ENSG00000171703

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343484 ENSG00000171703 HEK293_OSMI2_2hA HEK293_TMG_2hB TCEA2 protein_coding protein_coding 37.28559 63.12732 26.88027 0.3361138 0.816614 -1.231409 9.494071 18.427713 6.6727658 0.5880741 0.4169995 -1.464142 0.25720833 0.2919000 0.24796667 -0.04393333 2.375219e-01 1.211439e-09 FALSE  
ENST00000465111 ENSG00000171703 HEK293_OSMI2_2hA HEK293_TMG_2hB TCEA2 protein_coding processed_transcript 37.28559 63.12732 26.88027 0.3361138 0.816614 -1.231409 1.766640 1.141581 2.0729565 0.1543469 0.2110357 0.855017 0.05951250 0.0181000 0.07706667 0.05896667 1.211439e-09 1.211439e-09 TRUE  
ENST00000475236 ENSG00000171703 HEK293_OSMI2_2hA HEK293_TMG_2hB TCEA2 protein_coding processed_transcript 37.28559 63.12732 26.88027 0.3361138 0.816614 -1.231409 2.248823 3.475515 0.9793475 0.2552498 0.1070524 -1.816823 0.05930417 0.0551000 0.03626667 -0.01883333 1.275610e-01 1.211439e-09 FALSE  
ENST00000476113 ENSG00000171703 HEK293_OSMI2_2hA HEK293_TMG_2hB TCEA2 protein_coding processed_transcript 37.28559 63.12732 26.88027 0.3361138 0.816614 -1.231409 8.594539 16.416754 5.8095729 0.3995779 0.1861713 -1.497062 0.22597500 0.2601333 0.21613333 -0.04400000 9.011187e-02 1.211439e-09    
MSTRG.21018.10 ENSG00000171703 HEK293_OSMI2_2hA HEK293_TMG_2hB TCEA2 protein_coding   37.28559 63.12732 26.88027 0.3361138 0.816614 -1.231409 7.514917 12.815072 4.9957660 1.8385902 0.7896977 -1.357304 0.19274583 0.2027000 0.18676667 -0.01593333 9.103028e-01 1.211439e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171703 E001 1.839156 0.0101248622 9.085766e-01 9.459052e-01 20 64049836 64050052 217 + 0.406 0.422 0.091
ENSG00000171703 E002 0.000000       20 64057293 64057651 359 +      
ENSG00000171703 E003 1.544658 0.0110588233 2.046612e-01 3.319726e-01 20 64062430 64062503 74 + 0.180 0.422 1.676
ENSG00000171703 E004 4.200609 0.0137320672 6.036804e-01 7.244187e-01 20 64062504 64062867 364 + 0.612 0.690 0.337
ENSG00000171703 E005 6.647228 0.0515044698 1.755563e-03 6.457733e-03 20 64063149 64063157 9 + 1.126 0.638 -1.886
ENSG00000171703 E006 10.618342 0.0667794645 2.815473e-04 1.304753e-03 20 64063158 64063173 16 + 1.335 0.786 -2.013
ENSG00000171703 E007 18.383809 0.1097667766 2.381021e-03 8.401045e-03 20 64063174 64063195 22 + 1.538 1.036 -1.765
ENSG00000171703 E008 17.790448 0.0924663407 1.333822e-03 5.088988e-03 20 64063196 64063197 2 + 1.525 1.023 -1.766
ENSG00000171703 E009 46.003085 0.0265647795 1.470008e-03 5.539505e-03 20 64063198 64063226 29 + 1.809 1.511 -1.013
ENSG00000171703 E010 58.739623 0.0082857210 1.307132e-03 5.000550e-03 20 64063227 64063236 10 + 1.858 1.646 -0.716
ENSG00000171703 E011 257.103522 0.0004745661 3.244999e-01 4.678646e-01 20 64063237 64063384 148 + 2.328 2.348 0.068
ENSG00000171703 E012 92.148365 0.0094561131 1.361146e-01 2.426371e-01 20 64063385 64063480 96 + 1.829 1.922 0.314
ENSG00000171703 E013 338.845002 0.0001532766 3.393636e-09 4.559999e-08 20 64063481 64063891 411 + 2.365 2.492 0.424
ENSG00000171703 E014 145.313818 0.0002651076 7.110542e-04 2.938394e-03 20 64063892 64063917 26 + 2.015 2.126 0.371
ENSG00000171703 E015 187.468957 0.0005267771 8.758497e-04 3.529838e-03 20 64063918 64063949 32 + 2.135 2.233 0.330
ENSG00000171703 E016 215.106985 0.0027943766 4.057914e-03 1.330402e-02 20 64063950 64064086 137 + 2.192 2.295 0.347
ENSG00000171703 E017 90.006296 0.0103653489 9.043814e-01 9.431017e-01 20 64064087 64064325 239 + 1.905 1.897 -0.027
ENSG00000171703 E018 7.846081 0.0022027095 1.660401e-03 6.154769e-03 20 64064326 64064352 27 + 1.126 0.759 -1.384
ENSG00000171703 E019 37.633718 0.0005269029 2.609030e-27 3.466150e-25 20 64065550 64066210 661 + 1.890 1.272 -2.116
ENSG00000171703 E020 15.565740 0.0364142518 4.486841e-04 1.961946e-03 20 64066211 64066332 122 + 1.436 0.993 -1.572
ENSG00000171703 E021 6.104178 0.0267497004 8.821511e-05 4.666047e-04 20 64066333 64066364 32 + 1.126 0.568 -2.196
ENSG00000171703 E022 6.575079 0.0142172465 2.723438e-03 9.442490e-03 20 64066365 64066405 41 + 1.072 0.674 -1.538
ENSG00000171703 E023 10.840612 0.0018150817 1.184166e-03 4.587383e-03 20 64066406 64066475 70 + 1.229 0.892 -1.232
ENSG00000171703 E024 150.379675 0.0028073303 7.322180e-01 8.237175e-01 20 64066476 64066538 63 + 2.106 2.116 0.035
ENSG00000171703 E025 211.996278 0.0010565745 3.312372e-01 4.748392e-01 20 64066915 64067020 106 + 2.242 2.267 0.085
ENSG00000171703 E026 187.420335 0.0015466043 9.469777e-01 9.707064e-01 20 64068047 64068134 88 + 2.213 2.206 -0.022
ENSG00000171703 E027 213.085520 0.0002388928 7.685205e-01 8.504142e-01 20 64069361 64069463 103 + 2.262 2.264 0.007
ENSG00000171703 E028 122.255141 0.0002661881 9.334350e-01 9.620507e-01 20 64069464 64069491 28 + 2.032 2.023 -0.030
ENSG00000171703 E029 157.473104 0.0002641964 2.312997e-01 3.640302e-01 20 64069765 64069821 57 + 2.108 2.140 0.109
ENSG00000171703 E030 31.497983 0.0013029251 1.263149e-08 1.528193e-07 20 64069822 64070213 392 + 1.689 1.318 -1.276
ENSG00000171703 E031 16.396305 0.0011324658 1.773239e-06 1.395078e-05 20 64070214 64070259 46 + 1.444 1.036 -1.439
ENSG00000171703 E032 165.444945 0.0006014161 2.993461e-01 4.408547e-01 20 64070260 64070290 31 + 2.183 2.144 -0.130
ENSG00000171703 E033 171.432017 0.0005527715 9.458496e-01 9.700051e-01 20 64070291 64070327 37 + 2.174 2.166 -0.027
ENSG00000171703 E034 225.611095 0.0002217140 9.380485e-01 9.650625e-01 20 64070328 64070414 87 + 2.290 2.286 -0.013
ENSG00000171703 E035 8.221973 0.0021054435 2.491313e-02 6.169243e-02 20 64070415 64070488 74 + 1.091 0.830 -0.976
ENSG00000171703 E036 112.305414 0.0005050877 9.617041e-01 9.798585e-01 20 64070489 64070491 3 + 1.993 1.988 -0.014
ENSG00000171703 E037 276.968730 0.0011245305 5.868669e-01 7.103166e-01 20 64070492 64070635 144 + 2.371 2.382 0.035
ENSG00000171703 E038 6.145257 0.0028487872 3.751255e-01 5.195357e-01 20 64071858 64071869 12 + 0.709 0.830 0.484
ENSG00000171703 E039 181.336801 0.0064988775 1.117088e-01 2.080669e-01 20 64071870 64071941 72 + 2.140 2.216 0.255
ENSG00000171703 E040 36.848877 0.0076876808 2.258468e-02 5.688871e-02 20 64071942 64072171 230 + 1.641 1.472 -0.577
ENSG00000171703 E041 137.786393 0.0031846158 1.679596e-01 2.855452e-01 20 64072172 64072347 176 + 2.038 2.093 0.186