ENSG00000171714

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000532043 ENSG00000171714 HEK293_OSMI2_2hA HEK293_TMG_2hB ANO5 protein_coding processed_transcript 2.868006 0.4868667 4.917553 0.05218162 0.4046026 3.309941 0.18346204 0.0000000 0.39997523 0.0000000 0.39997523 5.357465 0.02938333 0.0000000 0.070966667 0.070966667 1.000000e+00 1.254859e-06 FALSE FALSE
ENST00000682266 ENSG00000171714 HEK293_OSMI2_2hA HEK293_TMG_2hB ANO5 protein_coding protein_coding 2.868006 0.4868667 4.917553 0.05218162 0.4046026 3.309941 0.05790318 0.1761271 0.00000000 0.1761271 0.00000000 -4.218216 0.08442083 0.3273333 0.000000000 -0.327333333 6.771547e-01 1.254859e-06 FALSE TRUE
ENST00000682341 ENSG00000171714 HEK293_OSMI2_2hA HEK293_TMG_2hB ANO5 protein_coding protein_coding 2.868006 0.4868667 4.917553 0.05218162 0.4046026 3.309941 1.43379820 0.0000000 2.66299031 0.0000000 0.13015921 8.062311 0.34446250 0.0000000 0.553233333 0.553233333 1.254859e-06 1.254859e-06 FALSE TRUE
ENST00000683437 ENSG00000171714 HEK293_OSMI2_2hA HEK293_TMG_2hB ANO5 protein_coding protein_coding 2.868006 0.4868667 4.917553 0.05218162 0.4046026 3.309941 0.07308567 0.0000000 0.04520677 0.0000000 0.04520677 2.464845 0.07989583 0.0000000 0.008033333 0.008033333 9.970461e-01 1.254859e-06 FALSE TRUE
ENST00000684663 ENSG00000171714 HEK293_OSMI2_2hA HEK293_TMG_2hB ANO5 protein_coding protein_coding 2.868006 0.4868667 4.917553 0.05218162 0.4046026 3.309941 0.84859815 0.2642631 1.28476387 0.1323745 0.26955443 2.239057 0.29934583 0.5866000 0.255866667 -0.330733333 6.386309e-01 1.254859e-06 FALSE TRUE
MSTRG.5297.15 ENSG00000171714 HEK293_OSMI2_2hA HEK293_TMG_2hB ANO5 protein_coding   2.868006 0.4868667 4.917553 0.05218162 0.4046026 3.309941 0.11571609 0.0000000 0.26431268 0.0000000 0.13231825 4.777749 0.02279583 0.0000000 0.058166667 0.058166667 7.173564e-01 1.254859e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171714 E001 0.0000000       11 21782659 21782668 10 +      
ENSG00000171714 E002 0.0000000       11 21782669 21782726 58 +      
ENSG00000171714 E003 0.0000000       11 21794777 21794904 128 +      
ENSG00000171714 E004 0.0000000       11 21799934 21799988 55 +      
ENSG00000171714 E005 0.0000000       11 21800761 21801228 468 +      
ENSG00000171714 E006 0.0000000       11 21818160 21818343 184 +      
ENSG00000171714 E007 0.0000000       11 21842805 21843210 406 +      
ENSG00000171714 E008 0.0000000       11 21853688 21853830 143 +      
ENSG00000171714 E009 0.0000000       11 21856341 21856411 71 +      
ENSG00000171714 E010 0.0000000       11 21932349 21932733 385 +      
ENSG00000171714 E011 0.0000000       11 21932778 21932816 39 +      
ENSG00000171714 E012 0.0000000       11 21944730 21944911 182 +      
ENSG00000171714 E013 0.0000000       11 21982966 21983078 113 +      
ENSG00000171714 E014 0.0000000       11 22079541 22079702 162 +      
ENSG00000171714 E015 0.0000000       11 22119726 22119899 174 +      
ENSG00000171714 E016 0.4460135 0.0322013023 1.000000e+00 1.000000e+00 11 22193033 22193044 12 + 0.118 0.001 -7.811
ENSG00000171714 E017 1.6671076 0.0083167090 1.000000e+00 1.000000e+00 11 22193045 22193068 24 + 0.310 0.305 -0.033
ENSG00000171714 E018 2.1120889 0.0069715618 5.694710e-01 6.960216e-01 11 22193069 22193072 4 + 0.352 0.482 0.703
ENSG00000171714 E019 2.2636043 0.0064191856 6.332123e-01 7.479551e-01 11 22193073 22193078 6 + 0.372 0.482 0.588
ENSG00000171714 E020 2.2636043 0.0064191856 6.332123e-01 7.479551e-01 11 22193079 22193084 6 + 0.372 0.482 0.588
ENSG00000171714 E021 2.5560260 0.0059022465 7.599785e-01 8.441992e-01 11 22193085 22193089 5 + 0.409 0.482 0.381
ENSG00000171714 E022 5.0914280 0.0085909157 4.479049e-01 5.892533e-01 11 22193090 22193130 41 + 0.637 0.482 -0.713
ENSG00000171714 E023 5.9772260 0.0032538539 2.907151e-01 4.315183e-01 11 22193131 22193154 24 + 0.695 0.482 -0.960
ENSG00000171714 E024 6.6726730 0.0029961942 4.865278e-02 1.067753e-01 11 22193155 22193174 20 + 0.747 0.305 -2.171
ENSG00000171714 E025 6.9671710 0.0081705388 4.231230e-02 9.529398e-02 11 22193175 22193206 32 + 0.763 0.305 -2.236
ENSG00000171714 E026 7.4476399 0.0119440171 1.463034e-01 2.566555e-01 11 22193207 22193247 41 + 0.778 0.482 -1.298
ENSG00000171714 E027 6.8226637 0.0044637948 1.876671e-01 3.108048e-01 11 22193248 22193321 74 + 0.747 0.482 -1.171
ENSG00000171714 E028 20.5275794 0.0008743073 5.448736e-02 1.171035e-01 11 22193322 22193532 211 + 1.162 0.910 -0.926
ENSG00000171714 E029 11.3909760 0.0015950284 1.546637e-02 4.155166e-02 11 22203804 22203850 47 + 0.945 0.482 -1.940
ENSG00000171714 E030 0.1515154 0.0425737746 6.008246e-01   11 22208003 22211236 3234 + 0.043 0.000 -8.353
ENSG00000171714 E031 0.0000000       11 22211237 22211263 27 +      
ENSG00000171714 E032 4.1404932 0.0046475038 3.495177e-02 8.156175e-02 11 22211264 22211266 3 + 0.593 0.000 -12.410
ENSG00000171714 E033 8.2079456 0.0019944202 2.680858e-01 4.064963e-01 11 22211267 22211314 48 + 0.807 0.608 -0.827
ENSG00000171714 E034 0.0000000       11 22213660 22213720 61 +      
ENSG00000171714 E035 0.1472490 0.0440327516 6.019627e-01   11 22218246 22218287 42 + 0.043 0.000 -8.345
ENSG00000171714 E036 0.0000000       11 22218288 22218585 298 +      
ENSG00000171714 E037 0.0000000       11 22218586 22218661 76 +      
ENSG00000171714 E038 0.0000000       11 22218662 22218742 81 +      
ENSG00000171714 E039 0.0000000       11 22218743 22218863 121 +      
ENSG00000171714 E040 0.2903454 0.3354126222 1.000000e+00   11 22219923 22221096 1174 + 0.082 0.000 -8.642
ENSG00000171714 E041 15.0822294 0.0011607461 3.700518e-01 5.144618e-01 11 22221097 22221210 114 + 1.029 0.910 -0.443
ENSG00000171714 E042 3.7423569 0.0585034922 8.927514e-05 4.715895e-04 11 22221211 22225102 3892 + 0.372 1.080 3.025
ENSG00000171714 E043 14.4938407 0.0057200332 1.294602e-01 2.334106e-01 11 22225984 22226052 69 + 1.020 0.785 -0.896
ENSG00000171714 E044 29.2614892 0.0006969768 3.715880e-03 1.234285e-02 11 22227302 22227586 285 + 1.311 0.961 -1.258
ENSG00000171714 E045 19.9937038 0.0085504349 1.768623e-01 2.971683e-01 11 22236163 22236276 114 + 1.144 0.962 -0.664
ENSG00000171714 E046 22.1235361 0.0178583590 2.007553e-01 3.271415e-01 11 22239569 22239684 116 + 1.184 1.009 -0.636
ENSG00000171714 E047 0.0000000       11 22248673 22248947 275 +      
ENSG00000171714 E048 0.1515154 0.0425737746 6.008246e-01   11 22250039 22250236 198 + 0.043 0.000 -8.353
ENSG00000171714 E049 19.5948771 0.0009660123 4.824852e-01 6.206189e-01 11 22250237 22250371 135 + 1.127 1.048 -0.284
ENSG00000171714 E050 18.0459927 0.0013273765 1.915985e-03 6.964935e-03 11 22250741 22250846 106 + 1.123 0.608 -2.009
ENSG00000171714 E051 17.2342667 0.0010619626 5.448352e-05 3.041352e-04 11 22250951 22251011 61 + 1.113 0.305 -3.557
ENSG00000171714 E052 25.7649873 0.0013722079 5.589621e-04 2.380918e-03 11 22255371 22255522 152 + 1.267 0.784 -1.782
ENSG00000171714 E053 0.0000000       11 22255523 22255932 410 +      
ENSG00000171714 E054 16.9797109 0.0012158580 3.820949e-02 8.774469e-02 11 22257680 22257754 75 + 1.092 0.784 -1.158
ENSG00000171714 E055 24.5965946 0.0008034712 1.949018e-01 3.198728e-01 11 22259519 22259741 223 + 1.229 1.086 -0.510
ENSG00000171714 E056 21.2088694 0.0008536874 4.319937e-02 9.691619e-02 11 22262129 22262298 170 + 1.175 0.910 -0.970
ENSG00000171714 E057 18.2608546 0.0009845053 7.034313e-03 2.131457e-02 11 22262946 22263043 98 + 1.123 0.705 -1.594
ENSG00000171714 E058 16.7722528 0.0010737271 3.885526e-01 5.326270e-01 11 22270312 22270396 85 + 1.069 0.961 -0.398
ENSG00000171714 E059 10.2393548 0.0299003784 8.078891e-01 8.779368e-01 11 22270397 22270442 46 + 0.866 0.910 0.167
ENSG00000171714 E060 23.6479210 0.0064768028 4.163663e-01 5.597297e-01 11 22272784 22272989 206 + 1.209 1.121 -0.316
ENSG00000171714 E061 25.3672909 0.0066965426 5.262090e-02 1.138181e-01 11 22274569 22274747 179 + 1.247 1.007 -0.861
ENSG00000171714 E062 18.6178669 0.0101115447 8.432471e-01 9.023779e-01 11 22276094 22276199 106 + 1.103 1.086 -0.059
ENSG00000171714 E063 1.0748747 0.0352309426 1.263512e-02 3.505075e-02 11 22277786 22277833 48 + 0.118 0.609 3.296
ENSG00000171714 E064 23.7787468 0.0050464358 5.850885e-01 7.088480e-01 11 22279544 22279788 245 + 1.207 1.153 -0.191
ENSG00000171714 E065 123.1676111 0.0008207324 9.391028e-04 3.751006e-03 11 22279789 22281973 2185 + 1.872 2.029 0.526
ENSG00000171714 E066 18.0927814 0.0070448339 1.697957e-03 6.276667e-03 11 22281974 22282123 150 + 1.037 1.387 1.239
ENSG00000171714 E067 37.6986623 0.0007083769 2.910730e-06 2.184310e-05 11 22282124 22282459 336 + 1.337 1.688 1.206
ENSG00000171714 E068 60.9760010 0.0050647914 1.153924e-13 3.249702e-12 11 22282460 22283567 1108 + 1.512 1.974 1.564