ENSG00000171914

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000494733 ENSG00000171914 HEK293_OSMI2_2hA HEK293_TMG_2hB TLN2 protein_coding protein_coding 3.272277 3.93328 2.124369 0.2048076 0.2998717 -0.8855866 0.84717631 1.61239621 0.0000000 0.15813904 0.0000000 -7.3419824 0.19899167 0.41233333 0.00000000 -0.41233333 6.338269e-15 6.338269e-15 FALSE TRUE
ENST00000559174 ENSG00000171914 HEK293_OSMI2_2hA HEK293_TMG_2hB TLN2 protein_coding retained_intron 3.272277 3.93328 2.124369 0.2048076 0.2998717 -0.8855866 0.09405537 0.41429931 0.0000000 0.24640058 0.0000000 -5.4070104 0.02569167 0.11250000 0.00000000 -0.11250000 2.628408e-01 6.338269e-15 FALSE FALSE
ENST00000561197 ENSG00000171914 HEK293_OSMI2_2hA HEK293_TMG_2hB TLN2 protein_coding processed_transcript 3.272277 3.93328 2.124369 0.2048076 0.2998717 -0.8855866 0.21153820 0.14046634 0.2613884 0.14046634 0.2613884 0.8509182 0.07432917 0.03336667 0.09596667 0.06260000 9.489479e-01 6.338269e-15   FALSE
ENST00000636159 ENSG00000171914 HEK293_OSMI2_2hA HEK293_TMG_2hB TLN2 protein_coding protein_coding 3.272277 3.93328 2.124369 0.2048076 0.2998717 -0.8855866 0.32762151 0.90161637 0.0000000 0.49034788 0.0000000 -6.5103549 0.09665000 0.21920000 0.00000000 -0.21920000 2.491319e-01 6.338269e-15 FALSE TRUE
MSTRG.10975.1 ENSG00000171914 HEK293_OSMI2_2hA HEK293_TMG_2hB TLN2 protein_coding   3.272277 3.93328 2.124369 0.2048076 0.2998717 -0.8855866 0.64485293 0.40726865 0.8122712 0.40726865 0.3389279 0.9786377 0.20693333 0.09673333 0.42890000 0.33216667 1.969772e-01 6.338269e-15 FALSE TRUE
MSTRG.10975.10 ENSG00000171914 HEK293_OSMI2_2hA HEK293_TMG_2hB TLN2 protein_coding   3.272277 3.93328 2.124369 0.2048076 0.2998717 -0.8855866 0.23082795 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000 0.09862500 0.00000000 0.00000000 0.00000000   6.338269e-15 FALSE TRUE
MSTRG.10975.4 ENSG00000171914 HEK293_OSMI2_2hA HEK293_TMG_2hB TLN2 protein_coding   3.272277 3.93328 2.124369 0.2048076 0.2998717 -0.8855866 0.18224550 0.07419271 0.5471935 0.07419271 0.1916943 2.7264113 0.06763333 0.02100000 0.27630000 0.25530000 4.193535e-02 6.338269e-15 FALSE TRUE
MSTRG.10975.7 ENSG00000171914 HEK293_OSMI2_2hA HEK293_TMG_2hB TLN2 protein_coding   3.272277 3.93328 2.124369 0.2048076 0.2998717 -0.8855866 0.46755373 0.25541481 0.4007603 0.25541481 0.4007603 0.6300479 0.13232500 0.07230000 0.14713333 0.07483333 9.686014e-01 6.338269e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171914 E001 0.1515154 0.0433253460 2.935625e-01   15 62390513 62390525 13 + 0.151 0.000 -9.743
ENSG00000171914 E002 0.4783925 0.0211462130 3.057915e-01 4.479373e-01 15 62390526 62390549 24 + 0.262 0.099 -1.694
ENSG00000171914 E003 0.9233738 0.0150834695 1.483665e-01 2.594530e-01 15 62390550 62390559 10 + 0.424 0.179 -1.696
ENSG00000171914 E004 5.6933089 0.0251835443 3.786876e-01 5.229829e-01 15 62390560 62390685 126 + 0.858 0.752 -0.415
ENSG00000171914 E005 0.6923622 0.4365161280 8.120931e-01 8.808059e-01 15 62453592 62453709 118 + 0.150 0.249 0.906
ENSG00000171914 E006 0.3289534 0.0292046913 7.004868e-01   15 62453710 62453741 32 + 0.150 0.099 -0.694
ENSG00000171914 E007 0.0000000       15 62476326 62476414 89 +      
ENSG00000171914 E008 0.7384326 0.0299115209 6.136094e-01 7.322612e-01 15 62556550 62556576 27 + 0.150 0.248 0.894
ENSG00000171914 E009 0.0000000       15 62559267 62559357 91 +      
ENSG00000171914 E010 0.0000000       15 62561365 62561482 118 +      
ENSG00000171914 E011 0.1515154 0.0433253460 2.935625e-01   15 62579713 62579740 28 + 0.151 0.000 -12.499
ENSG00000171914 E012 7.3709133 0.0023165983 2.189567e-03 7.809305e-03 15 62589687 62589762 76 + 1.086 0.749 -1.279
ENSG00000171914 E013 4.8053103 0.0597413968 4.329071e-01 5.753599e-01 15 62618351 62618475 125 + 0.804 0.691 -0.459
ENSG00000171914 E014 14.8892910 0.0047304934 3.462487e-06 2.557440e-05 15 62647275 62647446 172 + 1.391 0.988 -1.436
ENSG00000171914 E015 0.0000000       15 62649999 62650083 85 +      
ENSG00000171914 E016 12.3607018 0.0045389511 5.198573e-05 2.916617e-04 15 62650084 62650181 98 + 1.302 0.926 -1.356
ENSG00000171914 E017 13.2165103 0.0470057744 5.753290e-03 1.796334e-02 15 62652005 62652134 130 + 1.320 0.988 -1.187
ENSG00000171914 E018 14.8679100 0.0093953838 8.519517e-05 4.525944e-04 15 62653162 62653314 153 + 1.376 1.021 -1.263
ENSG00000171914 E019 12.6148913 0.0020757014 1.298830e-04 6.583533e-04 15 62655944 62656086 143 + 1.302 0.963 -1.218
ENSG00000171914 E020 13.5253892 0.0140727786 4.976032e-03 1.586309e-02 15 62657771 62657898 128 + 1.302 1.030 -0.970
ENSG00000171914 E021 0.0000000       15 62657899 62658174 276 +      
ENSG00000171914 E022 10.2834746 0.1074457447 1.119360e-01 2.084019e-01 15 62673827 62673890 64 + 1.200 0.918 -1.028
ENSG00000171914 E023 10.2802378 0.0591846040 1.314288e-01 2.361329e-01 15 62675217 62675321 105 + 1.165 0.948 -0.791
ENSG00000171914 E024 12.6513292 0.0014918282 1.161921e-01 2.145465e-01 15 62686641 62686796 156 + 1.190 1.060 -0.466
ENSG00000171914 E025 11.8662232 0.0014690315 1.505240e-02 4.060708e-02 15 62692840 62692941 102 + 1.213 0.998 -0.775
ENSG00000171914 E026 8.6427436 0.0024486359 4.406568e-02 9.850394e-02 15 62694316 62694392 77 + 1.086 0.884 -0.749
ENSG00000171914 E027 14.9619369 0.0011647322 4.303595e-04 1.891304e-03 15 62697688 62697868 181 + 1.345 1.060 -1.009
ENSG00000171914 E028 16.1046504 0.0011422743 2.253691e-03 8.010712e-03 15 62698754 62698867 114 + 1.345 1.106 -0.843
ENSG00000171914 E029 16.2383123 0.0027065053 6.846366e-05 3.727293e-04 15 62701106 62701214 109 + 1.391 1.070 -1.133
ENSG00000171914 E030 22.8739730 0.0173979192 1.564036e-04 7.756187e-04 15 62701992 62702200 209 + 1.533 1.206 -1.135
ENSG00000171914 E031 15.9468690 0.0018771012 2.075417e-04 9.962032e-04 15 62702766 62702864 99 + 1.368 1.070 -1.055
ENSG00000171914 E032 17.6042305 0.0010764085 7.688439e-03 2.299657e-02 15 62707086 62707253 168 + 1.361 1.163 -0.694
ENSG00000171914 E033 19.7421769 0.0011284905 1.083958e-02 3.078058e-02 15 62708502 62708796 295 + 1.398 1.220 -0.621
ENSG00000171914 E034 11.7178148 0.0055656585 3.764528e-02 8.666437e-02 15 62711911 62712077 167 + 1.190 0.999 -0.691
ENSG00000171914 E035 10.1668474 0.0078859467 5.934791e-01 7.158682e-01 15 62716331 62716459 129 + 1.039 1.000 -0.144
ENSG00000171914 E036 7.2462708 0.0023371711 6.133933e-01 7.320678e-01 15 62717576 62717689 114 + 0.832 0.912 0.306
ENSG00000171914 E037 7.4010985 0.0028385152 2.672355e-01 4.055306e-01 15 62719767 62719880 114 + 0.968 0.854 -0.431
ENSG00000171914 E038 10.1249165 0.0169856436 6.107951e-01 7.300729e-01 15 62722353 62722487 135 + 1.039 1.001 -0.139
ENSG00000171914 E039 17.0720511 0.0138533856 1.737450e-01 2.930540e-01 15 62724976 62725104 129 + 1.293 1.183 -0.390
ENSG00000171914 E040 7.8856273 0.0025424375 4.052201e-01 5.489056e-01 15 62727087 62727089 3 + 0.832 0.951 0.454
ENSG00000171914 E041 17.5973401 0.0107643212 7.098622e-01 8.071246e-01 15 62727090 62727189 100 + 1.245 1.230 -0.050
ENSG00000171914 E042 0.0000000       15 62733902 62734091 190 +      
ENSG00000171914 E043 25.8190291 0.0009029830 1.016463e-01 1.929983e-01 15 62736878 62737086 209 + 1.465 1.371 -0.323
ENSG00000171914 E044 17.9284164 0.0024062184 4.611259e-02 1.022447e-01 15 62738214 62738333 120 + 1.345 1.200 -0.509
ENSG00000171914 E045 20.1986956 0.0009284773 7.499720e-02 1.515293e-01 15 62739348 62739545 198 + 1.376 1.259 -0.410
ENSG00000171914 E046 0.2214452 0.0382760006 7.864248e-01   15 62740445 62740629 185 + 0.000 0.099 10.854
ENSG00000171914 E047 18.1714041 0.0010346482 7.717784e-02 1.549717e-01 15 62740630 62740769 140 + 1.336 1.213 -0.432
ENSG00000171914 E048 18.5179904 0.0009932620 2.210328e-02 5.588862e-02 15 62748351 62748444 94 + 1.368 1.207 -0.567
ENSG00000171914 E049 20.7341445 0.0009315772 9.569875e-02 1.839323e-01 15 62750402 62750491 90 + 1.384 1.277 -0.373
ENSG00000171914 E050 21.3986085 0.0009540621 8.362277e-02 1.652130e-01 15 62752305 62752427 123 + 1.398 1.288 -0.383
ENSG00000171914 E051 18.4529421 0.0012498051 7.326689e-01 8.240927e-01 15 62753773 62753916 144 + 1.224 1.271 0.168
ENSG00000171914 E052 0.8396112 0.5804775419 8.573148e-01 9.118798e-01 15 62753917 62755531 1615 + 0.262 0.250 -0.091
ENSG00000171914 E053 22.5287131 0.0010767240 2.846898e-01 4.249453e-01 15 62755532 62755693 162 + 1.265 1.367 0.358
ENSG00000171914 E054 0.0000000       15 62758590 62758659 70 +      
ENSG00000171914 E055 23.5329570 0.0258168417 7.815883e-01 8.596849e-01 15 62761681 62761821 141 + 1.361 1.356 -0.017
ENSG00000171914 E056 25.1239084 0.0089892874 6.481160e-02 1.347346e-01 15 62762272 62762453 182 + 1.465 1.336 -0.447
ENSG00000171914 E057 0.0000000       15 62763226 62763562 337 +      
ENSG00000171914 E058 22.5052825 0.0014257581 1.082902e-01 2.030052e-01 15 62763563 62763695 133 + 1.405 1.305 -0.348
ENSG00000171914 E059 20.2785141 0.0013142237 3.704457e-01 5.148673e-01 15 62766321 62766422 102 + 1.328 1.277 -0.179
ENSG00000171914 E060 29.9866851 0.0150715165 9.437831e-01 9.687265e-01 15 62770964 62771134 171 + 1.440 1.471 0.107
ENSG00000171914 E061 30.8203541 0.0006356766 5.213115e-01 6.551869e-01 15 62776764 62776910 147 + 1.433 1.494 0.211
ENSG00000171914 E062 32.1190864 0.0006897676 3.062327e-01 4.483916e-01 15 62781140 62781241 102 + 1.433 1.518 0.295
ENSG00000171914 E063 30.5841209 0.0006823951 5.573606e-01 6.857859e-01 15 62783771 62783890 120 + 1.433 1.491 0.199
ENSG00000171914 E064 2.1765271 0.0108800678 8.894389e-02 1.735090e-01 15 62783891 62784838 948 + 0.262 0.581 1.762
ENSG00000171914 E065 29.4234375 0.0007388778 8.827620e-01 9.289650e-01 15 62792641 62792787 147 + 1.439 1.468 0.100
ENSG00000171914 E066 30.8220382 0.0007271810 5.584246e-01 6.866615e-01 15 62796127 62796293 167 + 1.433 1.491 0.199
ENSG00000171914 E067 35.0472800 0.0005941321 9.478942e-01 9.712484e-01 15 62797219 62797402 184 + 1.511 1.535 0.080
ENSG00000171914 E068 29.1556453 0.0007010362 8.553530e-01 9.105743e-01 15 62800368 62800493 126 + 1.446 1.453 0.025
ENSG00000171914 E069 27.8796899 0.0044737971 1.017525e-01 1.931689e-01 15 62800653 62800769 117 + 1.328 1.474 0.503
ENSG00000171914 E070 44.9330255 0.0046890833 1.855460e-02 4.835227e-02 15 62805600 62805785 186 + 1.506 1.681 0.596
ENSG00000171914 E071 35.0640831 0.0006214478 5.064547e-02 1.103060e-01 15 62809925 62810032 108 + 1.426 1.569 0.492
ENSG00000171914 E072 34.2965667 0.0028381605 7.966167e-02 1.590220e-01 15 62819516 62819621 106 + 1.419 1.558 0.477
ENSG00000171914 E073 32.0097041 0.0033380782 8.593461e-02 1.688802e-01 15 62820486 62820610 125 + 1.398 1.538 0.480
ENSG00000171914 E074 32.1459081 0.0008717236 1.648411e-04 8.128864e-04 15 62833504 62833629 126 + 1.293 1.572 0.963
ENSG00000171914 E075 0.0000000       15 62835645 62835736 92 +      
ENSG00000171914 E076 23.8793012 0.0008715498 3.579184e-05 2.087255e-04 15 62835737 62835799 63 + 1.100 1.457 1.254
ENSG00000171914 E077 41.7721007 0.0005839701 2.389431e-07 2.256358e-06 15 62835891 62836073 183 + 1.353 1.693 1.167
ENSG00000171914 E078 0.0000000       15 62836074 62836118 45 +      
ENSG00000171914 E079 40.1670033 0.0012193541 1.860550e-04 9.038508e-04 15 62838856 62838981 126 + 1.405 1.658 0.867
ENSG00000171914 E080 306.2719232 0.0050647470 7.515090e-12 1.596268e-10 15 62840482 62844631 4150 + 2.268 2.536 0.896