ENSG00000171566

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302078 ENSG00000171566 HEK293_OSMI2_2hA HEK293_TMG_2hB PLRG1 protein_coding protein_coding 51.92223 22.80495 71.12077 2.535758 1.326258 1.640494 22.766167 9.237067 32.7735089 0.6216511 0.3613842 1.8259026 0.43928750 0.40870000 0.461266667 0.05256667 0.3175309883 0.0001647509 FALSE TRUE
ENST00000499023 ENSG00000171566 HEK293_OSMI2_2hA HEK293_TMG_2hB PLRG1 protein_coding protein_coding 51.92223 22.80495 71.12077 2.535758 1.326258 1.640494 8.209255 3.761504 12.5822513 0.3555408 0.6653615 1.7393245 0.16085000 0.16560000 0.176800000 0.01120000 0.7812285402 0.0001647509 FALSE TRUE
ENST00000504341 ENSG00000171566 HEK293_OSMI2_2hA HEK293_TMG_2hB PLRG1 protein_coding protein_coding 51.92223 22.80495 71.12077 2.535758 1.326258 1.640494 9.006913 1.236579 14.0807900 0.6262990 1.2160988 3.4987061 0.15097917 0.06083333 0.197866667 0.13703333 0.4630470571 0.0001647509 FALSE FALSE
ENST00000506627 ENSG00000171566 HEK293_OSMI2_2hA HEK293_TMG_2hB PLRG1 protein_coding nonsense_mediated_decay 51.92223 22.80495 71.12077 2.535758 1.326258 1.640494 1.542526 2.790578 0.7200555 0.4679256 0.5040309 -1.9396467 0.04639167 0.12106667 0.009866667 -0.11120000 0.0002474545 0.0001647509 TRUE FALSE
ENST00000512773 ENSG00000171566 HEK293_OSMI2_2hA HEK293_TMG_2hB PLRG1 protein_coding retained_intron 51.92223 22.80495 71.12077 2.535758 1.326258 1.640494 2.592737 2.861719 1.7292354 1.3605497 0.2196257 -0.7234615 0.05713750 0.11616667 0.024300000 -0.09186667 0.0308072501 0.0001647509   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171566 E001 222.251911 0.0012060053 7.221266e-03 2.179808e-02 4 154535005 154536431 1427 - 2.342 2.262 -0.267
ENSG00000171566 E002 26.772034 0.0007977182 2.354217e-01 3.688627e-01 4 154536432 154536462 31 - 1.437 1.354 -0.288
ENSG00000171566 E003 33.498852 0.0019614359 9.835601e-02 1.880171e-01 4 154536463 154536509 47 - 1.539 1.428 -0.381
ENSG00000171566 E004 32.481829 0.0058053606 1.961644e-01 3.214299e-01 4 154536510 154536520 11 - 1.465 1.564 0.341
ENSG00000171566 E005 64.401545 0.0098727978 1.639350e-07 1.598157e-06 4 154536521 154536599 79 - 1.648 1.997 1.178
ENSG00000171566 E006 56.363005 0.0122169707 7.367512e-11 1.328277e-09 4 154536600 154536618 19 - 1.523 1.999 1.611
ENSG00000171566 E007 153.735054 0.0056962844 1.645448e-12 3.890244e-11 4 154536619 154536740 122 - 2.029 2.360 1.106
ENSG00000171566 E008 108.352808 0.0037898471 5.126164e-08 5.514061e-07 4 154536741 154536744 4 - 1.917 2.170 0.847
ENSG00000171566 E009 283.344376 0.0003662802 1.686879e-16 7.057735e-15 4 154537286 154537479 194 - 2.356 2.549 0.644
ENSG00000171566 E010 6.435024 0.1261192768 6.437538e-01 7.562207e-01 4 154537480 154537542 63 - 0.859 0.847 -0.049
ENSG00000171566 E011 264.323451 0.0002080485 9.075589e-06 6.090266e-05 4 154537969 154538082 114 - 2.357 2.465 0.361
ENSG00000171566 E012 170.532904 0.0002149249 5.032201e-02 1.097389e-01 4 154538083 154538108 26 - 2.185 2.247 0.209
ENSG00000171566 E013 2.849504 0.0186882144 8.647217e-01 9.167978e-01 4 154539014 154539104 91 - 0.582 0.559 -0.103
ENSG00000171566 E014 300.760302 0.0001741441 8.526652e-04 3.447107e-03 4 154539105 154539213 109 - 2.424 2.502 0.260
ENSG00000171566 E015 304.598295 0.0002052058 4.921406e-01 6.293381e-01 4 154539951 154540053 103 - 2.449 2.469 0.069
ENSG00000171566 E016 1.618719 0.4062218093 9.316309e-01 9.609336e-01 4 154540054 154540272 219 - 0.415 0.398 -0.094
ENSG00000171566 E017 254.431366 0.0001624105 7.970522e-01 8.704977e-01 4 154540594 154540670 77 - 2.379 2.378 -0.002
ENSG00000171566 E018 178.156660 0.0004405943 6.626605e-01 7.709302e-01 4 154540671 154540695 25 - 2.227 2.219 -0.026
ENSG00000171566 E019 323.662238 0.0001443943 7.276239e-01 8.202724e-01 4 154540785 154540934 150 - 2.484 2.482 -0.006
ENSG00000171566 E020 4.777686 0.0037871842 3.754210e-02 8.648432e-02 4 154540935 154540936 2 - 0.822 0.492 -1.420
ENSG00000171566 E021 8.858028 0.0022846886 7.491413e-06 5.120232e-05 4 154541958 154542186 229 - 1.089 0.412 -2.834
ENSG00000171566 E022 188.306997 0.0001885330 3.146857e-01 4.574184e-01 4 154542187 154542230 44 - 2.256 2.233 -0.076
ENSG00000171566 E023 184.520918 0.0001956839 2.996939e-01 4.412640e-01 4 154542231 154542279 49 - 2.247 2.222 -0.081
ENSG00000171566 E024 228.223969 0.0012357034 9.999701e-02 1.904833e-01 4 154544445 154544546 102 - 2.345 2.299 -0.156
ENSG00000171566 E025 141.371396 0.0004364426 9.680628e-05 5.071248e-04 4 154545836 154545852 17 - 2.163 2.035 -0.431
ENSG00000171566 E026 200.244806 0.0029226279 3.586836e-03 1.197363e-02 4 154545853 154545923 71 - 2.306 2.197 -0.363
ENSG00000171566 E027 6.606989 0.0735848771 2.835965e-01 4.237373e-01 4 154545924 154546122 199 - 0.915 0.713 -0.794
ENSG00000171566 E028 142.243914 0.0032104470 1.265643e-02 3.510265e-02 4 154546123 154546149 27 - 2.157 2.052 -0.351
ENSG00000171566 E029 183.252444 0.0002194261 1.528678e-06 1.220082e-05 4 154546150 154546213 64 - 2.276 2.138 -0.461
ENSG00000171566 E030 17.667324 0.0603699093 4.128256e-03 1.350100e-02 4 154546543 154547010 468 - 1.338 0.871 -1.692
ENSG00000171566 E031 141.884063 0.0002074769 8.306741e-07 7.019748e-06 4 154547011 154547037 27 - 2.171 2.009 -0.543
ENSG00000171566 E032 149.247061 0.0002223378 2.706597e-05 1.627437e-04 4 154547038 154547064 27 - 2.186 2.053 -0.444
ENSG00000171566 E033 2.187431 0.0144845683 2.394028e-01 3.734264e-01 4 154547482 154547710 229 - 0.533 0.313 -1.195
ENSG00000171566 E034 253.441217 0.0002033032 1.259792e-05 8.179863e-05 4 154547711 154547853 143 - 2.407 2.302 -0.349
ENSG00000171566 E035 205.097052 0.0028269446 4.160784e-03 1.359400e-02 4 154548829 154548932 104 - 2.314 2.208 -0.354
ENSG00000171566 E036 113.325810 0.0125768039 3.334026e-02 7.846225e-02 4 154548933 154548935 3 - 2.068 1.920 -0.499
ENSG00000171566 E037 1.329746 0.1337644098 5.587676e-01 6.869673e-01 4 154549053 154549141 89 - 0.303 0.415 0.666
ENSG00000171566 E038 1.300487 0.0193444477 5.637052e-01 6.911449e-01 4 154549664 154549772 109 - 0.302 0.412 0.651
ENSG00000171566 E039 143.425371 0.0042418033 5.258968e-03 1.663543e-02 4 154550300 154550400 101 - 2.165 2.037 -0.431