ENSG00000172009

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000585673 ENSG00000172009 HEK293_OSMI2_2hA HEK293_TMG_2hB THOP1 protein_coding processed_transcript 155.6955 271.7477 92.65219 18.89046 2.153773 -1.552268 33.97261 58.256193 23.559797 6.810617 0.07402169 -1.30571970 0.22337917 0.2129667 0.2545667 0.041600000 1.839208e-01 3.137217e-73 FALSE TRUE
ENST00000586677 ENSG00000172009 HEK293_OSMI2_2hA HEK293_TMG_2hB THOP1 protein_coding protein_coding 155.6955 271.7477 92.65219 18.89046 2.153773 -1.552268 14.15312 40.132662 0.000000 2.271373 0.00000000 -11.97092058 0.05735417 0.1486333 0.0000000 -0.148633333 3.137217e-73 3.137217e-73 FALSE TRUE
MSTRG.16137.3 ENSG00000172009 HEK293_OSMI2_2hA HEK293_TMG_2hB THOP1 protein_coding   155.6955 271.7477 92.65219 18.89046 2.153773 -1.552268 31.00969 56.691172 18.994341 3.341566 0.87327137 -1.57704955 0.19433333 0.2089667 0.2052000 -0.003766667 9.396060e-01 3.137217e-73 TRUE TRUE
MSTRG.16137.8 ENSG00000172009 HEK293_OSMI2_2hA HEK293_TMG_2hB THOP1 protein_coding   155.6955 271.7477 92.65219 18.89046 2.153773 -1.552268 11.06208 9.671187 9.514153 1.161218 0.97499566 -0.02359322 0.08811667 0.0358000 0.1026000 0.066800000 5.657655e-06 3.137217e-73 FALSE TRUE
MSTRG.16137.9 ENSG00000172009 HEK293_OSMI2_2hA HEK293_TMG_2hB THOP1 protein_coding   155.6955 271.7477 92.65219 18.89046 2.153773 -1.552268 39.22525 72.275032 21.782355 5.391528 2.21790407 -1.72987481 0.25128750 0.2658000 0.2361000 -0.029700000 6.961244e-01 3.137217e-73 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172009 E001 4.066981 7.830202e-02 6.191449e-04 2.603550e-03 19 2785478 2785501 24 + 1.028 0.414 -2.600
ENSG00000172009 E002 6.706108 8.032056e-02 5.683869e-03 1.777618e-02 19 2785502 2785502 1 + 1.136 0.655 -1.851
ENSG00000172009 E003 7.146823 7.533690e-02 3.225606e-03 1.093149e-02 19 2785503 2785503 1 + 1.173 0.670 -1.916
ENSG00000172009 E004 26.048565 1.059945e-02 2.527515e-07 2.375621e-06 19 2785504 2785513 10 + 1.638 1.203 -1.502
ENSG00000172009 E005 114.871191 7.872197e-03 2.169696e-06 1.674307e-05 19 2785514 2785547 34 + 2.155 1.894 -0.875
ENSG00000172009 E006 227.387392 5.828136e-03 1.352940e-05 8.718632e-05 19 2785548 2785566 19 + 2.400 2.208 -0.640
ENSG00000172009 E007 533.488754 1.024262e-03 6.192945e-04 2.604121e-03 19 2785567 2785678 112 + 2.683 2.605 -0.260
ENSG00000172009 E008 7.039101 9.201894e-02 3.012814e-03 1.030340e-02 19 2786949 2787034 86 + 1.190 0.651 -2.059
ENSG00000172009 E009 891.228462 2.059461e-04 5.315275e-08 5.697425e-07 19 2790421 2790554 134 + 2.908 2.826 -0.272
ENSG00000172009 E010 894.188522 1.071747e-03 1.731788e-08 2.042910e-07 19 2790555 2790633 79 + 2.934 2.822 -0.373
ENSG00000172009 E011 672.455265 1.342380e-04 1.208617e-14 3.926752e-13 19 2794764 2794792 29 + 2.819 2.693 -0.421
ENSG00000172009 E012 1261.291719 1.244147e-04 1.533928e-19 9.308075e-18 19 2794793 2794912 120 + 3.081 2.970 -0.369
ENSG00000172009 E013 2.988112 5.293522e-03 6.357870e-01 7.499732e-01 19 2796007 2796080 74 + 0.450 0.537 0.428
ENSG00000172009 E014 1264.611098 1.105808e-04 8.514645e-07 7.179748e-06 19 2796081 2796188 108 + 3.043 2.983 -0.201
ENSG00000172009 E015 1226.443415 1.178141e-04 1.601659e-03 5.966443e-03 19 2799689 2799791 103 + 3.013 2.974 -0.130
ENSG00000172009 E016 6.774192 9.591102e-03 8.511073e-01 9.076777e-01 19 2804611 2804656 46 + 0.767 0.797 0.117
ENSG00000172009 E017 1450.663749 2.497170e-04 4.591520e-02 1.018846e-01 19 2805016 2805176 161 + 3.075 3.052 -0.079
ENSG00000172009 E018 35.509077 1.123072e-02 2.961800e-09 4.022828e-08 19 2806017 2806916 900 + 1.786 1.323 -1.582
ENSG00000172009 E019 1011.196509 1.412165e-04 4.619942e-01 6.019161e-01 19 2806917 2806984 68 + 2.906 2.897 -0.030
ENSG00000172009 E020 1037.573531 6.773927e-04 5.033917e-01 6.393591e-01 19 2806985 2807052 68 + 2.918 2.910 -0.028
ENSG00000172009 E021 1083.578911 7.338982e-04 1.908789e-01 3.148465e-01 19 2807442 2807571 130 + 2.906 2.934 0.094
ENSG00000172009 E022 831.645197 8.202308e-04 3.107385e-04 1.423216e-03 19 2807572 2807685 114 + 2.750 2.828 0.261
ENSG00000172009 E023 745.207479 2.050207e-04 1.827773e-04 8.897782e-04 19 2807686 2807773 88 + 2.709 2.777 0.225
ENSG00000172009 E024 412.274800 1.622892e-04 8.024095e-02 1.599306e-01 19 2807774 2807780 7 + 2.478 2.518 0.134
ENSG00000172009 E025 490.697253 1.328382e-04 6.735203e-02 1.389561e-01 19 2807781 2807808 28 + 2.554 2.592 0.128
ENSG00000172009 E026 113.999235 7.056093e-03 9.994039e-06 6.642135e-05 19 2807809 2808242 434 + 2.138 1.897 -0.808
ENSG00000172009 E027 838.306140 9.401298e-05 1.721710e-03 6.350866e-03 19 2808243 2808357 115 + 2.776 2.826 0.169
ENSG00000172009 E028 869.147771 9.017216e-05 8.148953e-06 5.524799e-05 19 2808358 2808444 87 + 2.774 2.845 0.236
ENSG00000172009 E029 39.866991 5.586827e-04 7.884305e-10 1.192256e-08 19 2808818 2808890 73 + 1.772 1.409 -1.239
ENSG00000172009 E030 62.383197 4.158449e-04 7.538168e-05 4.060746e-04 19 2809538 2809806 269 + 1.849 1.650 -0.674
ENSG00000172009 E031 28.918449 6.774623e-04 1.266874e-02 3.513063e-02 19 2809807 2809845 39 + 1.512 1.331 -0.624
ENSG00000172009 E032 67.531126 7.926930e-04 3.049952e-04 1.399821e-03 19 2809846 2810098 253 + 1.868 1.688 -0.607
ENSG00000172009 E033 19.885435 2.106372e-02 2.179951e-02 5.525624e-02 19 2810099 2810152 54 + 1.392 1.153 -0.839
ENSG00000172009 E034 38.510080 7.312325e-03 8.798692e-05 4.655456e-04 19 2810153 2810303 151 + 1.700 1.416 -0.969
ENSG00000172009 E035 1339.877973 7.855438e-05 3.153757e-09 4.262162e-08 19 2810304 2810490 187 + 2.957 3.034 0.255
ENSG00000172009 E036 31.728258 2.410925e-03 6.799817e-03 2.070270e-02 19 2810491 2810639 149 + 1.565 1.372 -0.666
ENSG00000172009 E037 665.962708 1.594338e-04 1.335850e-04 6.748786e-04 19 2810640 2810662 23 + 2.659 2.730 0.236
ENSG00000172009 E038 1307.534966 8.392475e-05 2.504361e-08 2.863825e-07 19 2810663 2810768 106 + 2.950 3.023 0.243
ENSG00000172009 E039 931.065836 2.388738e-04 3.353124e-04 1.521714e-03 19 2811598 2811633 36 + 2.815 2.875 0.199
ENSG00000172009 E040 1326.757667 2.718504e-04 1.149630e-09 1.685059e-08 19 2811634 2811734 101 + 2.943 3.034 0.301
ENSG00000172009 E041 12.337157 1.808569e-02 2.625028e-02 6.445264e-02 19 2811864 2811954 91 + 1.224 0.965 -0.940
ENSG00000172009 E042 22.586947 4.885194e-02 1.947910e-02 5.037206e-02 19 2812027 2812188 162 + 1.488 1.199 -1.007
ENSG00000172009 E043 27.709412 7.304969e-03 3.959634e-03 1.302985e-02 19 2812199 2812372 174 + 1.528 1.294 -0.810
ENSG00000172009 E044 1905.515391 9.448846e-04 2.511367e-18 1.317195e-16 19 2813115 2813495 381 + 3.043 3.203 0.533
ENSG00000172009 E045 407.305418 3.997885e-03 9.546397e-03 2.765050e-02 19 2813496 2815807 2312 + 2.422 2.526 0.348