ENSG00000172046

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398888 ENSG00000172046 HEK293_OSMI2_2hA HEK293_TMG_2hB USP19 protein_coding protein_coding 53.71408 73.54899 33.31175 5.938999 1.129566 -1.142438 6.008493 10.311874 3.458460 0.9888372 0.34310824 -1.5733377 0.10573333 0.13996667 0.10383333 -0.036133333 1.419748e-01 9.165146e-12 FALSE TRUE
ENST00000398896 ENSG00000172046 HEK293_OSMI2_2hA HEK293_TMG_2hB USP19 protein_coding protein_coding 53.71408 73.54899 33.31175 5.938999 1.129566 -1.142438 1.162617 3.881496 0.000000 0.7638359 0.00000000 -8.6041812 0.01706667 0.05496667 0.00000000 -0.054966667 3.994072e-11 9.165146e-12 FALSE TRUE
ENST00000417901 ENSG00000172046 HEK293_OSMI2_2hA HEK293_TMG_2hB USP19 protein_coding protein_coding 53.71408 73.54899 33.31175 5.938999 1.129566 -1.142438 14.359259 21.205438 9.497161 3.3419579 1.03060388 -1.1580279 0.27354583 0.28493333 0.28733333 0.002400000 1.000000e+00 9.165146e-12 FALSE TRUE
ENST00000483667 ENSG00000172046 HEK293_OSMI2_2hA HEK293_TMG_2hB USP19 protein_coding processed_transcript 53.71408 73.54899 33.31175 5.938999 1.129566 -1.142438 9.897115 13.158645 5.212660 2.9856553 0.52816687 -1.3342501 0.18177083 0.17710000 0.15573333 -0.021366667 8.910576e-01 9.165146e-12 FALSE FALSE
ENST00000691288 ENSG00000172046 HEK293_OSMI2_2hA HEK293_TMG_2hB USP19 protein_coding protein_coding 53.71408 73.54899 33.31175 5.938999 1.129566 -1.142438 4.453451 4.578126 2.333038 1.7080810 0.33519968 -0.9695249 0.08484583 0.06376667 0.07073333 0.006966667 8.539475e-01 9.165146e-12 FALSE TRUE
MSTRG.22945.18 ENSG00000172046 HEK293_OSMI2_2hA HEK293_TMG_2hB USP19 protein_coding   53.71408 73.54899 33.31175 5.938999 1.129566 -1.142438 2.297473 1.537447 2.428647 0.2369974 0.07786377 0.6561904 0.04921667 0.02070000 0.07320000 0.052500000 9.165146e-12 9.165146e-12 FALSE TRUE
MSTRG.22945.7 ENSG00000172046 HEK293_OSMI2_2hA HEK293_TMG_2hB USP19 protein_coding   53.71408 73.54899 33.31175 5.938999 1.129566 -1.142438 7.335100 10.755079 6.081795 2.2218013 1.59063968 -0.8214196 0.13300417 0.14503333 0.18036667 0.035333333 7.952385e-01 9.165146e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172046 E001 0.5169874 0.0200551753 8.200807e-01 8.864727e-01 3 49108046 49108049 4 - 0.184 0.147 -0.392
ENSG00000172046 E002 1.5101892 0.0098092820 7.161433e-01 8.118725e-01 3 49108050 49108057 8 - 0.313 0.381 0.416
ENSG00000172046 E003 4.2329623 0.0046270080 3.874428e-01 5.315750e-01 3 49108058 49108088 31 - 0.560 0.700 0.608
ENSG00000172046 E004 27.3145857 0.0008269498 8.507098e-07 7.174023e-06 3 49108089 49108130 42 - 0.998 1.453 1.610
ENSG00000172046 E005 37.8821088 0.0005832268 2.017628e-07 1.931741e-06 3 49108131 49108156 26 - 1.183 1.584 1.394
ENSG00000172046 E006 69.5347836 0.0012101484 4.645366e-01 6.042560e-01 3 49108157 49108163 7 - 1.747 1.785 0.130
ENSG00000172046 E007 637.2374600 0.0021632683 8.436162e-07 7.120225e-06 3 49108164 49108528 365 - 2.623 2.765 0.475
ENSG00000172046 E008 5.1919995 0.0031653804 2.874702e-01 4.279659e-01 3 49108673 49108674 2 - 0.832 0.683 -0.601
ENSG00000172046 E009 18.0549734 0.0020616166 6.341101e-01 7.486745e-01 3 49108675 49108698 24 - 1.183 1.227 0.158
ENSG00000172046 E010 22.2095985 0.0009708631 3.391331e-01 4.830586e-01 3 49108699 49108712 14 - 1.239 1.320 0.284
ENSG00000172046 E011 42.9338160 0.0007398780 1.147797e-03 4.464106e-03 3 49108713 49108752 40 - 1.402 1.619 0.744
ENSG00000172046 E012 48.6416398 0.0004885915 3.442649e-04 1.557157e-03 3 49108753 49108786 34 - 1.445 1.671 0.770
ENSG00000172046 E013 41.7600255 0.0005516904 9.743546e-05 5.100258e-04 3 49108787 49108801 15 - 1.344 1.613 0.924
ENSG00000172046 E014 48.0807654 0.0004724628 4.799372e-07 4.260070e-06 3 49108802 49108832 31 - 1.344 1.680 1.152
ENSG00000172046 E015 99.6911896 0.0006293062 9.292106e-07 7.764474e-06 3 49108833 49108961 129 - 1.747 1.972 0.760
ENSG00000172046 E016 163.8636856 0.0040026065 3.947651e-04 1.754453e-03 3 49108962 49109185 224 - 2.012 2.180 0.564
ENSG00000172046 E017 26.3783122 0.0007300869 7.338226e-07 6.275470e-06 3 49109739 49109754 16 - 1.596 1.253 -1.187
ENSG00000172046 E018 47.2605467 0.0024451490 6.183273e-09 7.934181e-08 3 49109755 49109869 115 - 1.835 1.506 -1.120
ENSG00000172046 E019 38.6604587 0.0006552728 9.790338e-06 6.523919e-05 3 49110013 49110183 171 - 1.708 1.446 -0.893
ENSG00000172046 E020 702.5782485 0.0025371109 4.947109e-05 2.790908e-04 3 49110184 49110355 172 - 2.681 2.804 0.408
ENSG00000172046 E021 324.0313664 0.0042703220 1.150701e-03 4.473659e-03 3 49110356 49110362 7 - 2.336 2.471 0.452
ENSG00000172046 E022 310.2976768 0.0027426959 5.350619e-04 2.291013e-03 3 49110444 49110447 4 - 2.324 2.450 0.422
ENSG00000172046 E023 705.7031854 0.0029367230 1.348453e-04 6.805308e-04 3 49110448 49110604 157 - 2.683 2.806 0.409
ENSG00000172046 E024 608.0226906 0.0002676267 1.910736e-12 4.472241e-11 3 49110711 49110863 153 - 2.607 2.740 0.443
ENSG00000172046 E025 627.3584191 0.0001425871 2.490595e-09 3.431034e-08 3 49110950 49111166 217 - 2.644 2.748 0.348
ENSG00000172046 E026 401.6684575 0.0004356935 9.851263e-06 6.559211e-05 3 49111255 49111365 111 - 2.451 2.554 0.345
ENSG00000172046 E027 690.7820461 0.0025293422 1.920510e-02 4.978107e-02 3 49111500 49111813 314 - 2.716 2.786 0.233
ENSG00000172046 E028 457.5300828 0.0008262527 6.887925e-03 2.093462e-02 3 49111911 49112048 138 - 2.540 2.606 0.219
ENSG00000172046 E029 383.7617258 0.0001999788 1.467693e-02 3.976232e-02 3 49112284 49112402 119 - 2.471 2.525 0.180
ENSG00000172046 E030 381.3004847 0.0001763009 5.253156e-01 6.586942e-01 3 49112489 49112629 141 - 2.498 2.513 0.048
ENSG00000172046 E031 380.4365362 0.0003708451 8.805272e-01 9.273655e-01 3 49113992 49114093 102 - 2.505 2.509 0.015
ENSG00000172046 E032 406.4828424 0.0001846004 8.801012e-01 9.271108e-01 3 49114174 49114284 111 - 2.539 2.537 -0.009
ENSG00000172046 E033 402.6455674 0.0002503078 5.408281e-02 1.163942e-01 3 49114763 49114873 111 - 2.561 2.522 -0.132
ENSG00000172046 E034 461.9577736 0.0015938743 1.042381e-02 2.980321e-02 3 49114959 49115117 159 - 2.639 2.577 -0.207
ENSG00000172046 E035 446.2415270 0.0002440274 1.954838e-07 1.876841e-06 3 49115228 49115361 134 - 2.650 2.549 -0.336
ENSG00000172046 E036 541.8648598 0.0001537139 8.513953e-13 2.115057e-11 3 49115444 49115639 196 - 2.751 2.629 -0.408
ENSG00000172046 E037 473.8088127 0.0010078869 9.607421e-08 9.785521e-07 3 49115724 49115938 215 - 2.693 2.573 -0.401
ENSG00000172046 E038 89.6564351 0.0016605213 4.967412e-02 1.085811e-01 3 49115939 49115944 6 - 1.947 1.859 -0.295
ENSG00000172046 E039 127.0607559 0.0023113760 3.469872e-02 8.107008e-02 3 49116047 49116047 1 - 2.096 2.011 -0.286
ENSG00000172046 E040 291.3435889 0.0020239305 8.150065e-02 1.618999e-01 3 49116048 49116162 115 - 2.431 2.380 -0.170
ENSG00000172046 E041 246.3283997 0.0022668955 2.232243e-01 3.542400e-01 3 49116280 49116351 72 - 2.350 2.312 -0.128
ENSG00000172046 E042 416.5595971 0.0003810287 4.336278e-06 3.128789e-05 3 49116451 49116607 157 - 2.617 2.522 -0.317
ENSG00000172046 E043 14.4984916 0.1085986412 7.358603e-02 1.492655e-01 3 49116721 49116726 6 - 1.334 1.039 -1.051
ENSG00000172046 E044 444.3452033 0.0008916352 3.191717e-08 3.574070e-07 3 49116727 49116943 217 - 2.667 2.542 -0.414
ENSG00000172046 E045 204.5160611 0.0046197287 5.401246e-01 6.713092e-01 3 49117059 49117208 150 - 2.257 2.236 -0.070
ENSG00000172046 E046 185.9679085 0.0030427316 4.417715e-01 5.834167e-01 3 49117209 49117358 150 - 2.220 2.193 -0.090
ENSG00000172046 E047 79.8830301 0.0028288429 2.085043e-01 3.366815e-01 3 49117359 49117361 3 - 1.883 1.821 -0.209
ENSG00000172046 E048 138.2652821 0.0068804734 8.881440e-01 9.324980e-01 3 49117437 49117466 30 - 2.077 2.074 -0.012
ENSG00000172046 E049 212.9259844 0.0043675180 3.112077e-01 4.536613e-01 3 49117467 49117570 104 - 2.287 2.250 -0.126
ENSG00000172046 E050 257.9898245 0.0051448943 6.569730e-04 2.741082e-03 3 49117657 49117785 129 - 2.442 2.305 -0.457
ENSG00000172046 E051 137.3623481 0.0035471478 2.807328e-05 1.681069e-04 3 49117786 49117830 45 - 2.196 2.018 -0.594
ENSG00000172046 E052 331.8467218 0.0035179677 2.226152e-08 2.572513e-07 3 49117947 49118120 174 - 2.590 2.397 -0.641
ENSG00000172046 E053 396.5339216 0.0036346010 3.644570e-07 3.313750e-06 3 49119022 49119281 260 - 2.652 2.481 -0.570
ENSG00000172046 E054 15.1009496 0.0059591530 4.861015e-01 6.239234e-01 3 49120468 49120755 288 - 1.082 1.155 0.265
ENSG00000172046 E055 138.4322612 0.0039009581 7.548803e-04 3.097059e-03 3 49120756 49120949 194 - 2.178 2.031 -0.491