ENSG00000172167

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305949 ENSG00000172167 HEK293_OSMI2_2hA HEK293_TMG_2hB MTBP protein_coding protein_coding 7.471366 1.936724 12.30275 0.1651507 0.8230389 2.661033 6.6257445 1.45804711 10.64830401 0.20157565 0.31910584 2.8600077 0.84894583 0.74663333 0.870800000 0.12416667 0.3451583283 0.0003246526 FALSE  
ENST00000519556 ENSG00000172167 HEK293_OSMI2_2hA HEK293_TMG_2hB MTBP protein_coding nonsense_mediated_decay 7.471366 1.936724 12.30275 0.1651507 0.8230389 2.661033 0.1338430 0.16982433 0.09351412 0.04475552 0.04679567 -0.7967606 0.02636250 0.08840000 0.007166667 -0.08123333 0.0003246526 0.0003246526    
ENST00000522449 ENSG00000172167 HEK293_OSMI2_2hA HEK293_TMG_2hB MTBP protein_coding retained_intron 7.471366 1.936724 12.30275 0.1651507 0.8230389 2.661033 0.2807289 0.08704887 0.37198970 0.01533276 0.04234659 1.9767504 0.05021250 0.04523333 0.030400000 -0.01483333 0.6643167881 0.0003246526    
ENST00000523373 ENSG00000172167 HEK293_OSMI2_2hA HEK293_TMG_2hB MTBP protein_coding nonsense_mediated_decay 7.471366 1.936724 12.30275 0.1651507 0.8230389 2.661033 0.1611171 0.02770131 0.84719884 0.02770131 0.42886063 4.5069432 0.02460417 0.01230000 0.064833333 0.05253333 0.6816492015 0.0003246526 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172167 E001 1.1093195 0.0113939261 1.0000000000 1.0000000000 8 120445400 120445418 19 + 0.254 0.255 0.009
ENSG00000172167 E002 1.5469139 0.0087153976 0.6960584215 0.7965125103 8 120445419 120445421 3 + 0.341 0.255 -0.576
ENSG00000172167 E003 47.9587840 0.0006503827 0.4424122372 0.5840343837 8 120445422 120445588 167 + 1.572 1.518 -0.183
ENSG00000172167 E004 41.4865485 0.0005360636 0.7702713310 0.8516418610 8 120446433 120446513 81 + 1.507 1.485 -0.075
ENSG00000172167 E005 34.9338181 0.0006061159 0.9322631322 0.9613323613 8 120451003 120451076 74 + 1.431 1.437 0.022
ENSG00000172167 E006 0.0000000       8 120451077 120451170 94 +      
ENSG00000172167 E007 47.9216786 0.0124103467 0.7429418381 0.8317331235 8 120451171 120451322 152 + 1.572 1.545 -0.091
ENSG00000172167 E008 2.5934975 0.0075544001 0.0001112857 0.0005736644 8 120451323 120452829 1507 + 0.285 0.913 2.953
ENSG00000172167 E009 26.8379745 0.0071847700 0.0005331166 0.0022836942 8 120453847 120453905 59 + 1.369 0.954 -1.486
ENSG00000172167 E010 41.9180169 0.0118809189 0.0061048001 0.0188846880 8 120455435 120455579 145 + 1.545 1.268 -0.959
ENSG00000172167 E011 37.3425270 0.0155897791 0.2333557746 0.3663924898 8 120456553 120456670 118 + 1.478 1.354 -0.427
ENSG00000172167 E012 24.1399759 0.0009348559 0.7637197618 0.8469844091 8 120459215 120459275 61 + 1.279 1.250 -0.102
ENSG00000172167 E013 26.5075144 0.0095926588 0.9580684200 0.9777212114 8 120459276 120459349 74 + 1.315 1.306 -0.029
ENSG00000172167 E014 34.9769676 0.0006437621 0.9593186631 0.9784805546 8 120461161 120461255 95 + 1.429 1.425 -0.015
ENSG00000172167 E015 0.9620705 0.0130038558 0.8672648299 0.9186355288 8 120463687 120463691 5 + 0.221 0.255 0.272
ENSG00000172167 E016 34.2379193 0.0008005287 0.1180753573 0.2171749729 8 120463692 120463761 70 + 1.439 1.305 -0.466
ENSG00000172167 E017 43.7621229 0.0005086132 0.0204983355 0.0525430016 8 120470820 120470937 118 + 1.550 1.369 -0.622
ENSG00000172167 E018 19.4484100 0.0073538301 0.0623417883 0.1305903953 8 120470938 120473950 3013 + 1.150 1.338 0.664
ENSG00000172167 E019 17.5551597 0.0066818907 0.0732294586 0.1486855072 8 120488159 120488160 2 + 1.181 0.954 -0.827
ENSG00000172167 E020 50.7105383 0.0004779419 0.1745308097 0.2940882176 8 120488161 120488332 172 + 1.602 1.508 -0.322
ENSG00000172167 E021 37.4318182 0.0013072420 0.7615596154 0.8453894770 8 120490463 120490570 108 + 1.462 1.438 -0.084
ENSG00000172167 E022 0.4449813 0.0227911604 0.3732108122 0.5176494570 8 120490571 120490703 133 + 0.102 0.255 1.590
ENSG00000172167 E023 40.2171335 0.0006571421 0.1701190098 0.2883443473 8 120497393 120497554 162 + 1.505 1.398 -0.371
ENSG00000172167 E024 39.2760414 0.0006453635 0.3224630210 0.4657572462 8 120502492 120502609 118 + 1.468 1.539 0.243
ENSG00000172167 E025 59.6243107 0.0004410454 0.2001297845 0.3264141889 8 120506706 120506861 156 + 1.643 1.717 0.253
ENSG00000172167 E026 41.9104333 0.0007613935 0.7429950853 0.8317616361 8 120509934 120510029 96 + 1.505 1.528 0.079
ENSG00000172167 E027 86.6884445 0.0004293151 0.1704243909 0.2887147189 8 120515925 120516191 267 + 1.801 1.868 0.224
ENSG00000172167 E028 82.9712269 0.0004216034 0.2358779544 0.3694126517 8 120517851 120518100 250 + 1.785 1.844 0.199
ENSG00000172167 E029 0.1817044 0.0402917376 0.0603919852   8 120518703 120518703 1 + 0.000 0.255 11.340
ENSG00000172167 E030 45.2175854 0.0006132488 0.0954567878 0.1835641123 8 120518704 120518817 114 + 1.519 1.629 0.374
ENSG00000172167 E031 30.7690532 0.0014420290 0.0395269443 0.0901537547 8 120522654 120522719 66 + 1.346 1.508 0.557
ENSG00000172167 E032 26.9072405 0.0160846738 0.0381887627 0.0877087812 8 120523298 120523636 339 + 1.282 1.486 0.708
ENSG00000172167 E033 0.7300267 0.0315449219 0.0068165539 0.0207456575 8 120538694 120538694 1 + 0.054 0.532 4.182
ENSG00000172167 E034 1.3567123 0.0190532150 0.0020342699 0.0073328704 8 120538695 120538859 165 + 0.145 0.699 3.331
ENSG00000172167 E035 0.5085815 0.2543015425 0.0624871361 0.1308268735 8 120538860 120538863 4 + 0.054 0.416 3.602
ENSG00000172167 E036 0.3289534 0.0286417543 0.1933608892   8 120541162 120541219 58 + 0.054 0.255 2.593
ENSG00000172167 E037 0.6633060 0.0208579087 0.5500433042 0.6797128217 8 120541846 120541965 120 + 0.145 0.255 1.010
ENSG00000172167 E038 0.6633060 0.0208579087 0.5500433042 0.6797128217 8 120541994 120542133 140 + 0.145 0.255 1.010