ENSG00000171681

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261168 ENSG00000171681 HEK293_OSMI2_2hA HEK293_TMG_2hB ATF7IP protein_coding protein_coding 7.812613 3.480333 10.42511 0.1798082 0.3513531 1.58001 5.0014886 2.4815406 6.8750644 0.5229141 0.36176543 1.466432 0.63695833 0.72706667 0.66266667 -0.06440000 7.530182e-01 3.027608e-06 FALSE TRUE
ENST00000536444 ENSG00000171681 HEK293_OSMI2_2hA HEK293_TMG_2hB ATF7IP protein_coding protein_coding 7.812613 3.480333 10.42511 0.1798082 0.3513531 1.58001 0.4249302 0.1687496 0.0000000 0.1687496 0.00000000 -4.159868 0.07501667 0.04543333 0.00000000 -0.04543333 5.443780e-01 3.027608e-06 FALSE TRUE
ENST00000539659 ENSG00000171681 HEK293_OSMI2_2hA HEK293_TMG_2hB ATF7IP protein_coding processed_transcript 7.812613 3.480333 10.42511 0.1798082 0.3513531 1.58001 1.0259769 0.0000000 1.6848828 0.0000000 0.51240250 7.405042 0.09622917 0.00000000 0.15890000 0.15890000 3.027608e-06 3.027608e-06 FALSE TRUE
ENST00000541654 ENSG00000171681 HEK293_OSMI2_2hA HEK293_TMG_2hB ATF7IP protein_coding processed_transcript 7.812613 3.480333 10.42511 0.1798082 0.3513531 1.58001 0.4017713 0.0000000 0.7875162 0.0000000 0.54123140 6.317442 0.03542917 0.00000000 0.07850000 0.07850000 3.890396e-01 3.027608e-06 FALSE TRUE
MSTRG.6877.1 ENSG00000171681 HEK293_OSMI2_2hA HEK293_TMG_2hB ATF7IP protein_coding   7.812613 3.480333 10.42511 0.1798082 0.3513531 1.58001 0.2509315 0.5616086 0.1640477 0.5616086 0.06115485 -1.715545 0.05832917 0.15116667 0.01543333 -0.13573333 9.655939e-01 3.027608e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171681 E001 0.7363589 0.0155182260 1.086007e-01 2.034720e-01 12 14365662 14365675 14 + 0.313 0.000 -15.449
ENSG00000171681 E002 0.8836079 0.0133087333 6.879852e-02 1.413816e-01 12 14365676 14365676 1 + 0.355 0.000 -15.709
ENSG00000171681 E003 1.0308569 0.0177729220 4.523825e-02 1.006264e-01 12 14365677 14365681 5 + 0.394 0.000 -15.931
ENSG00000171681 E004 1.0308569 0.0177729220 4.523825e-02 1.006264e-01 12 14365682 14365683 2 + 0.394 0.000 -15.931
ENSG00000171681 E005 1.0308569 0.0177729220 4.523825e-02 1.006264e-01 12 14365684 14365687 4 + 0.394 0.000 -15.931
ENSG00000171681 E006 1.5489902 0.0085847786 1.137507e-01 2.109971e-01 12 14365688 14365692 5 + 0.462 0.177 -1.917
ENSG00000171681 E007 10.7689230 0.0077904313 3.022524e-02 7.241329e-02 12 14365693 14365728 36 + 1.108 0.878 -0.851
ENSG00000171681 E008 21.2817168 0.0028055321 2.004133e-03 7.238837e-03 12 14365729 14365827 99 + 1.387 1.148 -0.840
ENSG00000171681 E009 0.0000000       12 14367324 14367352 29 +      
ENSG00000171681 E010 0.0000000       12 14367363 14367372 10 +      
ENSG00000171681 E011 0.0000000       12 14367373 14367449 77 +      
ENSG00000171681 E012 0.0000000       12 14369146 14369324 179 +      
ENSG00000171681 E013 1.1834165 0.0108330431 2.199118e-01 3.503068e-01 12 14385064 14385315 252 + 0.394 0.177 -1.556
ENSG00000171681 E014 1.0457324 0.0196562978 4.548195e-02 1.010816e-01 12 14385316 14385400 85 + 0.394 0.000 -15.932
ENSG00000171681 E015 0.0000000       12 14394863 14395252 390 +      
ENSG00000171681 E016 0.0000000       12 14408490 14408544 55 +      
ENSG00000171681 E017 0.0000000       12 14416913 14416948 36 +      
ENSG00000171681 E018 0.0000000       12 14419136 14419163 28 +      
ENSG00000171681 E019 0.0000000       12 14419164 14419187 24 +      
ENSG00000171681 E020 0.0000000       12 14419188 14419190 3 +      
ENSG00000171681 E021 0.0000000       12 14419191 14419192 2 +      
ENSG00000171681 E022 0.0000000       12 14419193 14419210 18 +      
ENSG00000171681 E023 0.0000000       12 14419211 14419218 8 +      
ENSG00000171681 E024 0.0000000       12 14419219 14419361 143 +      
ENSG00000171681 E025 0.0000000       12 14419971 14420301 331 +      
ENSG00000171681 E026 0.0000000       12 14420302 14420446 145 +      
ENSG00000171681 E027 0.0000000       12 14423761 14423908 148 +      
ENSG00000171681 E028 50.0886572 0.0166952299 1.775773e-04 8.678763e-04 12 14423909 14424125 217 + 1.760 1.475 -0.971
ENSG00000171681 E029 27.6895425 0.0007145971 1.366036e-06 1.101733e-05 12 14424126 14424170 45 + 1.522 1.178 -1.198
ENSG00000171681 E030 32.8348007 0.0013797607 6.366013e-06 4.426906e-05 12 14424171 14424273 103 + 1.584 1.292 -1.006
ENSG00000171681 E031 26.3192067 0.0182583935 2.127903e-02 5.417472e-02 12 14424274 14424319 46 + 1.470 1.269 -0.697
ENSG00000171681 E032 151.5967105 0.0070856970 1.791758e-07 1.733799e-06 12 14424320 14425077 758 + 2.223 1.991 -0.776
ENSG00000171681 E033 101.4198252 0.0234633076 6.482482e-02 1.347547e-01 12 14425078 14425473 396 + 2.020 1.907 -0.379
ENSG00000171681 E034 26.4441928 0.0032145964 1.387873e-02 3.795265e-02 12 14434337 14434339 3 + 1.463 1.303 -0.556
ENSG00000171681 E035 49.2537241 0.0059144350 3.952020e-02 9.014271e-02 12 14434340 14434423 84 + 1.707 1.605 -0.347
ENSG00000171681 E036 44.6176644 0.0038939856 8.737453e-01 9.228610e-01 12 14436106 14436194 89 + 1.624 1.647 0.075
ENSG00000171681 E037 37.0735519 0.0006660005 4.827348e-01 6.208514e-01 12 14436195 14436251 57 + 1.556 1.546 -0.035
ENSG00000171681 E038 55.1458350 0.0015145480 4.745740e-01 6.133921e-01 12 14438130 14438267 138 + 1.723 1.718 -0.017
ENSG00000171681 E039 43.1871600 0.0005684687 1.432734e-01 2.524809e-01 12 14446988 14447053 66 + 1.633 1.582 -0.175
ENSG00000171681 E040 44.1860553 0.0049941181 8.755776e-02 1.714316e-01 12 14456561 14456634 74 + 1.656 1.576 -0.272
ENSG00000171681 E041 46.8953513 0.0005048628 4.290588e-01 5.717925e-01 12 14457207 14457295 89 + 1.660 1.650 -0.033
ENSG00000171681 E042 158.1979565 0.0028236396 4.988959e-01 6.352846e-01 12 14460495 14461133 639 + 2.156 2.214 0.193
ENSG00000171681 E043 0.1472490 0.0435191345 1.000000e+00   12 14466110 14466525 416 + 0.083 0.000 -13.124
ENSG00000171681 E044 45.1588324 0.0005559285 3.749853e-01 5.194261e-01 12 14466526 14466590 65 + 1.607 1.688 0.275
ENSG00000171681 E045 47.8208532 0.0005203245 4.344640e-04 1.907262e-03 12 14475890 14475968 79 + 1.576 1.791 0.728
ENSG00000171681 E046 0.3686942 0.0318471152 5.617932e-01 6.895193e-01 12 14475969 14476432 464 + 0.083 0.177 1.255
ENSG00000171681 E047 34.9506523 0.0006271353 3.467527e-03 1.163192e-02 12 14478317 14478335 19 + 1.447 1.655 0.712
ENSG00000171681 E048 72.2964945 0.0004093682 1.004990e-03 3.975535e-03 12 14478336 14478472 137 + 1.774 1.946 0.581
ENSG00000171681 E049 85.6345464 0.0003304313 2.494053e-03 8.746269e-03 12 14481003 14481185 183 + 1.855 2.006 0.508
ENSG00000171681 E050 1.0663539 0.0121989077 8.965529e-03 2.619352e-02 12 14481186 14481607 422 + 0.083 0.546 3.575
ENSG00000171681 E051 2.4542873 0.0162993097 2.785214e-03 9.630241e-03 12 14481608 14482653 1046 + 0.266 0.781 2.578
ENSG00000171681 E052 58.7623569 0.0067816679 9.727371e-02 1.863218e-01 12 14496231 14496343 113 + 1.700 1.835 0.456
ENSG00000171681 E053 650.2018646 0.0290547089 8.351722e-02 1.650524e-01 12 14497654 14502931 5278 + 2.739 2.875 0.454