ENSG00000172037

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305544 ENSG00000172037 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMB2 protein_coding protein_coding 38.81442 46.78376 28.82423 4.73359 1.381729 -0.6985336 12.899903 12.085919 14.913021 0.9087101 1.11402877 0.3030192 0.35935000 0.26470000 0.51626667 0.25156667 1.951583e-04 1.55784e-08 FALSE TRUE
ENST00000418109 ENSG00000172037 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMB2 protein_coding protein_coding 38.81442 46.78376 28.82423 4.73359 1.381729 -0.6985336 2.313331 2.736041 2.352367 0.2963460 0.32698202 -0.2171198 0.06310417 0.05890000 0.08300000 0.02410000 5.111842e-01 1.55784e-08 FALSE TRUE
ENST00000467506 ENSG00000172037 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMB2 protein_coding retained_intron 38.81442 46.78376 28.82423 4.73359 1.381729 -0.6985336 3.751783 5.749991 1.505569 0.7868123 0.03470781 -1.9262073 0.08897083 0.12313333 0.05256667 -0.07056667 1.015425e-04 1.55784e-08 FALSE TRUE
ENST00000469665 ENSG00000172037 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMB2 protein_coding retained_intron 38.81442 46.78376 28.82423 4.73359 1.381729 -0.6985336 3.431717 3.050419 2.281529 0.2742587 0.12688073 -0.4174190 0.08607083 0.06543333 0.07973333 0.01430000 4.930315e-01 1.55784e-08 FALSE TRUE
ENST00000484713 ENSG00000172037 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMB2 protein_coding retained_intron 38.81442 46.78376 28.82423 4.73359 1.381729 -0.6985336 2.297604 8.560360 0.000000 3.4564925 0.00000000 -9.7432120 0.04855417 0.17453333 0.00000000 -0.17453333 1.557840e-08 1.55784e-08 FALSE FALSE
ENST00000498377 ENSG00000172037 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMB2 protein_coding retained_intron 38.81442 46.78376 28.82423 4.73359 1.381729 -0.6985336 6.071804 8.313237 2.808735 1.0186500 0.38030141 -1.5620965 0.14790000 0.17790000 0.09806667 -0.07983333 2.176632e-02 1.55784e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172037 E001 1.0674006 0.0114934146 6.000267e-01 7.213227e-01 3 49121114 49121114 1 - 0.371 0.288 -0.524
ENSG00000172037 E002 93.7533123 0.0097540413 1.762204e-07 1.706945e-06 3 49121115 49121256 142 - 1.743 2.092 1.174
ENSG00000172037 E003 186.3241041 0.0080378561 3.061135e-09 4.145563e-08 3 49121257 49121362 106 - 2.054 2.384 1.104
ENSG00000172037 E004 20.2807086 0.0099552000 3.405465e-04 1.542511e-03 3 49121363 49121432 70 - 1.096 1.449 1.240
ENSG00000172037 E005 239.2397572 0.0056400088 5.869580e-14 1.724258e-12 3 49121433 49121592 160 - 2.145 2.497 1.174
ENSG00000172037 E006 0.2998086 0.0294831944 9.325759e-01   3 49121593 49121596 4 - 0.126 0.118 -0.111
ENSG00000172037 E007 299.5569655 0.0033596686 2.725597e-16 1.112836e-14 3 49121684 49121860 177 - 2.274 2.582 1.028
ENSG00000172037 E008 289.4727143 0.0020804244 7.086524e-12 1.512529e-10 3 49121944 49122085 142 - 2.315 2.543 0.762
ENSG00000172037 E009 300.7763755 0.0021207579 3.531472e-08 3.919735e-07 3 49122163 49122370 208 - 2.360 2.546 0.621
ENSG00000172037 E010 33.3783875 0.0163897788 1.461280e-01 2.564214e-01 3 49122371 49122493 123 - 1.436 1.583 0.504
ENSG00000172037 E011 35.1718591 0.0279620693 8.254039e-01 8.900353e-01 3 49122494 49122703 210 - 1.528 1.567 0.133
ENSG00000172037 E012 359.6805483 0.0030193776 1.358075e-04 6.848831e-04 3 49122704 49123052 349 - 2.467 2.609 0.472
ENSG00000172037 E013 14.0723217 0.0014040541 8.937245e-01 9.360228e-01 3 49123053 49123131 79 - 1.152 1.179 0.099
ENSG00000172037 E014 294.7999850 0.0001888568 4.736432e-07 4.207751e-06 3 49123132 49123324 193 - 2.390 2.515 0.417
ENSG00000172037 E015 153.1631515 0.0002653666 2.307054e-02 5.789593e-02 3 49123325 49123373 49 - 2.133 2.217 0.280
ENSG00000172037 E016 8.8741089 0.0020749997 1.080012e-01 2.025698e-01 3 49123374 49123446 73 - 1.072 0.914 -0.584
ENSG00000172037 E017 247.7187037 0.0017279932 7.773965e-02 1.558388e-01 3 49123447 49123631 185 - 2.348 2.418 0.235
ENSG00000172037 E018 2.2475908 0.0069394268 2.347271e-01 3.680362e-01 3 49123720 49123727 8 - 0.371 0.582 1.063
ENSG00000172037 E019 211.0522979 0.0002326535 1.781595e-03 6.541171e-03 3 49123728 49123958 231 - 2.262 2.358 0.320
ENSG00000172037 E020 135.3627418 0.0003778021 2.564725e-01 3.934357e-01 3 49123959 49124100 142 - 2.094 2.147 0.177
ENSG00000172037 E021 112.2767478 0.0008210677 2.156391e-01 3.451753e-01 3 49124190 49124286 97 - 2.009 2.070 0.207
ENSG00000172037 E022 0.6997360 0.0166819052 4.775720e-02 1.051883e-01 3 49124287 49124394 108 - 0.000 0.353 12.149
ENSG00000172037 E023 92.6551798 0.0013423148 7.330658e-01 8.243788e-01 3 49124395 49124442 48 - 1.945 1.976 0.103
ENSG00000172037 E024 193.1869922 0.0002237776 5.504398e-01 6.800741e-01 3 49124443 49124612 170 - 2.263 2.295 0.109
ENSG00000172037 E025 0.5932745 0.0375354569 9.041635e-01 9.430042e-01 3 49124613 49124623 11 - 0.224 0.211 -0.114
ENSG00000172037 E026 0.8073328 0.0161079169 5.696612e-01 6.961887e-01 3 49124681 49124700 20 - 0.304 0.211 -0.692
ENSG00000172037 E027 161.3723217 0.0002572790 1.473888e-01 2.581425e-01 3 49124701 49124810 110 - 2.168 2.227 0.196
ENSG00000172037 E028 106.1836496 0.0009305651 7.813275e-02 1.564712e-01 3 49124811 49124851 41 - 1.971 2.054 0.278
ENSG00000172037 E029 121.7727085 0.0004193620 5.733479e-01 6.992830e-01 3 49124852 49124925 74 - 2.060 2.096 0.119
ENSG00000172037 E030 0.7061804 0.0905723125 9.271946e-01 9.581942e-01 3 49125005 49125005 1 - 0.224 0.213 -0.099
ENSG00000172037 E031 167.9491221 0.0002497990 1.598849e-01 2.749561e-01 3 49125006 49125169 164 - 2.188 2.244 0.189
ENSG00000172037 E032 2.2584049 0.0176516988 7.706850e-02 1.547964e-01 3 49125170 49125204 35 - 0.641 0.353 -1.427
ENSG00000172037 E033 58.5673033 0.0088898533 7.866454e-01 8.633626e-01 3 49125253 49125268 16 - 1.749 1.782 0.113
ENSG00000172037 E034 80.2126074 0.0073205928 7.320990e-01 8.236375e-01 3 49125269 49125286 18 - 1.905 1.903 -0.007
ENSG00000172037 E035 169.4906745 0.0025020733 3.824747e-02 8.781487e-02 3 49125287 49125484 198 - 2.259 2.202 -0.188
ENSG00000172037 E036 4.3231745 0.0347628739 1.978030e-01 3.234825e-01 3 49125485 49125539 55 - 0.829 0.645 -0.750
ENSG00000172037 E037 14.5986387 0.0454047079 3.953606e-01 5.391739e-01 3 49125540 49125746 207 - 1.245 1.135 -0.391
ENSG00000172037 E038 147.5468571 0.0002560138 4.487608e-04 1.962203e-03 3 49125747 49125890 144 - 2.212 2.125 -0.290
ENSG00000172037 E039 161.8953338 0.0002143391 4.155538e-03 1.357944e-02 3 49125967 49126159 193 - 2.240 2.176 -0.212
ENSG00000172037 E040 0.3686942 0.0292320434 9.358453e-01 9.636384e-01 3 49126160 49126183 24 - 0.126 0.119 -0.105
ENSG00000172037 E041 0.3634088 0.4341360957 3.397812e-01   3 49126363 49126364 2 - 0.000 0.213 11.161
ENSG00000172037 E042 126.3635560 0.0002415894 1.358845e-02 3.727831e-02 3 49126365 49126497 133 - 2.134 2.073 -0.205
ENSG00000172037 E043 108.2800392 0.0012078120 2.701668e-02 6.603230e-02 3 49128458 49128572 115 - 2.070 2.005 -0.220
ENSG00000172037 E044 58.0362032 0.0031905877 1.763427e-01 2.964842e-01 3 49128573 49128585 13 - 1.796 1.741 -0.186
ENSG00000172037 E045 1.1769720 0.2732910980 4.583878e-01 5.987162e-01 3 49128586 49128660 75 - 0.429 0.280 -0.895
ENSG00000172037 E046 101.9127213 0.0009728431 1.705137e-03 6.299028e-03 3 49128661 49128819 159 - 2.061 1.961 -0.338
ENSG00000172037 E047 124.2695164 0.0048221044 3.995092e-04 1.772460e-03 3 49129020 49129152 133 - 2.169 2.022 -0.493
ENSG00000172037 E048 105.9088890 0.0111372567 3.199069e-02 7.584018e-02 3 49129245 49129324 80 - 2.085 1.967 -0.396
ENSG00000172037 E049 123.5032810 0.0040846663 2.275464e-06 1.748448e-05 3 49129604 49129716 113 - 2.187 1.995 -0.643
ENSG00000172037 E050 157.3823623 0.0002956168 3.380301e-10 5.449182e-09 3 49129839 49130018 180 - 2.277 2.113 -0.548
ENSG00000172037 E051 161.6031964 0.0006148675 4.231168e-06 3.059708e-05 3 49130231 49130419 189 - 2.267 2.147 -0.401
ENSG00000172037 E052 123.3454236 0.0002658826 1.060595e-10 1.863710e-09 3 49130740 49130860 121 - 2.186 1.995 -0.639
ENSG00000172037 E053 60.2525609 0.0043124170 6.316520e-03 1.944722e-02 3 49130950 49130964 15 - 1.849 1.716 -0.448
ENSG00000172037 E054 160.9621681 0.0006826439 2.988395e-17 1.372466e-15 3 49130965 49131152 188 - 2.319 2.081 -0.797
ENSG00000172037 E055 102.3053410 0.0002964355 3.928899e-20 2.541202e-18 3 49131379 49131442 64 - 2.155 1.845 -1.040
ENSG00000172037 E056 135.7195603 0.0002359970 7.588832e-21 5.384575e-19 3 49131535 49131723 189 - 2.261 1.989 -0.909
ENSG00000172037 E057 60.9825381 0.0044093826 1.629827e-07 1.589692e-06 3 49132116 49132154 39 - 1.918 1.645 -0.921
ENSG00000172037 E058 50.2974951 0.0019792854 1.183720e-06 9.678999e-06 3 49132155 49132189 35 - 1.823 1.580 -0.822
ENSG00000172037 E059 109.3728789 0.0019903314 3.240961e-08 3.625142e-07 3 49132270 49132405 136 - 2.140 1.938 -0.678
ENSG00000172037 E060 126.7157202 0.0034059593 6.266826e-07 5.437286e-06 3 49132491 49132663 173 - 2.199 2.007 -0.643
ENSG00000172037 E061 99.6758790 0.0129309598 6.374958e-04 2.671467e-03 3 49132792 49132868 77 - 2.102 1.894 -0.698
ENSG00000172037 E062 84.4939016 0.0212341517 4.448459e-04 1.946928e-03 3 49132869 49132954 86 - 2.057 1.791 -0.894
ENSG00000172037 E063 73.3578854 0.0121814322 5.831304e-07 5.094411e-06 3 49132955 49133118 164 - 2.019 1.695 -1.091