ENSG00000172460

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000476276 ENSG00000172460 HEK293_OSMI2_2hA HEK293_TMG_2hB PRSS30P lncRNA retained_intron 4.103888 5.654255 2.092969 0.6383026 0.3728618 -1.429459 0.4523057 0.2450841 0.2354372 0.04673094 0.03415382 -0.05561898 0.11966250 0.04270000 0.11463333 0.071933333 0.03768044 0.03768044 FALSE  
ENST00000489864 ENSG00000172460 HEK293_OSMI2_2hA HEK293_TMG_2hB PRSS30P lncRNA lncRNA 4.103888 5.654255 2.092969 0.6383026 0.3728618 -1.429459 1.5320781 3.1285596 0.6374375 0.53792363 0.08543033 -2.27728983 0.35222917 0.54613333 0.33070000 -0.215433333 0.12890363 0.03768044 FALSE  
ENST00000506153 ENSG00000172460 HEK293_OSMI2_2hA HEK293_TMG_2hB PRSS30P lncRNA lncRNA 4.103888 5.654255 2.092969 0.6383026 0.3728618 -1.429459 0.8145409 0.8068356 0.4452074 0.11918808 0.24366509 -0.84352173 0.20089167 0.14910000 0.18953333 0.040433333 1.00000000 0.03768044 FALSE  
ENST00000659874 ENSG00000172460 HEK293_OSMI2_2hA HEK293_TMG_2hB PRSS30P lncRNA lncRNA 4.103888 5.654255 2.092969 0.6383026 0.3728618 -1.429459 0.5718967 0.5693042 0.2961938 0.11554701 0.02058471 -0.91987600 0.14991667 0.09933333 0.14960000 0.050266667 0.48408764 0.03768044 FALSE  
ENST00000687903 ENSG00000172460 HEK293_OSMI2_2hA HEK293_TMG_2hB PRSS30P lncRNA lncRNA 4.103888 5.654255 2.092969 0.6383026 0.3728618 -1.429459 0.2991038 0.4085967 0.1080992 0.25144965 0.10809924 -1.82556142 0.06939167 0.07040000 0.06656667 -0.003833333 0.79614792 0.03768044 FALSE  
MSTRG.11887.11 ENSG00000172460 HEK293_OSMI2_2hA HEK293_TMG_2hB PRSS30P lncRNA   4.103888 5.654255 2.092969 0.6383026 0.3728618 -1.429459 0.1046495 0.0000000 0.2656580 0.00000000 0.26565800 4.78480757 0.03060833 0.00000000 0.09390000 0.093900000 0.63793655 0.03768044 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172460 E001 0.000000       16 2839568 2839572 5 -      
ENSG00000172460 E002 4.772941 0.0103228441 7.907825e-01 0.8662100273 16 2839573 2839618 46 - 0.719 0.682 -0.152
ENSG00000172460 E003 8.273785 0.0022564334 3.553271e-01 0.4996796896 16 2839619 2839655 37 - 0.799 0.924 0.483
ENSG00000172460 E004 11.653605 0.0168006624 4.273202e-02 0.0960554000 16 2839656 2839678 23 - 0.799 1.077 1.045
ENSG00000172460 E005 56.766152 0.0005758341 2.225820e-02 0.0562083391 16 2839679 2839931 253 - 1.587 1.713 0.429
ENSG00000172460 E006 15.772248 0.0013508828 3.109451e-01 0.4533865762 16 2839932 2840147 216 - 1.214 1.127 -0.308
ENSG00000172460 E007 15.303563 0.0039391900 7.422030e-02 0.1502865952 16 2840148 2840308 161 - 1.254 1.094 -0.570
ENSG00000172460 E008 19.834452 0.0100192993 3.544876e-03 0.0118538163 16 2840309 2840809 501 - 1.422 1.172 -0.875
ENSG00000172460 E009 6.013037 0.0031236512 4.656699e-02 0.1030592645 16 2840810 2840841 32 - 0.952 0.699 -0.989
ENSG00000172460 E010 16.983386 0.0011113921 3.834797e-01 0.5276853250 16 2840842 2841079 238 - 1.241 1.170 -0.251
ENSG00000172460 E011 3.760057 0.0047294779 8.850880e-01 0.9305478101 16 2841080 2841162 83 - 0.621 0.602 -0.082
ENSG00000172460 E012 43.157463 0.0044165957 2.170695e-03 0.0077522146 16 2841163 2841328 166 - 1.404 1.620 0.741
ENSG00000172460 E013 6.176019 0.0084748796 2.290378e-02 0.0575410191 16 2841329 2841407 79 - 1.000 0.715 -1.104
ENSG00000172460 E014 13.200817 0.0013435484 5.116588e-02 0.1112411844 16 2841408 2841572 165 - 1.214 1.033 -0.649
ENSG00000172460 E015 7.998296 0.0023166371 9.790706e-02 0.1873274064 16 2841573 2841599 27 - 1.023 0.833 -0.717
ENSG00000172460 E016 9.001047 0.0020513427 5.577582e-01 0.6861142194 16 2841600 2841679 80 - 0.977 0.914 -0.235
ENSG00000172460 E017 29.734020 0.0124906928 9.578761e-05 0.0005022467 16 2841680 2841771 92 - 1.102 1.490 1.361
ENSG00000172460 E018 42.612830 0.0006382498 7.340264e-02 0.1489637037 16 2841772 2842448 677 - 1.637 1.544 -0.318
ENSG00000172460 E019 21.354395 0.0010913165 3.493123e-01 0.4935255913 16 2842449 2842607 159 - 1.325 1.255 -0.243
ENSG00000172460 E020 16.340867 0.0106153458 4.004273e-01 0.5441290111 16 2842608 2844550 1943 - 1.102 1.193 0.325