ENSG00000172493

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307808 ENSG00000172493 HEK293_OSMI2_2hA HEK293_TMG_2hB AFF1 protein_coding protein_coding 4.520472 3.257475 5.493045 0.09726172 0.5477912 0.7520539 0.8867819 0.50651690 0.6177572 0.09107945 0.3334388 0.2813911 0.18752917 0.15706667 0.1074333 -0.04963333 0.76070739 0.00293681 FALSE TRUE
ENST00000395146 ENSG00000172493 HEK293_OSMI2_2hA HEK293_TMG_2hB AFF1 protein_coding protein_coding 4.520472 3.257475 5.493045 0.09726172 0.5477912 0.7520539 2.9956071 2.57436640 2.8578339 0.26262673 0.1328809 0.1501508 0.68581250 0.78820000 0.5276667 -0.26053333 0.04985435 0.00293681 FALSE TRUE
ENST00000511722 ENSG00000172493 HEK293_OSMI2_2hA HEK293_TMG_2hB AFF1 protein_coding protein_coding 4.520472 3.257475 5.493045 0.09726172 0.5477912 0.7520539 0.2835241 0.03402390 1.1908139 0.03402390 0.4660304 4.7695817 0.05261667 0.01040000 0.2069667 0.19656667 0.00293681 0.00293681 FALSE FALSE
ENST00000544085 ENSG00000172493 HEK293_OSMI2_2hA HEK293_TMG_2hB AFF1 protein_coding protein_coding 4.520472 3.257475 5.493045 0.09726172 0.5477912 0.7520539 0.1381700 0.04454945 0.5019445 0.04454945 0.2869807 3.2303509 0.02952917 0.01363333 0.1003333 0.08670000 0.57843772 0.00293681 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172493 E001 0.4418608 0.0256300571 1.554338e-01 2.689788e-01 4 86935002 86935010 9 + 0.236 0.000 -10.650
ENSG00000172493 E002 1.1782197 0.0106160858 7.134920e-03 2.157456e-02 4 86935011 86935042 32 + 0.466 0.000 -14.025
ENSG00000172493 E003 1.1782197 0.0106160858 7.134920e-03 2.157456e-02 4 86935043 86935049 7 + 0.466 0.000 -14.025
ENSG00000172493 E004 1.4812505 0.0093071331 2.279642e-03 8.088994e-03 4 86935050 86935073 24 + 0.532 0.000 -14.315
ENSG00000172493 E005 4.9500255 0.0063198110 2.444728e-02 6.074528e-02 4 86935074 86935240 167 + 0.846 0.611 -0.967
ENSG00000172493 E006 0.3729606 0.0292155928 7.931692e-01 8.677639e-01 4 86936410 86936481 72 + 0.094 0.159 0.872
ENSG00000172493 E007 5.4156439 0.0038572297 1.265557e-01 2.293504e-01 4 86948498 86948571 74 + 0.846 0.732 -0.453
ENSG00000172493 E008 0.5149111 0.0216269454 3.804805e-01 5.247590e-01 4 86973830 86974068 239 + 0.094 0.274 1.870
ENSG00000172493 E009 0.5138669 0.0215434658 7.917658e-01 8.668051e-01 4 87006753 87006987 235 + 0.171 0.159 -0.128
ENSG00000172493 E010 3.8200806 0.0056531704 3.789801e-02 8.715829e-02 4 87006988 87007242 255 + 0.746 0.505 -1.055
ENSG00000172493 E011 9.3255903 0.0020663616 5.630070e-04 2.395777e-03 4 87007243 87007424 182 + 1.099 0.798 -1.130
ENSG00000172493 E012 15.5742541 0.0214959414 1.079877e-04 5.588791e-04 4 87046166 87046286 121 + 1.322 0.970 -1.261
ENSG00000172493 E013 58.2969672 0.0005688970 3.534888e-17 1.605933e-15 4 87046695 87047594 900 + 1.863 1.548 -1.069
ENSG00000172493 E014 0.0000000       4 87047595 87048049 455 +      
ENSG00000172493 E015 0.0000000       4 87049652 87049762 111 +      
ENSG00000172493 E016 7.2791039 0.0024187791 2.621260e-02 6.438099e-02 4 87084120 87084122 3 + 0.974 0.798 -0.675
ENSG00000172493 E017 16.1508941 0.0098800837 6.058868e-04 2.554831e-03 4 87084123 87084164 42 + 1.307 1.063 -0.869
ENSG00000172493 E018 20.8937648 0.0012026141 8.026631e-04 3.268888e-03 4 87089984 87090070 87 + 1.387 1.226 -0.560
ENSG00000172493 E019 15.2227880 0.0011990673 1.893040e-04 9.182475e-04 4 87091793 87091829 37 + 1.286 1.046 -0.855
ENSG00000172493 E020 16.6132547 0.0013186779 1.474964e-05 9.428971e-05 4 87094915 87094969 55 + 1.332 1.046 -1.017
ENSG00000172493 E021 15.9574242 0.0016480151 7.308880e-06 5.009389e-05 4 87105628 87105682 55 + 1.322 1.010 -1.114
ENSG00000172493 E022 16.1641076 0.0011277983 1.283361e-05 8.314089e-05 4 87105808 87105845 38 + 1.322 1.028 -1.046
ENSG00000172493 E023 24.4235821 0.0008366430 2.760730e-08 3.130496e-07 4 87108159 87108315 157 + 1.496 1.178 -1.108
ENSG00000172493 E024 27.5516097 0.0050564822 2.821528e-06 2.124692e-05 4 87114367 87114942 576 + 1.531 1.270 -0.905
ENSG00000172493 E025 30.8150310 0.0008319787 7.473904e-08 7.778864e-07 4 87114943 87115299 357 + 1.575 1.318 -0.886
ENSG00000172493 E026 16.9726694 0.0165112913 5.168134e-03 1.638534e-02 4 87125037 87125143 107 + 1.316 1.123 -0.683
ENSG00000172493 E027 0.0000000       4 87125144 87125277 134 +      
ENSG00000172493 E028 10.1656645 0.0137660653 4.313631e-02 9.679880e-02 4 87126099 87126107 9 + 1.090 0.950 -0.514
ENSG00000172493 E029 33.0699960 0.0151820891 7.411222e-03 2.228802e-02 4 87126108 87126336 229 + 1.569 1.450 -0.407
ENSG00000172493 E030 21.6563564 0.0189252497 3.735698e-02 8.614199e-02 4 87127026 87127117 92 + 1.382 1.282 -0.350
ENSG00000172493 E031 15.7182481 0.0390024045 4.432520e-01 5.848215e-01 4 87127643 87127703 61 + 1.208 1.226 0.063
ENSG00000172493 E032 20.1809856 0.0045238235 1.460548e-02 3.960500e-02 4 87131083 87131219 137 + 1.351 1.249 -0.356
ENSG00000172493 E033 12.1312360 0.0251039052 4.169787e-02 9.418338e-02 4 87131793 87131864 72 + 1.161 1.011 -0.543
ENSG00000172493 E034 17.0972578 0.0029118456 1.109240e-04 5.720910e-04 4 87132271 87132408 138 + 1.327 1.079 -0.878
ENSG00000172493 E035 10.1686407 0.0016513246 2.140521e-05 1.317764e-04 4 87134471 87134473 3 + 1.154 0.766 -1.452
ENSG00000172493 E036 30.6864261 0.0007509210 1.136135e-08 1.386348e-07 4 87134474 87134694 221 + 1.581 1.299 -0.971
ENSG00000172493 E037 655.6966641 0.0020967458 5.982055e-75 1.039709e-71 4 87135580 87141039 5460 + 2.637 2.982 1.148