ENSG00000172006

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317243 ENSG00000172006 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF554 protein_coding protein_coding 3.909175 5.200225 3.306203 0.2278519 0.2979962 -0.6518133 1.6103564 2.1267659 1.79926519 0.4376221 0.03789883 -0.240025 0.41920833 0.41336667 0.55143333 0.1380667 0.53510339 0.01639436 FALSE TRUE
ENST00000590116 ENSG00000172006 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF554 protein_coding nonsense_mediated_decay 3.909175 5.200225 3.306203 0.2278519 0.2979962 -0.6518133 0.4752746 0.5816759 0.09530157 0.2548184 0.09530157 -2.490280 0.12731250 0.11483333 0.02443333 -0.0904000 0.28330103 0.01639436 FALSE TRUE
ENST00000591265 ENSG00000172006 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF554 protein_coding protein_coding 3.909175 5.200225 3.306203 0.2278519 0.2979962 -0.6518133 0.3414239 0.3063244 0.64119117 0.2118382 0.14689024 1.041676 0.09890417 0.05566667 0.20373333 0.1480667 0.26449789 0.01639436 FALSE FALSE
MSTRG.16135.2 ENSG00000172006 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF554 protein_coding   3.909175 5.200225 3.306203 0.2278519 0.2979962 -0.6518133 1.1680560 2.0494577 0.44452499 0.4057627 0.15656346 -2.179833 0.26878750 0.38956667 0.12853333 -0.2610333 0.01639436 0.01639436 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172006 E001 0.2998086 0.0284502477 7.224293e-01   19 2819868 2819894 27 + 0.147 0.101 -0.612
ENSG00000172006 E002 0.8115105 0.0154287092 3.902048e-01 0.5342000345 19 2819895 2819918 24 + 0.147 0.312 1.388
ENSG00000172006 E003 1.4758462 0.0107311909 1.080015e-01 0.2025698230 19 2819919 2819949 31 + 0.147 0.454 2.200
ENSG00000172006 E004 1.6241393 0.0087409901 7.018562e-02 0.1436693518 19 2819950 2819961 12 + 0.147 0.493 2.391
ENSG00000172006 E005 12.7830351 0.0014442175 4.030983e-01 0.5468917227 19 2819962 2820124 163 + 1.154 1.100 -0.194
ENSG00000172006 E006 18.3728234 0.0013697970 8.399199e-01 0.9000298399 19 2823040 2823112 73 + 1.243 1.283 0.141
ENSG00000172006 E007 40.1118848 0.0355181258 1.766134e-05 0.0001108791 19 2823511 2823969 459 + 1.232 1.707 1.637
ENSG00000172006 E008 2.2004751 0.0067043060 2.501940e-01 0.3861667699 19 2826250 2826272 23 + 0.344 0.560 1.127
ENSG00000172006 E009 3.9644025 0.0056611959 1.794314e-01 0.3004191987 19 2826273 2826346 74 + 0.533 0.759 0.974
ENSG00000172006 E010 26.9881338 0.0014272000 8.671470e-01 0.9185364200 19 2827617 2827743 127 + 1.427 1.440 0.047
ENSG00000172006 E011 5.0603831 0.0044713408 7.697341e-01 0.8512972759 19 2830558 2832302 1745 + 0.734 0.797 0.251
ENSG00000172006 E012 27.8716294 0.0009249577 3.120401e-01 0.4545633711 19 2832303 2832494 192 + 1.476 1.436 -0.137
ENSG00000172006 E013 1.4414926 0.1196855238 5.785224e-01 0.7035980363 19 2833163 2833269 107 + 0.417 0.318 -0.576
ENSG00000172006 E014 17.3470003 0.0178752673 1.183466e-01 0.2175689626 19 2833681 2833752 72 + 1.332 1.206 -0.443
ENSG00000172006 E015 33.6602956 0.0007144416 2.504755e-03 0.0087776474 19 2833753 2833943 191 + 1.615 1.465 -0.512
ENSG00000172006 E016 73.9636087 0.0011205413 4.255128e-02 0.0957274973 19 2833944 2834396 453 + 1.893 1.838 -0.185
ENSG00000172006 E017 41.5744841 0.0006363068 2.236566e-01 0.3547685796 19 2834397 2834564 168 + 1.636 1.596 -0.134
ENSG00000172006 E018 139.1290192 0.0093575054 6.801363e-01 0.7841107503 19 2834565 2836735 2171 + 2.099 2.146 0.158