ENSG00000171298

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302262 ENSG00000171298 HEK293_OSMI2_2hA HEK293_TMG_2hB GAA protein_coding protein_coding 54.39325 76.72661 39.73531 5.173491 1.382649 -0.9491306 5.580557 5.719066 5.3570422 1.1913147 0.2377452 -0.09417272 0.10744167 0.07373333 0.13536667 0.06163333 4.952000e-02 1.360435e-07 FALSE TRUE
ENST00000390015 ENSG00000171298 HEK293_OSMI2_2hA HEK293_TMG_2hB GAA protein_coding protein_coding 54.39325 76.72661 39.73531 5.173491 1.382649 -0.9491306 12.083413 16.655123 11.8412572 0.2236311 1.4775640 -0.49179185 0.23742083 0.21886667 0.29643333 0.07756667 1.827071e-01 1.360435e-07 FALSE TRUE
ENST00000570716 ENSG00000171298 HEK293_OSMI2_2hA HEK293_TMG_2hB GAA protein_coding retained_intron 54.39325 76.72661 39.73531 5.173491 1.382649 -0.9491306 6.108934 5.561670 4.6865196 0.6231852 0.1030162 -0.24651779 0.11722917 0.07213333 0.11813333 0.04600000 3.519289e-04 1.360435e-07   FALSE
ENST00000572803 ENSG00000171298 HEK293_OSMI2_2hA HEK293_TMG_2hB GAA protein_coding retained_intron 54.39325 76.72661 39.73531 5.173491 1.382649 -0.9491306 4.198674 3.872419 2.9476607 1.1007917 0.3671290 -0.39249928 0.07797083 0.04906667 0.07460000 0.02553333 3.666657e-01 1.360435e-07 TRUE FALSE
ENST00000573556 ENSG00000171298 HEK293_OSMI2_2hA HEK293_TMG_2hB GAA protein_coding retained_intron 54.39325 76.72661 39.73531 5.173491 1.382649 -0.9491306 6.971852 17.796564 0.7312191 3.1408731 0.2738337 -4.58636527 0.10240833 0.23300000 0.01816667 -0.21483333 7.590277e-06 1.360435e-07 FALSE TRUE
ENST00000574376 ENSG00000171298 HEK293_OSMI2_2hA HEK293_TMG_2hB GAA protein_coding processed_transcript 54.39325 76.72661 39.73531 5.173491 1.382649 -0.9491306 3.377844 5.910304 1.0135142 0.1940175 0.1550404 -2.53214006 0.06050417 0.07780000 0.02526667 -0.05253333 1.360435e-07 1.360435e-07   FALSE
MSTRG.15217.1 ENSG00000171298 HEK293_OSMI2_2hA HEK293_TMG_2hB GAA protein_coding   54.39325 76.72661 39.73531 5.173491 1.382649 -0.9491306 14.033656 19.319689 11.4412211 2.7296771 0.6437951 -0.75531701 0.25816250 0.25043333 0.28940000 0.03896667 6.831459e-01 1.360435e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171298 E001 2.314313 0.0067939363 5.966011e-01 7.185178e-01 17 80101532 80101555 24 + 0.437 0.537 0.494
ENSG00000171298 E002 11.063972 0.0015578708 6.991919e-02 1.432462e-01 17 80101556 80101580 25 + 1.159 0.991 -0.611
ENSG00000171298 E003 19.023775 0.0009507117 2.621071e-02 6.437719e-02 17 80101581 80101586 6 + 1.372 1.208 -0.573
ENSG00000171298 E004 23.340616 0.0008502879 2.057265e-02 5.269713e-02 17 80101587 80101593 7 + 1.452 1.297 -0.537
ENSG00000171298 E005 29.627171 0.0006649130 1.568425e-02 4.203019e-02 17 80101594 80101596 3 + 1.542 1.397 -0.497
ENSG00000171298 E006 78.996871 0.0022173937 6.580743e-01 7.672862e-01 17 80101597 80101625 29 + 1.871 1.864 -0.022
ENSG00000171298 E007 40.744422 0.0007444306 6.966351e-03 2.113636e-02 17 80101626 80101810 185 + 1.672 1.532 -0.476
ENSG00000171298 E008 110.804003 0.0014167892 9.550013e-03 2.765928e-02 17 80101811 80101890 80 + 2.070 1.984 -0.290
ENSG00000171298 E009 15.949880 0.0287839104 3.090357e-03 1.053192e-02 17 80101891 80101925 35 + 0.899 1.288 1.412
ENSG00000171298 E010 82.056402 0.0032673503 2.173098e-20 1.454724e-18 17 80101926 80102733 808 + 1.445 2.002 1.888
ENSG00000171298 E011 565.485645 0.0038958936 2.684062e-03 9.325939e-03 17 80104555 80105132 578 + 2.772 2.694 -0.257
ENSG00000171298 E012 263.890313 0.0046430596 3.528043e-02 8.218595e-02 17 80105749 80105894 146 + 2.432 2.368 -0.212
ENSG00000171298 E013 316.041409 0.0007627676 1.412087e-05 9.059424e-05 17 80107557 80107722 166 + 2.524 2.435 -0.297
ENSG00000171298 E014 254.860687 0.0004328489 6.750701e-05 3.680924e-04 17 80107800 80107896 97 + 2.428 2.345 -0.279
ENSG00000171298 E015 292.404254 0.0001827506 1.268813e-05 8.232509e-05 17 80108290 80108409 120 + 2.487 2.406 -0.271
ENSG00000171298 E016 319.712350 0.0001633786 2.223973e-04 1.059549e-03 17 80108489 80108607 119 + 2.513 2.449 -0.211
ENSG00000171298 E017 354.549982 0.0001349303 7.797398e-07 6.630133e-06 17 80108697 80108828 132 + 2.570 2.487 -0.278
ENSG00000171298 E018 360.686479 0.0012910327 1.549227e-02 4.161123e-02 17 80109945 80110055 111 + 2.552 2.508 -0.149
ENSG00000171298 E019 360.109094 0.0003064001 1.893039e-04 9.182475e-04 17 80110727 80110840 114 + 2.562 2.500 -0.209
ENSG00000171298 E020 271.361879 0.0002233084 5.237283e-04 2.248431e-03 17 80110941 80111001 61 + 2.445 2.379 -0.219
ENSG00000171298 E021 206.659328 0.0001764138 5.055573e-04 2.181047e-03 17 80111002 80111025 24 + 2.333 2.257 -0.253
ENSG00000171298 E022 56.154234 0.0163960405 1.972257e-02 5.090160e-02 17 80111733 80111982 250 + 1.817 1.665 -0.513
ENSG00000171298 E023 366.977307 0.0001321053 2.943636e-02 7.084675e-02 17 80111983 80112100 118 + 2.549 2.521 -0.095
ENSG00000171298 E024 46.516204 0.0004867542 3.673837e-05 2.136468e-04 17 80112384 80112577 194 + 1.771 1.570 -0.684
ENSG00000171298 E025 314.586902 0.0001575480 4.921887e-02 1.077712e-01 17 80112578 80112711 134 + 2.483 2.455 -0.093
ENSG00000171298 E026 18.833748 0.0009880431 1.892824e-01 3.128319e-01 17 80112845 80112875 31 + 1.321 1.228 -0.327
ENSG00000171298 E027 342.494901 0.0001805302 2.968111e-01 4.380896e-01 17 80112876 80113027 152 + 2.475 2.511 0.120
ENSG00000171298 E028 375.302461 0.0006560605 4.609235e-03 1.484539e-02 17 80113218 80113366 149 + 2.482 2.563 0.269
ENSG00000171298 E029 6.304150 0.0027289922 8.468370e-01 9.048240e-01 17 80116826 80116967 142 + 0.849 0.836 -0.050
ENSG00000171298 E030 388.776471 0.0002021588 6.088224e-06 4.251523e-05 17 80116968 80117109 142 + 2.479 2.585 0.353
ENSG00000171298 E031 431.207842 0.0001855482 2.546257e-10 4.185880e-09 17 80117600 80117749 150 + 2.502 2.639 0.456
ENSG00000171298 E032 502.836702 0.0014293300 2.854876e-04 1.320816e-03 17 80118193 80118357 165 + 2.595 2.701 0.353
ENSG00000171298 E033 540.584316 0.0013172933 3.513874e-07 3.204761e-06 17 80118653 80118805 153 + 2.600 2.739 0.463
ENSG00000171298 E034 881.086009 0.0045369224 1.262633e-08 1.527764e-07 17 80119272 80119881 610 + 2.762 2.970 0.695