ENSG00000171163

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306601 ENSG00000171163 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF692 protein_coding protein_coding 21.65126 20.94062 15.99459 3.006949 0.5164634 -0.3885077 0.7296263 2.0874392 0.1768186 0.6975423 0.1768186 -3.48891910 0.03375000 0.09633333 0.01063333 -0.085700000 5.832806e-02 6.616421e-07 FALSE  
ENST00000462037 ENSG00000171163 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF692 protein_coding retained_intron 21.65126 20.94062 15.99459 3.006949 0.5164634 -0.3885077 2.4198329 1.3438895 2.2434893 0.1053328 0.3445925 0.73505058 0.11220833 0.06556667 0.13913333 0.073566667 5.839678e-03 6.616421e-07    
ENST00000463519 ENSG00000171163 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF692 protein_coding nonsense_mediated_decay 21.65126 20.94062 15.99459 3.006949 0.5164634 -0.3885077 1.0584044 0.8379592 0.7201918 0.1309637 0.3601828 -0.21571940 0.05134167 0.04293333 0.04600000 0.003066667 9.154897e-01 6.616421e-07 FALSE  
ENST00000474351 ENSG00000171163 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF692 protein_coding retained_intron 21.65126 20.94062 15.99459 3.006949 0.5164634 -0.3885077 1.5291259 0.9404605 1.0497997 0.2141509 0.4304122 0.15709303 0.06860417 0.04433333 0.06480000 0.020466667 7.763864e-01 6.616421e-07 FALSE  
ENST00000476503 ENSG00000171163 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF692 protein_coding protein_coding 21.65126 20.94062 15.99459 3.006949 0.5164634 -0.3885077 2.4721623 4.7526959 2.1506653 0.5606494 0.6477931 -1.14030286 0.11745417 0.22940000 0.13466667 -0.094733333 2.690194e-01 6.616421e-07 FALSE  
ENST00000477070 ENSG00000171163 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF692 protein_coding nonsense_mediated_decay 21.65126 20.94062 15.99459 3.006949 0.5164634 -0.3885077 1.5172468 1.1072090 0.0000000 0.6500735 0.0000000 -6.80375529 0.06445417 0.04676667 0.00000000 -0.046766667 1.556565e-01 6.616421e-07 FALSE  
ENST00000482023 ENSG00000171163 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF692 protein_coding nonsense_mediated_decay 21.65126 20.94062 15.99459 3.006949 0.5164634 -0.3885077 1.2341684 1.0450123 0.5211960 0.5797525 0.2865109 -0.98994368 0.05508333 0.04476667 0.03290000 -0.011866667 9.676189e-01 6.616421e-07    
ENST00000497847 ENSG00000171163 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF692 protein_coding retained_intron 21.65126 20.94062 15.99459 3.006949 0.5164634 -0.3885077 1.9385511 0.2212565 1.6855840 0.2212565 0.2086000 2.87421617 0.08540417 0.01300000 0.10606667 0.093066667 5.947872e-02 6.616421e-07 FALSE  
ENST00000533927 ENSG00000171163 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF692 protein_coding retained_intron 21.65126 20.94062 15.99459 3.006949 0.5164634 -0.3885077 4.6649744 3.6013684 3.5320492 0.1563730 0.5238674 -0.02796135 0.21074167 0.17753333 0.22153333 0.044000000 6.807735e-01 6.616421e-07 FALSE  
MSTRG.3458.12 ENSG00000171163 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF692 protein_coding   21.65126 20.94062 15.99459 3.006949 0.5164634 -0.3885077 1.0707919 1.9614914 0.1864691 0.1612321 0.1864691 -3.32691310 0.05140417 0.09876667 0.01120000 -0.087566667 5.622657e-02 6.616421e-07 FALSE  
MSTRG.3458.8 ENSG00000171163 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF692 protein_coding   21.65126 20.94062 15.99459 3.006949 0.5164634 -0.3885077 0.2612987 0.0000000 0.9268987 0.0000000 0.2819696 6.54982110 0.01475417 0.00000000 0.05870000 0.058700000 6.616421e-07 6.616421e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171163 E001 0.5514428 0.0197291602 1.877294e-01 3.108780e-01 1 248850006 248850007 2 - 0.000 0.247 10.549
ENSG00000171163 E002 0.5514428 0.0197291602 1.877294e-01 3.108780e-01 1 248850008 248850008 1 - 0.000 0.247 13.288
ENSG00000171163 E003 3.9686412 0.0040372399 3.301406e-02 7.783188e-02 1 248850009 248850023 15 - 0.425 0.767 1.549
ENSG00000171163 E004 10.8896366 0.0015622230 5.546422e-01 6.835988e-01 1 248850024 248850041 18 - 1.005 1.069 0.234
ENSG00000171163 E005 11.4828093 0.0018878913 3.436006e-01 4.876511e-01 1 248850042 248850044 3 - 1.005 1.105 0.365
ENSG00000171163 E006 16.5693795 0.0010897440 8.013595e-01 8.734395e-01 1 248850045 248850059 15 - 1.202 1.226 0.086
ENSG00000171163 E007 23.9487227 0.0008807043 4.293857e-01 5.721046e-01 1 248850060 248850065 6 - 1.406 1.351 -0.189
ENSG00000171163 E008 52.0556089 0.0071370442 2.494521e-01 3.852697e-01 1 248850066 248850108 43 - 1.645 1.727 0.278
ENSG00000171163 E009 50.8752867 0.0123765981 1.611001e-01 2.765538e-01 1 248850109 248850110 2 - 1.611 1.727 0.394
ENSG00000171163 E010 76.3192416 0.0062197758 1.699866e-01 2.881844e-01 1 248850111 248850158 48 - 1.803 1.889 0.288
ENSG00000171163 E011 122.9507015 0.0003303243 2.236343e-03 7.955467e-03 1 248850159 248850281 123 - 1.991 2.099 0.359
ENSG00000171163 E012 123.3319059 0.0002871874 8.088753e-06 5.486538e-05 1 248850282 248850376 95 - 1.957 2.113 0.524
ENSG00000171163 E013 63.5453393 0.0004274127 4.176991e-03 1.364177e-02 1 248850377 248850383 7 - 1.684 1.822 0.469
ENSG00000171163 E014 129.5783353 0.0002555108 3.316623e-06 2.459662e-05 1 248850384 248850516 133 - 1.973 2.132 0.534
ENSG00000171163 E015 98.5545937 0.0014132500 8.936703e-04 3.591954e-03 1 248850682 248850781 100 - 1.869 2.012 0.482
ENSG00000171163 E016 7.2562915 0.0134768919 4.373552e-01 5.793251e-01 1 248850863 248850947 85 - 0.949 0.854 -0.359
ENSG00000171163 E017 122.4254339 0.0075697179 2.407177e-01 3.750236e-01 1 248853937 248854051 115 - 2.013 2.087 0.250
ENSG00000171163 E018 28.9404401 0.0047891824 8.859910e-08 9.084177e-07 1 248854052 248854523 472 - 1.661 1.283 -1.301
ENSG00000171163 E019 60.5113725 0.0395145776 6.713565e-01 7.776041e-01 1 248855380 248855383 4 - 1.718 1.784 0.223
ENSG00000171163 E020 92.2433638 0.0049539991 7.338445e-02 1.489343e-01 1 248855384 248855458 75 - 1.874 1.972 0.330
ENSG00000171163 E021 59.3900669 0.0004962680 3.095967e-01 4.519144e-01 1 248855558 248855594 37 - 1.716 1.767 0.174
ENSG00000171163 E022 58.4576841 0.0053437912 3.686904e-01 5.130888e-01 1 248855595 248855635 41 - 1.705 1.761 0.190
ENSG00000171163 E023 51.2251881 0.0013557104 4.653541e-01 6.050744e-01 1 248855636 248855724 89 - 1.709 1.673 -0.122
ENSG00000171163 E024 43.3838202 0.0089010190 4.583364e-01 5.986739e-01 1 248855725 248855727 3 - 1.648 1.599 -0.167
ENSG00000171163 E025 68.0722932 0.0016590995 2.590269e-01 3.963898e-01 1 248855728 248855781 54 - 1.768 1.825 0.194
ENSG00000171163 E026 110.5618353 0.0050693830 1.770274e-01 2.973798e-01 1 248855782 248855943 162 - 1.971 2.041 0.237
ENSG00000171163 E027 40.1058545 0.0049843055 6.646978e-01 7.724797e-01 1 248855944 248855946 3 - 1.559 1.594 0.120
ENSG00000171163 E028 7.9920347 0.0431972529 1.521601e-02 4.097727e-02 1 248855947 248856086 140 - 1.128 0.771 -1.342
ENSG00000171163 E029 68.4771735 0.0007403610 6.336493e-01 7.483155e-01 1 248856288 248856372 85 - 1.798 1.822 0.083
ENSG00000171163 E030 56.0397359 0.0004707348 8.645729e-01 9.167067e-01 1 248856373 248856422 50 - 1.723 1.734 0.036
ENSG00000171163 E031 43.5206294 0.0005014222 2.481223e-01 3.837133e-01 1 248856514 248856514 1 - 1.661 1.600 -0.205
ENSG00000171163 E032 59.5228328 0.0003936033 3.377612e-01 4.816582e-01 1 248856515 248856562 48 - 1.780 1.738 -0.144
ENSG00000171163 E033 55.0019732 0.0004261465 6.941948e-01 7.950736e-01 1 248857234 248857272 39 - 1.730 1.713 -0.057
ENSG00000171163 E034 59.5936093 0.0004260301 5.287977e-01 6.616765e-01 1 248857273 248857312 40 - 1.733 1.765 0.109
ENSG00000171163 E035 64.0045591 0.0004474121 9.251798e-01 9.569106e-01 1 248857313 248857364 52 - 1.786 1.784 -0.007
ENSG00000171163 E036 47.5256215 0.0005101901 9.474624e-01 9.709564e-01 1 248857365 248857390 26 - 1.657 1.655 -0.005
ENSG00000171163 E037 52.7247681 0.0028929292 2.736925e-01 4.127710e-01 1 248857391 248857436 46 - 1.743 1.684 -0.199
ENSG00000171163 E038 35.6419499 0.0012993979 7.547466e-02 1.522764e-01 1 248857437 248857439 3 - 1.606 1.501 -0.361
ENSG00000171163 E039 51.9831492 0.0004800786 1.436142e-01 2.529264e-01 1 248857440 248857468 29 - 1.743 1.672 -0.240
ENSG00000171163 E040 52.9110169 0.0005569286 1.019833e-01 1.935297e-01 1 248857469 248857497 29 - 1.756 1.677 -0.267
ENSG00000171163 E041 36.4290362 0.0020076593 3.640008e-03 1.212698e-02 1 248857498 248857556 59 - 1.657 1.483 -0.594
ENSG00000171163 E042 24.2188475 0.0008187113 1.594126e-02 4.260122e-02 1 248857557 248857568 12 - 1.477 1.310 -0.580
ENSG00000171163 E043 32.9512235 0.0007430034 4.414450e-02 9.865221e-02 1 248857569 248857609 41 - 1.579 1.456 -0.419
ENSG00000171163 E044 24.4629912 0.0008659611 6.766791e-01 7.815852e-01 1 248857610 248857651 42 - 1.399 1.371 -0.097
ENSG00000171163 E045 16.4876388 0.0031242190 2.725567e-01 4.114861e-01 1 248857652 248857668 17 - 1.284 1.191 -0.327
ENSG00000171163 E046 13.5766944 0.0203892849 2.402170e-02 5.986134e-02 1 248857669 248857738 70 - 1.293 1.047 -0.879
ENSG00000171163 E047 26.8255099 0.0007512849 8.097505e-07 6.857919e-06 1 248857739 248857827 89 - 1.606 1.282 -1.119
ENSG00000171163 E048 36.7050233 0.0007839642 1.559713e-02 4.184067e-02 1 248857828 248857845 18 - 1.636 1.497 -0.476
ENSG00000171163 E049 35.7001784 0.0050488225 4.193021e-02 9.459989e-02 1 248857846 248857859 14 - 1.620 1.484 -0.462
ENSG00000171163 E050 22.1198454 0.0014817658 1.543551e-03 5.776675e-03 1 248857860 248857864 5 - 1.477 1.246 -0.805
ENSG00000171163 E051 46.3687151 0.0004952539 3.181268e-03 1.080133e-02 1 248857865 248857974 110 - 1.743 1.592 -0.513
ENSG00000171163 E052 32.8823028 0.0044174936 4.992199e-02 1.090348e-01 1 248857975 248858017 43 - 1.588 1.456 -0.451
ENSG00000171163 E053 21.9428938 0.0012466567 1.564923e-02 4.195608e-02 1 248858018 248858034 17 - 1.446 1.270 -0.613
ENSG00000171163 E054 19.9647943 0.0089669438 2.070253e-02 5.296037e-02 1 248858035 248858065 31 - 1.420 1.220 -0.699
ENSG00000171163 E055 25.2453464 0.0108249296 7.326053e-02 1.487329e-01 1 248858066 248858130 65 - 1.483 1.334 -0.517
ENSG00000171163 E056 52.5808720 0.0100591535 3.589586e-01 5.032944e-01 1 248858131 248858321 191 - 1.733 1.677 -0.190
ENSG00000171163 E057 8.2380803 0.0635681564 6.198379e-01 7.371355e-01 1 248858322 248858385 64 - 0.988 0.905 -0.310
ENSG00000171163 E058 4.7131847 0.1850516525 6.592774e-01 7.681264e-01 1 248858386 248858419 34 - 0.836 0.667 -0.682
ENSG00000171163 E059 9.0205362 0.0397312957 2.723972e-01 4.112781e-01 1 248858420 248858511 92 - 1.072 0.914 -0.584
ENSG00000171163 E060 17.4624930 0.0012011954 2.491022e-02 6.168763e-02 1 248858512 248858860 349 - 1.345 1.163 -0.642
ENSG00000171163 E061 14.8226303 0.0082054142 8.772436e-01 9.251603e-01 1 248858918 248859014 97 - 1.179 1.164 -0.052
ENSG00000171163 E062 7.4823800 0.0023457982 7.872678e-01 8.637603e-01 1 248859015 248859144 130 - 0.928 0.897 -0.114