ENSG00000172379

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303329 ENSG00000172379 HEK293_OSMI2_2hA HEK293_TMG_2hB ARNT2 protein_coding protein_coding 5.108239 6.277538 5.933815 0.2816997 0.1383326 -0.08110617 4.8753021 6.21061132 5.2423773 0.26524709 0.30773512 -0.2440858 0.9557333 0.989533333 0.88240000 -0.1071333 0.011017955 0.002332486 FALSE TRUE
ENST00000529181 ENSG00000172379 HEK293_OSMI2_2hA HEK293_TMG_2hB ARNT2 protein_coding retained_intron 5.108239 6.277538 5.933815 0.2816997 0.1383326 -0.08110617 0.1223019 0.03872979 0.3705695 0.03872979 0.05083777 2.9652839 0.0228250 0.005666667 0.06256667 0.0569000 0.002332486 0.002332486 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172379 E001 3.2765894 0.0052064045 1.176788e-03 4.562903e-03 15 80404350 80404381 32 + 0.804 0.369 -2.004
ENSG00000172379 E002 13.9804952 0.0030634490 1.283574e-04 6.517185e-04 15 80404382 80404546 165 + 1.294 1.030 -0.941
ENSG00000172379 E003 0.0000000       15 80441231 80441238 8 +      
ENSG00000172379 E004 0.0000000       15 80441239 80441239 1 +      
ENSG00000172379 E005 0.0000000       15 80441240 80441378 139 +      
ENSG00000172379 E006 0.4482035 0.0372228684 6.430359e-02 1.338739e-01 15 80442837 80443025 189 + 0.290 0.000 -12.504
ENSG00000172379 E007 16.8385409 0.0363260737 1.293911e-02 3.576886e-02 15 80450880 80450994 115 + 1.347 1.140 -0.729
ENSG00000172379 E008 16.0601312 0.0115330016 2.313068e-01 3.640382e-01 15 80457929 80457976 48 + 1.242 1.216 -0.092
ENSG00000172379 E009 15.9251874 0.0199115201 4.389267e-01 5.807290e-01 15 80470218 80470242 25 + 1.218 1.227 0.033
ENSG00000172379 E010 42.1616108 0.0102372431 1.001874e-03 3.964864e-03 15 80470243 80470431 189 + 1.702 1.563 -0.473
ENSG00000172379 E011 52.4076867 0.0004958779 6.527686e-08 6.874482e-07 15 80475010 80475223 214 + 1.808 1.642 -0.561
ENSG00000172379 E012 0.2987644 0.0290785164 1.619364e-01   15 80475224 80475580 357 + 0.213 0.000 -12.027
ENSG00000172379 E013 0.0000000       15 80487734 80487874 141 +      
ENSG00000172379 E014 0.2214452 0.0396882542 5.578567e-01   15 80488566 80488735 170 + 0.000 0.126 10.285
ENSG00000172379 E015 36.2835133 0.0015397991 9.097803e-04 3.648186e-03 15 80508156 80508258 103 + 1.621 1.516 -0.358
ENSG00000172379 E016 34.4375277 0.0049037877 4.167348e-02 9.414063e-02 15 80513911 80513976 66 + 1.569 1.522 -0.160
ENSG00000172379 E017 37.3776236 0.0006118362 2.115134e-02 5.391702e-02 15 80514320 80514405 86 + 1.601 1.562 -0.131
ENSG00000172379 E018 0.0000000       15 80551104 80551198 95 +      
ENSG00000172379 E019 36.3771745 0.0022793024 6.440966e-03 1.976860e-02 15 80551199 80551275 77 + 1.608 1.534 -0.252
ENSG00000172379 E020 43.4736137 0.0049339462 7.848048e-03 2.340110e-02 15 80552640 80552774 135 + 1.685 1.615 -0.239
ENSG00000172379 E021 30.5781328 0.0006812142 6.061374e-03 1.877150e-02 15 80555065 80555139 75 + 1.542 1.464 -0.266
ENSG00000172379 E022 47.1383217 0.0006871368 1.719149e-02 4.536480e-02 15 80563088 80563239 152 + 1.696 1.668 -0.096
ENSG00000172379 E023 0.1451727 0.0428012171 4.237344e-01   15 80574066 80574147 82 + 0.119 0.000 -10.891
ENSG00000172379 E024 36.9345235 0.0083352857 2.037551e-02 5.227415e-02 15 80574148 80574220 73 + 1.611 1.540 -0.243
ENSG00000172379 E025 45.4990041 0.0005693259 2.379894e-03 8.398097e-03 15 80574987 80575110 124 + 1.696 1.632 -0.217
ENSG00000172379 E026 39.7365810 0.0096725907 4.051598e-01 5.488435e-01 15 80576866 80576965 100 + 1.587 1.619 0.109
ENSG00000172379 E027 46.8553405 0.0013491744 1.826453e-01 3.045092e-01 15 80580411 80580549 139 + 1.665 1.687 0.074
ENSG00000172379 E028 0.6256415 0.0175538671 2.445823e-01 3.795498e-01 15 80581103 80581238 136 + 0.290 0.125 -1.502
ENSG00000172379 E029 42.8670832 0.0005392186 3.700855e-02 8.548525e-02 15 80581239 80581404 166 + 1.653 1.635 -0.059
ENSG00000172379 E030 38.2681564 0.0033652423 9.943297e-01 1.000000e+00 15 80591568 80591704 137 + 1.546 1.638 0.314
ENSG00000172379 E031 771.9727072 0.0050867162 1.492080e-13 4.136231e-12 15 80593600 80597933 4334 + 2.745 2.983 0.790