ENSG00000172350

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000524604 ENSG00000172350 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCG4 protein_coding protein_coding 0.6569965 0.6266956 0.6891567 0.07988384 0.215967 0.1350121 0.05392630 0.00000000 0.21106350 0.000000000 0.21106350 4.4663889 0.06822083 0.00000000 0.19200000 0.192000000 0.77325085 0.04864014 FALSE FALSE
ENST00000533694 ENSG00000172350 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCG4 protein_coding retained_intron 0.6569965 0.6266956 0.6891567 0.07988384 0.215967 0.1350121 0.09331377 0.03329992 0.14654402 0.006887986 0.01588142 1.8541320 0.14017083 0.05563333 0.24513333 0.189500000 0.09897526 0.04864014 TRUE TRUE
ENST00000534402 ENSG00000172350 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCG4 protein_coding retained_intron 0.6569965 0.6266956 0.6891567 0.07988384 0.215967 0.1350121 0.04230875 0.01966463 0.01180376 0.019664632 0.01180376 -0.4441668 0.06314583 0.02530000 0.01963333 -0.005666667 0.85022373 0.04864014 FALSE FALSE
ENST00000619701 ENSG00000172350 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCG4 protein_coding protein_coding 0.6569965 0.6266956 0.6891567 0.07988384 0.215967 0.1350121 0.46744772 0.57373101 0.31974541 0.064057333 0.04297875 -0.8239511 0.72845417 0.91906667 0.54320000 -0.375866667 0.04864014 0.04864014 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172350 E001 0.5922303 0.018435529 0.146026658 0.256281554 11 119149052 119149252 201 + 0.346 0.101 -2.223
ENSG00000172350 E002 0.4439371 0.022107104 0.034083571 0.079917698 11 119149253 119149280 28 + 0.346 0.000 -11.570
ENSG00000172350 E003 1.7328847 0.008500107 0.003677559 0.012231828 11 119149281 119149363 83 + 0.668 0.183 -2.805
ENSG00000172350 E004 0.0000000       11 119149513 119149688 176 +      
ENSG00000172350 E005 0.0000000       11 119149896 119149953 58 +      
ENSG00000172350 E006 7.8063641 0.009583688 0.636258662 0.750295946 11 119149954 119150203 250 + 0.960 0.906 -0.203
ENSG00000172350 E007 4.7337877 0.003618752 0.001925320 0.006994308 11 119152875 119154025 1151 + 0.960 0.557 -1.637
ENSG00000172350 E008 5.0125895 0.003791066 0.048039970 0.105704227 11 119154026 119154143 118 + 0.897 0.643 -1.022
ENSG00000172350 E009 3.9439820 0.007293950 0.276039728 0.415447729 11 119154260 119154359 100 + 0.769 0.616 -0.636
ENSG00000172350 E010 1.9133519 0.008133366 0.138330803 0.245785203 11 119154360 119154392 33 + 0.258 0.525 1.534
ENSG00000172350 E011 2.7560850 0.015803078 0.432535342 0.574970691 11 119154525 119154575 51 + 0.481 0.615 0.622
ENSG00000172350 E012 3.9486096 0.273447978 0.607415015 0.727402873 11 119154770 119154915 146 + 0.583 0.728 0.623
ENSG00000172350 E013 0.3729606 0.027596268 0.743604167 0.832207438 11 119155630 119156328 699 + 0.148 0.101 -0.634
ENSG00000172350 E014 4.2495365 0.042563425 0.311497360 0.453951844 11 119156329 119156452 124 + 0.584 0.756 0.730
ENSG00000172350 E015 0.0000000       11 119156453 119156563 111 +      
ENSG00000172350 E016 3.7955714 0.004565402 0.247448920 0.382946988 11 119156564 119156678 115 + 0.536 0.714 0.779
ENSG00000172350 E017 4.6092469 0.003787869 0.541965574 0.672833715 11 119156872 119157014 143 + 0.668 0.756 0.364
ENSG00000172350 E018 3.2138405 0.005225316 0.579316212 0.704237102 11 119158234 119158332 99 + 0.668 0.588 -0.348
ENSG00000172350 E019 0.6717251 0.020480708 0.147556347 0.258367920 11 119158333 119158495 163 + 0.346 0.101 -2.220
ENSG00000172350 E020 0.6319842 0.020030579 0.147149118 0.257812049 11 119158496 119158556 61 + 0.346 0.101 -2.222
ENSG00000172350 E021 3.8779882 0.041071190 0.933535620 0.962124225 11 119158557 119158725 169 + 0.668 0.688 0.086
ENSG00000172350 E022 2.4388616 0.006479583 0.542529988 0.673260876 11 119158829 119158929 101 + 0.584 0.490 -0.445
ENSG00000172350 E023 2.3177492 0.135482939 0.972777075 0.987015964 11 119160227 119160371 145 + 0.482 0.498 0.080
ENSG00000172350 E024 1.2846917 0.022921111 0.570469644 0.696948758 11 119160372 119160385 14 + 0.258 0.364 0.691
ENSG00000172350 E025 3.7570491 0.011159624 0.192427266 0.316810654 11 119160538 119160656 119 + 0.481 0.694 0.957
ENSG00000172350 E026 9.2126025 0.182948386 0.389588908 0.533665338 11 119160881 119161436 556 + 0.877 1.032 0.577
ENSG00000172350 E027 5.5742198 0.005803566 0.039678062 0.090427662 11 119161437 119161648 212 + 0.584 0.877 1.200
ENSG00000172350 E028 18.7540472 0.002410563 0.313557262 0.456166691 11 119161649 119162653 1005 + 1.215 1.297 0.287