ENSG00000172081

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357066 ENSG00000172081 HEK293_OSMI2_2hA HEK293_TMG_2hB MOB3A protein_coding protein_coding 10.52468 16.64377 7.088836 0.8500993 0.3882884 -1.230194 9.345862 15.8058 5.983161 0.7141132 0.3185407 -1.399978 0.8708708 0.9504 0.8444667 -0.1059333 0.004745678 0.004745678 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172081 E001 772.1815835 0.0093352255 6.785082e-05 0.0003697648 19 2071036 2073034 1999 - 2.692 2.877 0.616
ENSG00000172081 E002 74.9933730 0.0004033735 3.440523e-01 0.4881019670 19 2073035 2073136 102 - 1.801 1.828 0.092
ENSG00000172081 E003 124.6636358 0.0003449704 1.066182e-01 0.2005630299 19 2073137 2073424 288 - 2.031 2.045 0.049
ENSG00000172081 E004 103.0977663 0.0003894949 4.214685e-01 0.5646187176 19 2076811 2077013 203 - 1.929 1.968 0.132
ENSG00000172081 E005 86.2962373 0.0005239032 4.453237e-03 0.0144100761 19 2078140 2078330 191 - 1.916 1.869 -0.159
ENSG00000172081 E006 39.0687182 0.0005812311 3.101736e-01 0.4525464452 19 2078331 2078371 41 - 1.542 1.548 0.022
ENSG00000172081 E007 20.6702444 0.0167346745 4.859765e-01 0.6237906142 19 2078372 2078373 2 - 1.282 1.284 0.006
ENSG00000172081 E008 32.5196884 0.0058536114 5.309251e-02 0.1146470785 19 2078374 2078396 23 - 1.523 1.451 -0.247
ENSG00000172081 E009 37.3794458 0.0007223348 1.767129e-01 0.2969700763 19 2078397 2078445 49 - 1.542 1.527 -0.053
ENSG00000172081 E010 54.4284206 0.0101551228 4.652292e-02 0.1029834013 19 2078446 2078510 65 - 1.732 1.666 -0.223
ENSG00000172081 E011 78.4797295 0.0023631567 1.739585e-04 0.0008524826 19 2078511 2078679 169 - 1.916 1.810 -0.356
ENSG00000172081 E012 1.4004935 0.2061932284 1.810966e-01 0.3025869498 19 2078680 2078719 40 - 0.537 0.267 -1.526
ENSG00000172081 E013 51.9862177 0.0006813191 8.140913e-03 0.0241417499 19 2085175 2085325 151 - 1.716 1.646 -0.238
ENSG00000172081 E014 16.0925320 0.0011443633 5.838055e-01 0.7078413382 19 2085326 2085328 3 - 1.168 1.184 0.055
ENSG00000172081 E015 0.1817044 0.0392533269 1.000000e+00   19 2085329 2085392 64 - 0.000 0.085 18.362
ENSG00000172081 E016 0.8104664 0.0152923635 5.410239e-01 0.6720698332 19 2085477 2085652 176 - 0.297 0.217 -0.599
ENSG00000172081 E017 0.7761102 0.0179265874 9.391934e-01 0.9658155729 19 2090075 2090176 102 - 0.173 0.217 0.406
ENSG00000172081 E018 5.6735255 0.0028989944 2.577571e-01 0.3949282801 19 2095241 2095323 83 - 0.838 0.743 -0.374
ENSG00000172081 E019 6.1333442 0.0050653266 3.087183e-02 0.0736670675 19 2095324 2095478 155 - 0.947 0.726 -0.859
ENSG00000172081 E020 18.5145340 0.0010860701 7.682604e-03 0.0229823042 19 2096226 2096326 101 - 1.344 1.190 -0.542
ENSG00000172081 E021 3.9052576 0.0041236630 2.217856e-01 0.3525238545 19 2096381 2096711 331 - 0.733 0.605 -0.545