ENSG00000171604

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302517 ENSG00000171604 HEK293_OSMI2_2hA HEK293_TMG_2hB CXXC5 protein_coding protein_coding 6.160658 7.529985 6.236017 0.2055784 0.3496729 -0.271625 1.7025740 1.591351 2.1856910 0.3078862 0.2361097 0.4553856 0.2802500 0.2136333 0.3560333 0.1424000 0.26187913 0.01539728 FALSE TRUE
ENST00000504844 ENSG00000171604 HEK293_OSMI2_2hA HEK293_TMG_2hB CXXC5 protein_coding protein_coding 6.160658 7.529985 6.236017 0.2055784 0.3496729 -0.271625 0.2604623 0.000000 0.8032144 0.0000000 0.4102337 6.3455639 0.0403000 0.0000000 0.1229333 0.1229333 0.15434071 0.01539728 FALSE FALSE
ENST00000511048 ENSG00000171604 HEK293_OSMI2_2hA HEK293_TMG_2hB CXXC5 protein_coding protein_coding 6.160658 7.529985 6.236017 0.2055784 0.3496729 -0.271625 3.5000138 5.305091 2.4161225 0.5421738 0.4409718 -1.1314419 0.5688417 0.7022667 0.3854000 -0.3168667 0.01539728 0.01539728 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171604 E001 0.0000000       5 139647299 139647435 137 +      
ENSG00000171604 E002 0.1515154 0.0432267064 3.228571e-01   5 139647904 139648004 101 + 0.148 0.000 -10.151
ENSG00000171604 E003 14.6728366 0.0021471070 5.788266e-03 1.805647e-02 5 139648349 139648660 312 + 1.310 1.070 -0.856
ENSG00000171604 E004 5.4064682 0.0038959365 2.258981e-02 5.689785e-02 5 139648661 139648711 51 + 0.959 0.668 -1.145
ENSG00000171604 E005 15.9616770 0.0012299858 6.141223e-07 5.338823e-06 5 139648712 139648845 134 + 1.430 1.018 -1.460
ENSG00000171604 E006 0.0000000       5 139648925 139648928 4 +      
ENSG00000171604 E007 0.1817044 0.0416089666 7.157629e-01   5 139648929 139648932 4 + 0.000 0.101 10.289
ENSG00000171604 E008 0.3268771 0.0315355119 7.490485e-01   5 139648933 139648937 5 + 0.148 0.101 -0.629
ENSG00000171604 E009 4.1610339 0.0039906565 3.776360e-01 5.219491e-01 5 139648938 139649009 72 + 0.768 0.644 -0.514
ENSG00000171604 E010 0.2214452 0.0408555326 7.153204e-01   5 139650989 139651166 178 + 0.000 0.101 10.295
ENSG00000171604 E011 0.3299976 0.0274424043 3.473213e-01   5 139659555 139659641 87 + 0.000 0.183 11.321
ENSG00000171604 E012 0.2955422 0.0289858012 7.464433e-01   5 139665580 139665803 224 + 0.148 0.101 -0.632
ENSG00000171604 E013 0.3729606 0.0318718882 7.504435e-01 8.371269e-01 5 139675436 139675442 7 + 0.148 0.101 -0.627
ENSG00000171604 E014 0.3729606 0.0318718882 7.504435e-01 8.371269e-01 5 139675443 139675473 31 + 0.148 0.101 -0.627
ENSG00000171604 E015 0.1515154 0.0432267064 3.228571e-01   5 139675474 139675533 60 + 0.148 0.000 -12.162
ENSG00000171604 E016 0.1515154 0.0432267064 3.228571e-01   5 139675534 139675538 5 + 0.148 0.000 -12.162
ENSG00000171604 E017 1.3212234 0.2617914864 2.482430e-01 3.838583e-01 5 139679683 139679846 164 + 0.148 0.419 2.000
ENSG00000171604 E018 2.2163697 0.0068236697 5.351989e-01 6.671261e-01 5 139679847 139679940 94 + 0.418 0.526 0.540
ENSG00000171604 E019 104.4875803 0.0034011259 1.545837e-05 9.836562e-05 5 139680364 139680957 594 + 2.102 1.934 -0.565
ENSG00000171604 E020 45.3450543 0.0018138078 1.408985e-01 2.492580e-01 5 139680958 139681113 156 + 1.692 1.614 -0.266
ENSG00000171604 E021 72.7992251 0.0012390592 3.243810e-01 4.677310e-01 5 139681114 139681447 334 + 1.871 1.831 -0.135
ENSG00000171604 E022 1.8152964 0.0082686100 8.535813e-01 9.093939e-01 5 139681448 139681468 21 + 0.418 0.452 0.176
ENSG00000171604 E023 42.3595863 0.0006938142 5.375813e-01 6.691228e-01 5 139682863 139682993 131 + 1.596 1.632 0.121
ENSG00000171604 E024 67.1031231 0.0004866992 1.137784e-01 2.110295e-01 5 139682994 139683153 160 + 1.767 1.837 0.237
ENSG00000171604 E025 98.8828330 0.0012571945 3.537783e-05 2.066037e-04 5 139683154 139683385 232 + 1.873 2.031 0.531
ENSG00000171604 E026 110.0026094 0.0039821153 2.999943e-05 1.785405e-04 5 139683386 139683882 497 + 1.905 2.083 0.596