550 2.301 -0.833
ENSG00000172534 E041 258.9894851 0.0153415367 2.622012e-05 1.581749e-04 X 153959331 153959470 140 - 2.537 2.267 -0.900
ENSG00000172534 E042 124.6274747 0.0185898531 1.323745e-04 6.692806e-04 X 153959471 153959491 21 - 2.232 1.945 -0.962
ENSG00000172534 E043 301.3707290 0.0150050944 1.280125e-05 8.295676e-05 X 153959802 153960008 207 - 2.608 2.330 -0.926
ENSG00000172534 E044 273.1199052 0.0109065574 1.069773e-07 1.080965e-06 X 153960009 153960161 153 - 2.576 2.279 -0.991
ENSG00000172534 E045 311.2080850 0.0171259634 3.080954e-07 2.843462e-06 X 153960235 153960414 180 - 2.659 2.318 -1.135
ENSG00000172534 E046 242.1846038 0.0193791886 5.215384e-06 3.695648e-05 X 153961542 153961648 107 - 2.540 2.217 -1.081
ENSG00000172534 E047 255.1558741 0.0174699271 1.102772e-08 1.349069e-07 X 153962222 153962306 85 - 2.600 2.211 -1.297
ENSG00000172534 E048 339.4274929 0.0202701341 1.889478e-07 1.819344e-06 X 153963225 153963433 209 - 2.714 2.343 -1.238
ENSG00000172534 E049 314.2986921 0.0154852298 6.049124e-10 9.346614e-09 X 153964124 153964284 161 - 2.697 2.296 -1.336
ENSG00000172534 E050 290.5176507 0.0099334466 5.844675e-17 2.585235e-15 X 153964578 153964726 149 - 2.687 2.239 -1.495
ENSG00000172534 E051 0.5827671 0.1422557122 7.636296e-03 2.286369e-02 X 153970009 153970129 121 - 0.482 0.000 -11.739
ENSG00000172534 E052 813.0514125 0.0210355843 8.840407e-10 1.323944e-08 X 153970648 153972522 1875 - 3.123 2.696 -1.421