ENSG00000171109

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000466287 ENSG00000171109 HEK293_OSMI2_2hA HEK293_TMG_2hB MFN1 protein_coding retained_intron 12.345 2.158141 22.74483 0.05503241 0.5748288 3.391642 0.5580782 0.0000000 1.345949 0.00000000 0.1650213 7.083159 0.04117083 0.0000000 0.05920000 0.05920000 4.446607e-04 8.251438e-10   FALSE
ENST00000467174 ENSG00000171109 HEK293_OSMI2_2hA HEK293_TMG_2hB MFN1 protein_coding protein_coding 12.345 2.158141 22.74483 0.05503241 0.5748288 3.391642 2.6547158 0.0000000 4.522937 0.00000000 0.4356888 8.824302 0.11725833 0.0000000 0.19963333 0.19963333 8.251438e-10 8.251438e-10 FALSE FALSE
ENST00000471841 ENSG00000171109 HEK293_OSMI2_2hA HEK293_TMG_2hB MFN1 protein_coding protein_coding 12.345 2.158141 22.74483 0.05503241 0.5748288 3.391642 6.1150283 1.7333770 10.652836 0.02782713 0.2871434 2.612635 0.61226250 0.8046000 0.46903333 -0.33556667 4.799013e-08 8.251438e-10 FALSE TRUE
ENST00000489329 ENSG00000171109 HEK293_OSMI2_2hA HEK293_TMG_2hB MFN1 protein_coding protein_coding 12.345 2.158141 22.74483 0.05503241 0.5748288 3.391642 1.7603973 0.0000000 4.422921 0.00000000 0.8373875 8.792114 0.07600000 0.0000000 0.19283333 0.19283333 2.025967e-07 8.251438e-10 FALSE FALSE
MSTRG.24107.1 ENSG00000171109 HEK293_OSMI2_2hA HEK293_TMG_2hB MFN1 protein_coding   12.345 2.158141 22.74483 0.05503241 0.5748288 3.391642 0.7849781 0.2869678 1.153101 0.15894311 0.2312175 1.969598 0.10267500 0.1294667 0.05113333 -0.07833333 7.344319e-01 8.251438e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171109 E001 0.4502799 0.0313810284 1.000000e+00 1.000000e+00 3 179347703 179347708 6 + 0.128 0.000 -8.331
ENSG00000171109 E002 5.3817734 0.0050029462 1.294325e-01 2.333739e-01 3 179347709 179347734 26 + 0.688 0.456 -1.062
ENSG00000171109 E003 47.7516763 0.0004619108 1.225554e-01 2.235981e-01 3 179347735 179347810 76 + 1.520 1.500 -0.069
ENSG00000171109 E004 0.3289534 0.0308002796 1.759536e-01   3 179348050 179348121 72 + 0.047 0.285 3.027
ENSG00000171109 E005 0.5202097 0.0209501290 3.425141e-01 4.865064e-01 3 179348761 179348844 84 + 0.089 0.286 2.028
ENSG00000171109 E006 39.7251971 0.0005482549 1.941903e-01 3.190257e-01 3 179348845 179348847 3 + 1.442 1.432 -0.036
ENSG00000171109 E007 73.0395653 0.0003244819 2.171481e-03 7.754728e-03 3 179348848 179348963 116 + 1.710 1.612 -0.332
ENSG00000171109 E008 83.8773132 0.0003233757 4.279051e-08 4.680446e-07 3 179351900 179352035 136 + 1.784 1.525 -0.880
ENSG00000171109 E009 86.3144188 0.0003496940 1.364583e-05 8.784699e-05 3 179358840 179359002 163 + 1.789 1.622 -0.567
ENSG00000171109 E010 0.2934659 0.0292759951 1.763194e-01   3 179359720 179359860 141 + 0.047 0.285 3.024
ENSG00000171109 E011 78.2671664 0.0007363214 6.663890e-03 2.034816e-02 3 179362358 179362482 125 + 1.737 1.668 -0.235
ENSG00000171109 E012 82.4381936 0.0047627830 2.634007e-02 6.462871e-02 3 179364297 179364405 109 + 1.756 1.702 -0.184
ENSG00000171109 E013 83.2680633 0.0048133191 5.167286e-03 1.638329e-02 3 179365118 179365225 108 + 1.764 1.669 -0.321
ENSG00000171109 E014 99.8862812 0.0023169984 1.081173e-02 3.071346e-02 3 179367439 179367592 154 + 1.837 1.789 -0.163
ENSG00000171109 E015 60.4951848 0.0005429504 1.216122e-02 3.391738e-02 3 179368036 179368103 68 + 1.626 1.549 -0.264
ENSG00000171109 E016 76.6543723 0.0014172666 2.076332e-03 7.460672e-03 3 179375220 179375341 122 + 1.732 1.631 -0.340
ENSG00000171109 E017 2.5057647 0.0061443484 5.408283e-02 1.163942e-01 3 179376922 179377041 120 + 0.468 0.000 -10.825
ENSG00000171109 E018 38.4900152 0.0010417748 3.198786e-02 7.583631e-02 3 179377042 179377061 20 + 1.440 1.349 -0.315
ENSG00000171109 E019 52.5587775 0.0005311334 9.680051e-03 2.797432e-02 3 179377062 179377129 68 + 1.571 1.474 -0.332
ENSG00000171109 E020 35.0434720 0.0005995908 2.385077e-01 3.724106e-01 3 179377130 179377168 39 + 1.391 1.384 -0.023
ENSG00000171109 E021 0.0000000       3 179377169 179377343 175 +      
ENSG00000171109 E022 31.8943464 0.0240848552 9.875442e-01 9.962921e-01 3 179377344 179377448 105 + 1.336 1.419 0.290
ENSG00000171109 E023 46.9057841 0.0103913839 7.315939e-01 8.232256e-01 3 179378341 179378443 103 + 1.501 1.562 0.210
ENSG00000171109 E024 1.0653123 0.0120490999 9.673021e-01 9.835275e-01 3 179378444 179378584 141 + 0.226 0.285 0.442
ENSG00000171109 E025 95.8941846 0.0003604723 6.832221e-01 7.864957e-01 3 179378585 179378814 230 + 1.796 1.913 0.393
ENSG00000171109 E026 84.9750498 0.0004539601 8.902572e-01 9.338783e-01 3 179385569 179385721 153 + 1.749 1.838 0.301
ENSG00000171109 E027 104.7565605 0.0002777395 1.635478e-01 2.797494e-01 3 179386433 179386629 197 + 1.848 1.877 0.096
ENSG00000171109 E028 92.8357235 0.0006525722 4.489065e-01 5.901160e-01 3 179390004 179390138 135 + 1.783 1.918 0.454
ENSG00000171109 E029 351.7792120 0.0160295843 2.414466e-11 4.727267e-10 3 179391981 179394936 2956 + 2.286 2.728 1.472