ENSG00000171617

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302351 ENSG00000171617 HEK293_OSMI2_2hA HEK293_TMG_2hB ENC1 protein_coding protein_coding 1.30671 1.159508 1.453617 0.09294324 0.05862351 0.3236363 0.9159978 0.84881238 0.8163992 0.328019222 0.40836039 -0.05550417 0.69582083 0.69856667 0.5607667 -0.13780000 0.82468811 0.02940172 FALSE  
ENST00000510316 ENSG00000171617 HEK293_OSMI2_2hA HEK293_TMG_2hB ENC1 protein_coding protein_coding 1.30671 1.159508 1.453617 0.09294324 0.05862351 0.3236363 0.1228883 0.23463315 0.2857211 0.234633151 0.28572108 0.27361716 0.10758333 0.23523333 0.1986333 -0.03660000 1.00000000 0.02940172 FALSE  
ENST00000618628 ENSG00000171617 HEK293_OSMI2_2hA HEK293_TMG_2hB ENC1 protein_coding protein_coding 1.30671 1.159508 1.453617 0.09294324 0.05862351 0.3236363 0.1552535 0.05537980 0.1296232 0.027764561 0.12962321 1.09462198 0.11220000 0.04903333 0.0901000 0.04106667 0.88175501 0.02940172 FALSE  
ENST00000651128 ENSG00000171617 HEK293_OSMI2_2hA HEK293_TMG_2hB ENC1 protein_coding protein_coding 1.30671 1.159508 1.453617 0.09294324 0.05862351 0.3236363 0.1024058 0.02068237 0.1682222 0.007896533 0.01214407 2.53819523 0.07785833 0.01716667 0.1161667 0.09900000 0.02940172 0.02940172 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171617 E001 0.0000000       5 74627406 74627408 3 -      
ENSG00000171617 E002 0.1482932 0.0411597534 4.280267e-01   5 74627409 74627430 22 - 0.000 0.133 9.556
ENSG00000171617 E003 111.1534643 0.0040594697 4.841881e-12 1.061421e-10 5 74627431 74629551 2121 - 1.926 2.154 0.764
ENSG00000171617 E004 19.0062038 0.0011116549 9.806623e-01 9.918868e-01 5 74629552 74629928 377 - 1.292 1.316 0.084
ENSG00000171617 E005 7.7187709 0.0022772468 8.791279e-02 1.719544e-01 5 74629929 74629992 64 - 1.019 0.851 -0.633
ENSG00000171617 E006 0.1515154 0.0431532680 5.629497e-01   5 74632133 74632262 130 - 0.112 0.000 -12.166
ENSG00000171617 E007 57.6144679 0.0005667172 8.220126e-04 3.338074e-03 5 74634684 74636336 1653 - 1.821 1.712 -0.368
ENSG00000171617 E008 3.4760732 0.0047414217 9.014925e-01 9.412238e-01 5 74636337 74636362 26 - 0.657 0.661 0.016
ENSG00000171617 E009 5.9077780 0.0641754681 3.699540e-01 5.143561e-01 5 74636363 74636473 111 - 0.908 0.775 -0.517
ENSG00000171617 E010 3.4302938 0.2165505606 3.485452e-01 4.927841e-01 5 74636474 74636498 25 - 0.757 0.498 -1.136
ENSG00000171617 E011 0.7416694 0.0172673460 2.190836e-01 3.492724e-01 5 74637494 74637564 71 - 0.339 0.133 -1.721
ENSG00000171617 E012 0.9598924 0.0142456156 8.756745e-01 9.241485e-01 5 74637565 74637618 54 - 0.276 0.317 0.279
ENSG00000171617 E013 0.5922303 0.0180001318 3.780557e-01 5.223539e-01 5 74637619 74637701 83 - 0.276 0.133 -1.306
ENSG00000171617 E014 4.6972465 0.0034894858 6.141801e-05 3.384664e-04 5 74637702 74640125 2424 - 0.953 0.386 -2.475
ENSG00000171617 E015 5.2653761 0.0281794835 5.640806e-03 1.766007e-02 5 74640307 74640429 123 - 0.953 0.546 -1.664
ENSG00000171617 E016 6.0614475 0.0030389172 7.046299e-04 2.915457e-03 5 74640430 74640627 198 - 1.007 0.588 -1.674
ENSG00000171617 E017 4.0673622 0.0232336252 2.227585e-02 5.624521e-02 5 74640628 74641424 797 - 0.839 0.499 -1.455