ENSG00000171160

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307450 ENSG00000171160 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN4 protein_coding protein_coding 21.08754 30.55213 13.91019 0.5102077 1.389028 -1.134567 8.706958 10.683048 6.6972414 0.7437698 0.1856745 -0.6728817 0.43010000 0.3496333 0.48790000 0.138266667 0.05101431 0.04073522 FALSE TRUE
ENST00000370635 ENSG00000171160 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN4 protein_coding protein_coding 21.08754 30.55213 13.91019 0.5102077 1.389028 -1.134567 7.420937 13.485205 4.1922933 0.1567444 0.8409903 -1.6831982 0.33525833 0.4418333 0.29696667 -0.144866667 0.04073522 0.04073522   FALSE
MSTRG.4451.1 ENSG00000171160 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN4 protein_coding   21.08754 30.55213 13.91019 0.5102077 1.389028 -1.134567 1.152685 3.270196 0.3900898 0.6177196 0.3006090 -3.0353861 0.04900417 0.1066667 0.03133333 -0.075333333 0.25869707 0.04073522 FALSE TRUE
MSTRG.4451.4 ENSG00000171160 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN4 protein_coding   21.08754 30.55213 13.91019 0.5102077 1.389028 -1.134567 2.387451 3.064416 1.4363561 0.2899701 0.2878797 -1.0878895 0.11426250 0.1003667 0.10440000 0.004033333 1.00000000 0.04073522 FALSE FALSE
MSTRG.4451.5 ENSG00000171160 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN4 protein_coding   21.08754 30.55213 13.91019 0.5102077 1.389028 -1.134567 1.363762 0.000000 1.1942055 0.0000000 0.6831048 6.9119378 0.06849167 0.0000000 0.07936667 0.079366667 0.10733942 0.04073522   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171160 E001 0.5514428 0.0198991665 0.3155949093 0.4583527887 10 97614406 97614552 147 - 0.000 0.218 9.688
ENSG00000171160 E002 0.7728880 0.0159605192 0.1917425739 0.3159469732 10 97614553 97614554 2 - 0.000 0.272 11.074
ENSG00000171160 E003 7.4090445 0.0023254812 0.0012346897 0.0047584883 10 97614555 97614571 17 - 0.470 0.976 2.116
ENSG00000171160 E004 686.8651035 0.0047788363 0.1998869395 0.3261051396 10 97614572 97616411 1840 - 2.755 2.797 0.141
ENSG00000171160 E005 103.1826540 0.0014264780 0.1524645950 0.2650293633 10 97616678 97616787 110 - 1.992 1.954 -0.127
ENSG00000171160 E006 1.5113352 0.0090794579 0.8198166917 0.8862631133 10 97616857 97616928 72 - 0.392 0.362 -0.169
ENSG00000171160 E007 94.2013071 0.0008447510 0.0001074668 0.0005564771 10 97617208 97617322 115 - 2.019 1.889 -0.437
ENSG00000171160 E008 43.0516592 0.0005515453 0.0018985888 0.0069100505 10 97619410 97619586 177 - 1.429 1.643 0.733
ENSG00000171160 E009 130.6024495 0.0003296191 0.1673701930 0.2847808171 10 97619587 97619683 97 - 2.088 2.064 -0.082
ENSG00000171160 E010 90.1969922 0.0012255700 0.3164248088 0.4591818455 10 97633347 97633500 154 - 1.924 1.901 -0.077
ENSG00000171160 E011 26.5097282 0.0160027033 0.2765373297 0.4160079619 10 97634005 97634215 211 - 1.301 1.427 0.436