ENSG00000171853

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324266 ENSG00000171853 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC12 protein_coding protein_coding 54.44444 88.25678 30.73997 5.703662 1.07887 -1.521285 18.268936 24.646375 12.6215333 2.407442 0.4671338 -0.9649310 0.34962500 0.28466667 0.41053333 0.12586667 1.413437e-01 5.327144e-07 FALSE  
ENST00000415624 ENSG00000171853 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC12 protein_coding protein_coding 54.44444 88.25678 30.73997 5.703662 1.07887 -1.521285 4.039647 10.266966 0.9417522 1.084119 0.1773201 -3.4326847 0.06013333 0.11580000 0.03090000 -0.08490000 5.327144e-07 5.327144e-07 FALSE  
ENST00000416918 ENSG00000171853 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC12 protein_coding protein_coding 54.44444 88.25678 30.73997 5.703662 1.07887 -1.521285 6.883647 15.134855 0.7720452 5.542024 0.7720452 -4.2754321 0.10625000 0.16590000 0.02386667 -0.14203333 7.812627e-02 5.327144e-07 FALSE  
ENST00000441983 ENSG00000171853 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC12 protein_coding protein_coding 54.44444 88.25678 30.73997 5.703662 1.07887 -1.521285 3.284898 7.178647 0.8613495 1.190566 0.6877740 -3.0443969 0.06189583 0.08060000 0.02953333 -0.05106667 3.382562e-01 5.327144e-07 FALSE  
ENST00000469400 ENSG00000171853 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC12 protein_coding processed_transcript 54.44444 88.25678 30.73997 5.703662 1.07887 -1.521285 3.506562 4.247747 3.8293227 1.150755 0.4211037 -0.1492384 0.07125417 0.04736667 0.12390000 0.07653333 1.844902e-02 5.327144e-07 FALSE  
ENST00000493792 ENSG00000171853 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC12 protein_coding retained_intron 54.44444 88.25678 30.73997 5.703662 1.07887 -1.521285 4.408730 7.315487 2.7309453 1.025970 0.3736740 -1.4182512 0.07525000 0.08213333 0.08913333 0.00700000 9.054888e-01 5.327144e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171853 E001 3.2814904 0.0324987044 6.121460e-01 7.311414e-01 2 3379675 3379693 19 + 0.513 0.599 0.398
ENSG00000171853 E002 17.7389984 0.0064093259 1.281255e-01 2.315549e-01 2 3379694 3379719 26 + 1.305 1.146 -0.563
ENSG00000171853 E003 105.3935477 0.0094165627 3.513001e-02 8.189091e-02 2 3379720 3379839 120 + 2.041 1.905 -0.457
ENSG00000171853 E004 95.8650621 0.0090681356 5.881300e-02 1.246015e-01 2 3379840 3379876 37 + 1.991 1.867 -0.419
ENSG00000171853 E005 307.9103351 0.0122122723 6.505946e-04 2.718061e-03 2 3387620 3388126 507 + 2.550 2.353 -0.659
ENSG00000171853 E006 383.2312297 0.0096667892 7.435479e-04 3.055982e-03 2 3388127 3388670 544 + 2.630 2.454 -0.584
ENSG00000171853 E007 7.0497290 0.0146897440 6.270177e-01 7.428900e-01 2 3388671 3389000 330 + 0.890 0.810 -0.311
ENSG00000171853 E008 0.2965864 0.2203902992 7.734974e-01   2 3389686 3389693 8 + 0.001 0.136 8.205
ENSG00000171853 E009 3.2420403 0.0050057241 1.236800e-01 2.251966e-01 2 3389694 3389779 86 + 0.742 0.487 -1.128
ENSG00000171853 E010 213.0052024 0.0013317871 2.489418e-01 3.846855e-01 2 3401777 3401893 117 + 2.283 2.231 -0.172
ENSG00000171853 E011 1.2417181 0.0490861929 3.875071e-02 8.872298e-02 2 3421700 3421786 87 + 0.582 0.194 -2.326
ENSG00000171853 E012 105.0309205 0.0003183003 6.345769e-01 7.490027e-01 2 3421881 3421882 2 + 1.963 1.929 -0.114
ENSG00000171853 E013 231.2417744 0.0005566866 5.864274e-01 7.099887e-01 2 3421883 3421994 112 + 2.278 2.279 0.003
ENSG00000171853 E014 223.5711789 0.0001903778 2.021790e-02 5.194245e-02 2 3424525 3424597 73 + 2.223 2.274 0.171
ENSG00000171853 E015 162.3149972 0.0002358767 7.495372e-01 8.364636e-01 2 3424598 3424618 21 + 2.128 2.123 -0.015
ENSG00000171853 E016 207.8760855 0.0002416324 8.020348e-01 8.738790e-01 2 3424619 3424663 45 + 2.250 2.228 -0.074
ENSG00000171853 E017 0.7761102 0.0397942018 1.000000e+00 1.000000e+00 2 3443726 3443778 53 + 0.194 0.195 0.005
ENSG00000171853 E018 145.9126552 0.0004346687 3.337727e-01 4.775232e-01 2 3443779 3443791 13 + 2.067 2.086 0.065
ENSG00000171853 E019 148.0112627 0.0014280510 5.465442e-01 6.767086e-01 2 3443792 3443795 4 + 2.081 2.090 0.030
ENSG00000171853 E020 234.5563870 0.0003092965 6.315662e-01 7.465423e-01 2 3443796 3443867 72 + 2.288 2.286 -0.005
ENSG00000171853 E021 169.6274247 0.0002284033 4.029721e-01 5.467791e-01 2 3443868 3443891 24 + 2.137 2.149 0.040
ENSG00000171853 E022 3.7515547 0.0083432828 8.407765e-03 2.480728e-02 2 3449196 3449477 282 + 0.891 0.486 -1.713
ENSG00000171853 E023 18.0536316 0.0143340354 3.851081e-01 5.292784e-01 2 3454612 3457149 2538 + 1.280 1.178 -0.361
ENSG00000171853 E024 3.5688036 0.0050196933 9.197126e-02 1.781836e-01 2 3457150 3457229 80 + 0.784 0.512 -1.172
ENSG00000171853 E025 248.1382555 0.0002376023 4.225042e-01 5.656329e-01 2 3457621 3457693 73 + 2.304 2.310 0.022
ENSG00000171853 E026 8.2690888 0.0020382117 2.194159e-03 7.823622e-03 2 3457795 3458181 387 + 1.146 0.783 -1.357
ENSG00000171853 E027 5.1452665 0.0162985896 5.753617e-03 1.796406e-02 2 3458313 3458461 149 + 1.001 0.601 -1.594
ENSG00000171853 E028 3.5740880 0.0403890536 2.542402e-01 3.908897e-01 2 3459931 3460262 332 + 0.741 0.538 -0.882
ENSG00000171853 E029 145.8842600 0.0003184912 9.084317e-01 9.458535e-01 2 3460263 3460281 19 + 2.090 2.079 -0.037
ENSG00000171853 E030 145.3900826 0.0004380522 4.776761e-01 6.161944e-01 2 3460282 3460300 19 + 2.071 2.081 0.034
ENSG00000171853 E031 156.0528706 0.0013231257 1.748818e-01 2.945251e-01 2 3460301 3460336 36 + 2.084 2.120 0.121
ENSG00000171853 E032 18.7947358 0.0030925321 3.380690e-01 4.819422e-01 2 3460647 3460942 296 + 1.146 1.225 0.283
ENSG00000171853 E033 4.0064060 0.0062605181 4.114074e-01 5.549765e-01 2 3462858 3463071 214 + 0.513 0.642 0.585
ENSG00000171853 E034 211.2086620 0.0002133977 3.772375e-04 1.686406e-03 2 3465597 3465672 76 + 2.168 2.259 0.305
ENSG00000171853 E035 167.3433686 0.0002156716 1.349546e-05 8.698541e-05 2 3465673 3465695 23 + 2.030 2.164 0.448
ENSG00000171853 E036 1.8529515 0.0365010401 8.805113e-05 4.658332e-04 2 3465696 3465708 13 + 0.823 0.138 -3.910
ENSG00000171853 E037 3.3769747 0.0252801912 3.005540e-06 2.248245e-05 2 3465709 3465807 99 + 1.025 0.287 -3.358
ENSG00000171853 E038 4.9873724 0.0382572902 3.798493e-05 2.201257e-04 2 3466254 3466393 140 + 1.109 0.460 -2.652
ENSG00000171853 E039 18.6612969 0.0362081492 7.267000e-07 6.219613e-06 2 3467430 3468006 577 + 1.596 0.989 -2.135
ENSG00000171853 E040 18.0097379 0.0010982367 1.225854e-08 1.487347e-07 2 3472421 3472602 182 + 1.521 1.047 -1.667
ENSG00000171853 E041 11.1302335 0.0042696825 5.273188e-01 6.604092e-01 2 3477692 3477694 3 + 1.069 0.984 -0.311
ENSG00000171853 E042 152.8599353 0.0002385951 1.270390e-02 3.521730e-02 2 3477695 3477714 20 + 2.043 2.115 0.240
ENSG00000171853 E043 285.3234489 0.0003158869 2.205398e-04 1.051719e-03 2 3477715 3477795 81 + 2.304 2.386 0.274
ENSG00000171853 E044 22.2172776 0.0008899637 5.937113e-01 7.160571e-01 2 3477796 3478101 306 + 1.329 1.270 -0.204
ENSG00000171853 E045 18.9479286 0.0240706494 9.877564e-01 9.964096e-01 2 3478714 3478845 132 + 1.225 1.222 -0.013
ENSG00000171853 E046 361.1730932 0.0072820653 1.717399e-02 4.532559e-02 2 3478846 3478933 88 + 2.397 2.494 0.322
ENSG00000171853 E047 540.2279891 0.0078761345 1.767068e-02 4.642753e-02 2 3479219 3479571 353 + 2.574 2.668 0.312
ENSG00000171853 E048 9.9534120 0.0017439782 3.861833e-01 5.303768e-01 2 3484720 3485094 375 + 0.891 0.984 0.350