ENSG00000172175

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000345724 ENSG00000172175 HEK293_OSMI2_2hA HEK293_TMG_2hB MALT1 protein_coding protein_coding 2.415927 0.5643865 4.533564 0.04457461 0.5053262 2.983731 0.3053548 0.01932366 0.6003745 0.01932366 0.14107713 4.379558 0.08270417 0.03966667 0.1317000 0.09203333 0.2176307842 0.0001289809 FALSE TRUE
ENST00000591792 ENSG00000172175 HEK293_OSMI2_2hA HEK293_TMG_2hB MALT1 protein_coding protein_coding 2.415927 0.5643865 4.533564 0.04457461 0.5053262 2.983731 0.4835628 0.00000000 1.0508999 0.00000000 0.52613328 6.729145 0.10708750 0.00000000 0.2086000 0.20860000 0.4581001074 0.0001289809 FALSE FALSE
ENST00000649217 ENSG00000172175 HEK293_OSMI2_2hA HEK293_TMG_2hB MALT1 protein_coding protein_coding 2.415927 0.5643865 4.533564 0.04457461 0.5053262 2.983731 1.3911851 0.54506281 2.3192561 0.06205142 0.12486920 2.069146 0.72991250 0.96033333 0.5256667 -0.43466667 0.0001289809 0.0001289809 FALSE TRUE
ENST00000649756 ENSG00000172175 HEK293_OSMI2_2hA HEK293_TMG_2hB MALT1 protein_coding processed_transcript 2.415927 0.5643865 4.533564 0.04457461 0.5053262 2.983731 0.1134464 0.00000000 0.5214649 0.00000000 0.09539246 5.731903 0.02998333 0.00000000 0.1236000 0.12360000 0.0415978672 0.0001289809 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172175 E001 2.1974353 0.1082151526 3.453816e-01 4.894893e-01 18 58671465 58671531 67 + 0.472 0.242 -1.399
ENSG00000172175 E002 2.4919333 0.1335048170 2.858558e-01 4.262256e-01 18 58671532 58671565 34 + 0.512 0.242 -1.593
ENSG00000172175 E003 11.2063946 0.0016569538 3.437001e-01 4.877593e-01 18 58671566 58671852 287 + 1.007 0.890 -0.440
ENSG00000172175 E004 0.0000000       18 58672207 58672336 130 +      
ENSG00000172175 E005 5.5306182 0.0030345520 3.617924e-01 5.062112e-01 18 58681170 58681170 1 + 0.752 0.602 -0.632
ENSG00000172175 E006 21.0836552 0.0008495176 6.462900e-01 7.582456e-01 18 58681171 58681323 153 + 1.229 1.279 0.178
ENSG00000172175 E007 11.8324268 0.0015227166 8.670225e-01 9.184251e-01 18 58681324 58681336 13 + 1.013 1.000 -0.047
ENSG00000172175 E008 24.6406809 0.0007883842 1.789723e-01 2.998600e-01 18 58696366 58696487 122 + 1.323 1.205 -0.415
ENSG00000172175 E009 26.1702061 0.0007624263 3.331702e-02 7.842219e-02 18 58700441 58700591 151 + 1.356 1.162 -0.684
ENSG00000172175 E010 1.5374627 0.3354434453 6.097018e-01 7.291320e-01 18 58709322 58709377 56 + 0.327 0.399 0.427
ENSG00000172175 E011 31.2912904 0.0008075228 2.290466e-01 3.612945e-01 18 58709378 58709556 179 + 1.419 1.328 -0.316
ENSG00000172175 E012 0.0000000       18 58709557 58709975 419 +      
ENSG00000172175 E013 23.4848921 0.0073514434 8.143682e-02 1.618035e-01 18 58709976 58710072 97 + 1.314 1.138 -0.623
ENSG00000172175 E014 13.3247775 0.0297115382 8.328969e-01 8.953122e-01 18 58710921 58710953 33 + 1.059 1.032 -0.100
ENSG00000172175 E015 13.7747673 0.0017344684 3.047149e-01 4.467506e-01 18 58714083 58714109 27 + 1.084 0.967 -0.431
ENSG00000172175 E016 15.0124214 0.0012771728 2.861566e-01 4.265601e-01 18 58715935 58715967 33 + 1.118 1.001 -0.428
ENSG00000172175 E017 0.0000000       18 58720380 58720422 43 +      
ENSG00000172175 E018 31.3529314 0.0006818945 3.471334e-03 1.164283e-02 18 58723048 58723251 204 + 1.440 1.184 -0.894
ENSG00000172175 E019 20.4800783 0.0009802292 1.067148e-01 2.006970e-01 18 58733397 58733451 55 + 1.250 1.089 -0.575
ENSG00000172175 E020 21.4209450 0.0031459405 7.088806e-02 1.448162e-01 18 58733452 58733509 58 + 1.273 1.089 -0.656
ENSG00000172175 E021 25.2075217 0.0008305776 9.686738e-01 9.843921e-01 18 58733510 58733574 65 + 1.308 1.312 0.016
ENSG00000172175 E022 0.5891098 0.0182769829 5.732830e-01 6.992270e-01 18 58733575 58733641 67 + 0.194 0.000 -11.500
ENSG00000172175 E023 0.5933762 0.0210660228 5.747766e-01 7.005392e-01 18 58733642 58733881 240 + 0.194 0.000 -11.476
ENSG00000172175 E024 0.1472490 0.0437456158 1.000000e+00   18 58733882 58733980 99 + 0.057 0.000 -9.413
ENSG00000172175 E025 0.7362451 1.0995377777 1.000000e+00 1.000000e+00 18 58733981 58734306 326 + 0.231 0.000 -10.507
ENSG00000172175 E026 25.5781811 0.0007853759 5.640102e-01 6.914115e-01 18 58734307 58734381 75 + 1.323 1.279 -0.151
ENSG00000172175 E027 0.1472490 0.0437456158 1.000000e+00   18 58734382 58734450 69 + 0.057 0.000 -9.413
ENSG00000172175 E028 0.1472490 0.0437456158 1.000000e+00   18 58734451 58734566 116 + 0.057 0.000 -9.413
ENSG00000172175 E029 34.3363210 0.0008887332 9.725423e-01 9.868732e-01 18 58735202 58735329 128 + 1.437 1.448 0.036
ENSG00000172175 E030 0.7384352 0.0194381681 4.223802e-01 5.655189e-01 18 58737768 58737926 159 + 0.232 0.000 -11.778
ENSG00000172175 E031 0.0000000       18 58741431 58741864 434 +      
ENSG00000172175 E032 30.6414978 0.0007718637 1.207463e-01 2.210297e-01 18 58741865 58742014 150 + 1.367 1.492 0.431
ENSG00000172175 E033 33.8161772 0.0007237287 9.767168e-01 9.894553e-01 18 58744338 58744495 158 + 1.437 1.448 0.035
ENSG00000172175 E034 33.7988049 0.0055162925 2.345134e-01 3.677711e-01 18 58745666 58745791 126 + 1.419 1.521 0.351
ENSG00000172175 E035 0.0000000       18 58745792 58745792 1 +      
ENSG00000172175 E036 226.5431468 0.0016514044 2.768672e-06 2.088626e-05 18 58747405 58754477 7073 + 2.218 2.353 0.450