ENSG00000171988

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327520 ENSG00000171988 HEK293_OSMI2_2hA HEK293_TMG_2hB JMJD1C protein_coding protein_coding 4.654972 1.372977 6.614932 0.1349466 0.4380535 2.260129 0.27185603 0.07942857 0.46165377 0.02474941 0.06131912 2.3989204 0.05571667 0.05810000 0.06923333 0.01113333 9.013964e-01 3.773151e-05 FALSE TRUE
ENST00000399262 ENSG00000171988 HEK293_OSMI2_2hA HEK293_TMG_2hB JMJD1C protein_coding protein_coding 4.654972 1.372977 6.614932 0.1349466 0.4380535 2.260129 0.44976279 0.17502987 0.60071430 0.05644515 0.19111038 1.7227394 0.09901667 0.13223333 0.09123333 -0.04100000 7.914995e-01 3.773151e-05 FALSE TRUE
ENST00000467356 ENSG00000171988 HEK293_OSMI2_2hA HEK293_TMG_2hB JMJD1C protein_coding retained_intron 4.654972 1.372977 6.614932 0.1349466 0.4380535 2.260129 0.97695159 0.81458808 0.33727088 0.14463683 0.22269955 -1.2476122 0.35440833 0.58990000 0.04706667 -0.54283333 3.509042e-03 3.773151e-05   FALSE
ENST00000497922 ENSG00000171988 HEK293_OSMI2_2hA HEK293_TMG_2hB JMJD1C protein_coding processed_transcript 4.654972 1.372977 6.614932 0.1349466 0.4380535 2.260129 0.05536346 0.09345945 0.06332621 0.09345945 0.06332621 -0.4966645 0.02029167 0.07070000 0.00850000 -0.06220000 7.783843e-01 3.773151e-05 FALSE FALSE
ENST00000542921 ENSG00000171988 HEK293_OSMI2_2hA HEK293_TMG_2hB JMJD1C protein_coding protein_coding 4.654972 1.372977 6.614932 0.1349466 0.4380535 2.260129 0.33588294 0.00000000 0.36561261 0.00000000 0.21664199 5.2311736 0.04100833 0.00000000 0.05300000 0.05300000 5.025410e-01 3.773151e-05 FALSE TRUE
MSTRG.4045.1 ENSG00000171988 HEK293_OSMI2_2hA HEK293_TMG_2hB JMJD1C protein_coding   4.654972 1.372977 6.614932 0.1349466 0.4380535 2.260129 0.70996877 0.01409242 1.71719994 0.01409242 0.38599260 6.1637117 0.11711250 0.01206667 0.26926667 0.25720000 2.237915e-03 3.773151e-05 FALSE TRUE
MSTRG.4045.5 ENSG00000171988 HEK293_OSMI2_2hA HEK293_TMG_2hB JMJD1C protein_coding   4.654972 1.372977 6.614932 0.1349466 0.4380535 2.260129 1.19811405 0.00000000 2.34077118 0.00000000 0.76986710 7.8769903 0.17115833 0.00000000 0.34206667 0.34206667 3.773151e-05 3.773151e-05 FALSE TRUE
MSTRG.4045.7 ENSG00000171988 HEK293_OSMI2_2hA HEK293_TMG_2hB JMJD1C protein_coding   4.654972 1.372977 6.614932 0.1349466 0.4380535 2.260129 0.54065216 0.19637818 0.51924737 0.10263778 0.51924737 1.3586517 0.12395000 0.13703333 0.08716667 -0.04986667 5.076667e-01 3.773151e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171988 E001 0.0000000       10 63167221 63167224 4 -      
ENSG00000171988 E002 2.0291658 0.2023155628 1.420736e-04 7.124440e-04 10 63167225 63167347 123 - 0.127 0.996 4.710
ENSG00000171988 E003 12.5742979 0.0295952629 4.182732e-05 2.399848e-04 10 63167348 63167589 242 - 0.860 1.385 1.900
ENSG00000171988 E004 14.1049570 0.0018660022 1.687510e-03 6.243288e-03 10 63167590 63167702 113 - 0.952 1.294 1.231
ENSG00000171988 E005 60.1055756 0.0064831188 1.040115e-07 1.052993e-06 10 63167703 63168109 407 - 1.551 1.890 1.149
ENSG00000171988 E006 25.4996147 0.0026463648 4.184608e-05 2.400852e-04 10 63168110 63168134 25 - 1.191 1.539 1.208
ENSG00000171988 E007 41.3577534 0.0005623547 7.093325e-04 2.932545e-03 10 63168435 63168566 132 - 1.418 1.652 0.798
ENSG00000171988 E008 40.9410203 0.0006358814 6.543346e-05 3.580432e-04 10 63176297 63176473 177 - 1.405 1.678 0.933
ENSG00000171988 E009 0.5954526 0.0182592978 1.000000e+00 1.000000e+00 10 63176474 63176555 82 - 0.163 0.000 -9.516
ENSG00000171988 E010 7.0091099 0.0031230757 3.181979e-01 4.611567e-01 10 63176800 63177716 917 - 0.726 0.877 0.598
ENSG00000171988 E011 36.9324928 0.0005855055 1.590310e-02 4.251756e-02 10 63177717 63177856 140 - 1.383 1.562 0.613
ENSG00000171988 E012 30.8212230 0.0063614103 2.748438e-01 4.140659e-01 10 63183447 63183569 123 - 1.322 1.418 0.333
ENSG00000171988 E013 29.4566669 0.0136333255 2.933244e-01 4.343567e-01 10 63184608 63184738 131 - 1.302 1.402 0.348
ENSG00000171988 E014 25.7959891 0.0025638213 2.273473e-02 5.720355e-02 10 63185563 63185653 91 - 1.231 1.433 0.706
ENSG00000171988 E015 34.6155184 0.0006041407 4.139698e-02 9.361873e-02 10 63186215 63186383 169 - 1.358 1.515 0.541
ENSG00000171988 E016 23.9205173 0.0016009969 7.201144e-02 1.466796e-01 10 63189168 63189286 119 - 1.204 1.369 0.578
ENSG00000171988 E017 28.6588912 0.0091736365 1.364434e-01 2.431031e-01 10 63189287 63189446 160 - 1.283 1.419 0.472
ENSG00000171988 E018 39.3676270 0.0005289194 3.831951e-01 5.273818e-01 10 63190894 63191108 215 - 1.428 1.489 0.211
ENSG00000171988 E019 11.7666246 0.0016042166 8.057533e-01 8.765080e-01 10 63192938 63192938 1 - 0.946 0.973 0.099
ENSG00000171988 E020 31.0854079 0.0007634631 7.369849e-02 1.494456e-01 10 63192939 63193097 159 - 1.317 1.462 0.502
ENSG00000171988 E021 12.7597101 0.0062717153 1.167060e-02 3.274915e-02 10 63193098 63193109 12 - 0.929 1.226 1.080
ENSG00000171988 E022 15.0579747 0.0012062261 1.712370e-01 2.898010e-01 10 63193110 63193151 42 - 1.023 1.176 0.552
ENSG00000171988 E023 0.6256415 0.0175759717 3.888525e-01 5.329456e-01 10 63193152 63193344 193 - 0.127 0.286 1.453
ENSG00000171988 E024 25.7629429 0.0007292009 4.083358e-01 5.519303e-01 10 63193345 63193472 128 - 1.272 1.176 -0.341
ENSG00000171988 E025 0.0000000       10 63193473 63193649 177 -      
ENSG00000171988 E026 24.9074138 0.0506869535 1.838963e-01 3.061120e-01 10 63194286 63194375 90 - 1.270 1.052 -0.776
ENSG00000171988 E027 0.4375944 0.0278570460 1.000000e+00 1.000000e+00 10 63194376 63194694 319 - 0.127 0.000 -9.054
ENSG00000171988 E028 31.1653655 0.1147554912 2.820263e-01 4.219870e-01 10 63197411 63197563 153 - 1.359 1.176 -0.644
ENSG00000171988 E029 29.5179455 0.0049958930 3.268305e-04 1.488033e-03 10 63198513 63198727 215 - 1.356 0.877 -1.732
ENSG00000171988 E030 28.7339622 0.0007272754 2.990183e-01 4.405020e-01 10 63200476 63200677 202 - 1.317 1.202 -0.405
ENSG00000171988 E031 171.3199331 0.0002594222 1.692587e-09 2.403534e-08 10 63206595 63208801 2207 - 2.091 1.803 -0.968
ENSG00000171988 E032 25.9551593 0.0007664813 1.401814e-03 5.312984e-03 10 63209063 63209235 173 - 1.298 0.877 -1.530
ENSG00000171988 E033 89.4333237 0.0033175934 1.758880e-08 2.072488e-07 10 63213473 63214723 1251 - 1.820 1.370 -1.538
ENSG00000171988 E034 30.2587356 0.0074337580 6.696601e-07 5.773681e-06 10 63214724 63215139 416 - 1.375 0.580 -3.020
ENSG00000171988 E035 8.2143901 0.0019909496 1.008011e-02 2.895774e-02 10 63215140 63215151 12 - 0.853 0.286 -2.717
ENSG00000171988 E036 26.6167729 0.0007244556 1.992157e-07 1.909380e-06 10 63215263 63215423 161 - 1.324 0.457 -3.430
ENSG00000171988 E037 14.6352776 0.0013360771 4.198096e-06 3.038111e-05 10 63215424 63215437 14 - 1.088 0.001 -13.063
ENSG00000171988 E038 14.8233247 0.0012186836 7.936658e-05 4.248830e-04 10 63215438 63215455 18 - 1.088 0.286 -3.591
ENSG00000171988 E039 17.5489639 0.0012241548 1.193018e-04 6.107159e-04 10 63215553 63215617 65 - 1.151 0.457 -2.820
ENSG00000171988 E040 11.3400729 0.0017172367 7.692394e-03 2.300578e-02 10 63215618 63215696 79 - 0.973 0.457 -2.172
ENSG00000171988 E041 12.3620729 0.0154837584 9.226070e-04 3.693996e-03 10 63217207 63217331 125 - 1.014 0.286 -3.321
ENSG00000171988 E042 0.0000000       10 63219877 63219877 1 -      
ENSG00000171988 E043 8.9999661 0.0019470666 3.451158e-02 8.073441e-02 10 63219878 63219983 106 - 0.880 0.457 -1.820
ENSG00000171988 E044 13.2997028 0.0015024507 1.044626e-02 2.985432e-02 10 63264651 63264764 114 - 1.032 0.580 -1.804
ENSG00000171988 E045 2.5227165 0.0059257140 1.004389e-01 1.911348e-01 10 63268663 63269253 591 - 0.467 0.000 -11.375
ENSG00000171988 E046 16.1463140 0.0011039273 2.320412e-02 5.816981e-02 10 63380318 63380482 165 - 1.032 1.272 0.860
ENSG00000171988 E047 5.7966943 0.0329952652 3.886427e-04 1.730816e-03 10 63465495 63465977 483 - 0.571 1.116 2.147
ENSG00000171988 E048 6.3692713 0.0048992651 2.208179e-01 3.514073e-01 10 63521738 63521902 165 - 0.687 0.877 0.759