ENSG00000171552

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307677 ENSG00000171552 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL2L1 protein_coding protein_coding 17.95466 30.7464 13.08711 0.5206644 0.1926027 -1.231638 1.053348 0.5901647 1.0946109 0.2966279 0.21528466 0.8801079 0.06762083 0.01906667 0.08383333 0.064766667 0.2628041970 0.0001530453 FALSE TRUE
ENST00000420488 ENSG00000171552 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL2L1 protein_coding protein_coding 17.95466 30.7464 13.08711 0.5206644 0.1926027 -1.231638 1.526379 2.1333567 0.7886173 1.0128435 0.56207933 -1.4242958 0.09001667 0.07033333 0.06136667 -0.008966667 0.8868748218 0.0001530453 FALSE TRUE
ENST00000439267 ENSG00000171552 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL2L1 protein_coding protein_coding 17.95466 30.7464 13.08711 0.5206644 0.1926027 -1.231638 4.644755 7.3280820 3.3776357 0.8191127 0.29804368 -1.1151243 0.26422083 0.23860000 0.25793333 0.019333333 0.8570937653 0.0001530453 FALSE TRUE
ENST00000456404 ENSG00000171552 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL2L1 protein_coding protein_coding 17.95466 30.7464 13.08711 0.5206644 0.1926027 -1.231638 1.883039 2.9550173 1.8240837 0.6641557 0.05974873 -0.6929811 0.10718750 0.09576667 0.13940000 0.043633333 0.4195933290 0.0001530453 FALSE TRUE
ENST00000676582 ENSG00000171552 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL2L1 protein_coding protein_coding 17.95466 30.7464 13.08711 0.5206644 0.1926027 -1.231638 2.735835 4.5742319 3.1568357 0.1351299 0.10366537 -0.5336380 0.15780417 0.14890000 0.24126667 0.092366667 0.0001530453 0.0001530453 FALSE TRUE
ENST00000677494 ENSG00000171552 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL2L1 protein_coding processed_transcript 17.95466 30.7464 13.08711 0.5206644 0.1926027 -1.231638 2.215576 5.3367473 0.3506426 1.2728555 0.35064262 -3.8900197 0.09162917 0.17420000 0.02610000 -0.148100000 0.0803387941 0.0001530453 FALSE FALSE
ENST00000678563 ENSG00000171552 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL2L1 protein_coding protein_coding 17.95466 30.7464 13.08711 0.5206644 0.1926027 -1.231638 2.790329 5.7222399 2.1649320 1.4139705 0.26892984 -1.3981287 0.15870833 0.18473333 0.16493333 -0.019800000 0.9257079665 0.0001530453 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171552 E001 0.3697384 0.0274424043 5.826766e-01 7.069793e-01 20 31664452 31664457 6 - 0.000 0.152 9.344
ENSG00000171552 E002 0.5149111 0.0200530434 8.555821e-01 9.107112e-01 20 31664458 31664462 5 - 0.177 0.152 -0.264
ENSG00000171552 E003 33.6684249 0.0048139707 4.729217e-04 2.056550e-03 20 31664463 31664574 112 - 1.247 1.546 1.036
ENSG00000171552 E004 67.2269653 0.0178705627 3.655754e-03 1.217152e-02 20 31664575 31664644 70 - 1.577 1.829 0.854
ENSG00000171552 E005 495.9510795 0.0020916371 1.327175e-07 1.316993e-06 20 31664645 31665258 614 - 2.524 2.671 0.488
ENSG00000171552 E006 588.2735244 0.0009756853 6.950974e-01 7.957777e-01 20 31665259 31665948 690 - 2.693 2.716 0.076
ENSG00000171552 E007 168.2915234 0.0002914456 1.529190e-01 2.656292e-01 20 31665949 31666086 138 - 2.187 2.159 -0.093
ENSG00000171552 E008 2.2486350 0.0064516380 6.508852e-01 7.618627e-01 20 31666991 31667147 157 - 0.400 0.491 0.473
ENSG00000171552 E009 0.1482932 0.0411864793 1.000000e+00   20 31684367 31684588 222 - 0.000 0.083 9.818
ENSG00000171552 E010 0.0000000       20 31719345 31719417 73 -      
ENSG00000171552 E011 218.1594228 0.0002456637 1.401913e-03 5.313146e-03 20 31721655 31721843 189 - 2.327 2.260 -0.224
ENSG00000171552 E012 352.5587344 0.0014291108 5.278657e-03 1.669018e-02 20 31721844 31722330 487 - 2.526 2.473 -0.177
ENSG00000171552 E013 20.9254062 0.0008743426 7.057888e-02 1.443044e-01 20 31722331 31722348 18 - 1.375 1.245 -0.452
ENSG00000171552 E014 1.9272443 0.2948327387 8.086019e-01 8.784275e-01 20 31722349 31722443 95 - 0.401 0.411 0.052
ENSG00000171552 E015 1.6284799 0.4173267526 5.577829e-01 6.861307e-01 20 31722444 31722476 33 - 0.178 0.415 1.659
ENSG00000171552 E016 1.4070346 0.0227724463 3.759242e-01 5.203088e-01 20 31722477 31722597 121 - 0.177 0.356 1.330
ENSG00000171552 E017 140.0944334 0.0009150101 1.843715e-07 1.778896e-06 20 31722618 31723529 912 - 2.202 2.043 -0.533
ENSG00000171552 E018 39.0023227 0.0134692786 4.310266e-01 5.736211e-01 20 31723735 31723847 113 - 1.572 1.526 -0.158
ENSG00000171552 E019 22.9077872 0.0118708557 8.690096e-01 9.198202e-01 20 31723848 31723863 16 - 1.315 1.315 0.001
ENSG00000171552 E020 41.5118850 0.0006078433 9.917227e-02 1.892147e-01 20 31723864 31723989 126 - 1.627 1.544 -0.282