ENSG00000172375

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336702 ENSG00000172375 HEK293_OSMI2_2hA HEK293_TMG_2hB C2CD2L protein_coding protein_coding 10.94998 13.85463 8.985629 0.7989726 0.1418327 -0.624113 1.9479386 3.0942193 2.00301712 0.33072922 0.08624563 -0.6248710 0.17205833 0.22373333 0.222866667 -0.0008666667 1.00000000 0.001255594 FALSE TRUE
ENST00000525598 ENSG00000172375 HEK293_OSMI2_2hA HEK293_TMG_2hB C2CD2L protein_coding retained_intron 10.94998 13.85463 8.985629 0.7989726 0.1418327 -0.624113 0.6221890 0.4090079 0.59563310 0.02412253 0.06601049 0.5314665 0.06066667 0.02956667 0.066300000 0.0367333333 0.01708180 0.001255594 TRUE TRUE
ENST00000528586 ENSG00000172375 HEK293_OSMI2_2hA HEK293_TMG_2hB C2CD2L protein_coding protein_coding 10.94998 13.85463 8.985629 0.7989726 0.1418327 -0.624113 0.2907612 0.7490030 0.05909066 0.43776998 0.05909066 -3.4575430 0.02539167 0.05723333 0.006566667 -0.0506666667 0.25227687 0.001255594 FALSE TRUE
ENST00000529874 ENSG00000172375 HEK293_OSMI2_2hA HEK293_TMG_2hB C2CD2L protein_coding retained_intron 10.94998 13.85463 8.985629 0.7989726 0.1418327 -0.624113 0.8493680 0.2401256 0.96654067 0.13711341 0.18255890 1.9650272 0.08896250 0.01630000 0.107066667 0.0907666667 0.04852235 0.001255594 FALSE TRUE
ENST00000648610 ENSG00000172375 HEK293_OSMI2_2hA HEK293_TMG_2hB C2CD2L protein_coding protein_coding 10.94998 13.85463 8.985629 0.7989726 0.1418327 -0.624113 6.3452872 8.4630215 4.43549630 0.95097261 0.21489111 -0.9305320 0.57115417 0.60693333 0.494166667 -0.1127666667 0.20503371 0.001255594 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172375 E001 3.2731742 0.0046494583 6.836676e-01 7.868078e-01 11 119102198 119102375 178 + 0.651 0.593 -0.254
ENSG00000172375 E002 0.3332198 0.0284427164 6.641933e-01   11 119106715 119106741 27 + 0.157 0.095 -0.838
ENSG00000172375 E003 0.3332198 0.0284427164 6.641933e-01   11 119106742 119106749 8 + 0.157 0.095 -0.838
ENSG00000172375 E004 0.7782011 0.0164429348 2.723401e-01 4.112059e-01 11 119106750 119106774 25 + 0.363 0.172 -1.424
ENSG00000172375 E005 1.8758793 0.0186999120 3.471119e-02 8.109523e-02 11 119106775 119106878 104 + 0.651 0.295 -1.838
ENSG00000172375 E006 1.7005176 0.0130287742 1.407223e-02 3.838871e-02 11 119106879 119106941 63 + 0.651 0.238 -2.254
ENSG00000172375 E007 1.3287029 0.2082908799 1.022797e-02 2.932647e-02 11 119106942 119107070 129 + 0.651 0.094 -3.853
ENSG00000172375 E008 0.6632174 0.0200839119 6.595054e-01 7.683165e-01 11 119107071 119107126 56 + 0.157 0.238 0.746
ENSG00000172375 E009 0.6266857 0.0181710481 5.583398e-01 6.865977e-01 11 119107127 119107343 217 + 0.272 0.172 -0.839
ENSG00000172375 E010 3.8469415 0.0638702225 6.884108e-01 7.905599e-01 11 119107344 119107374 31 + 0.692 0.625 -0.287
ENSG00000172375 E011 5.5660199 0.0028722817 2.490456e-01 3.847862e-01 11 119107375 119107382 8 + 0.877 0.731 -0.574
ENSG00000172375 E012 41.2402920 0.0005271226 3.830843e-02 8.792820e-02 11 119107383 119107512 130 + 1.661 1.551 -0.374
ENSG00000172375 E013 63.3655191 0.0090573559 2.269935e-01 3.588089e-01 11 119107513 119107751 239 + 1.816 1.749 -0.226
ENSG00000172375 E014 87.5780978 0.0144005803 4.710219e-03 1.512461e-02 11 119107752 119108095 344 + 2.028 1.850 -0.598
ENSG00000172375 E015 0.9921577 0.0127033777 9.103611e-01 9.470192e-01 11 119110103 119110103 1 + 0.272 0.295 0.162
ENSG00000172375 E016 88.3065932 0.0003365463 7.444158e-03 2.237177e-02 11 119110104 119110199 96 + 1.980 1.882 -0.327
ENSG00000172375 E017 62.4773063 0.0005136185 7.912491e-01 8.665027e-01 11 119110561 119110586 26 + 1.750 1.769 0.064
ENSG00000172375 E018 114.3587904 0.0049206364 2.058843e-01 3.335286e-01 11 119110587 119110680 94 + 2.064 2.011 -0.178
ENSG00000172375 E019 4.8005850 0.0033943102 3.365922e-05 1.977191e-04 11 119110681 119110846 166 + 1.024 0.470 -2.296
ENSG00000172375 E020 118.6967581 0.0032169328 8.000080e-03 2.377995e-02 11 119110847 119110957 111 + 2.110 2.007 -0.346
ENSG00000172375 E021 64.7490880 0.0011116670 4.692721e-02 1.036930e-01 11 119111052 119111056 5 + 1.838 1.751 -0.294
ENSG00000172375 E022 132.4738935 0.0002562289 1.045915e-02 2.988393e-02 11 119111057 119111168 112 + 2.140 2.065 -0.251
ENSG00000172375 E023 136.2510888 0.0034619263 8.320168e-02 1.645868e-01 11 119111263 119111374 112 + 2.144 2.083 -0.206
ENSG00000172375 E024 93.4289525 0.0030846186 2.922517e-01 4.332050e-01 11 119111521 119111560 40 + 1.966 1.926 -0.131
ENSG00000172375 E025 114.8293215 0.0014382985 6.794726e-01 7.836317e-01 11 119111561 119111629 69 + 2.010 2.034 0.079
ENSG00000172375 E026 15.2326683 0.0011818302 1.290013e-08 1.558107e-07 11 119111630 119112327 698 + 1.447 0.967 -1.705
ENSG00000172375 E027 95.5453469 0.0027104813 2.050549e-02 5.255423e-02 11 119112328 119112392 65 + 1.867 1.981 0.384
ENSG00000172375 E028 0.7406253 0.0156846350 2.654928e-03 9.237925e-03 11 119112393 119112481 89 + 0.502 0.000 -12.490
ENSG00000172375 E029 131.1006039 0.0029610832 1.755549e-01 2.954066e-01 11 119112482 119112609 128 + 2.037 2.103 0.221
ENSG00000172375 E030 158.8904516 0.0002226628 7.337542e-02 1.489207e-01 11 119112700 119112874 175 + 2.126 2.186 0.200
ENSG00000172375 E031 7.7049486 0.0022170042 1.521090e-02 4.096700e-02 11 119112875 119113610 736 + 1.075 0.803 -1.022
ENSG00000172375 E032 78.7738387 0.0003689146 3.614860e-02 8.387934e-02 11 119113611 119113636 26 + 1.801 1.897 0.324
ENSG00000172375 E033 120.8734370 0.0003013634 3.079401e-01 4.501762e-01 11 119113637 119113712 76 + 2.025 2.066 0.138
ENSG00000172375 E034 6.1523644 0.0163999966 1.599497e-03 5.959789e-03 11 119113713 119113851 139 + 1.059 0.645 -1.614
ENSG00000172375 E035 18.4380406 0.0012520059 6.677672e-02 1.380307e-01 11 119113852 119113854 3 + 1.349 1.207 -0.498
ENSG00000172375 E036 157.6186428 0.0021406749 5.542307e-01 6.832384e-01 11 119113855 119113988 134 + 2.148 2.177 0.097
ENSG00000172375 E037 1.6232115 0.0224776289 1.294916e-01 2.334471e-01 11 119113989 119114079 91 + 0.558 0.295 -1.422
ENSG00000172375 E038 243.6800051 0.0002217408 2.591572e-02 6.377418e-02 11 119114080 119114365 286 + 2.311 2.371 0.201
ENSG00000172375 E039 30.5081557 0.0014431577 2.123739e-05 1.308750e-04 11 119114366 119116024 1659 + 1.631 1.365 -0.915
ENSG00000172375 E040 2.7195414 0.0176581848 3.534455e-01 4.976861e-01 11 119116025 119116044 20 + 0.651 0.503 -0.670
ENSG00000172375 E041 616.5838561 0.0018734157 6.455490e-09 8.250511e-08 11 119116045 119118544 2500 + 2.659 2.797 0.462