ENSG00000172262

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306938 ENSG00000172262 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF131 protein_coding protein_coding 15.17272 5.528398 25.05101 0.5695267 0.9239447 2.177904 2.0755141 1.57874521 2.6546765 0.30332479 0.50923900 0.7460726 0.15862500 0.281166667 0.10486667 -0.17630000 4.096503e-03 5.102784e-12 FALSE TRUE
ENST00000503599 ENSG00000172262 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF131 protein_coding retained_intron 15.17272 5.528398 25.05101 0.5695267 0.9239447 2.177904 0.4681909 0.52980826 0.4843226 0.12890387 0.17496926 -0.1269942 0.04635833 0.097400000 0.01893333 -0.07846667 3.607831e-03 5.102784e-12   FALSE
ENST00000505606 ENSG00000172262 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF131 protein_coding protein_coding 15.17272 5.528398 25.05101 0.5695267 0.9239447 2.177904 1.8277110 0.70758880 2.6802398 0.25143487 0.16504676 1.9065055 0.13200417 0.124433333 0.10726667 -0.01716667 9.693082e-01 5.102784e-12 FALSE TRUE
ENST00000509156 ENSG00000172262 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF131 protein_coding protein_coding 15.17272 5.528398 25.05101 0.5695267 0.9239447 2.177904 1.6275337 0.00000000 1.9162383 0.00000000 0.41380046 7.5896424 0.07586250 0.000000000 0.07600000 0.07600000 3.904888e-07 5.102784e-12 FALSE TRUE
ENST00000509634 ENSG00000172262 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF131 protein_coding protein_coding 15.17272 5.528398 25.05101 0.5695267 0.9239447 2.177904 2.4625030 0.74405322 4.4774184 0.23629721 0.20864387 2.5731475 0.15383750 0.129233333 0.17903333 0.04980000 3.968188e-01 5.102784e-12 FALSE TRUE
ENST00000510026 ENSG00000172262 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF131 protein_coding nonsense_mediated_decay 15.17272 5.528398 25.05101 0.5695267 0.9239447 2.177904 1.4266531 0.22982353 1.8863881 0.22982353 0.01995575 2.9832091 0.08757500 0.045333333 0.07550000 0.03016667 3.658864e-01 5.102784e-12 FALSE TRUE
ENST00000515326 ENSG00000172262 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF131 protein_coding protein_coding 15.17272 5.528398 25.05101 0.5695267 0.9239447 2.177904 0.5044533 0.00000000 2.3123089 0.00000000 0.30287405 7.8594161 0.02180000 0.000000000 0.09346667 0.09346667 7.543848e-09 5.102784e-12 FALSE TRUE
ENST00000682664 ENSG00000172262 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF131 protein_coding protein_coding 15.17272 5.528398 25.05101 0.5695267 0.9239447 2.177904 0.1746749 0.53155293 0.0000000 0.14401991 0.00000000 -5.7590304 0.02885833 0.098533333 0.00000000 -0.09853333 1.504294e-11 5.102784e-12 FALSE TRUE
MSTRG.26133.18 ENSG00000172262 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF131 protein_coding   15.17272 5.528398 25.05101 0.5695267 0.9239447 2.177904 1.9210576 0.06449719 4.9124522 0.06449719 0.17662512 6.0460475 0.08296667 0.009666667 0.19683333 0.18716667 5.102784e-12 5.102784e-12 FALSE TRUE
MSTRG.26133.4 ENSG00000172262 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF131 protein_coding   15.17272 5.528398 25.05101 0.5695267 0.9239447 2.177904 0.6309944 0.32359559 0.7188761 0.05618618 0.09942558 1.1275735 0.06529167 0.060366667 0.02866667 -0.03170000 9.819804e-02 5.102784e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172262 E001 1.8948057 0.0571767732 2.440816e-02 6.066009e-02 5 43065176 43065233 58 + 0.284 0.708 2.150
ENSG00000172262 E002 4.9643435 0.0524640953 2.414292e-02 6.010570e-02 5 43067475 43067580 106 + 0.593 0.968 1.505
ENSG00000172262 E003 2.7314988 0.0681393561 1.328350e-01 2.380497e-01 5 43067581 43067589 9 + 0.430 0.711 1.293
ENSG00000172262 E004 4.0213888 0.1023304145 1.896161e-02 4.924830e-02 5 43067590 43067634 45 + 0.499 0.932 1.812
ENSG00000172262 E005 2.7689609 0.0057355773 7.981409e-03 2.373078e-02 5 43067635 43067786 152 + 0.377 0.814 1.993
ENSG00000172262 E006 7.4162577 0.0549005789 7.723069e-03 2.308367e-02 5 43067970 43068050 81 + 0.726 1.144 1.582
ENSG00000172262 E007 4.2586425 0.0355603221 3.972243e-02 9.050917e-02 5 43068051 43068056 6 + 0.558 0.896 1.391
ENSG00000172262 E008 8.5422640 0.0785210900 2.177713e-02 5.521208e-02 5 43068057 43068115 59 + 0.795 1.166 1.384
ENSG00000172262 E009 10.8491649 0.0022611802 5.980449e-05 3.304974e-04 5 43068116 43068217 102 + 0.864 1.292 1.560
ENSG00000172262 E010 4.6468940 0.0035490406 5.101120e-01 6.453531e-01 5 43071167 43071438 272 + 0.657 0.765 0.447
ENSG00000172262 E011 3.2616110 0.2231713942 1.376614e-01 2.448231e-01 5 43079900 43079954 55 + 0.475 0.807 1.446
ENSG00000172262 E012 6.2529465 0.1207717499 3.785506e-03 1.254180e-02 5 43079955 43080205 251 + 0.592 1.163 2.222
ENSG00000172262 E013 3.5019932 0.0045579491 1.749131e-06 1.378286e-05 5 43080206 43080503 298 + 0.317 1.027 3.163
ENSG00000172262 E014 0.1482932 0.0419323128 9.391652e-02   5 43093023 43093558 536 + 0.000 0.227 12.535
ENSG00000172262 E015 1.0769655 0.0128093674 5.191591e-01 6.532878e-01 5 43099020 43099338 319 + 0.248 0.376 0.840
ENSG00000172262 E016 0.2987644 0.0274944490 1.000000e+00   5 43116447 43116630 184 + 0.116 0.000 -11.726
ENSG00000172262 E017 0.1515154 0.0431119443 1.000000e+00   5 43119923 43120051 129 + 0.062 0.000 -10.634
ENSG00000172262 E018 0.7490443 0.0972447841 3.639689e-01 5.083817e-01 5 43120883 43120913 31 + 0.248 0.000 -12.621
ENSG00000172262 E019 0.8942170 0.0135858127 2.514155e-01 3.876637e-01 5 43120914 43120917 4 + 0.284 0.000 -13.333
ENSG00000172262 E020 1.0414660 0.0128183810 1.899408e-01 3.136894e-01 5 43120918 43120919 2 + 0.317 0.000 -13.539
ENSG00000172262 E021 15.1685299 0.0012014397 1.959568e-02 5.061781e-02 5 43120920 43121123 204 + 1.171 0.897 -1.006
ENSG00000172262 E022 1.3370082 0.0176182727 5.527391e-01 6.819765e-01 5 43121508 43121528 21 + 0.348 0.227 -0.838
ENSG00000172262 E023 0.8846520 0.0136300909 9.342589e-01 9.625595e-01 5 43121533 43121535 3 + 0.248 0.227 -0.160
ENSG00000172262 E024 1.3349319 0.0099611451 5.512989e-01 6.807893e-01 5 43121536 43121539 4 + 0.348 0.227 -0.838
ENSG00000172262 E025 4.1867156 0.0040145622 8.775406e-02 1.717262e-01 5 43121540 43121568 29 + 0.699 0.376 -1.537
ENSG00000172262 E026 0.0000000       5 43121596 43121597 2 +      
ENSG00000172262 E027 10.4285802 0.0017832559 8.474261e-01 9.052585e-01 5 43121598 43121683 86 + 0.969 0.998 0.109
ENSG00000172262 E028 28.7947794 0.0007955779 6.800058e-01 7.840237e-01 5 43121684 43121828 145 + 1.390 1.363 -0.093
ENSG00000172262 E029 27.9817351 0.0007317306 8.866946e-02 1.730877e-01 5 43121829 43122038 210 + 1.400 1.261 -0.487
ENSG00000172262 E030 29.4380473 0.0006952762 2.387240e-02 5.954256e-02 5 43122039 43122043 5 + 1.431 1.244 -0.652
ENSG00000172262 E031 49.2388476 0.0005503509 5.099257e-03 1.620136e-02 5 43122044 43122088 45 + 1.647 1.466 -0.618
ENSG00000172262 E032 64.7165356 0.0016464027 1.306232e-03 4.997509e-03 5 43122089 43122177 89 + 1.765 1.574 -0.647
ENSG00000172262 E033 49.8463634 0.0004322829 9.685141e-06 6.460864e-05 5 43123209 43123250 42 + 1.669 1.363 -1.051
ENSG00000172262 E034 58.0720640 0.0004262046 1.233316e-05 8.023351e-05 5 43123251 43123310 60 + 1.732 1.456 -0.941
ENSG00000172262 E035 2.9729964 0.0058916020 8.343849e-03 2.465094e-02 5 43123311 43125046 1736 + 0.610 0.000 -14.862
ENSG00000172262 E036 89.2935726 0.0003259114 1.706881e-03 6.303503e-03 5 43139165 43139309 145 + 1.896 1.749 -0.495
ENSG00000172262 E037 172.5409994 0.0006192221 3.420826e-04 1.548543e-03 5 43161249 43161606 358 + 2.174 2.054 -0.401
ENSG00000172262 E038 10.9391417 0.0128211922 6.594369e-01 7.682556e-01 5 43161607 43161613 7 + 1.016 0.965 -0.190
ENSG00000172262 E039 10.8983501 0.0016533652 1.387442e-01 2.463626e-01 5 43161614 43161708 95 + 0.954 1.127 0.633
ENSG00000172262 E040 100.4922808 0.0003538706 3.540629e-03 1.184233e-02 5 43161709 43161830 122 + 1.940 1.814 -0.426
ENSG00000172262 E041 90.4107121 0.0002960847 2.253497e-02 5.679218e-02 5 43161831 43161931 101 + 1.891 1.790 -0.342
ENSG00000172262 E042 0.1451727 0.0429276177 1.000000e+00   5 43167930 43168029 100 + 0.062 0.000 -10.635
ENSG00000172262 E043 0.3666179 0.0273485446 2.795750e-01 4.193392e-01 5 43173132 43173317 186 + 0.062 0.228 2.166
ENSG00000172262 E044 91.7448102 0.0003298344 5.006662e-02 1.092802e-01 5 43173318 43173448 131 + 1.894 1.809 -0.287
ENSG00000172262 E045 66.1319139 0.0006731345 1.744819e-02 4.592989e-02 5 43174447 43174494 48 + 1.763 1.634 -0.436
ENSG00000172262 E046 322.1595307 0.0003108241 3.564448e-02 8.289537e-02 5 43174495 43175455 961 + 2.407 2.461 0.181
ENSG00000172262 E047 155.9125243 0.0002362410 5.193722e-40 1.795502e-37 5 43175456 43176324 869 + 1.987 2.382 1.322
ENSG00000172262 E048 0.5546650 0.0204734780 6.746166e-02 1.391307e-01 5 43179829 43179950 122 + 0.062 0.377 3.166
ENSG00000172262 E049 0.5944058 0.1671910613 9.261427e-02 1.792076e-01 5 43191753 43192021 269 + 0.062 0.382 3.194