ENSG00000171490

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355674 ENSG00000171490 HEK293_OSMI2_2hA HEK293_TMG_2hB RSL1D1 protein_coding protein_coding 210.2468 135.1523 311.178 2.743378 1.651749 1.203093 57.94540 34.403410 88.16016 2.420553 2.353697 1.3573196 0.27148333 0.25520000 0.28326667 0.028066667 0.658842191 0.00100267 FALSE  
ENST00000396503 ENSG00000171490 HEK293_OSMI2_2hA HEK293_TMG_2hB RSL1D1 protein_coding nonsense_mediated_decay 210.2468 135.1523 311.178 2.743378 1.651749 1.203093 76.41390 55.426384 106.34053 1.892857 3.579515 0.9399222 0.37229583 0.40986667 0.34166667 -0.068200000 0.004565166 0.00100267 FALSE  
ENST00000573251 ENSG00000171490 HEK293_OSMI2_2hA HEK293_TMG_2hB RSL1D1 protein_coding protein_coding 210.2468 135.1523 311.178 2.743378 1.651749 1.203093 18.10116 11.712567 28.33668 2.135479 4.882136 1.2738912 0.07847083 0.08696667 0.09103333 0.004066667 0.966452739 0.00100267 FALSE  
ENST00000574287 ENSG00000171490 HEK293_OSMI2_2hA HEK293_TMG_2hB RSL1D1 protein_coding retained_intron 210.2468 135.1523 311.178 2.743378 1.651749 1.203093 18.80540 2.188145 33.24671 2.188145 7.770623 3.9192873 0.08153333 0.01580000 0.10700000 0.091200000 0.071087074 0.00100267 FALSE  
MSTRG.12073.2 ENSG00000171490 HEK293_OSMI2_2hA HEK293_TMG_2hB RSL1D1 protein_coding   210.2468 135.1523 311.178 2.743378 1.651749 1.203093 30.15922 26.570433 40.09293 2.052133 1.552789 0.5933430 0.15227083 0.19633333 0.12880000 -0.067533333 0.001002670 0.00100267 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171490 E001 349.7071398 0.0058562584 2.890071e-02 6.980497e-02 16 11833850 11836212 2363 - 2.569 2.485 -0.281
ENSG00000171490 E002 1654.7042550 0.0017697600 1.325873e-04 6.702314e-04 16 11836213 11837717 1505 - 3.174 3.260 0.285
ENSG00000171490 E003 1901.1471240 0.0013555233 4.610987e-10 7.264346e-09 16 11837718 11837954 237 - 3.219 3.338 0.396
ENSG00000171490 E004 786.3924008 0.0000985887 7.571880e-15 2.539334e-13 16 11837955 11837965 11 - 2.842 2.949 0.355
ENSG00000171490 E005 750.3089658 0.0003253848 2.018718e-13 5.494829e-12 16 11837966 11837969 4 - 2.818 2.934 0.387
ENSG00000171490 E006 1673.7177817 0.0001845922 1.644137e-22 1.390522e-20 16 11837970 11838113 144 - 3.171 3.276 0.349
ENSG00000171490 E007 1627.9493580 0.0001899792 5.301256e-10 8.267263e-09 16 11839695 11839848 154 - 3.175 3.244 0.230
ENSG00000171490 E008 1314.1338717 0.0001701334 3.380064e-01 4.818848e-01 16 11839849 11839985 137 - 3.114 3.105 -0.027
ENSG00000171490 E009 18.8295782 0.0026465948 1.795114e-04 8.759534e-04 16 11841406 11841694 289 - 1.395 1.062 -1.177
ENSG00000171490 E010 609.2495152 0.0001182178 1.816920e-04 8.852181e-04 16 11841695 11841707 13 - 2.797 2.742 -0.184
ENSG00000171490 E011 734.7182051 0.0001045291 5.375635e-01 6.691094e-01 16 11841708 11841743 36 - 2.860 2.854 -0.019
ENSG00000171490 E012 948.4916086 0.0001077445 1.492663e-01 2.606632e-01 16 11841744 11841817 74 - 2.974 2.959 -0.051
ENSG00000171490 E013 473.7094015 0.0002702990 1.204827e-01 2.206537e-01 16 11841818 11841820 3 - 2.677 2.651 -0.088
ENSG00000171490 E014 701.6610828 0.0001599082 1.246660e-02 3.465737e-02 16 11841907 11841929 23 - 2.851 2.816 -0.115
ENSG00000171490 E015 926.2499034 0.0001039827 1.658166e-03 6.148169e-03 16 11841930 11842000 71 - 2.974 2.937 -0.123
ENSG00000171490 E016 864.9223403 0.0001077420 6.618874e-09 8.439966e-08 16 11846501 11846559 59 - 2.957 2.883 -0.246
ENSG00000171490 E017 765.1034504 0.0001486507 8.994878e-07 7.541724e-06 16 11846560 11846602 43 - 2.901 2.833 -0.225
ENSG00000171490 E018 821.4719718 0.0002541475 2.639643e-05 1.591309e-04 16 11846695 11846733 39 - 2.929 2.870 -0.198
ENSG00000171490 E019 1094.6530209 0.0003205229 5.952233e-05 3.290629e-04 16 11846734 11846843 110 - 3.051 2.998 -0.178
ENSG00000171490 E020 0.5181333 0.0205152297 9.847653e-01 9.945403e-01 16 11847574 11847667 94 - 0.171 0.159 -0.127
ENSG00000171490 E021 1050.4074616 0.0008479002 1.080909e-04 5.592956e-04 16 11847668 11847806 139 - 3.038 2.971 -0.226
ENSG00000171490 E022 0.9900693 0.0998713168 9.456016e-01 9.698750e-01 16 11849258 11849385 128 - 0.293 0.276 -0.118
ENSG00000171490 E023 1134.0153615 0.0020491346 1.593761e-07 1.556999e-06 16 11850279 11850413 135 - 3.092 2.965 -0.420
ENSG00000171490 E024 536.0279226 0.0024178555 9.265488e-09 1.149596e-07 16 11850414 11850418 5 - 2.779 2.612 -0.555
ENSG00000171490 E025 0.6256415 0.0175428169 6.620605e-01 7.704309e-01 16 11851008 11851045 38 - 0.236 0.159 -0.714
ENSG00000171490 E026 2.5495920 0.0058119616 5.060424e-01 6.417377e-01 16 11851102 11851403 302 - 0.501 0.610 0.506
ENSG00000171490 E027 3.5651355 0.0236379667 3.658996e-01 5.102170e-01 16 11851404 11851407 4 - 0.707 0.560 -0.638
ENSG00000171490 E028 766.7642951 0.0033838387 2.503430e-07 2.354502e-06 16 11851408 11851580 173 - 2.933 2.772 -0.537