ENSG00000171320

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305188 ENSG00000171320 HEK293_OSMI2_2hA HEK293_TMG_2hB ESCO2 protein_coding protein_coding 8.15498 1.093512 13.50085 0.04779577 0.6175512 3.613944 5.1205256 0.98018220 9.290205 0.04372032 0.3142182 3.231497 0.73320833 0.8963 0.68893333 -0.20736667 0.0005794818 0.0005794818 FALSE TRUE
ENST00000523910 ENSG00000171320 HEK293_OSMI2_2hA HEK293_TMG_2hB ESCO2 protein_coding processed_transcript 8.15498 1.093512 13.50085 0.04779577 0.6175512 3.613944 1.4796252 0.00000000 1.366010 0.00000000 0.7020078 7.104347 0.09528333 0.0000 0.09703333 0.09703333 0.5424952350 0.0005794818 FALSE FALSE
MSTRG.31313.3 ENSG00000171320 HEK293_OSMI2_2hA HEK293_TMG_2hB ESCO2 protein_coding   8.15498 1.093512 13.50085 0.04779577 0.6175512 3.613944 0.3778572 0.01100222 1.093866 0.01100222 0.3629181 5.715879 0.03728750 0.0097 0.08376667 0.07406667 0.1479486160 0.0005794818 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171320 E001 0.0000000       8 27771949 27772068 120 +      
ENSG00000171320 E002 0.1515154 0.0428817041 4.874728e-01   8 27774501 27774534 34 + 0.039 0.000 -7.010
ENSG00000171320 E003 0.2987644 0.0272610599 1.000000e+00   8 27774535 27774536 2 + 0.074 0.000 -9.759
ENSG00000171320 E004 1.3338878 0.0096765512 5.836055e-01 7.076902e-01 8 27774537 27774553 17 + 0.264 0.000 -11.870
ENSG00000171320 E005 11.0822908 0.0065355107 4.726396e-01 6.116891e-01 8 27774554 27774607 54 + 0.875 0.745 -0.512
ENSG00000171320 E006 0.1472490 0.0434936645 4.878842e-01   8 27774669 27774827 159 + 0.039 0.000 -8.666
ENSG00000171320 E007 0.0000000       8 27775497 27775498 2 +      
ENSG00000171320 E008 21.9816608 0.0008220553 1.714746e-01 2.901204e-01 8 27775499 27775567 69 + 1.146 0.953 -0.706
ENSG00000171320 E009 40.5744781 0.0005189410 6.973756e-03 2.115442e-02 8 27776362 27776509 148 + 1.404 1.093 -1.095
ENSG00000171320 E010 62.7747425 0.0004661684 3.905952e-01 5.345606e-01 8 27776510 27776678 169 + 1.571 1.502 -0.236
ENSG00000171320 E011 105.9868984 0.0002879085 1.661214e-02 4.408409e-02 8 27776679 27777169 491 + 1.800 1.647 -0.519
ENSG00000171320 E012 6.0232894 0.0327351950 1.409794e-03 5.339405e-03 8 27777170 27780095 2926 + 0.567 1.093 2.081
ENSG00000171320 E013 24.0486851 0.0007735694 1.873153e-01 3.103633e-01 8 27780174 27780198 25 + 1.182 1.005 -0.641
ENSG00000171320 E014 30.7808056 0.0006570005 1.169725e-01 2.156405e-01 8 27780199 27780267 69 + 1.284 1.093 -0.676
ENSG00000171320 E015 34.0041535 0.0006309695 1.662932e-01 2.833784e-01 8 27784000 27784057 58 + 1.324 1.167 -0.554
ENSG00000171320 E016 30.0755311 0.0007457445 7.173668e-02 1.462397e-01 8 27787885 27787927 43 + 1.277 1.051 -0.806
ENSG00000171320 E017 35.8322448 0.0116297881 9.128052e-02 1.771243e-01 8 27787928 27788002 75 + 1.348 1.131 -0.766
ENSG00000171320 E018 46.3003330 0.0005176619 5.124244e-02 1.113629e-01 8 27788847 27788978 132 + 1.454 1.258 -0.681
ENSG00000171320 E019 38.6120663 0.0005354799 2.889325e-02 6.978873e-02 8 27791963 27792052 90 + 1.379 1.132 -0.872
ENSG00000171320 E020 48.2253209 0.0004932492 6.336898e-01 7.483334e-01 8 27792668 27792811 144 + 1.459 1.416 -0.148
ENSG00000171320 E021 49.9417422 0.0004557391 5.073863e-01 6.429404e-01 8 27799541 27799716 176 + 1.463 1.517 0.186
ENSG00000171320 E022 25.4878859 0.0008015192 7.121873e-01 8.089986e-01 8 27803306 27803373 68 + 1.188 1.229 0.148
ENSG00000171320 E023 19.2038578 0.0012980987 8.267451e-01 8.909946e-01 8 27803374 27803392 19 + 1.081 1.051 -0.109
ENSG00000171320 E024 179.9566239 0.0003196849 5.411991e-16 2.117483e-14 8 27803393 27805316 1924 + 1.983 2.263 0.936
ENSG00000171320 E025 2.7795595 0.0054430825 1.044185e-02 2.984305e-02 8 27808194 27808338 145 + 0.344 0.826 2.237
ENSG00000171320 E026 1.7671020 0.2799025552 5.722613e-01 6.983946e-01 8 27811305 27811339 35 + 0.325 0.000 -11.462
ENSG00000171320 E027 4.8789284 0.0103392753 4.607528e-02 1.021728e-01 8 27811340 27811699 360 + 0.609 0.000 -13.306
ENSG00000171320 E028 6.3244864 0.0131859379 3.328216e-01 4.765011e-01 8 27811977 27812640 664 + 0.647 0.826 0.727