ENSG00000171456

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306058 ENSG00000171456 HEK293_OSMI2_2hA HEK293_TMG_2hB ASXL1 protein_coding protein_coding 37.93921 39.28251 36.02385 2.136111 0.5490373 -0.1249015 7.442120 11.1346499 4.216305 0.4347612 0.06449132 -1.3988825 0.19377917 0.28603333 0.11713333 -0.16890000 4.903274e-08 1.361954e-20 FALSE TRUE
ENST00000375687 ENSG00000171456 HEK293_OSMI2_2hA HEK293_TMG_2hB ASXL1 protein_coding protein_coding 37.93921 39.28251 36.02385 2.136111 0.5490373 -0.1249015 5.958648 6.2348517 4.956669 0.3936654 0.93931881 -0.3303888 0.15650833 0.15960000 0.13713333 -0.02246667 7.751005e-01 1.361954e-20 FALSE TRUE
ENST00000644615 ENSG00000171456 HEK293_OSMI2_2hA HEK293_TMG_2hB ASXL1 protein_coding retained_intron 37.93921 39.28251 36.02385 2.136111 0.5490373 -0.1249015 2.586122 0.6139829 3.200799 0.3491992 0.11112163 2.3633540 0.06942917 0.01533333 0.08896667 0.07363333 1.569920e-01 1.361954e-20 FALSE FALSE
ENST00000646367 ENSG00000171456 HEK293_OSMI2_2hA HEK293_TMG_2hB ASXL1 protein_coding protein_coding 37.93921 39.28251 36.02385 2.136111 0.5490373 -0.1249015 3.265509 8.0080019 1.401483 0.3960587 0.13515409 -2.5060314 0.08453333 0.20460000 0.03900000 -0.16560000 1.361954e-20 1.361954e-20   FALSE
ENST00000646985 ENSG00000171456 HEK293_OSMI2_2hA HEK293_TMG_2hB ASXL1 protein_coding protein_coding 37.93921 39.28251 36.02385 2.136111 0.5490373 -0.1249015 4.718210 5.5839571 3.120433 0.5275320 0.54872501 -0.8375069 0.12265000 0.14160000 0.08690000 -0.05470000 1.012597e-01 1.361954e-20 FALSE TRUE
MSTRG.20555.10 ENSG00000171456 HEK293_OSMI2_2hA HEK293_TMG_2hB ASXL1 protein_coding   37.93921 39.28251 36.02385 2.136111 0.5490373 -0.1249015 2.344537 1.7178108 3.280187 0.8590033 0.56386122 0.9292245 0.06281250 0.04613333 0.09076667 0.04463333 6.746793e-01 1.361954e-20 FALSE TRUE
MSTRG.20555.12 ENSG00000171456 HEK293_OSMI2_2hA HEK293_TMG_2hB ASXL1 protein_coding   37.93921 39.28251 36.02385 2.136111 0.5490373 -0.1249015 5.409149 2.4015169 7.565492 1.4595608 0.96408672 1.6513986 0.14413333 0.05753333 0.21013333 0.15260000 4.132834e-01 1.361954e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171456 E001 3.0562094 0.2315465847 9.752422e-01 9.885723e-01 20 32358195 32358329 135 + 0.578 0.615 0.165
ENSG00000171456 E002 3.0927411 0.2839494782 8.142500e-01 8.822974e-01 20 32358330 32358330 1 + 0.536 0.647 0.496
ENSG00000171456 E003 10.3893935 0.0624891134 8.360349e-01 8.974723e-01 20 32358331 32358343 13 + 1.044 1.057 0.047
ENSG00000171456 E004 15.5438317 0.0301211376 7.425121e-01 8.313831e-01 20 32358344 32358348 5 + 1.211 1.213 0.006
ENSG00000171456 E005 25.4697377 0.0132145990 3.493878e-01 4.935978e-01 20 32358349 32358358 10 + 1.339 1.468 0.449
ENSG00000171456 E006 42.6608349 0.0121437351 4.302501e-01 5.728856e-01 20 32358359 32358412 54 + 1.569 1.677 0.369
ENSG00000171456 E007 50.3394823 0.0127801838 7.573281e-01 8.422033e-01 20 32358413 32358542 130 + 1.663 1.733 0.236
ENSG00000171456 E008 18.7984546 0.0018529419 6.969223e-01 7.971757e-01 20 32358543 32358595 53 + 1.287 1.300 0.043
ENSG00000171456 E009 6.8421498 0.0061015637 7.085634e-05 3.842758e-04 20 32358596 32358646 51 + 1.095 0.640 -1.767
ENSG00000171456 E010 4.1675816 0.0039202002 1.148505e-02 3.231799e-02 20 32358647 32358681 35 + 0.860 0.537 -1.352
ENSG00000171456 E011 2.6720499 0.0639071399 2.237229e-01 3.548559e-01 20 32358682 32358688 7 + 0.651 0.455 -0.908
ENSG00000171456 E012 3.0020474 0.0273027969 3.817790e-01 5.260625e-01 20 32358689 32358697 9 + 0.650 0.538 -0.501
ENSG00000171456 E013 6.5955630 0.0024458532 4.237743e-02 9.541231e-02 20 32358698 32358722 25 + 0.683 0.980 1.165
ENSG00000171456 E014 29.3088682 0.0006773588 1.716496e-03 6.333949e-03 20 32358723 32358763 41 + 1.310 1.565 0.880
ENSG00000171456 E015 104.1382864 0.0002759418 4.090742e-09 5.413754e-08 20 32358764 32358832 69 + 1.847 2.108 0.877
ENSG00000171456 E016 1.3932440 0.0117757330 2.663806e-01 4.045648e-01 20 32358966 32359064 99 + 0.229 0.452 1.403
ENSG00000171456 E017 1.5341503 0.0111079692 5.115947e-01 6.465822e-01 20 32359065 32359087 23 + 0.310 0.452 0.818
ENSG00000171456 E018 1.3524459 0.0111775042 7.031466e-01 8.018649e-01 20 32359088 32359109 22 + 0.310 0.403 0.555
ENSG00000171456 E019 2.0845489 0.0549173243 4.847186e-01 6.226758e-01 20 32359110 32359168 59 + 0.378 0.539 0.829
ENSG00000171456 E020 2.6121455 0.0063585894 3.950197e-01 5.388642e-01 20 32359169 32359236 68 + 0.437 0.608 0.818
ENSG00000171456 E021 1.6585973 0.0086514302 7.904920e-01 8.659890e-01 20 32359237 32359237 1 + 0.378 0.452 0.402
ENSG00000171456 E022 3.0686678 0.0052631189 8.567125e-01 9.114126e-01 20 32359238 32359334 97 + 0.577 0.639 0.275
ENSG00000171456 E023 2.6958089 0.0054818466 4.763412e-01 6.149707e-01 20 32359335 32359452 118 + 0.615 0.537 -0.354
ENSG00000171456 E024 2.6582330 0.0056564346 9.446928e-02 1.820865e-01 20 32359453 32359521 69 + 0.683 0.452 -1.058
ENSG00000171456 E025 2.8399374 0.0053770080 1.566922e-01 2.706966e-01 20 32359522 32359564 43 + 0.683 0.497 -0.836
ENSG00000171456 E026 3.8772613 0.0113095947 1.842857e-01 3.066120e-01 20 32359565 32359642 78 + 0.768 0.608 -0.668
ENSG00000171456 E027 3.9126366 0.0040899462 5.045543e-02 1.099768e-01 20 32359643 32359746 104 + 0.816 0.574 -1.014
ENSG00000171456 E028 2.7678176 0.0054644373 5.890331e-02 1.247533e-01 20 32359747 32359791 45 + 0.713 0.452 -1.184
ENSG00000171456 E029 2.5422052 0.0059168266 1.484506e-01 2.595679e-01 20 32359792 32359851 60 + 0.650 0.452 -0.920
ENSG00000171456 E030 2.7917379 0.0401337256 1.351470e-01 2.412960e-01 20 32360017 32360347 331 + 0.682 0.454 -1.046
ENSG00000171456 E031 3.2272534 0.1752459306 7.133347e-01 8.098576e-01 20 32360348 32360586 239 + 0.648 0.584 -0.282
ENSG00000171456 E032 2.5056735 0.0058615822 5.139550e-02 1.116341e-01 20 32360634 32360709 76 + 0.683 0.403 -1.321
ENSG00000171456 E033 3.8321823 0.0041247795 2.463209e-01 3.816405e-01 20 32360710 32360793 84 + 0.741 0.608 -0.560
ENSG00000171456 E034 3.4936770 0.0045501926 4.624087e-01 6.022762e-01 20 32360794 32360806 13 + 0.683 0.608 -0.319
ENSG00000171456 E035 173.9014305 0.0021837105 2.432175e-06 1.857263e-05 20 32366384 32366466 83 + 2.102 2.316 0.714
ENSG00000171456 E036 0.0000000       20 32366467 32366467 1 +      
ENSG00000171456 E037 28.5838536 0.0011231700 9.035017e-02 1.756735e-01 20 32367640 32367726 87 + 1.365 1.524 0.545
ENSG00000171456 E038 107.5527906 0.0004419129 1.651276e-04 8.141721e-04 20 32367727 32367729 3 + 1.920 2.101 0.607
ENSG00000171456 E039 1.0736416 0.0876821459 4.686920e-01 6.080893e-01 20 32369013 32369014 2 + 0.229 0.398 1.113
ENSG00000171456 E040 223.2242150 0.0002048569 2.553846e-07 2.397752e-06 20 32369015 32369123 109 + 2.236 2.410 0.579
ENSG00000171456 E041 6.3697496 0.0031193122 9.722467e-03 2.808019e-02 20 32371778 32371874 97 + 0.615 0.993 1.504
ENSG00000171456 E042 82.7191076 0.0045256063 1.505570e-26 1.871559e-24 20 32372164 32372553 390 + 1.420 2.089 2.266
ENSG00000171456 E043 1.3211242 0.0138775764 7.069670e-01 8.050152e-01 20 32427072 32428127 1056 + 0.310 0.403 0.554
ENSG00000171456 E044 71.1276793 0.0038039662 2.566925e-03 8.963987e-03 20 32428128 32428130 3 + 1.909 1.801 -0.365
ENSG00000171456 E045 107.8454846 0.0093024191 5.808091e-04 2.462956e-03 20 32428131 32428171 41 + 2.111 1.959 -0.509
ENSG00000171456 E046 143.3534012 0.0085081281 4.798557e-06 3.431367e-05 20 32428172 32428248 77 + 2.255 2.059 -0.655
ENSG00000171456 E047 4.3557200 0.0035691795 6.899960e-06 4.759254e-05 20 32428249 32428324 76 + 0.969 0.347 -2.767
ENSG00000171456 E048 161.5645498 0.0033971443 6.083227e-14 1.783149e-12 20 32428325 32428422 98 + 2.331 2.081 -0.835
ENSG00000171456 E049 0.7320925 0.0560474771 1.106021e-02 3.130847e-02 20 32428764 32429206 443 + 0.437 0.000 -16.302
ENSG00000171456 E050 0.9264823 0.0466841344 5.873265e-02 1.244614e-01 20 32429207 32429337 131 + 0.437 0.116 -2.505
ENSG00000171456 E051 152.3804643 0.0044924656 3.778055e-10 6.050733e-09 20 32429338 32429431 94 + 2.294 2.069 -0.750
ENSG00000171456 E052 45.9137527 0.0237479145 5.431157e-09 7.040140e-08 20 32429432 32429739 308 + 1.878 1.383 -1.687
ENSG00000171456 E053 26.5679001 0.0007139376 4.536979e-14 1.354210e-12 20 32429740 32429881 142 + 1.643 1.169 -1.645
ENSG00000171456 E054 11.6906511 0.0015914506 1.355217e-02 3.719980e-02 20 32429882 32429900 19 + 1.202 1.007 -0.703
ENSG00000171456 E055 93.9888810 0.0006202296 1.438991e-03 5.436378e-03 20 32429901 32430053 153 + 2.013 1.937 -0.253
ENSG00000171456 E056 24.3203788 0.0008767832 2.028800e-10 3.396520e-09 20 32430054 32430861 808 + 1.585 1.178 -1.414
ENSG00000171456 E057 18.3963765 0.0009917993 2.394917e-06 1.831543e-05 20 32430862 32431176 315 + 1.442 1.111 -1.164
ENSG00000171456 E058 14.8827303 0.0014344288 7.121215e-09 9.021015e-08 20 32431177 32431320 144 + 1.409 0.936 -1.689
ENSG00000171456 E059 166.5341998 0.0003625339 4.000277e-12 8.886497e-11 20 32431321 32431484 164 + 2.299 2.148 -0.504
ENSG00000171456 E060 0.1472490 0.0428093772 3.962391e-01   20 32431556 32431582 27 + 0.129 0.000 -14.123
ENSG00000171456 E061 148.0510250 0.0002484204 4.723091e-14 1.407101e-12 20 32431583 32431679 97 + 2.259 2.083 -0.589
ENSG00000171456 E062 1.7338151 0.0082856483 5.943719e-02 1.256732e-01 20 32432359 32432879 521 + 0.577 0.282 -1.598
ENSG00000171456 E063 187.1961031 0.0009705631 3.235542e-11 6.196559e-10 20 32432880 32432985 106 + 2.347 2.196 -0.503
ENSG00000171456 E064 575.3413365 0.0060157996 1.659070e-04 8.175469e-04 20 32433284 32433917 634 + 2.807 2.712 -0.319
ENSG00000171456 E065 8.9916189 0.0019369475 1.008746e-01 1.917983e-01 20 32433918 32434431 514 + 1.070 0.936 -0.494
ENSG00000171456 E066 207.9179934 0.0053427723 2.671065e-01 4.053846e-01 20 32434432 32434581 150 + 2.314 2.313 -0.005
ENSG00000171456 E067 95.5910181 0.0059264146 5.852172e-01 7.089676e-01 20 32434582 32434617 36 + 1.969 1.986 0.057
ENSG00000171456 E068 103.1015278 0.0063540834 2.988741e-01 4.403546e-01 20 32434618 32434696 79 + 2.017 2.007 -0.032
ENSG00000171456 E069 73.4051191 0.0006882237 6.730006e-02 1.388634e-01 20 32434697 32434722 26 + 1.882 1.849 -0.111
ENSG00000171456 E070 3128.2313879 0.0025005281 1.410888e-04 7.082741e-04 20 32434723 32438429 3707 + 3.428 3.530 0.338
ENSG00000171456 E071 503.4511092 0.0077132192 3.768372e-14 1.138063e-12 20 32438430 32439319 890 + 2.435 2.822 1.288