ENSG00000172270

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000353555 ENSG00000172270 HEK293_OSMI2_2hA HEK293_TMG_2hB BSG protein_coding protein_coding 1013.675 1462.894 643.7063 64.67529 10.70547 -1.184338 745.88677 1137.80090 434.95743 28.28948 8.738320 -1.387282 0.7247417 0.77916667 0.6756333 -0.10353333 5.986421e-04 7.830317e-06 FALSE TRUE
ENST00000573216 ENSG00000172270 HEK293_OSMI2_2hA HEK293_TMG_2hB BSG protein_coding protein_coding 1013.675 1462.894 643.7063 64.67529 10.70547 -1.184338 91.99464 30.11908 110.35598 12.54151 1.964905 1.873067 0.1075875 0.01996667 0.1715333 0.15156667 7.607590e-04 7.830317e-06 FALSE FALSE
ENST00000680065 ENSG00000172270 HEK293_OSMI2_2hA HEK293_TMG_2hB BSG protein_coding protein_coding 1013.675 1462.894 643.7063 64.67529 10.70547 -1.184338 143.86104 243.25068 80.03118 17.84901 1.221596 -1.603689 0.1367000 0.16590000 0.1243333 -0.04156667 3.715478e-05 7.830317e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172270 E001 2.998086e-01 2.907852e-02 4.791139e-01   19 571277 571309 33 + 0.183 0.080 -1.379
ENSG00000172270 E002 1.512762e+01 1.233064e-03 1.853144e-01 3.078909e-01 19 571310 571579 270 + 1.224 1.105 -0.425
ENSG00000172270 E003 2.246633e+00 1.074113e-02 8.419864e-01 9.014767e-01 19 572474 572528 55 + 0.410 0.451 0.213
ENSG00000172270 E004 3.616691e+01 7.723969e-03 2.640387e-01 4.019910e-01 19 572529 572570 42 + 1.418 1.517 0.340
ENSG00000172270 E005 3.796753e+01 1.073366e-02 3.854008e-01 5.295826e-01 19 572571 572571 1 + 1.451 1.534 0.285
ENSG00000172270 E006 6.721958e+02 4.138352e-03 4.545346e-01 5.951668e-01 19 572572 572593 22 + 2.769 2.755 -0.046
ENSG00000172270 E007 7.051830e+02 4.156550e-03 4.953159e-01 6.321340e-01 19 572594 572595 2 + 2.788 2.777 -0.037
ENSG00000172270 E008 1.637142e+03 3.714216e-03 2.683088e-09 3.676694e-08 19 572596 572609 14 + 3.271 3.097 -0.577
ENSG00000172270 E009 2.929310e+03 1.234006e-03 1.689135e-03 6.248199e-03 19 572610 572618 9 + 3.434 3.386 -0.158
ENSG00000172270 E010 3.243518e+03 1.287052e-03 1.698334e-01 2.879993e-01 19 572619 572622 4 + 3.454 3.439 -0.049
ENSG00000172270 E011 3.636143e+03 9.161803e-04 2.849610e-01 4.252546e-01 19 572623 572634 12 + 3.497 3.491 -0.022
ENSG00000172270 E012 5.762121e+03 6.663675e-04 1.971936e-02 5.089471e-02 19 572635 572701 67 + 3.708 3.687 -0.069
ENSG00000172270 E013 5.033965e+00 3.728504e-03 9.176537e-01 9.519651e-01 19 575047 575048 2 + 0.716 0.736 0.082
ENSG00000172270 E014 8.062035e+00 2.114219e-03 5.140413e-01 6.487913e-01 19 575049 575140 92 + 0.948 0.873 -0.283
ENSG00000172270 E015 1.121722e+01 3.260513e-03 5.306267e-02 1.145957e-01 19 575213 575386 174 + 1.165 0.968 -0.719
ENSG00000172270 E016 2.175316e+01 5.622956e-02 9.605493e-01 9.791664e-01 19 577774 578121 348 + 1.297 1.286 -0.039
ENSG00000172270 E017 8.503955e+00 1.633624e-02 4.330545e-01 5.755073e-01 19 578122 578212 91 + 0.973 0.877 -0.362
ENSG00000172270 E018 3.524942e+01 8.590985e-04 1.236813e-01 2.251969e-01 19 578850 579499 650 + 1.558 1.464 -0.323
ENSG00000172270 E019 3.628720e+03 5.449610e-04 1.654418e-02 4.393807e-02 19 579500 579508 9 + 3.508 3.486 -0.073
ENSG00000172270 E020 4.178992e+03 3.303809e-04 3.355980e-04 1.522900e-03 19 579509 579523 15 + 3.574 3.545 -0.097
ENSG00000172270 E021 6.807736e+03 7.122468e-05 1.662153e-23 1.558090e-21 19 579524 579579 56 + 3.803 3.750 -0.178
ENSG00000172270 E022 8.313254e+03 3.488805e-05 4.535058e-34 1.038879e-31 19 579580 579656 77 + 3.890 3.836 -0.178
ENSG00000172270 E023 2.616253e+02 1.686435e-04 6.254092e-01 7.415454e-01 19 579657 580378 722 + 2.334 2.353 0.062
ENSG00000172270 E024 8.358983e+03 1.191599e-04 1.234091e-13 3.460552e-12 19 580379 580461 83 + 3.884 3.843 -0.135
ENSG00000172270 E025 6.790405e+01 4.980206e-03 2.467297e-02 6.120974e-02 19 580462 580645 184 + 1.860 1.737 -0.413
ENSG00000172270 E026 4.683899e+03 2.314199e-04 1.823691e-12 4.282790e-11 19 580646 580646 1 + 3.644 3.588 -0.188
ENSG00000172270 E027 5.012670e+03 2.432373e-04 4.442336e-15 1.540522e-13 19 580647 580655 9 + 3.679 3.615 -0.212
ENSG00000172270 E028 1.030042e+04 2.611559e-04 6.182981e-04 2.600740e-03 19 580656 580782 127 + 3.959 3.940 -0.064
ENSG00000172270 E029 1.262667e+04 1.948332e-05 9.023239e-11 1.604492e-09 19 581315 581591 277 + 4.006 4.039 0.109
ENSG00000172270 E030 4.526916e+03 9.960753e-05 9.652356e-13 2.376361e-11 19 582306 582330 25 + 3.538 3.600 0.208
ENSG00000172270 E031 1.366110e+02 7.760200e-03 5.161404e-01 6.507123e-01 19 582331 582513 183 + 2.096 2.065 -0.103
ENSG00000172270 E032 3.585391e+03 8.377398e-05 2.934596e-11 5.661410e-10 19 582514 582517 4 + 3.437 3.498 0.203
ENSG00000172270 E033 3.507862e+03 1.223990e-04 3.251474e-08 3.636042e-07 19 582518 582519 2 + 3.432 3.488 0.185
ENSG00000172270 E034 3.550738e+03 1.062878e-04 6.772991e-09 8.619662e-08 19 582520 582522 3 + 3.437 3.493 0.187
ENSG00000172270 E035 5.221067e+03 4.939398e-05 1.851110e-11 3.688338e-10 19 582523 582578 56 + 3.609 3.659 0.168
ENSG00000172270 E036 2.487552e+03 2.644881e-04 5.085333e-06 3.613657e-05 19 582579 582582 4 + 3.281 3.341 0.199
ENSG00000172270 E037 1.133463e+01 4.128674e-03 6.275705e-01 7.433637e-01 19 582583 582613 31 + 1.060 1.013 -0.174
ENSG00000172270 E038 1.885388e+04 1.311784e-03 6.283565e-14 1.837325e-12 19 582750 583494 745 + 4.107 4.236 0.429