ENSG00000171302

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302345 ENSG00000171302 HEK293_OSMI2_2hA HEK293_TMG_2hB CANT1 protein_coding protein_coding 52.41519 73.23487 39.19348 4.198904 0.7055176 -0.9017459 17.217199 20.7217577 14.713582 1.7266497 0.1349479 -0.4937137 0.33878333 0.282866667 0.37566667 0.0928 0.007671386 0.002871163 FALSE TRUE
ENST00000392446 ENSG00000171302 HEK293_OSMI2_2hA HEK293_TMG_2hB CANT1 protein_coding protein_coding 52.41519 73.23487 39.19348 4.198904 0.7055176 -0.9017459 28.020067 45.1026658 16.854309 3.4511379 1.2275142 -1.4195593 0.51396250 0.614633333 0.43093333 -0.1837 0.004431769 0.002871163 FALSE TRUE
MSTRG.15196.9 ENSG00000171302 HEK293_OSMI2_2hA HEK293_TMG_2hB CANT1 protein_coding   52.41519 73.23487 39.19348 4.198904 0.7055176 -0.9017459 1.197662 0.2970089 2.227111 0.1728555 0.2608672 2.8652841 0.02710417 0.004033333 0.05663333 0.0526 0.002871163 0.002871163 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171302 E001 8.8292406 2.005491e-03 1.819050e-06 1.428154e-05 17 78991716 78991716 1 - 0.289 1.071 3.511
ENSG00000171302 E002 9.0109450 1.966562e-03 1.301578e-06 1.054797e-05 17 78991717 78991719 3 - 0.289 1.079 3.541
ENSG00000171302 E003 30.2115104 2.609176e-03 9.054227e-06 6.078946e-05 17 78991720 78991726 7 - 1.138 1.534 1.379
ENSG00000171302 E004 62.8507553 1.113760e-02 2.237490e-06 1.722203e-05 17 78991727 78991768 42 - 1.446 1.844 1.355
ENSG00000171302 E005 162.7161539 6.993281e-03 1.661439e-08 1.966233e-07 17 78991769 78991805 37 - 1.905 2.242 1.129
ENSG00000171302 E006 507.7679369 9.472931e-03 4.572358e-07 4.074985e-06 17 78991806 78991912 107 - 2.437 2.725 0.961
ENSG00000171302 E007 910.0176285 5.520936e-03 4.831102e-09 6.322449e-08 17 78991913 78992140 228 - 2.723 2.971 0.824
ENSG00000171302 E008 675.4428940 2.079959e-03 1.010169e-15 3.810704e-14 17 78992141 78992409 269 - 2.594 2.840 0.818
ENSG00000171302 E009 901.5208252 1.088508e-03 1.027631e-09 1.520951e-08 17 78992410 78992761 352 - 2.793 2.946 0.507
ENSG00000171302 E010 668.2164684 1.378540e-04 1.457416e-03 5.498529e-03 17 78992762 78992980 219 - 2.719 2.798 0.263
ENSG00000171302 E011 1080.3548013 8.521441e-05 5.987952e-02 1.264082e-01 17 78992981 78993486 506 - 2.981 2.987 0.022
ENSG00000171302 E012 779.9258399 3.123547e-03 5.952151e-04 2.515823e-03 17 78993487 78993783 297 - 2.891 2.826 -0.216
ENSG00000171302 E013 413.1508431 8.047781e-03 1.881572e-01 3.114162e-01 17 78993784 78993920 137 - 2.588 2.563 -0.085
ENSG00000171302 E014 636.4307214 2.185037e-03 1.493077e-04 7.440132e-04 17 78995018 78995221 204 - 2.803 2.737 -0.222
ENSG00000171302 E015 1.1769825 1.064774e-02 3.164095e-01 4.591702e-01 17 78995222 78995249 28 - 0.168 0.370 1.510
ENSG00000171302 E016 2.1401103 7.653185e-03 5.615138e-01 6.893102e-01 17 78996976 78996991 16 - 0.526 0.446 -0.396
ENSG00000171302 E017 532.1286112 1.496883e-04 1.365838e-23 1.291188e-21 17 78996992 78997105 114 - 2.772 2.636 -0.455
ENSG00000171302 E018 549.7889467 1.377018e-04 1.619661e-26 2.012064e-24 17 78997106 78997329 224 - 2.790 2.647 -0.478
ENSG00000171302 E019 181.1993148 2.684526e-04 1.682422e-09 2.390175e-08 17 78997330 78997392 63 - 2.308 2.166 -0.472
ENSG00000171302 E020 107.4095545 2.594457e-03 2.758185e-02 6.717695e-02 17 78997393 78997426 34 - 2.032 1.965 -0.225
ENSG00000171302 E021 58.8613691 2.775654e-03 1.233610e-01 2.247496e-01 17 78997427 78997439 13 - 1.768 1.712 -0.188
ENSG00000171302 E022 87.9129398 3.457027e-04 8.509688e-01 9.075805e-01 17 78997440 78997490 51 - 1.884 1.904 0.069
ENSG00000171302 E023 97.7385685 3.371996e-03 6.085930e-01 7.282926e-01 17 78997491 78997506 16 - 1.905 1.959 0.183
ENSG00000171302 E024 145.1111205 3.614154e-03 3.369755e-01 4.808379e-01 17 78997507 78997576 70 - 2.123 2.113 -0.034
ENSG00000171302 E025 205.1082071 6.284077e-03 1.552308e-02 4.167861e-02 17 78997577 78997644 68 - 2.322 2.243 -0.267
ENSG00000171302 E026 64.8767873 9.709434e-03 1.619145e-01 2.776249e-01 17 78997645 78997665 21 - 1.817 1.753 -0.215
ENSG00000171302 E027 115.4611785 3.409829e-03 6.632763e-03 2.027038e-02 17 78997666 78997774 109 - 2.084 1.992 -0.307
ENSG00000171302 E028 104.1907713 9.490093e-04 1.062483e-07 1.074031e-06 17 78997775 78997839 65 - 2.096 1.922 -0.584
ENSG00000171302 E029 280.7110804 1.696070e-03 1.077686e-11 2.233746e-10 17 78997840 78997963 124 - 2.515 2.347 -0.561
ENSG00000171302 E030 5.6023732 3.878450e-03 4.140536e-01 5.574672e-01 17 78998148 78998228 81 - 0.679 0.820 0.569
ENSG00000171302 E031 4.5266407 1.044487e-02 9.802061e-02 1.875009e-01 17 78998229 78998286 58 - 0.461 0.758 1.323
ENSG00000171302 E032 0.6934063 1.218371e-01 2.116250e-01 3.404095e-01 17 78998287 78998293 7 - 0.000 0.278 10.226
ENSG00000171302 E033 20.1573695 2.021569e-03 3.691099e-03 1.227022e-02 17 79000100 79000270 171 - 1.415 1.211 -0.714
ENSG00000171302 E034 3.5730715 4.513315e-03 6.471005e-02 1.345667e-01 17 79005372 79005481 110 - 0.792 0.540 -1.074
ENSG00000171302 E035 0.6685028 1.649272e-02 4.289509e-01 5.716820e-01 17 79005957 79006213 257 - 0.289 0.161 -1.074
ENSG00000171302 E036 2.3313665 7.050839e-03 3.490309e-01 4.932554e-01 17 79008063 79008171 109 - 0.584 0.446 -0.659
ENSG00000171302 E037 194.9171252 6.959081e-03 5.742000e-07 5.022415e-06 17 79009664 79009867 204 - 2.382 2.175 -0.692