ENSG00000171307

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000352634 ENSG00000171307 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC16 protein_coding protein_coding 63.06802 101.7276 34.93199 1.764802 0.6324561 -1.541819 17.529698 30.24808 7.853584 0.8847912 1.32091245 -1.944062 0.27324583 0.2973000 0.22450000 -7.280000e-02 0.33551849 5.465777e-20 FALSE TRUE
ENST00000370854 ENSG00000171307 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC16 protein_coding protein_coding 63.06802 101.7276 34.93199 1.764802 0.6324561 -1.541819 13.988617 20.45846 10.087008 1.3468276 0.63811714 -1.019475 0.22190000 0.2012333 0.28926667 8.803333e-02 0.04350519 5.465777e-20 FALSE TRUE
MSTRG.4456.6 ENSG00000171307 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC16 protein_coding   63.06802 101.7276 34.93199 1.764802 0.6324561 -1.541819 4.883845 8.85724 2.982721 4.5250143 1.02175146 -1.567027 0.06970833 0.0856000 0.08553333 -6.666667e-05 0.93669517 5.465777e-20 FALSE TRUE
MSTRG.4456.7 ENSG00000171307 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC16 protein_coding   63.06802 101.7276 34.93199 1.764802 0.6324561 -1.541819 5.668752 10.67284 2.797908 0.9806948 0.05301931 -1.927727 0.08536250 0.1047333 0.08013333 -2.460000e-02 0.21727661 5.465777e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171307 E001 0.1482932 0.0414380672 1.0000000000   10 97446071 97446118 48 + 0.000 0.073 8.066
ENSG00000171307 E002 0.1482932 0.0414380672 1.0000000000   10 97446119 97446138 20 + 0.000 0.073 10.143
ENSG00000171307 E003 0.5911836 0.0300725670 0.4707279913 0.6099559914 10 97446139 97446154 16 + 0.000 0.190 11.895
ENSG00000171307 E004 0.8126288 0.1823348931 0.3615328902 0.5059265276 10 97446155 97446157 3 + 0.000 0.242 11.448
ENSG00000171307 E005 2.7250107 0.4038239292 0.8736233480 0.9227652093 10 97446158 97446158 1 + 0.438 0.505 0.338
ENSG00000171307 E006 3.4613801 0.2481186145 0.9555446065 0.9760942603 10 97446159 97446159 1 + 0.522 0.575 0.245
ENSG00000171307 E007 4.9579651 0.2142054840 0.7973185736 0.8706688461 10 97446160 97446161 2 + 0.591 0.709 0.505
ENSG00000171307 E008 7.7517887 0.0906616525 0.9817810899 0.9926482585 10 97446162 97446169 8 + 0.832 0.852 0.077
ENSG00000171307 E009 10.7713240 0.0681042006 0.8214236796 0.8874101952 10 97446170 97446174 5 + 0.987 0.972 -0.054
ENSG00000171307 E010 10.7713240 0.0681042006 0.8214236796 0.8874101952 10 97446175 97446175 1 + 0.987 0.972 -0.054
ENSG00000171307 E011 10.7713240 0.0681042006 0.8214236796 0.8874101952 10 97446176 97446176 1 + 0.987 0.972 -0.054
ENSG00000171307 E012 53.6532921 0.0205957801 0.0018540639 0.0067705016 10 97446177 97446190 14 + 1.827 1.576 -0.851
ENSG00000171307 E013 67.5605330 0.0281831022 0.0195488476 0.0505161054 10 97446191 97446193 3 + 1.890 1.693 -0.666
ENSG00000171307 E014 75.9389293 0.0264918256 0.0047778465 0.0153113993 10 97446194 97446194 1 + 1.967 1.732 -0.792
ENSG00000171307 E015 80.4633945 0.0243143560 0.0053174246 0.0167962208 10 97446195 97446195 1 + 1.983 1.760 -0.749
ENSG00000171307 E016 82.1897435 0.0224244739 0.0058820231 0.0183016348 10 97446196 97446196 1 + 1.985 1.772 -0.718
ENSG00000171307 E017 100.3369341 0.0215900428 0.0093941840 0.0272667379 10 97446197 97446201 5 + 2.055 1.865 -0.640
ENSG00000171307 E018 106.7757808 0.0205583256 0.0171030260 0.0451722754 10 97446202 97446203 2 + 2.066 1.898 -0.566
ENSG00000171307 E019 135.4539794 0.0164549344 0.0554747116 0.1188026237 10 97446204 97446209 6 + 2.131 2.014 -0.392
ENSG00000171307 E020 140.2072516 0.0160580267 0.0569439217 0.1213632187 10 97446210 97446211 2 + 2.143 2.029 -0.383
ENSG00000171307 E021 328.0626678 0.0073156654 0.3118411625 0.4543644361 10 97446212 97446353 142 + 2.450 2.416 -0.114
ENSG00000171307 E022 7.3230227 0.0799676857 0.4932592235 0.6302878735 10 97448190 97448350 161 + 0.933 0.804 -0.498
ENSG00000171307 E023 31.2349530 0.0027007136 0.7725228846 0.8531751210 10 97450357 97450380 24 + 1.395 1.424 0.102
ENSG00000171307 E024 58.3128299 0.0004200663 0.4208609770 0.5640349292 10 97450381 97450536 156 + 1.637 1.690 0.179
ENSG00000171307 E025 22.5110507 0.0146829507 0.1224302018 0.2234105304 10 97450828 97451193 366 + 1.395 1.252 -0.497
ENSG00000171307 E026 274.8410355 0.0075282390 0.7511998219 0.8376993417 10 97451671 97451735 65 + 2.349 2.346 -0.010
ENSG00000171307 E027 185.3166542 0.0092037910 0.6478814827 0.7594797331 10 97451736 97451748 13 + 2.185 2.174 -0.039
ENSG00000171307 E028 382.1134366 0.0046359244 0.7348208926 0.8256895909 10 97451749 97451850 102 + 2.493 2.489 -0.012
ENSG00000171307 E029 360.6596454 0.0013661833 0.3755403327 0.5199706882 10 97451851 97451918 68 + 2.477 2.460 -0.056
ENSG00000171307 E030 725.2010984 0.0001190699 0.1027767597 0.1947308557 10 97452090 97452284 195 + 2.782 2.763 -0.061
ENSG00000171307 E031 652.8177602 0.0004012102 0.6719863125 0.7780956833 10 97452415 97452503 89 + 2.710 2.726 0.054
ENSG00000171307 E032 6.2008339 0.0092605197 0.1530080791 0.2657643859 10 97452807 97452809 3 + 0.932 0.744 -0.733
ENSG00000171307 E033 22.9791348 0.0077908416 0.0440089699 0.0984015594 10 97452810 97452894 85 + 1.424 1.254 -0.593
ENSG00000171307 E034 423.2095073 0.0001821278 0.3213025812 0.4645373950 10 97452895 97452923 29 + 2.511 2.540 0.096
ENSG00000171307 E035 342.1850681 0.0001677647 0.5877336239 0.7109935343 10 97453530 97453553 24 + 2.446 2.441 -0.017
ENSG00000171307 E036 463.2924062 0.0001673161 0.6953537340 0.7959774671 10 97453554 97453617 64 + 2.573 2.572 -0.001
ENSG00000171307 E037 461.1974607 0.0001364717 0.1379909795 0.2452803256 10 97453618 97453663 46 + 2.540 2.578 0.126
ENSG00000171307 E038 171.0932759 0.0009711220 0.0093268418 0.0271003405 10 97453799 97453846 48 + 2.208 2.127 -0.270
ENSG00000171307 E039 606.3106506 0.0003718020 0.3756877641 0.5200949962 10 97454714 97454799 86 + 2.697 2.688 -0.029
ENSG00000171307 E040 91.0120956 0.0007738852 0.0022779563 0.0080839202 10 97455602 97455638 37 + 1.745 1.902 0.529
ENSG00000171307 E041 81.4834434 0.0003435825 0.0435548158 0.0975657331 10 97455639 97455659 21 + 1.736 1.843 0.360
ENSG00000171307 E042 468.8555619 0.0009914310 0.3481912560 0.4924103947 10 97455660 97455713 54 + 2.590 2.576 -0.046
ENSG00000171307 E043 399.9657510 0.0002333035 0.1299856651 0.2341506936 10 97455714 97455716 3 + 2.528 2.503 -0.084
ENSG00000171307 E044 686.5446075 0.0006029334 0.9489866274 0.9720136333 10 97455717 97455783 67 + 2.738 2.746 0.026
ENSG00000171307 E045 709.7402135 0.0009252528 0.0003628103 0.0016299491 10 97455974 97456044 71 + 2.690 2.776 0.287
ENSG00000171307 E046 20.3737408 0.0363832213 0.0166898349 0.0442549498 10 97456045 97456428 384 + 1.452 1.175 -0.970
ENSG00000171307 E047 1934.3120971 0.0052953384 0.0001686083 0.0008292186 10 97456777 97457922 1146 + 3.088 3.219 0.436