ENSG00000171316

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000423902 ENSG00000171316 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD7 protein_coding protein_coding 10.7977 9.010257 11.41737 0.6640012 0.842661 0.3412536 1.8482443 0.0000000 4.4480585 0.0000000 0.5019959 8.8002717 0.1634958 0.0000000 0.388833333 0.38883333 1.159233e-35 3.493584e-39 FALSE TRUE
ENST00000527921 ENSG00000171316 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD7 protein_coding processed_transcript 10.7977 9.010257 11.41737 0.6640012 0.842661 0.3412536 1.7958007 0.5814817 2.6246859 0.5814817 0.3140333 2.1552255 0.1575292 0.0567000 0.229133333 0.17243333 1.173092e-01 3.493584e-39 FALSE FALSE
ENST00000528280 ENSG00000171316 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD7 protein_coding retained_intron 10.7977 9.010257 11.41737 0.6640012 0.842661 0.3412536 0.2600501 1.0812549 0.0134058 0.3915036 0.0134058 -5.5429783 0.0298375 0.1259667 0.001333333 -0.12463333 2.284385e-05 3.493584e-39 FALSE TRUE
ENST00000695850 ENSG00000171316 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD7 protein_coding processed_transcript 10.7977 9.010257 11.41737 0.6640012 0.842661 0.3412536 1.7042704 3.5568610 0.0000000 0.3252816 0.0000000 -8.4785112 0.1657708 0.3957000 0.000000000 -0.39570000 3.493584e-39 3.493584e-39 FALSE TRUE
MSTRG.31555.6 ENSG00000171316 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD7 protein_coding   10.7977 9.010257 11.41737 0.6640012 0.842661 0.3412536 2.2254109 1.3851195 2.0402405 0.3970347 0.4277243 0.5554044 0.2092542 0.1543667 0.186100000 0.03173333 8.724992e-01 3.493584e-39 FALSE TRUE
MSTRG.31555.7 ENSG00000171316 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD7 protein_coding   10.7977 9.010257 11.41737 0.6640012 0.842661 0.3412536 1.7206897 1.8552828 0.4303167 0.1938248 0.4303167 -2.0827808 0.1642000 0.2066000 0.038166667 -0.16843333 8.694715e-02 3.493584e-39 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171316 E001 0.0000000       8 60678740 60678743 4 +      
ENSG00000171316 E002 0.4449813 0.0217098429 8.068876e-01 8.773298e-01 8 60678744 60678799 56 + 0.176 0.154 -0.234
ENSG00000171316 E003 2.4087770 0.0063112666 1.454746e-02 3.947084e-02 8 60678800 60678822 23 + 0.652 0.267 -2.040
ENSG00000171316 E004 8.5339107 0.0021203796 4.928642e-03 1.573078e-02 8 60678823 60678918 96 + 1.060 0.785 -1.038
ENSG00000171316 E005 17.4375504 0.0043670468 4.481789e-06 3.226040e-05 8 60678919 60679082 164 + 1.370 0.998 -1.327
ENSG00000171316 E006 2.1079216 0.0067886817 1.886735e-01 3.120651e-01 8 60679564 60679791 228 + 0.543 0.357 -0.967
ENSG00000171316 E007 21.2326265 0.0015454266 4.566943e-08 4.965244e-07 8 60741259 60741364 106 + 1.461 1.065 -1.394
ENSG00000171316 E008 19.4774742 0.0086070468 2.169034e-04 1.036256e-03 8 60741365 60741432 68 + 1.397 1.112 -1.001
ENSG00000171316 E009 51.5462616 0.0004604006 5.088215e-14 1.508997e-12 8 60741433 60741854 422 + 1.822 1.482 -1.156
ENSG00000171316 E010 9.3669532 0.0018558236 5.477916e-03 1.722934e-02 8 60741855 60741885 31 + 1.096 0.842 -0.947
ENSG00000171316 E011 100.8304670 0.0015539676 5.290247e-22 4.218104e-20 8 60741886 60742819 934 + 2.112 1.767 -1.161
ENSG00000171316 E012 43.1726651 0.0005355590 2.686422e-11 5.213425e-10 8 60742820 60743031 212 + 1.745 1.423 -1.099
ENSG00000171316 E013 24.8949370 0.0007410002 5.625391e-07 4.928610e-06 8 60743032 60743097 66 + 1.511 1.200 -1.080
ENSG00000171316 E014 22.9567466 0.0009198266 3.650442e-04 1.638897e-03 8 60781000 60781050 51 + 1.450 1.245 -0.715
ENSG00000171316 E015 61.6611164 0.0004007323 2.207680e-08 2.554284e-07 8 60781051 60781430 380 + 1.862 1.663 -0.674
ENSG00000171316 E016 42.2507602 0.0024886957 2.803959e-03 9.686919e-03 8 60794986 60795127 142 + 1.673 1.559 -0.387
ENSG00000171316 E017 44.5420744 0.0050293036 6.232180e-04 2.617831e-03 8 60800388 60800525 138 + 1.708 1.555 -0.522
ENSG00000171316 E018 0.1451727 0.0433702492 6.888019e-01   8 60800526 60800526 1 + 0.097 0.000 -16.704
ENSG00000171316 E019 28.1318501 0.0030415147 6.050046e-04 2.551752e-03 8 60801528 60801593 66 + 1.524 1.339 -0.637
ENSG00000171316 E020 16.1601144 0.0049855225 8.493010e-05 4.513761e-04 8 60808217 60808219 3 + 1.331 1.015 -1.127
ENSG00000171316 E021 26.4294601 0.0044662024 1.578826e-03 5.890074e-03 8 60808220 60808272 53 + 1.497 1.322 -0.607
ENSG00000171316 E022 0.6568746 0.0187982456 1.686607e-01 2.864286e-01 8 60808273 60809651 1379 + 0.097 0.357 2.353
ENSG00000171316 E023 33.5725289 0.0134927423 3.935783e-03 1.296103e-02 8 60816387 60816501 115 + 1.596 1.423 -0.591
ENSG00000171316 E024 31.8274918 0.0117945965 4.911616e-02 1.075799e-01 8 60820007 60820090 84 + 1.543 1.452 -0.312
ENSG00000171316 E025 40.9605167 0.0028589504 3.858371e-04 1.720020e-03 8 60821790 60821927 138 + 1.671 1.517 -0.523
ENSG00000171316 E026 34.5098611 0.0005984999 8.398025e-03 2.478433e-02 8 60822024 60822145 122 + 1.579 1.482 -0.332
ENSG00000171316 E027 53.5733307 0.0009597341 1.494584e-03 5.618169e-03 8 60822503 60822746 244 + 1.764 1.667 -0.328
ENSG00000171316 E028 51.3452718 0.0117550212 1.562340e-03 5.837422e-03 8 60823840 60824016 177 + 1.770 1.603 -0.565
ENSG00000171316 E029 0.8136755 0.0146756272 9.801747e-01 9.916248e-01 8 60824017 60825415 1399 + 0.243 0.267 0.184
ENSG00000171316 E030 46.1301907 0.0004980081 9.462185e-06 6.325051e-05 8 60828663 60828806 144 + 1.729 1.554 -0.595
ENSG00000171316 E031 59.1818352 0.0120294406 5.655332e-02 1.206842e-01 8 60830322 60830577 256 + 1.794 1.734 -0.203
ENSG00000171316 E032 48.3740040 0.0036742201 6.811758e-02 1.402453e-01 8 60836073 60836283 211 + 1.698 1.657 -0.138
ENSG00000171316 E033 51.4950460 0.0081104614 2.713046e-01 4.100379e-01 8 60836817 60837012 196 + 1.710 1.706 -0.016
ENSG00000171316 E034 51.8127255 0.0145271138 2.422672e-01 3.768604e-01 8 60837668 60837835 168 + 1.721 1.703 -0.059
ENSG00000171316 E035 63.5586977 0.0182769699 1.069782e-01 2.010784e-01 8 60838076 60838255 180 + 1.825 1.770 -0.185
ENSG00000171316 E036 51.8448107 0.0331049654 6.641159e-02 1.374124e-01 8 60841644 60841754 111 + 1.762 1.642 -0.407
ENSG00000171316 E037 69.6313545 0.0069840317 2.449654e-04 1.154283e-03 8 60841847 60842052 206 + 1.898 1.746 -0.513
ENSG00000171316 E038 64.2704546 0.0004036640 3.437017e-03 1.154429e-02 8 60844864 60845063 200 + 1.833 1.766 -0.226
ENSG00000171316 E039 52.7162398 0.0004452832 2.621564e-01 3.999061e-01 8 60845250 60845409 160 + 1.717 1.726 0.032
ENSG00000171316 E040 2.9020450 0.1132896881 7.384757e-02 1.496673e-01 8 60846500 60846567 68 + 0.699 0.356 -1.657
ENSG00000171316 E041 35.7909899 0.0005907330 8.133370e-01 8.816452e-01 8 60848515 60848604 90 + 1.521 1.598 0.266
ENSG00000171316 E042 40.6257617 0.0005099951 3.125114e-01 4.550505e-01 8 60849051 60849154 104 + 1.555 1.675 0.408
ENSG00000171316 E043 50.9335195 0.0016262550 7.145484e-01 8.107096e-01 8 60850493 60850622 130 + 1.685 1.730 0.155
ENSG00000171316 E044 0.0000000       8 60850737 60850761 25 +      
ENSG00000171316 E045 51.8462271 0.0044589261 2.247959e-01 3.561881e-01 8 60851032 60851104 73 + 1.713 1.707 -0.019
ENSG00000171316 E046 41.2292201 0.0065536076 1.359163e-01 2.423771e-01 8 60851262 60851319 58 + 1.628 1.592 -0.122
ENSG00000171316 E047 82.5870885 0.0003458667 1.612169e-02 4.300547e-02 8 60852019 60852247 229 + 1.924 1.894 -0.103
ENSG00000171316 E048 79.9674268 0.0003534484 3.214110e-02 7.613007e-02 8 60852498 60852706 209 + 1.910 1.889 -0.071
ENSG00000171316 E049 184.5500074 0.0008969332 5.826062e-01 7.069346e-01 8 60852829 60853500 672 + 2.225 2.307 0.276
ENSG00000171316 E050 20.8086622 0.0016961223 2.829704e-01 4.230388e-01 8 60854363 60854365 3 + 1.341 1.321 -0.070
ENSG00000171316 E051 68.0988999 0.0040325180 2.784790e-01 4.181489e-01 8 60854366 60854523 158 + 1.777 1.901 0.419
ENSG00000171316 E052 0.1451727 0.0433702492 6.888019e-01   8 60855093 60855209 117 + 0.097 0.000 -16.704
ENSG00000171316 E053 0.1451727 0.0433702492 6.888019e-01   8 60855571 60855682 112 + 0.097 0.000 -16.704
ENSG00000171316 E054 90.3377208 0.0004204222 8.804144e-04 3.545519e-03 8 60855975 60856202 228 + 1.864 2.054 0.638
ENSG00000171316 E055 136.5251841 0.0012047343 2.583264e-03 9.014231e-03 8 60856445 60856856 412 + 2.052 2.219 0.559
ENSG00000171316 E056 46.4729032 0.0042844527 3.153371e-03 1.071717e-02 8 60856857 60856888 32 + 1.549 1.789 0.815
ENSG00000171316 E057 37.6709152 0.0056633395 2.156346e-03 7.708816e-03 8 60860904 60860915 12 + 1.442 1.711 0.918
ENSG00000171316 E058 93.9156549 0.0032710376 3.434264e-04 1.553846e-03 8 60860916 60861125 210 + 1.859 2.085 0.760
ENSG00000171316 E059 1.9431837 0.1631060477 3.762413e-02 8.662622e-02 8 60861126 60861943 818 + 0.603 0.153 -2.836
ENSG00000171316 E060 0.4804688 0.0210457231 8.061978e-01 8.768035e-01 8 60861944 60862195 252 + 0.176 0.154 -0.231
ENSG00000171316 E061 32.9255763 0.0007624252 6.002206e-02 1.266413e-01 8 60862196 60862198 3 + 1.438 1.617 0.611
ENSG00000171316 E062 44.3594138 0.0005281053 4.590138e-03 1.479218e-02 8 60862199 60862228 30 + 1.546 1.760 0.726
ENSG00000171316 E063 72.1340271 0.0003771539 8.982900e-04 3.608379e-03 8 60862229 60862336 108 + 1.760 1.963 0.683
ENSG00000171316 E064 0.7385489 0.0637397303 5.297274e-02 1.144367e-01 8 60862337 60862530 194 + 0.352 0.000 -18.985
ENSG00000171316 E065 0.5870335 0.1382042929 1.108580e-01 2.068096e-01 8 60862531 60862547 17 + 0.300 0.000 -18.624
ENSG00000171316 E066 32.1348584 0.0072284247 1.157450e-01 2.138751e-01 8 60862548 60862549 2 + 1.430 1.608 0.607
ENSG00000171316 E067 64.3264807 0.0047810113 4.078524e-02 9.248701e-02 8 60862550 60862652 103 + 1.727 1.903 0.593
ENSG00000171316 E068 10.7898123 0.0015870454 2.012432e-03 7.264657e-03 8 60862653 60864935 2283 + 1.160 0.892 -0.987
ENSG00000171316 E069 1.7672383 0.0081666121 7.471946e-01 8.347528e-01 8 60864936 60865015 80 + 0.397 0.495 0.505
ENSG00000171316 E070 606.7333381 0.0094313272 4.711235e-19 2.696463e-17 8 60865016 60868028 3013 + 2.538 2.980 1.472