ENSG00000171757

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000446859 ENSG00000171757 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC34 protein_coding protein_coding 1.592692 0.7840617 3.276712 0.09529878 0.1547834 2.049322 0.26809001 0.21555709 0.08292316 0.16241865 0.08292316 -1.279383 0.22185833 0.29763333 0.02666667 -0.2709666667 4.508878e-01 5.403602e-06 FALSE TRUE
ENST00000522080 ENSG00000171757 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC34 protein_coding retained_intron 1.592692 0.7840617 3.276712 0.09529878 0.1547834 2.049322 0.08371523 0.05035423 0.24041686 0.05035423 0.24041686 2.052805 0.05093333 0.05166667 0.07670000 0.0250333333 8.659929e-01 5.403602e-06 FALSE TRUE
ENST00000522526 ENSG00000171757 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC34 protein_coding protein_coding 1.592692 0.7840617 3.276712 0.09529878 0.1547834 2.049322 0.19726200 0.02484992 0.67169616 0.02484992 0.16427175 4.289902 0.08495417 0.03596667 0.20420000 0.1682333333 4.401063e-02 5.403602e-06 FALSE TRUE
ENST00000522596 ENSG00000171757 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC34 protein_coding retained_intron 1.592692 0.7840617 3.276712 0.09529878 0.1547834 2.049322 0.27526640 0.11562640 0.49905185 0.02423085 0.02160522 2.018673 0.19539167 0.15330000 0.15353333 0.0002333333 9.486549e-01 5.403602e-06 FALSE TRUE
ENST00000522830 ENSG00000171757 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC34 protein_coding protein_coding 1.592692 0.7840617 3.276712 0.09529878 0.1547834 2.049322 0.23989166 0.19615718 0.63679461 0.10954473 0.32805276 1.649563 0.13709583 0.23076667 0.19860000 -0.0321666667 9.711640e-01 5.403602e-06 FALSE TRUE
ENST00000524327 ENSG00000171757 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC34 protein_coding processed_transcript 1.592692 0.7840617 3.276712 0.09529878 0.1547834 2.049322 0.25813238 0.00000000 0.97994498 0.00000000 0.50987267 6.629276 0.08187500 0.00000000 0.29073333 0.2907333333 3.565529e-01 5.403602e-06 FALSE TRUE
ENST00000602774 ENSG00000171757 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC34 protein_coding processed_transcript 1.592692 0.7840617 3.276712 0.09529878 0.1547834 2.049322 0.08375863 0.13091073 0.00000000 0.04982376 0.00000000 -3.816710 0.07045417 0.15740000 0.00000000 -0.1574000000 5.403602e-06 5.403602e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171757 E001 0.9609246 0.013136847 0.575712495 0.70124671 3 169793003 169793472 470 - 0.233 0.341 0.750
ENSG00000171757 E002 0.2955422 0.028833522 0.381088724   3 169793473 169793484 12 - 0.071 0.203 1.748
ENSG00000171757 E003 0.2955422 0.028833522 0.381088724   3 169793485 169793487 3 - 0.071 0.203 1.748
ENSG00000171757 E004 0.7415557 0.125057356 0.906336434 0.94448902 3 169793488 169793526 39 - 0.233 0.202 -0.261
ENSG00000171757 E005 13.2312562 0.044296497 0.431285317 0.57384859 3 169793527 169793838 312 - 1.073 1.194 0.433
ENSG00000171757 E006 12.0380515 0.001615592 0.150298248 0.26209151 3 169793839 169795484 1646 - 1.098 0.943 -0.571
ENSG00000171757 E007 12.8532837 0.002086077 0.171329694 0.28991913 3 169795485 169795611 127 - 1.046 1.185 0.502
ENSG00000171757 E008 5.0703445 0.068172260 0.770867229 0.85209282 3 169795612 169795779 168 - 0.722 0.765 0.175
ENSG00000171757 E009 7.7969116 0.079600970 0.554108493 0.68312623 3 169795780 169796164 385 - 0.870 0.947 0.290
ENSG00000171757 E010 2.2388276 0.070417499 0.017140711 0.04525225 3 169796165 169796213 49 - 0.564 0.000 -13.566
ENSG00000171757 E011 11.2441097 0.016930579 0.228888283 0.36112595 3 169796214 169796279 66 - 1.067 0.914 -0.567
ENSG00000171757 E012 10.4868556 0.001857142 0.875526340 0.92404850 3 169796280 169796369 90 - 1.010 0.998 -0.043
ENSG00000171757 E013 0.5514428 0.020080525 0.005873941 0.01828099 3 169796460 169796744 285 - 0.000 0.446 14.467
ENSG00000171757 E014 12.7870035 0.001368052 0.789825805 0.86555584 3 169796745 169796899 155 - 1.079 1.112 0.118
ENSG00000171757 E015 0.2214452 0.037091566 0.134607063   3 169796900 169797038 139 - 0.000 0.204 12.886
ENSG00000171757 E016 10.7083430 0.001778276 0.515821971 0.65044080 3 169800659 169800754 96 - 1.039 0.971 -0.250
ENSG00000171757 E017 0.1515154 0.042622564 1.000000000   3 169803971 169804052 82 - 0.071 0.000 -9.657
ENSG00000171757 E018 15.6488046 0.001343268 0.370908928 0.51532825 3 169804053 169804181 129 - 1.192 1.112 -0.286
ENSG00000171757 E019 13.7906141 0.009234279 0.736794930 0.82717629 3 169806848 169806931 84 - 1.122 1.093 -0.105
ENSG00000171757 E020 11.4586048 0.001703013 0.583834398 0.70786726 3 169807426 169807490 65 - 1.053 0.998 -0.200
ENSG00000171757 E021 11.4304060 0.001493226 0.229994612 0.36245790 3 169807588 169807709 122 - 1.073 0.943 -0.480
ENSG00000171757 E022 0.0000000       3 169808023 169808079 57 -      
ENSG00000171757 E023 10.4125813 0.001842043 0.282347918 0.42233811 3 169808628 169808745 118 - 0.970 1.091 0.444
ENSG00000171757 E024 6.1310495 0.013996194 0.805260751 0.87612410 3 169812410 169812569 160 - 0.801 0.842 0.162
ENSG00000171757 E025 9.6934999 0.032249321 0.250377645 0.38639047 3 169812570 169812986 417 - 0.936 1.090 0.569