ENSG00000172239

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306846 ENSG00000172239 HEK293_OSMI2_2hA HEK293_TMG_2hB PAIP1 protein_coding protein_coding 41.9568 21.22127 68.97526 1.701075 2.487756 1.700097 5.586587 4.1842495 10.458583 0.2522426 0.6057929 1.319582 0.13695417 0.19896667 0.15146667 -0.0475000 1.339936e-01 8.985944e-47 FALSE TRUE
ENST00000338972 ENSG00000172239 HEK293_OSMI2_2hA HEK293_TMG_2hB PAIP1 protein_coding protein_coding 41.9568 21.22127 68.97526 1.701075 2.487756 1.700097 2.219340 0.6573825 3.980496 0.1836020 0.4843474 2.579982 0.05473750 0.03156667 0.05836667 0.0268000 2.873407e-01 8.985944e-47 FALSE TRUE
ENST00000436644 ENSG00000172239 HEK293_OSMI2_2hA HEK293_TMG_2hB PAIP1 protein_coding protein_coding 41.9568 21.22127 68.97526 1.701075 2.487756 1.700097 25.507039 15.4773910 35.007726 1.8840309 2.6283576 1.176991 0.64955000 0.72483333 0.50653333 -0.2183000 6.881297e-04 8.985944e-47 FALSE TRUE
ENST00000511321 ENSG00000172239 HEK293_OSMI2_2hA HEK293_TMG_2hB PAIP1 protein_coding protein_coding 41.9568 21.22127 68.97526 1.701075 2.487756 1.700097 6.038535 0.0000000 15.039176 0.0000000 1.0657868 10.555469 0.09279583 0.00000000 0.21796667 0.2179667 8.985944e-47 8.985944e-47 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172239 E001 97.8797630 0.0030205291 5.081161e-03 1.615137e-02 5 43526267 43527091 825 - 1.924 2.054 0.436
ENSG00000172239 E002 17.0504142 0.0308293883 6.017875e-01 7.228634e-01 5 43527092 43527092 1 - 1.251 1.183 -0.243
ENSG00000172239 E003 17.7502519 0.0393684488 7.285409e-01 8.209800e-01 5 43527093 43527112 20 - 1.261 1.213 -0.172
ENSG00000172239 E004 18.1758216 0.0258389656 1.931975e-01 3.177943e-01 5 43527113 43527144 32 - 1.208 1.346 0.482
ENSG00000172239 E005 14.3413304 0.0148304529 2.357041e-02 5.892743e-02 5 43527145 43527184 40 - 1.069 1.304 0.833
ENSG00000172239 E006 153.0003912 0.0021688767 4.825324e-08 5.221861e-07 5 43527185 43527469 285 - 2.084 2.286 0.678
ENSG00000172239 E007 92.9392716 0.0036883592 9.049089e-05 4.773278e-04 5 43529786 43529796 11 - 1.875 2.065 0.637
ENSG00000172239 E008 215.7251028 0.0013002821 5.115673e-03 1.624517e-02 5 43529797 43529879 83 - 2.279 2.367 0.295
ENSG00000172239 E009 238.7575514 0.0002347061 5.085853e-02 1.107051e-01 5 43533738 43533792 55 - 2.335 2.385 0.169
ENSG00000172239 E010 333.8776343 0.0005732672 4.637969e-02 1.027276e-01 5 43534853 43534970 118 - 2.482 2.530 0.158
ENSG00000172239 E011 322.3673989 0.0019028567 6.224877e-01 7.392723e-01 5 43535534 43535640 107 - 2.478 2.496 0.058
ENSG00000172239 E012 191.6250437 0.0007138440 6.146223e-01 7.330267e-01 5 43536819 43536853 35 - 2.263 2.251 -0.041
ENSG00000172239 E013 168.1309610 0.0002100309 3.963548e-01 5.401253e-01 5 43536854 43536899 46 - 2.212 2.190 -0.073
ENSG00000172239 E014 229.0038917 0.0002288174 3.700123e-01 5.144221e-01 5 43536900 43536944 45 - 2.341 2.322 -0.066
ENSG00000172239 E015 199.6895195 0.0002565891 4.128215e-01 5.563976e-01 5 43538924 43538928 5 - 2.282 2.263 -0.065
ENSG00000172239 E016 361.8017760 0.0001371032 6.712580e-03 2.047659e-02 5 43538929 43539035 107 - 2.550 2.499 -0.170
ENSG00000172239 E017 275.6237871 0.0004217518 1.351178e-01 2.412530e-01 5 43543004 43543060 57 - 2.428 2.395 -0.110
ENSG00000172239 E018 228.7511068 0.0014955651 7.821551e-01 8.601336e-01 5 43543061 43543116 56 - 2.332 2.343 0.038
ENSG00000172239 E019 351.3841143 0.0001885751 1.865446e-02 4.857262e-02 5 43547728 43547913 186 - 2.536 2.491 -0.150
ENSG00000172239 E020 210.5342287 0.0003101549 7.779145e-03 2.322526e-02 5 43555830 43555961 132 - 2.323 2.254 -0.231
ENSG00000172239 E021 94.9790101 0.0101376383 1.088782e-01 2.038851e-01 5 43555962 43555999 38 - 1.989 1.890 -0.332
ENSG00000172239 E022 0.5181333 0.0202736283 8.877817e-01 9.322717e-01 5 43556203 43556439 237 - 0.153 0.177 0.256
ENSG00000172239 E023 5.2174918 0.0174142260 9.321934e-01 9.612993e-01 5 43556440 43556581 142 - 0.767 0.780 0.052
ENSG00000172239 E024 81.8723497 0.0073233272 2.450824e-04 1.154806e-03 5 43556582 43556818 237 - 1.956 1.732 -0.753
ENSG00000172239 E025 91.9210200 0.0003880717 1.485631e-03 5.590054e-03 5 43556819 43557093 275 - 1.980 1.851 -0.433
ENSG00000172239 E026 9.3609932 0.0056007511 1.690599e-02 4.472732e-02 5 43557340 43557350 11 - 1.078 0.780 -1.126
ENSG00000172239 E027 9.6597577 0.0099751332 1.416850e-02 3.860575e-02 5 43557351 43557700 350 - 1.093 0.779 -1.183
ENSG00000172239 E028 0.0000000       5 43557701 43557758 58 -