ENSG00000172432

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307126 ENSG00000172432 HEK293_OSMI2_2hA HEK293_TMG_2hB GTPBP2 protein_coding protein_coding 34.65823 40.67652 27.91093 2.570388 0.3700976 -0.5432036 10.414094 15.347228 9.884399 0.6959468 1.1690624 -0.63423390 0.30094167 0.37920000 0.3539000 -0.02530000 8.649358e-01 8.339081e-08 FALSE  
ENST00000432918 ENSG00000172432 HEK293_OSMI2_2hA HEK293_TMG_2hB GTPBP2 protein_coding protein_coding 34.65823 40.67652 27.91093 2.570388 0.3700976 -0.5432036 1.879957 1.409700 1.332411 0.4465382 0.0913787 -0.08076049 0.05295417 0.03456667 0.0478000 0.01323333 6.210025e-01 8.339081e-08 FALSE  
ENST00000459959 ENSG00000172432 HEK293_OSMI2_2hA HEK293_TMG_2hB GTPBP2 protein_coding processed_transcript 34.65823 40.67652 27.91093 2.570388 0.3700976 -0.5432036 4.894788 4.001805 3.911318 0.2274095 0.5046566 -0.03291292 0.13982500 0.09873333 0.1397333 0.04100000 1.974964e-01 8.339081e-08    
ENST00000476510 ENSG00000172432 HEK293_OSMI2_2hA HEK293_TMG_2hB GTPBP2 protein_coding processed_transcript 34.65823 40.67652 27.91093 2.570388 0.3700976 -0.5432036 9.428567 13.680261 4.570944 2.2587390 2.5108500 -1.57943311 0.26740000 0.33353333 0.1660000 -0.16753333 6.744644e-01 8.339081e-08 FALSE  
ENST00000480263 ENSG00000172432 HEK293_OSMI2_2hA HEK293_TMG_2hB GTPBP2 protein_coding processed_transcript 34.65823 40.67652 27.91093 2.570388 0.3700976 -0.5432036 4.222815 2.546187 3.740841 0.2848832 0.1014535 0.55322110 0.12393333 0.06223333 0.1342000 0.07196667 8.339081e-08 8.339081e-08 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172432 E001 0.1817044 0.0401317482 8.232423e-01   6 43605316 43605382 67 - 0.000 0.096 7.845
ENSG00000172432 E002 1.9282038 0.0159222370 3.318216e-01 4.754611e-01 6 43620119 43620333 215 - 0.553 0.395 -0.797
ENSG00000172432 E003 0.5212538 0.0211766270 9.431631e-01 9.683576e-01 6 43620482 43620489 8 - 0.155 0.174 0.205
ENSG00000172432 E004 0.5963950 0.3642343708 8.269744e-01 8.911652e-01 6 43620490 43620493 4 - 0.155 0.232 0.719
ENSG00000172432 E005 12.3332477 0.0018973728 4.275952e-01 5.704612e-01 6 43620494 43620569 76 - 1.142 1.074 -0.242
ENSG00000172432 E006 815.5100573 0.0009798448 2.078481e-17 9.729727e-16 6 43620570 43621508 939 - 2.763 2.929 0.554
ENSG00000172432 E007 91.4396234 0.0010635085 9.087418e-03 2.649936e-02 6 43621509 43621516 8 - 1.853 1.975 0.409
ENSG00000172432 E008 322.1959043 0.0007836803 4.005717e-02 9.113818e-02 6 43621517 43621721 205 - 2.438 2.499 0.203
ENSG00000172432 E009 164.9154233 0.0012222151 9.935628e-01 1.000000e+00 6 43621722 43621760 39 - 2.181 2.192 0.036
ENSG00000172432 E010 191.2704461 0.0002205071 6.544224e-01 7.645952e-01 6 43621761 43621790 30 - 2.253 2.251 -0.005
ENSG00000172432 E011 15.3393039 0.0064383884 2.009727e-04 9.679093e-04 6 43621791 43622002 212 - 1.383 1.055 -1.161
ENSG00000172432 E012 306.3665729 0.0001579618 7.322157e-01 8.237175e-01 6 43622003 43622167 165 - 2.443 2.461 0.060
ENSG00000172432 E013 232.9458421 0.0001845711 9.354008e-02 1.806539e-01 6 43622633 43622804 172 - 2.300 2.352 0.175
ENSG00000172432 E014 93.0296820 0.0006532784 3.111793e-11 5.974662e-10 6 43622951 43623612 662 - 2.089 1.847 -0.814
ENSG00000172432 E015 166.7247795 0.0002369051 1.066670e-01 2.006329e-01 6 43623737 43623795 59 - 2.151 2.209 0.195
ENSG00000172432 E016 243.1001720 0.0002398475 8.893803e-01 9.332973e-01 6 43623933 43624068 136 - 2.345 2.359 0.048
ENSG00000172432 E017 157.0845345 0.0002718628 6.940356e-01 7.949585e-01 6 43624510 43624560 51 - 2.169 2.168 -0.003
ENSG00000172432 E018 139.8330980 0.0002349240 5.586842e-01 6.868915e-01 6 43624561 43624613 53 - 2.122 2.115 -0.026
ENSG00000172432 E019 158.0741947 0.0002362689 1.341795e-02 3.688695e-02 6 43624614 43624662 49 - 2.210 2.148 -0.207
ENSG00000172432 E020 167.1140610 0.0002405221 2.617487e-03 9.119040e-03 6 43624663 43624729 67 - 2.242 2.167 -0.251
ENSG00000172432 E021 247.7549799 0.0001739138 5.383171e-02 1.159568e-01 6 43624888 43625062 175 - 2.387 2.353 -0.115
ENSG00000172432 E022 43.2970160 0.0004999005 1.069865e-09 1.577788e-08 6 43625063 43625362 300 - 1.800 1.487 -1.067
ENSG00000172432 E023 262.4323791 0.0006266779 3.416630e-01 4.855851e-01 6 43625363 43625560 198 - 2.396 2.383 -0.044
ENSG00000172432 E024 187.8727282 0.0008527501 2.612095e-04 1.221468e-03 6 43625756 43625864 109 - 2.305 2.209 -0.322
ENSG00000172432 E025 195.5630442 0.0002230838 2.256602e-05 1.382129e-04 6 43626226 43626386 161 - 2.326 2.226 -0.335
ENSG00000172432 E026 85.4000105 0.0003263148 6.635542e-02 1.373138e-01 6 43626387 43626410 24 - 1.947 1.884 -0.209
ENSG00000172432 E027 73.3816456 0.0003503606 1.826484e-01 3.045110e-01 6 43626922 43626948 27 - 1.871 1.824 -0.157
ENSG00000172432 E028 2.0432138 0.2106690294 2.200221e-01 3.504354e-01 6 43626949 43627017 69 - 0.648 0.346 -1.499
ENSG00000172432 E029 1.2104824 0.0117178019 7.137799e-01 8.101627e-01 6 43627279 43627353 75 - 0.359 0.299 -0.378
ENSG00000172432 E030 0.8211642 0.1395615448 7.436319e-02 1.505196e-01 6 43628789 43628831 43 - 0.434 0.097 -2.784
ENSG00000172432 E031 8.0673212 0.0030593409 7.539869e-01 8.397356e-01 6 43628832 43628976 145 - 0.940 0.912 -0.105
ENSG00000172432 E032 96.9798303 0.0003350770 6.819617e-02 1.403796e-01 6 43628977 43629264 288 - 1.996 1.938 -0.194