ENSG00000172273

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000350777 ENSG00000172273 HEK293_OSMI2_2hA HEK293_TMG_2hB HINFP protein_coding protein_coding 17.91662 20.241 13.87808 0.3976541 0.1530117 -0.5441462 6.989040 10.107216 5.080838 0.6048934 0.4993938 -0.9908373 0.38740417 0.50006667 0.36590000 -0.1341667 0.13300351 1.141654e-09 FALSE  
ENST00000529354 ENSG00000172273 HEK293_OSMI2_2hA HEK293_TMG_2hB HINFP protein_coding retained_intron 17.91662 20.241 13.87808 0.3976541 0.1530117 -0.5441462 1.892846 1.410818 1.709472 0.1392794 0.1158125 0.2752438 0.10885417 0.06970000 0.12320000 0.0535000 0.02308358 1.141654e-09 FALSE  
ENST00000529610 ENSG00000172273 HEK293_OSMI2_2hA HEK293_TMG_2hB HINFP protein_coding retained_intron 17.91662 20.241 13.87808 0.3976541 0.1530117 -0.5441462 1.937774 1.678796 1.656501 0.7213813 0.2682921 -0.0191730 0.10790417 0.08293333 0.11973333 0.0368000 0.62087573 1.141654e-09    
MSTRG.6432.1 ENSG00000172273 HEK293_OSMI2_2hA HEK293_TMG_2hB HINFP protein_coding   17.91662 20.241 13.87808 0.3976541 0.1530117 -0.5441462 1.663070 1.652546 1.150972 0.3678178 0.1696259 -0.5180607 0.09387083 0.08106667 0.08306667 0.0020000 0.98567666 1.141654e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172273 E001 2.242307 0.0072170373 9.379965e-01 0.9650352255 11 119121491 119121579 89 + 0.504 0.501 -0.014
ENSG00000172273 E002 2.394866 0.0242127247 9.302451e-01 0.9601153482 11 119121580 119121588 9 + 0.504 0.532 0.132
ENSG00000172273 E003 2.394866 0.0242127247 9.302451e-01 0.9601153482 11 119121589 119121589 1 + 0.504 0.532 0.132
ENSG00000172273 E004 2.688332 0.0942598561 9.194954e-01 0.9531544342 11 119121590 119121590 1 + 0.560 0.556 -0.015
ENSG00000172273 E005 2.909777 0.0357817944 9.292866e-01 0.9595343368 11 119121591 119121591 1 + 0.560 0.589 0.130
ENSG00000172273 E006 16.320214 0.0011254052 2.510324e-01 0.3871738349 11 119121592 119121608 17 + 1.268 1.183 -0.300
ENSG00000172273 E007 16.801727 0.0010883222 2.613170e-01 0.3989528290 11 119121609 119121609 1 + 1.278 1.197 -0.288
ENSG00000172273 E008 25.799587 0.0007790719 5.866976e-01 0.7102160053 11 119121610 119121615 6 + 1.360 1.413 0.182
ENSG00000172273 E009 47.980144 0.0006812759 1.665435e-01 0.2837003291 11 119121616 119121639 24 + 1.696 1.636 -0.203
ENSG00000172273 E010 1.809157 0.0082413028 1.163365e-02 0.0326600489 11 119121640 119121649 10 + 0.654 0.237 -2.273
ENSG00000172273 E011 3.749476 0.0042546085 8.809687e-01 0.9276945031 11 119121783 119122013 231 + 0.654 0.642 -0.052
ENSG00000172273 E012 16.256268 0.0013282257 6.087569e-01 0.7283882170 11 119123568 119123684 117 + 1.164 1.223 0.208
ENSG00000172273 E013 7.031079 0.0024463027 1.554779e-01 0.2690257705 11 119123733 119123987 255 + 0.731 0.929 0.772
ENSG00000172273 E014 11.420179 0.0387381859 7.667084e-01 0.8491169109 11 119123988 119124236 249 + 1.028 1.087 0.215
ENSG00000172273 E015 31.686714 0.0102030462 1.842098e-01 0.3065153704 11 119124237 119126934 2698 + 1.393 1.513 0.413
ENSG00000172273 E016 62.652232 0.0008723685 9.828997e-01 0.9933648161 11 119126935 119126993 59 + 1.760 1.774 0.048
ENSG00000172273 E017 102.984969 0.0003867203 3.875549e-01 0.5316913448 11 119126994 119127125 132 + 1.997 1.979 -0.060
ENSG00000172273 E018 3.124027 0.0280726272 6.397176e-03 0.0196556052 11 119127126 119127458 333 + 0.826 0.391 -1.965
ENSG00000172273 E019 11.460846 0.0067350658 1.758655e-04 0.0008605534 11 119129860 119130724 865 + 1.278 0.904 -1.356
ENSG00000172273 E020 165.819841 0.0041578723 1.887886e-01 0.3122254568 11 119130725 119130954 230 + 2.216 2.175 -0.138
ENSG00000172273 E021 14.100406 0.0082874542 7.543560e-04 0.0030952254 11 119130955 119131113 159 + 1.343 1.036 -1.095
ENSG00000172273 E022 13.076885 0.0013332465 1.920746e-03 0.0069795647 11 119131114 119131209 96 + 1.288 1.018 -0.968
ENSG00000172273 E023 22.705330 0.0119470846 2.378855e-04 0.0011245591 11 119131210 119131438 229 + 1.525 1.213 -1.082
ENSG00000172273 E024 19.317934 0.0576078508 6.950348e-02 0.1425363859 11 119131439 119131534 96 + 1.415 1.183 -0.811
ENSG00000172273 E025 77.558193 0.0046688041 3.013071e-01 0.4430951212 11 119131535 119131564 30 + 1.888 1.846 -0.141
ENSG00000172273 E026 110.160524 0.0031457233 2.170134e-01 0.3467955156 11 119131565 119131646 82 + 2.039 1.998 -0.138
ENSG00000172273 E027 3.156306 0.1487454250 1.534584e-01 0.2663682756 11 119131647 119131829 183 + 0.795 0.465 -1.450
ENSG00000172273 E028 134.280840 0.0007375939 1.731454e-01 0.2922814823 11 119131830 119131982 153 + 2.121 2.090 -0.105
ENSG00000172273 E029 3.273365 0.0055193506 2.429060e-02 0.0604146209 11 119131983 119132242 260 + 0.797 0.467 -1.444
ENSG00000172273 E030 6.432684 0.0114159721 9.861010e-01 0.9953108615 11 119132243 119132297 55 + 0.826 0.834 0.031
ENSG00000172273 E031 4.128781 0.0038419143 3.477034e-01 0.4918967610 11 119132298 119132495 198 + 0.765 0.642 -0.512
ENSG00000172273 E032 94.735472 0.0025519697 8.609497e-01 0.9143184125 11 119132496 119132573 78 + 1.937 1.959 0.073
ENSG00000172273 E033 118.248386 0.0014049233 4.289603e-01 0.5716905822 11 119132661 119132781 121 + 2.017 2.061 0.145
ENSG00000172273 E034 1.689817 0.0087505172 3.110024e-01 0.4534491830 11 119132839 119132863 25 + 0.273 0.467 1.139
ENSG00000172273 E035 142.270647 0.0002584847 5.179455e-01 0.6522588926 11 119132864 119133002 139 + 2.103 2.137 0.114
ENSG00000172273 E036 147.071534 0.0003781718 7.890410e-01 0.8649495987 11 119133095 119133219 125 + 2.127 2.149 0.075
ENSG00000172273 E037 12.442419 0.0274968145 2.186506e-01 0.3487991964 11 119133220 119133898 679 + 1.190 1.067 -0.440
ENSG00000172273 E038 2.658230 0.0057390311 4.646875e-01 0.6044149653 11 119134022 119134083 62 + 0.610 0.502 -0.498
ENSG00000172273 E039 556.393993 0.0025738116 3.357954e-06 0.0000248731 11 119134084 119136059 1976 + 2.627 2.750 0.409