ENSG00000172354

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303210 ENSG00000172354 HEK293_OSMI2_2hA HEK293_TMG_2hB GNB2 protein_coding protein_coding 267.0583 505.9621 135.023 19.70713 2.088555 -1.905746 19.18874 21.36938 12.68948 7.353417 1.1008092 -0.7514505 0.07215417 0.0418000 0.09423333 0.05243333 1.379679e-01 1.431721e-07 FALSE TRUE
ENST00000427895 ENSG00000172354 HEK293_OSMI2_2hA HEK293_TMG_2hB GNB2 protein_coding protein_coding 267.0583 505.9621 135.023 19.70713 2.088555 -1.905746 62.63031 132.79544 30.58076 15.575550 0.4343704 -2.1181463 0.22631667 0.2626667 0.22653333 -0.03613333 6.784458e-01 1.431721e-07 FALSE TRUE
ENST00000451587 ENSG00000172354 HEK293_OSMI2_2hA HEK293_TMG_2hB GNB2 protein_coding protein_coding 267.0583 505.9621 135.023 19.70713 2.088555 -1.905746 75.98995 124.81824 53.66081 9.482443 1.3971016 -1.2177348 0.31655833 0.2463667 0.39746667 0.15110000 2.880542e-07 1.431721e-07 FALSE FALSE
MSTRG.30348.11 ENSG00000172354 HEK293_OSMI2_2hA HEK293_TMG_2hB GNB2 protein_coding   267.0583 505.9621 135.023 19.70713 2.088555 -1.905746 100.57045 214.02510 33.75069 5.728227 3.1584102 -2.6644311 0.34674167 0.4234000 0.24936667 -0.17403333 4.444245e-07 1.431721e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172354 E001 45.359894 1.112745e-02 9.025890e-02 1.755284e-01 7 100673567 100673610 44 + 1.639 1.509 -0.443
ENSG00000172354 E002 12.545596 1.473949e-03 8.114654e-01 8.803713e-01 7 100673740 100673744 5 + 1.019 0.998 -0.079
ENSG00000172354 E003 14.595700 7.412806e-03 9.380810e-01 9.650802e-01 7 100673745 100673748 4 + 1.046 1.063 0.060
ENSG00000172354 E004 42.217258 7.144943e-02 6.993944e-05 3.797489e-04 7 100673749 100673822 74 + 1.893 1.362 -1.808
ENSG00000172354 E005 56.960796 9.075440e-02 1.035178e-03 4.080127e-03 7 100673823 100673877 55 + 1.987 1.509 -1.617
ENSG00000172354 E006 73.265474 6.056434e-02 1.957511e-03 7.093579e-03 7 100673878 100673923 46 + 2.025 1.651 -1.259
ENSG00000172354 E007 7.331055 2.276483e-03 1.501251e-05 9.581819e-05 7 100674793 100674852 60 + 1.181 0.664 -1.974
ENSG00000172354 E008 5.017789 3.245344e-03 3.103417e-08 3.480747e-07 7 100675286 100675441 156 + 1.161 0.436 -2.967
ENSG00000172354 E009 4.975783 1.756928e-02 9.533152e-06 6.367321e-05 7 100675727 100675850 124 + 1.119 0.503 -2.476
ENSG00000172354 E010 2.903611 1.537606e-01 5.821865e-02 1.235768e-01 7 100676118 100676120 3 + 0.805 0.388 -1.899
ENSG00000172354 E011 2.903611 1.537606e-01 5.821865e-02 1.235768e-01 7 100676121 100676137 17 + 0.805 0.388 -1.899
ENSG00000172354 E012 66.770543 3.960043e-04 1.145198e-02 3.223976e-02 7 100676138 100676176 39 + 1.800 1.673 -0.429
ENSG00000172354 E013 164.397119 7.165052e-03 1.154110e-01 2.134411e-01 7 100676177 100676222 46 + 2.142 2.070 -0.242
ENSG00000172354 E014 129.447881 6.570127e-03 5.354818e-01 6.673031e-01 7 100676223 100676232 10 + 1.998 1.975 -0.077
ENSG00000172354 E015 874.862991 1.921283e-03 2.030642e-01 3.300580e-01 7 100676233 100676322 90 + 2.827 2.804 -0.075
ENSG00000172354 E016 845.182340 1.660384e-03 1.486101e-01 2.597783e-01 7 100676535 100676547 13 + 2.814 2.788 -0.086
ENSG00000172354 E017 1002.199614 1.083309e-03 2.826860e-02 6.854125e-02 7 100676548 100676573 26 + 2.897 2.860 -0.121
ENSG00000172354 E018 1790.573526 8.829557e-04 3.792974e-01 5.235579e-01 7 100676693 100676799 107 + 3.123 3.118 -0.017
ENSG00000172354 E019 17.448376 1.051370e-03 4.690860e-04 2.041838e-03 7 100676800 100676835 36 + 1.379 1.067 -1.105
ENSG00000172354 E020 41.722990 4.260478e-03 1.135098e-09 1.665822e-08 7 100676836 100677351 516 + 1.795 1.400 -1.348
ENSG00000172354 E021 1036.699912 2.452930e-04 6.305949e-01 7.457524e-01 7 100677352 100677369 18 + 2.880 2.881 0.003
ENSG00000172354 E022 1373.485150 1.075477e-04 4.499787e-01 5.911563e-01 7 100677370 100677415 46 + 3.004 3.002 -0.005
ENSG00000172354 E023 2875.700196 8.904531e-05 9.896662e-02 1.888985e-01 7 100677498 100677660 163 + 3.328 3.322 -0.021
ENSG00000172354 E024 13.142324 9.773994e-03 8.245717e-03 2.440670e-02 7 100677661 100677751 91 + 1.252 0.969 -1.024
ENSG00000172354 E025 2386.458519 1.354281e-04 3.647157e-02 8.447926e-02 7 100677752 100677818 67 + 3.253 3.240 -0.043
ENSG00000172354 E026 4382.554505 3.141001e-04 5.667126e-01 6.936307e-01 7 100678098 100678299 202 + 3.494 3.510 0.053
ENSG00000172354 E027 4630.433388 6.081005e-04 5.638650e-02 1.204042e-01 7 100678398 100678614 217 + 3.503 3.537 0.112
ENSG00000172354 E028 3292.533492 1.310603e-03 1.210380e-09 1.765362e-08 7 100678695 100679174 480 + 3.280 3.401 0.402