ENSG00000171453

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000488601 ENSG00000171453 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR1C protein_coding retained_intron 98.42884 125.3474 85.20182 13.04698 0.4360792 -0.5569211 8.703117 4.434864 8.899147 0.1855283 0.4446180 1.0031481 0.09450833 0.03636667 0.1044 0.06803333 2.763571e-08 2.763571e-08 TRUE TRUE
ENST00000642195 ENSG00000171453 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR1C protein_coding protein_coding 98.42884 125.3474 85.20182 13.04698 0.4360792 -0.5569211 76.068023 106.090278 62.182813 10.0591848 0.3990166 -0.7706087 0.76365417 0.84840000 0.7298 -0.11860000 4.968528e-06 2.763571e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171453 E001 0.0000000       6 43509702 43509808 107 +      
ENSG00000171453 E002 0.0000000       6 43509971 43510003 33 +      
ENSG00000171453 E003 0.3697384 2.511371e-02 3.946148e-01 5.384513e-01 6 43512985 43513113 129 + 0.001 0.174 8.391
ENSG00000171453 E004 0.6695470 1.842143e-02 6.365767e-01 7.505589e-01 6 43517028 43517032 5 + 0.155 0.240 0.785
ENSG00000171453 E005 0.6695470 1.842143e-02 6.365767e-01 7.505589e-01 6 43517033 43517033 1 + 0.155 0.240 0.785
ENSG00000171453 E006 1.7734793 8.106559e-03 9.957013e-01 1.000000e+00 6 43517034 43517048 15 + 0.434 0.435 0.007
ENSG00000171453 E007 2.6957071 5.475199e-03 6.808132e-01 7.846667e-01 6 43517049 43517053 5 + 0.603 0.540 -0.286
ENSG00000171453 E008 11.9900767 1.628316e-03 2.639523e-01 4.018820e-01 6 43517054 43517082 29 + 1.168 1.064 -0.374
ENSG00000171453 E009 15.7981352 1.022938e-02 2.413656e-01 3.757840e-01 6 43517083 43517087 5 + 1.279 1.174 -0.373
ENSG00000171453 E010 15.7981352 1.022938e-02 2.413656e-01 3.757840e-01 6 43517088 43517088 1 + 1.279 1.174 -0.373
ENSG00000171453 E011 22.1464707 1.457253e-03 3.727908e-02 8.599796e-02 6 43517089 43517096 8 + 1.441 1.290 -0.526
ENSG00000171453 E012 22.2280563 2.516184e-03 2.108847e-02 5.378207e-02 6 43517097 43517097 1 + 1.454 1.284 -0.592
ENSG00000171453 E013 120.3162829 1.644209e-03 6.411601e-09 8.200503e-08 6 43517098 43517105 8 + 2.194 1.977 -0.726
ENSG00000171453 E014 146.3686199 1.309380e-03 1.535425e-07 1.504302e-06 6 43517106 43517111 6 + 2.256 2.079 -0.592
ENSG00000171453 E015 325.7370575 1.478213e-04 2.384657e-04 1.126852e-03 6 43517112 43517132 21 + 2.539 2.467 -0.242
ENSG00000171453 E016 508.9754207 1.142668e-04 1.213495e-01 2.218531e-01 6 43517133 43517178 46 + 2.700 2.677 -0.077
ENSG00000171453 E017 693.2982872 9.793436e-05 3.432862e-01 4.873303e-01 6 43517306 43517377 72 + 2.826 2.815 -0.037
ENSG00000171453 E018 9.8632388 1.698787e-03 4.479971e-07 4.000363e-06 6 43519159 43519332 174 + 1.289 0.773 -1.903
ENSG00000171453 E019 811.3187922 3.136865e-04 9.798941e-01 9.914676e-01 6 43519333 43519440 108 + 2.885 2.886 0.002
ENSG00000171453 E020 29.1053611 9.414077e-03 2.358185e-06 1.805566e-05 6 43519441 43519705 265 + 1.668 1.299 -1.268
ENSG00000171453 E021 894.6647817 1.540150e-04 2.807796e-01 4.206532e-01 6 43519706 43519838 133 + 2.937 2.925 -0.041
ENSG00000171453 E022 61.7945389 7.296511e-04 1.895135e-18 1.009355e-16 6 43519839 43519905 67 + 1.997 1.599 -1.343
ENSG00000171453 E023 62.4345050 2.063594e-03 5.029515e-13 1.294426e-11 6 43519906 43520065 160 + 1.980 1.625 -1.196
ENSG00000171453 E024 336.5119358 1.912649e-04 3.143400e-01 4.570492e-01 6 43520066 43520068 3 + 2.491 2.514 0.078
ENSG00000171453 E025 815.9976416 1.389606e-04 4.639621e-03 1.493031e-02 6 43520069 43520185 117 + 2.862 2.902 0.133
ENSG00000171453 E026 25.0504598 7.096296e-03 4.910576e-09 6.419362e-08 6 43520186 43520274 89 + 1.642 1.178 -1.607
ENSG00000171453 E027 561.9361714 1.621793e-04 2.533759e-01 3.898931e-01 6 43520275 43520315 41 + 2.714 2.734 0.069
ENSG00000171453 E028 767.5888165 9.666495e-05 8.960708e-01 9.375783e-01 6 43520316 43520427 112 + 2.862 2.863 0.001
ENSG00000171453 E029 21.6893738 9.252699e-04 2.816484e-11 5.449641e-10 6 43520428 43520624 197 + 1.598 1.117 -1.676
ENSG00000171453 E030 809.6242933 1.288964e-04 5.190061e-04 2.231128e-03 6 43520625 43520774 150 + 2.852 2.901 0.162
ENSG00000171453 E031 14.4001435 2.519463e-03 1.957569e-08 2.287538e-07 6 43520775 43520931 157 + 1.434 0.937 -1.776
ENSG00000171453 E032 731.6526391 9.199385e-04 5.560636e-09 7.197634e-08 6 43520932 43521048 117 + 2.760 2.872 0.372
ENSG00000171453 E033 14.8315853 2.914366e-02 1.688472e-01 2.866760e-01 6 43521049 43521181 133 + 1.280 1.114 -0.589
ENSG00000171453 E034 715.8599923 9.493514e-05 1.350742e-10 2.333735e-09 6 43521182 43521317 136 + 2.767 2.861 0.312
ENSG00000171453 E035 446.8106109 1.526684e-04 6.790667e-02 1.398962e-01 6 43521318 43521513 196 + 2.604 2.639 0.117
ENSG00000171453 E036 12.0861667 4.747882e-03 8.998392e-01 9.400986e-01 6 43529249 43529359 111 + 1.085 1.100 0.054
ENSG00000171453 E037 12.1689542 1.489704e-03 2.993194e-03 1.024409e-02 6 43529360 43530126 767 + 1.269 0.995 -0.987
ENSG00000171453 E038 0.0000000       6 43550968 43551011 44 +      
ENSG00000171453 E039 0.0000000       6 43553385 43553695 311 +      
ENSG00000171453 E040 0.5181333 2.118822e-02 2.975863e-01 4.389470e-01 6 43554962 43556107 1146 + 0.269 0.096 -1.796
ENSG00000171453 E041 0.3729606 3.874496e-02 6.912482e-01 7.927580e-01 6 43561400 43562419 1020 + 0.155 0.096 -0.795